Alterations in syncytiotrophoblast cytokine expression following treatment with lipopolysaccharide

American Journal of Reproductive Immunology

Volumn 55, Issue 1, 2006, Pages 12-18

  Ma, Yuehong ^a   Mor, Gil ^a   Abrahams, Vikki M ^a   Buhimschi, Irina A ^a   Buhimschi, Catalin S ^a   Guller, Seth ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cytokine; Glucocorticoid; Lipopolysaccharide; Placenta; Syncytiotrophoblast

Indexed keywords

DEXAMETHASONE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 11; INTERLEUKIN 12; INTERLEUKIN 1BETA; INTERLEUKIN 4; INTERLEUKIN 6; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL TYPE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GESTATION PERIOD; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; PLACENTA; PRIORITY JOURNAL; PROTEOMICS; QUANTITATIVE ANALYSIS; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; SYNCYTIOTROPHOBLAST;

ANTI-INFLAMMATORY AGENTS; CELLS, CULTURED; CULTURE MEDIA, CONDITIONED; CYTOKINES; DEXAMETHASONE; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; INTERLEUKIN-8; LIPOPOLYSACCHARIDES; PLACENTA; PREGNANCY; TROPHOBLASTS;

EID: 33644688417     PISSN: 10467408     EISSN: 16000897     Source Type: Journal    
DOI: 10.1111/j.1600-0897.2005.00347.x     Document Type: Article

References (27)

1. Castelucci M, Kaufmann P: Basic structure of the villous trees. Pathology of the Human Placenta, 4th edn, P Kaufmann, K Benirschke ( eds). New York, Springer-Verlag, 2001, pp 50-115.
2. Gude NM, Roberts CT, Kalionis B, King RG: Growth and function of the normal human placenta. Thromb Res 2004; 114: 397 - 407.
3. Maynard SE, Min JY, Merchan J, Lim KH, Li J, Mondal S, Libermann TA, Morgan JP, Sellke FW, Stillman IE, Epstein FH, Sukhatme VP, Karumanchi SA: Excess placental soluble fms-like tyrosine kinase 1 (sFlt-1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. J Clin Invest 2003; 111: 649 - 658.
4. Tjoa ML, Oudejans CB, van Vugt JM, Blankenstein MA, van Wijk IJ: Markers for presymptomatic prediction of preeclampsia and intrauterine growth restriction. Hypertens Pregnancy 2004; 23: 171 - 189.
5. Estelles A, Gilabert J, Grancha S, Yamamoto K, Thinnes T, Espana F Aznar J, Luskutoff DJ: Abnormal expression of type I plasminogen activator inhibitor and tissue factor in severe preeclampsia. Thromb Haemost 1998; 79: 500-508.
6. Shimoya K, Matsuzaki N, Tanaguchi T, Kameda T, Koyama M, Neki R, Saji F, Tanizawa O: Human placenta constitutively expresses interleukin-8 and enhances its production in intrauterine infection. Biol Reprod 1992; 47: 220 - 226.
7. Matsuzaki N, Taniguchi T, Shimoya K, Neki R, Okada T, Saji F, Nakayama M, Suehara N, Tanizawa O: Placental interleukin-6 production is enhanced in intrauterine infection but not in labor. Am J Obstet Gynecol 1993; 168: 94 - 97.
8. Keelan JA, Marvin KW, Sato TA, Coleman M, McCowan LM, Mitchell MD: Cytokine abundance in placental tissues: Evidence of inflammatory activation in gestational membranes with term and preterm parturition. Am J Obstet Gynecol 1999; 181: 1530 - 1536.
9. Lappas M, Permezel M, Georgiou HM, Rice GE: Nuclear factor kappa B regulation of proinflammatory cytokines in human gestational tissues in vitro. Biol Reprod 2002; 67: 668 - 673.
10. Griesinger G, Saleh L, Bauer S, Husslein P, Knofler M: Production of pro- and anti-inflammatory cytokines of human placental trophoblasts in response to pathogenic bacteria. J Soc Gynecol Investig 2001; 8: 334 - 340.
11. Shimoya K, Moriyama A, Matsuzaki N, Ogata I, Koyama M, Azuma C, Saji F, Murata Y: Human placental cells show enhanced production of interleukin (IL)-8 in response to lipopolysaccharide (LPS), IL-1 and tumour necrosis factor (TNF)-alpha, but not to IL-6. Mol Hum Reprod 1999; 5: 885 - 891.
12. Kliman HJ, Nestler JE, Sermasi E, Sanger JM, Strauss JF, III: Purification, characterization, and in vitro differentiation of cytotrophoblasts from human term placentae. Endocrinology 1986; 118: 1567 - 1582.
13. Guller S, LaCroix NC, Kirkun G, Wozniak R, Markiewicz L, Wang EY, Kaplan P, Lockwood CJ: Steroid regulation of oncofetal fibronectin expression in human cytotrophoblasts. J Steroid Biochem Mol Biol 1993; 46: 1 - 10.
14. Douglas GC, King BF: Isolation of pure villous cytotrophoblast from human term placenta using immunomagnetic microspheres. J Immunol Methods 1989; 119: 259 - 268.
15. Rosen T, Krikun G, Ma Y, Wang EY, Lockwood CJ, Guller S: Chronic antagonism of nuclear factor-kappaB activity in cytotrophoblasts by dexamethasone: A potential mechanism for antiinflammatory action of glucocorticoids in human placenta. J Clin Endocrinol Metab 1998; 83: 3647 - 3652.
16. Pomini F, Caruso A, Challis JR: Interleukin-10 modifies the effects of interleukin-1beta and tumor necrosis factor-alpha on the activity and expression of prostaglandin H synthase-2 and the NAD+-dependent 15-hydroxyprostaglandin dehydrogenase in cultured term human villous trophoblast and chorion trophoblast cells. J Clin Endocrinol Metab 1999 84: 4645 - 4651.
17. Abrahams VM, Mor G: Toll-like receptors and their role in the trophoblast. Placenta 2005; 26: 540 - 547.
18. Holmlund U, Cebers G, Dahlfors AR, Sandstedt B, Bremme K, Ekstrom ES, Scheynius A: Expression and regulation of the pattern recognition receptors Toll-like receptor-2 and Toll-like receptor-4 in the human placenta. Immunology 2002; 107: 145 - 151.
19. Kumazaki K, Nakayama M, Yanagihara I, Suehara N, Wada Y: Immunohistochemical distribution of Toll-like receptor 4 in term and preterm human placentas from normal and complicated pregnancy including chorioamnionitis. Hum Pathol 2004; 35: 47 - 54.
20. Abrahams VM, Bole-Aldo P, Kim YM, Straszewski-Chavez SL, Chaiworapongsa T, Romero R, Mor G: Divergent trophoblast responses to bacterial products mediated by TLRs. J Immunol 2004; 173: 4286 - 4296
21. Auphan N, DiDonato JA, Rosette C, Helmberg A, Karin M: Immunosuppression by glucocorticoids: Inhibition of NF-kappa B activity through induction of I kappa B synthesis. Science 1995; 270: 286 - 290.
22. Ray A, Prefontaine KE: Physical association and functional antagonism between the p65 subunit of transcription factor NF- κ B and the glucocorticoid receptor. Proc Natl Acad Sci U S A 1994; 91: 752 - 756
23. Mukaida N, Morita M, Ishikawa Y, Rice N, Okamoto S, Kasahara T, Matsushima K: Novel mechanism of glucocorticoid-mediated gene repression. Nuclear factor-kappa B is target for glucocorticoid-mediated interleukin 8 gene repression. J Biol Chem 1994; 269: 13289 - 13295.
24. Palsson-McDermott EM, O'Neill LA: Signal transduction by the lipopolysaccharide receptor, Toll-like receptor-4. Immunology 2004; 113: 153 - 162.
25. Benirschke K, Kaufmann P: Infectious diseases. In Pathology of the Human Placenta, 4th edn, K Benirschke, P Kaufman (eds). New York, Springer-Verlag, 2001, pp 591 - 684.
26. Xiao J, Garcia-Lloret M, Winkler-Lowen B, Miller R, Simpson K, Guilbert LJ: ICAM-1-mediated adhesion of peripheral blood monocytes to the maternal surface of placental syncytiotrophoblasts: Implications for placental villitis. Am J Pathol 1997; 150: 1845 - 1860.
27. Garcia-Lloret MI, Winkler-Lowen B, Guilbert LJ: Monocytes adhering by LFA-1 to placental syncytiotrophoblasts induce local apoptosis via release of TNF-alpha. A model for hematogenous initiation of placental inflammations. J Leukoc Biol 2000; 686: 903 - 908.