Effects of repeated maternal betamethasone administration on growth and hypothalamic-pituitary-adrenal function of the ovine fetus at term

Journal of Endocrinology

Volumn 165, Issue 1, 2000, Pages 79-91

  Sloboda, D M ^a,c   Newnham, J P ^b   Challis, J R G ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BETAMETHASONE; CORTICOTROPIN; CORTICOTROPIN RELEASING FACTOR RECEPTOR; ESTRADIOL; GROWTH HORMONE; MESSENGER RNA; OXYTOCIN; PROGESTERONE; PROOPIOMELANOCORTIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIRTH WEIGHT; CONTROLLED STUDY; CORTICOTROPIN BLOOD LEVEL; ESTRADIOL BLOOD LEVEL; FEMALE; FETUS; FETUS GROWTH; FETUS WEIGHT; HORMONE ACTION; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; MATERNAL PLASMA; NONHUMAN; PRENATAL EXPOSURE; PRIORITY JOURNAL; PROGESTERONE BLOOD LEVEL; SHEEP;

EID: 0034115174     PISSN: 00220795     EISSN: None     Source Type: Journal    
DOI: 10.1677/joe.0.1650079     Document Type: Article

References (59)

1. Antolovich GC, McMillen IC, Robinson PM, Silver M, Young IR & Perry RA 1991 The effect of hypothalamo-pituitary disconnection on the functional and morphologic development of the pituitary-adrenal axis in the fetal sheep in the last third of gestation. Neuroendocrinology 54 254-261.
2. Ballard PL & Ballard RA 1995 Scientific basis and therapeutic regimens for use of antenatal glucocorticoids. American Journal of Obstetrics and Gynecology 173 254-262.
3. Ballard PL, Kitternian JA, Bland RD, Clyman RI, Gluckman PD, Platzker ACF, Kaplan SL & Grumbach MM 1982 Ontogeny and regulation of corticosteroid binding globulin capacity in plasma of fetal and newborn lambs, Endocrinology 110 359-366.
4. Barker DJP, Osmond C, Simmonds SJ & Wield GA 1993 The relation of small head circumference and thinness at birth to death from cardiovascular disease in adult life. British Medical Journal 306 422-426.
5. Bell ME, Myers TR & Myers DA 1998 Expression of proopiomelanocortin and prohormone convertase 1 and 2 in the late gestation fetal sheep pituitary. Endocrinology 139 5135-5143.
6. Bennett HPJ, Browne CA & Solomon S 1981 Purification of the two major forms of rat pituitary corticotrophin using only reversed-phase liquid chromatography. Biochemistry 20 4530-4538.
7. Berdusco ETM, Milne WK & Challis JRG 1994 Low-dose cortisol infusion increases plasma corticosteroid-binding globulin (CBG) and the amount ot hepatic CBG mRNA in fetal sheep on day 100 of gestation. Journal of Endocrinology 140 425-430.
8. Berdusco ETM, Yang K, Hammond GL & Challis JRG 1995 Corticosteroid-binding globulin (CBG) production by hepatic and extra-hepatic sites in the ovine fetus; effects of CBG on glucocorticoid negative feedback on pituitary cells in vitro. Journal of Endocrinology 146 121-130.
9. Bradford MM 1976 A rapid and sensitive method for the quantitation of microgram quantities of protein utilising the principle of protein-dye binding. Analytical Biochemistry 72 248-254.
10. Broad KD, Kendrick KM, Sirinathsinghji DJ & Keverne EB 1993 Changes in oxytocin immunoreactivity and mRNA expression in the sheep brain during pregnancy, parturition and lactation and in response to oestrogen and progesterone. Journal of Neuroendocrinology 5 435-444.
11. Challis JRG, Patrick JE, Cross J, Workewych J, Manchester E & Power S 1981 Short-term fluctuations in the concentration of cortisol and progesterone in fetal plasma, maternal plasma, and amniotic and allantoic fluids from sheep during late pregnancy. Canadian Journal of Physiology and Pharmacology 59 261-266.
12. Challis JRG, Nancekievill A & Lye SJ 1985 Possible role of cortisol in the stimulation of cortisol-binding capacity in the plasma of fetal sheep. Endocrinology 116 1139-1144.
13. Challis JRG, Patel A & Pomini F 1999 Prostaglandin dehydrogenase and the initiation of labour. Journal of Perinatal Medicine 27 26-34.
14. Cudd TA & Wood CE 1995 Secretion and clearance of immunoreactive ACTH by fetal lung. American Journal of Physiology 268 E845-E848.
15. Dai G, Smeckens SP, Steiner DF, McMurtry JP & Kwok SCM 1995 Charactensation of multiple prohormone convertase PC1/3 transcripts m porcine ovary. Biochimica et Biophysica Acta 1263 1-6.
16. D'Ercole AJ 1987 Somatomedins/insulin-like growth factors and fetal growth. Journal of Development Physiology 9 481-495.
17. Dunlop SA, Archer MA, Quinlivanh JA, Beazley LD & Newnham JP 1997 Repeated prenatal corticosteroids delay myelination in the ovine central nervous system. Journal of Maternal and Fetal Medicine 6 309-313.
18. Durand P, Cathiard AM, Dacheux F, Naaman E & Saez JM 1986 In vitro stimulation and inhibition of adrenocorticotrophin release by pituitary cells from ovine fetuses and lambs. Endocrinology 118 1387-1394.
19. Eipper BA & Mains RE 1980 Structure and biosynthesis of proadrenocorticotrophin/endorphin and related peptides. Endocrine Renews 1 1-27.
20. French NP, Evans SF, Godfrey KM & Newnham JP 1999 Repeated antenatal corticosteroids: size at birth and subsequent development. American Journal of Obstetrics and Gynecology 180 114-121.
21. Gossard FJ, Chang ACY & Cohen SN 1986 Sequence of the cDNA encoding porcine pro-opiomelanocortin. Biochima et Biophysica Acta 866 68-74.
22. Ikegami M, Jobe AH, Newnham J. Polk DH, Willet KE & Sly P 1997 Repetitive prenatal glucocorticoids improve lung function and decrease growth in pretenn lambs. American Journal of Respiratory and Critical Care Medicine 156 178-184.
23. Ivell R, Hunt N, Abend N, Brackman B, Nollmeyer D, Lamsa JC & McCracken JA 1990 Structure and ovarian expression of the oxytocin gene in sheep. Reproduction, Fertility and Development 2 703-711.
24. Jacobs RA, Oosterhuis J, Porter DG, Lobb DK, Yuzpe AA & Challis JRG 1991 Immunoreactive adrenocorticotrophin is present in the ovary and in particular the oocyte of several mammalian species. Journal of Reproduction and Fertility 91 285-291.
25. Jeffray TM. Matthews SG, Hammond GL & Challis JRG 1998 Divergent changes in plasma ACTH and pituitary POMC mRNA after cortisol administration to late gestation ovine fetus. American Journal of Physiology 274 E417-E425.
26. Jeffray TM, Rice GE & Challis JRG 1999 Differential effects of cortisol on POMC-derived peptides in the fetal pars distalis, lung and placenta. Journal of the Society of Gynecological Investigation 6 78A (Abstract).
27. Jobe AH, Wada N, Berry LM, Ikegami M & Ervin MG 1998 Single and repetitive maternal glucocorticoid exposures reduce fetal growth in sheep. American Journal of Obstetrics and Gynecobgy 178 880-885.
28. Johnson JWC, Mitzner W, Beck JC, London WT, Sly DL, Lee PA, Khouzami VA & Cavaliere RL 1981 Long-term effects of betamethasone on fetal development. American Journal of Obstetrics and Gynecology 141 1063-1064.
29. Jones CT, Gu W & Parer JT 1989 The control of the output of corticotrophin-releasing hormone from sheep placenta. Journal of Developmental Physiology 11 121-134.
30. Kemppainen RJ, Clark TP, Sartin JL & Zerbe CA 1993 Hypothalamic peptide regulation of ACTH secretion from sheep pituitary. American Journal of Physiology 265 R840-R845.
31. Li J, Saunders JC, Gilmour RS, Silver M & Fowden AL 1993 Insulin-like growth factor Il messenger ribonucleic acid expression in fetal tissues of the sheep during late gestation: effects of cortisol. Endocrinology 132 2083-2089.
32. Liggins GC 1994 The role of cortisol in preparing the fetus tor birth. Reproduction, Fertility and Development 6 141-150.
33. Liggins GC & Howie RN 1972 A controlled trial of antepartum glucocorticoid treatment for prevention of the respiratory distress syndrome in premature infants. Pediatrics 50 515-525.
34. Liggins GC, Fairclough RJ, Grieves SA, Kendall JZ & Knox BS 1973 The mechanisms of initiation of parturition in the ewe. Recent Progress in Hormone Research 159 111-126.
35. 2. Nature 264 797-799.
36. McMillen IC, Antolovich GC, Mercer JE, Perry RA & Silver M 1990 Proopiomelanocortin messenger RNA levels are increased in the anterior pituitary of the sheep fetus after adrenalectomy in late gestation. Neuroendocrinology 52 297-302.
37. Marcinkiewicz M. Ramla D, Seidah NG & Chretien M 1994 Developmental expression of the prohormone convertase PC1 and PC2 in mouse pancreatic islets. Endocrinology 135 1651-1660.
38. Matthews SG 1999 Hypothalamic oxytocin in the developing ovine fetus: interaction with pituitary-adrenocortical function. Brain Research 820 92-100.
39. Matthews SG & Challis JRG 1995a Developmental regulation of preproenkephalin mRNA in the ovine paraventricular nucleus: effects of stress and glucocorticoids. Developmental Brain Research 86 259-267.
40. Matthews SG & Challis JRG 1995b Regulation of CRH and AVP mRNA in the developing ovine hypothalamus: effects of stress and glucocorticoids. American Journal of Physiology 268 E1096-E1107.
41. Matthews SG & Challis JRG 1997 CRH and AVP-induced changes in synthesis and release of ACTH from the ovine fetal pituitary in vitro: negative influences of cortisol. Endocrine 6 293-300.
42. Matthews SG, Heavens RP & Sirinathsinghji DJ 1991 Cellular localisation of corticotrophin releasing factor mRNA in the ovine brain. Brain Research, Molecular Brain Research 11 171-176.
43. Matthews SG, Parrott RA & Sirinathsinghji DJ 1993 Distribution and cellular localisation of vasopressin mRNA in the ovine brain, pituitary and pineal glands. Neuropeptides 25 11-17.
44. Matthews SG, Man X, Lu F & Challis JRG 1994 Developmental changes in the distribution of proopiomelanocortin and prolactin mRNA in the pituitary of the ovine fetus and lamb. Journal of Molecular Endocrinology 13 175-185.
45. Matthews SG, Yang K & Challis JRG 1995 Changes in glucocorticoid receptor mRNA in the developing ovine pituitary and the effects of exogenous cortisol. Journal of Endocrinology 144 483-190.
46. Meaney MJ & Aitken DH 1985 The effects of early postnatal handling on hippocampal glucocorticoid receptor concentrations: temporal parameters. Developmental Brain Research 22 301-304.
47. Newnham JP, Evans SF, Godfrey ME, Huang WL, Ikegami M & Jobe AH 1999 Maternal, but not fetal, administration of corticosteroids restricts fetal growth. Journal of Maternal and Fetal Medicine 8 81-87.
48. Noda M, Furutani Y, Takahashi H, Toyosato M, Hirose T, Inayama S, Nakanishi S & Numa S 1982 Cloning and sequence analysis of cDNA for bovine adrenal preproenkephalin. Nature 295 202-205.
49. Norman LJ, Lye SJ, Wlodek ME & Challis JRG 1985 Changes in pituitary responses to synthetic ovine corticotrophin releasing factor in fetal sheep. Canadian Journal of Physiology and Pharmacology 63 1398-1403.
50. Phillips DIW, Barker DJP, Fall CHD, Seckl JR, Whorwood CB, Wood PJ & Walker BR 1998 Elevated plasma cortisol concentrations: a link between low birth weight and the insulin resistance syndrome. Journal of Clinical Endocrinology and Metabolism 83 757-760.
51. 2 infusion in the fetal lamb on fetal plasma ACTH, prolactin and cortisol concentrations. Prostaglandins 18 101-117.
52. Reimsch JM, Simon NG, Karow WG & Gandelman R 1978 Prenatal exposure to prednisone in humans and animals retards intrauterine growth. Science 202 436-438.
53. Sapolsky RM, Armanini MP, Packan DR, Sutton SW & Plotsky PM 1990 Glucocorticoid feedback inhibition of adrenocorticotropic hormone secretagogue release: relationship to corticosteroid receptor occupancy in various limbic sites. Neuroendocrinology 51 328-336.
54. Seidah NG, Fournier H, Boileau G, Benjannet S, Rondeau N & Chretien M 1992 The cDNA structure of the porcine pre-hormone convertase PC2 and the comparative processing by PC1 and PC2 of the N-terminal glycopeptide segment of porcine POMC. FEBS Letters 310 235-239.
55. Uno H, Lohmiller L, Thieme C, Kemnitz JW, Engle MJ, Roecker EB & Farrell PM 1990 Brain damage induced by prenatal exposure to dexamethasone in fetal rhesus macaques. 1. Hippocampus. Developmental Brain Research 53 157-167.
56. Uno H, Eisele S, Sakai A, Shelton S, Baker E, DeJesus O & Holden J 1994 Neurotoxicity of glucocorticoids in the primate brain. Hormones and Behaviour 28 336-348.
57. Yang K, Jones SA & Challis JRG 1990 Changes in glucocorticoid receptor number in the hypothalamus and pituitary of the sheep fetus with gestational age and after adrenocorticotrophin treatment. Endocrinology 126 11-17.
58. Yang K, Challis JRG, Han VKM & Hammond GL 1991 Proopiomelanocortin messenger RNA levels increase in the fetal sheep pituitary during late gestation. Journal of Endocrinology 131 483-489.
59. Yang K, Hammond GL & Challis JRG 1992 Characterisation of an ovine glucocorticoid receptor cDNA and developmental changes in its mRNA levels in the fetal sheep hypothalamus, pituitary gland and adrenal. Journal of Molecular Endocrinology 8 173-180.