Chronic antagonism of nuclear factor-κb activity in cytotrophoblasts by dexamethasone: A potential mechanism for antiinflammatory action of glucocorticoids in human placenta

Journal of Clinical Endocrinology and Metabolism

Volumn 83, Issue 10, 1998, Pages 3647-3652

  Rosen, Todd ^a   Krikun, Graciela ^a   Ma, Yuehong ^a   Wang, En Yu ^a   Lockwood, Charles J ^a   Guller, Seth ^a,b  

^a NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

^b NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEXAMETHASONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CYTOKINE PRODUCTION; CYTOTROPHOBLAST; DRUG EFFECT; FEMALE; HUMAN; HUMAN CELL; INFLAMMATION; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION;

ANTI-INFLAMMATORY AGENTS; CELL NUCLEUS; DEXAMETHASONE; FEMALE; HUMANS; INTERLEUKIN-8; NF-KAPPA B; PLACENTA; PREGNANCY; TROPHOBLASTS;

EID: 0031796404     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.83.10.3647     Document Type: Article

References (49)

1. Dorr HG, Heller A, Versmold HT, et al. 1989 Longitudinal study of progestins, mineralocorticoids, and glucocorticoids throughout human pregnancy. J Clin Endocrinol Metab. 68:863-868.
2. Cawson MJ, Anderson ABM, Tumbull AC, Lampe C. 1974 Cortisol, cortisone, and 11-deoxycortisol in human umbilical and maternal plasma in relation to the onset of labour. J Obstet Gynaecol Br Common. 81:737-745.
3. Ballard PL, Ballard RA. 1995 Scientific basis and therapeutic regimens for use of antenatal glucocorticoids. Am J Obstet Gynecol. 173:254-262.
4. Guller S, Wozniak R, Krikun G, Burnham JM, Kaplan P, Lockwood CJ. 1993 Glucocorticoid suppression of human placental fibronectin expression: implications in uterine-placental adherence. Endocrinology. 133:1139-1146.
5. Karalis K, Goodwin G, Majzoub JA. 1996 Cortisol blockade of progesterone: a possible molecular mechanism involved in the initiation of human labor. Nat Med. 2:556-559.
6. Casey ML, MacDonald PC. 1997 The endocrinology of human parturition. Ann NY Acad Sci. 828:273-284.
7. Cato ACB, Wade E. 1996 Molecular mechanisms of antiinflammatory action of glucocorticoids. BioEssays. 18:371-378.
8. Salafia CM, Weigl C, Silberman L. 1989 The prevalence and distribution of acute placental inflammation in uncomplicated term pregnancies. Obstet Gynecol. 73:383-393.
9. Dudley DJ, Collmer D, Mitchell MD, Trautman MS. 1996 Inflammatory cytokine mRNA in human gestational tissues: implications for term and preterm labor. J Soc Gynecol Invest. 3:328-335.
10. Halgunset J, Hohnsen H, Kjollesdal AM, Qvigstad E, Espevik T, Austgulen R. 1994 Cytokine levels in amniotic fluid and inflammatory changes in the placenta from normal deliveries at term. Eur J Obstet Gynecol Reprod Biol. 56:153-160.
11. Verma IM, Stevenson JK, Schwarz EM, Van Antwerp D, Miyamoto S. 1995 Rel/NF-κB/IκB family: intimate tales of association and dissociation. Genes Dev. 9:2723-2735.
12. Yoshimura T, Matsushima K, Tanaka S, et al. 1987 Purification of a human monocyte-derived neutrophil chemotactic factor that has peptide sequence similarity to other host defense cytokines. Proc Natl Acad Sci USA. 94:9233-9237.
13. Yoshimura T, Matsushima K, Oppenheim JJ, Leonard EJ. 1987 Neutrophil chemotactic factor produced by lipopolysaccharide (LPS)-stimulated human blood mononuclear leukocytes: partial characterization and separation from interleukin 1 (IL-1). J Immunol. 139:788-793.
14. Mukaida N, Shiroo M, Matsushima K. 1989 Genomic structure of the human monocyte-derived neutrophil chemotactic factor IL-8. J Immunol. 143:1366-1371.
15. Saito S, Kasahara T, Sakakura S, Umekage H, Harada N, Ichijo M. 1994 Detection and localization of interleukin-8 mRNA and protein in human placenta and decidual tissues. J Reprod Immunol. 27:161-172.
16. Shimoya K, Matsuzaki N, Taniguchi T, et al. 1992 Human placenta constitutively produce interleukin-8 and enhances its production in intrauterine infection. Biol Reprod. 47:220-226.
17. Kliman HJ, Nestler JE, Sermasi E, Sanger JM, Strauss III JF. 1986 Purification, characterization, and in vitro differentiation of cytotrophoblasts from human term placentae. Endocrinology. 118:1567-1582.
18. Guller S, Markiewicz L, Wozniak R, et al. 1994 Developmental regulation of glucocorticoid-mediated effects on extracellular matrix protein expression in the human placenta. Endocrinology. 134:2064-2071.
19. Guller S, Wozniak R, Kong L, Lockwood CJ. 1995 Opposing actions of transforming growth factor-β and glucocorticoids in the regulation of fibronectin expression in the human placenta. J Clin Endocrinol Metab. 80:2373-3278.
20. Ringer GE, Kallen CB, Strauss III JF. 1989 Regulation of human trophoblast function by glucocorticoids: dexamethasone promotes increased secretion of chorionic gonadotropin. Endocrinology. 124:1625-1631.
21. Feinberg RF, Kliman HJ, Lockwood CJ. 1991 Is oncofetal fibronectin a trophoblast glue for human implantation? Am J Pathol. 138:537-543.
22. Heron E, Deloukas P, van Loon APGM. 1995 The complete exon-intron structure of the 156-kb human gene NF-κB1, which encodes the p105 and p50 proteins of transcription factors NF-κ-B and I-κ-B-γ: implications for NF-κ-B-mediated signal transduction. Genomics. 30:493-505.
23. Kerr LD, Duckett CS, Wamsley P, et al. 1992 The proto-oncogene bcl-3 encodes an IκB protein. Genes Dev. 6:2352-63.
24. Douglas GC, King BF. 1989 Isolation of pure villous cytotrophoblast from human term placenta using immunomagnetic microspheres. J Immunol Methods. 119:259-268.
25. Hoppe-Seyler F, Butz K, Rittmηller C, von Knebel M, Doeberitz K. 1991 A rapid microscale procedure for the simultaneous preparation of cytoplasmic RNA, nuclear DNA binding proteins and enzymatically active luciferase extracts. Nucleic Acids Res. 19:5080.
26. Sambrook J, Fritsch EF, Maniatis T. 1989 Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor: Cold Spring Harbor Laboratory; 7.37-7.45.
27. Seckl JR. 1997 Glucocorticoids, feto-placental 11β-hydroxysteroid dehydrogenase type 2, and the early origins of adult disease. Steroids. 62:89-94.
28. Ji L, Arcinas M, Boxer LM. 1994 NF-κB sites function as positive regulators of expression of the translocated c-myc allele in Burkitt's lymphoma. Mol Cell Biol. 14:7967-7974.
29. Baeuerle PA, Baltimore D. 1988 IκB: a specific inhibitor of the NF-κB transcription factor. Science. 242:540-546.
30. Baeuerle PA, Baltimore D. 1988 Activation of DNA-binding in an apparently cytoplasmic precursor of the NF-κB transcription factor. Cell. 53:211-217.
31. Adcock IM, Brown CR, Gelder CM, Shirasaki H, Peters MJ, Barnes PJ. 1995 Effects of glucocorticoids on transcription factor activation in human peripheral blood mononuclear cells. Am J Physiol. 268:C331-C338.
32. Brostjan C, Anrather J, Csizmadia V, et al. 1996 Glucocorticoid-mediated repression of NFκB activity in endothelial cells does not involve induction of IκBα synthesis. J Biol Chem. 271:19612-19616.
33. Scheinman RI, Cogswell PC, Lofquist AK, Baldwin Jr AS. 1995 Role of transcriptional activation of IκBα in mediation of immunosuppression by glucocorticoids. Science. 270:283-286.
34. Auphan N, DiDonato JA, Rosette C, Helmberg A, Karin M. 1995 Immunosuppression by glucocorticoids: inhibition of NF-κB activity through induction of IκB. Science. 270:286-289.
35. Mukaida N, Monta M, Ishikawa Y, et al. 1994 Novel mechanism of glucocorticoid-mediated gene repression. J Biol Chem. 269:13289-13295.
36. Mukaida N, Okamoto S-I, Ishikawa Y, Matsushima K. 1994 Molecular mechanism of IL-8 expression. J Leukocyte Biol. 56:554-558.
37. Ray A, Prefontaine KE. 1994 Physical association and functional antagonism between the p65 subunit of transcription factor NF-κB and the glucocorticoid receptor. Proc Natl Acad Sci USA. 91:752-756.
38. Goldfeld AE, McCaffrey PG, Strominger JL, Rao A. 1993 Identification of a novel cyclosporin-sensitive element in the human tumor necrosis factor a gene promoter. J Exp Med. 178:1365-1379.
39. Jonat C, Rahmsdorf HJ, Park K-K, et al. 1990 Antitumor promotion and antiinflammation: down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone. Cell. 62:1189-1204.
40. Yang-Yen H-F, Chambard J-C, Sun Y-L, et al. 1990 Transcriptional interference between c-Jun and the glucocorticoid receptor: mutual inhibition of DNA binding due to direct protein-protein interaction. Cell. 62:1205-1215.
41. Schule R, Rangarajan P, Kliewer S, et al. 1990 Funtional antagonism between oncoprotein c-Jun and the glucocorticoid receptor. Cell. 62:1217-1226.
42. Ghosh S, Baltimore D. 1990 Activation in vitro of NF-κB by phosphorylation of its inhibitor IκB. Nature. 344:678-682.
43. Barnes PJ, Karin M. 1997 Nuclear factor-κB: a pivotal transcription factor in chronic inflammatory diseases. N Engl J Med. 336:1066-1071.
44. Brack A, Rittner HL, Younge BR, Kaltschmidt C, Weyand CM, Goronzy JJ. 1997 Glucocorticoid-mediated repression of cytokine gene transcription in human arteritis-SCID chimeras. J Clin Invest. 99:2842-2850.
45. Harada A, Sekido N, Akahoshi T, Takashi W, Mukaida N, Matsushima K. 1994 Essential involvement of interleukln-8 (IL-8) in acute inflammation. J Leukocyte Biol. 56:559-564.
46. Liou H-C, Sha WC, Scott ML, Baltimore D. 1994 Sequential induction of NF-κB/Rel family proteins during B-cell terminal differentiation. Mol Cell Biol. 14:349-5359.
47. Sovak MA, Bellas RE, Kim DW, et al. 1997 Abberant nuclear factor-κB/Rel expression and the pathogenesis of breast cancer. J Clin Invest. 100:2952-2960.
48. Bargou RC, Emmerich F, Krappmann D, et al. 1997 Constitutive Nuclear Factor-κB-activation is required for proliferation and survival of Hodgkin's disease tumor cells. J Clin Invest. 100:2961-2969.
49. McClean M, Bisits A, Davies J, Woods R, Lowry P, Smith R. 1995 A placental clock controlling the length of human pregnancy. Nat Med. 1:460-463.