Altered cardiovascular haemodynamics and baroreceptor-heart rate reflex in adult sheep after prenatal exposure to dexamethasone

Clinical Science

Volumn 97, Issue 1, 1999, Pages 103-109

  Dodic, M ^a   Peers, A ^a   Coghlan, J P ^a   May, C N ^a   Lumbers, E ^b   Yu, Z Y ^b   Wintour, E M ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

Dexamethasone; Hypertension; Sheep

Indexed keywords

DEXAMETHASONE; PROPRANOLOL;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; FEMALE; GESTATIONAL AGE; HEART OUTPUT; HEART RATE; HEART STROKE VOLUME; HEMODYNAMICS; HYPERTENSION; INTRAVENOUS DRUG ADMINISTRATION; MALE; MEAN ARTERIAL PRESSURE; NEWBORN; NONHUMAN; PREGNANCY; PRENATAL EXPOSURE; PRESSORECEPTOR; PRESSORECEPTOR REFLEX; PRIORITY JOURNAL; SHEEP;

ANIMALS; BAROREFLEX; BLOOD PRESSURE; DEXAMETHASONE; FEMALE; GLUCOCORTICOIDS; HEART RATE; HEMODYNAMIC PROCESSES; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; SHEEP;

EID: 0032817087     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS19980356     Document Type: Article

References (29)

1. Barker, D. J. P. (1998) In utero programming of chronic disease. Clin. Sci. 95, 115-128
2. Barker, D. J. P., Hales, C. N., Fall, C. H. D., Osmond, C., Phipps, K. and Clark, P. M. S. (1993) Type 2 (non-insulin-dependent) diabetes mellitus, hypertension and hyperlipidaemia (syndrome X): relation to fetal growth. Diabetologia 36, 62-67
3. Phillips, D. I. W. and Barker, D. J. P. (1997) Association between low birthweight and high resting pulse in adult life: is the sympathetic nervous system involved in programming of the insulin resistance syndrome? Diabetes Med. 14, 673-677
4. Phillips, D. I. W., Barker, D. J. P., Fall, C. H. D. et al. (1998) Elevated plasma cortisol concentrations: a link between birth weight and the insulin resistance syndrome? J. Clin. Endocrinol. Metab. 83, 757-760
5. Burns, S. P., Desai, M., Cohen, R. D. et al. (1997) Gluconeogenesis, glucose handling, and structural changes in livers of adult offspring of rats partially deprived of protein during pregnancy and lactation. J. Clin. Invest. 100, 1768-1774
6. Langley, S. C. and Jackson, A. A. (1994) Increased systolic blood pressure in adult rats induced by fetal exposure to maternal low protein diets. Clin. Sci. 86, 217-222
7. Kind, K., Clifton, P., Katsman, A., Simonetta, G., Robinson, J. and Owens, J. (1997) Prenatal programming of glucose and cholesterol homeostasis in the guinea pig. Proc. Aust. Soc. Med. Res. 36th National Scientific Conference, Abstr. S8-2
8. Owens, J. A., McMillen, C., Moore, V., Robinson, J., Kind, K. and Clifton, P. (1998) Relationship of birth phenotype and intrauterine nutrition to insulin resistance and the metabolic syndrome. Proc. Endocr. Soc. Aust. Postgrad. Semin. Meet. Adelaide, Abstr. 10
9. Hawkins, P., Crowe, C., Calder, N. A. et al. (1997) Cardiovascular development in late gestation fetal sheep and young lambs following modest maternal nutrient restriction in early gestation. J. Physiol. (London) 505P, Abstr. 18P
10. Langley-Evans, S. C. (1997) Intrauterine programming of hypertension by glucocorticoids. Life Sci. 60, 1213-1221
11. Langley-Evans, S. C. (1997) Maternal carbenoxolone treatment lowers birthweight and induces hypertension in the offspring of rats fed a protein-replete diet. Clin. Sci. 93, 423-429
12. Seckl, J. R. (1997) Glucocorticoids, fetoplacental 11β-hydroxysteroid dehydrogenase type 2, and the early life origins of adult disease. Steroids 62, 89-94
13. Langley-Evans, S. C. (1997) Hypertension induced by fetal exposure to a maternal low-protein diet, in the rat, is prevented by pharmacological blockade of maternal glucocorticoid synthesis. J. Hypertens. 15, 537-544
14. Edwards, C. R. W., Benediktsson, R., Lindsay, R. and Seckl, J. R. (1993) Dysfunction of the placental glucocorticoid barrier: a link between fetal environment and adult hypertension? Lancet 341, 355-357
15. Levitt, N., Lindsay, R. S., Holmes, M. C. and Seckl, J. R. (1996) Dexamethasone in the last week of pregnancy attenuates hippocampal glucocorticoid gene expression and elevates blood pressure in the adult offspring in the rat. Neuroendocrinology 64, 412-418
16. Dodic, M., May, C. N., Wintour, E. M. and Coghlan, J. P. (1998) An early prenatal exposure to excess glucocorticoid leads to hypertensive offspring in sheep. Clin. Sci. 94, 149-155
17. Bednarik, J. A. and May, C. N. (1995) Evaluation of a transit-time system for the chronic measurement of blood flow in conscious sheep. J. Appl. Physiol. 78, 524-530
18. Kent, B. B., Drane, J. W., Blumenstein, B. and Manning, J. W. (1972) A mathematical model to assess changes in the baroreceptor reflex. Cardiology 57, 295-310
19. Whitworth, J. A. (1994) Studies on the mechanism of glucocorticoid hypertension in humans. Blood Pressure 3, 24-32
20. Pirpiris, M., Yeung, S., Dewar, E., Jennings, G. L. and Whitworth, J. A. (1993) Hydrocortisone-induced hypertension in men. Am. J. Hypertens. 6, 287-294
21. May, C. N. and Bednarik, J. A. (1995) Regional hemodynamic and endocrine effects of aldosterone and cortisol in conscious sheep. Hypertension 26, 294-300
22. Bednarik, J. A. and May, C. N. (1994) Differential hemodynamic effects of corticotropin in conscious sheep. Hypertension 24, 49-55
23. Shulkes, A. A., Coghlan, J. P., Denton, D. A., Fan, J. S. K., Robinson, P. M. and Scoggins, B. A. (1974) The effect of adrenal denervation on ACTH-induced hypertension in sheep. Clin. Exp. Pharmacol. Physiol. 1, 479-493
24. Head, G. A. (1994) Cardiac baroreflex and hypertension. Clin. Exp. Pharmacol. Physiol. 21, 791-802
25. Korner, P. I. (1989) Baroreceptor resetting and other determinants of baroreflex properties in hypertension. Clin. Exp. Pharmacol. Physiol. 15, 45-64
26. Head, G. A. (1995) Baroreflex and cardiovascular regulation in hypertension. J. Cardiovasc. Pharmacol. 26, S7-S16
27. Gordon, F. J., Matsuguchi, H. and Mark, A. L. (1981) Abnormal baroreflex control of heart rate in prehypertensive and hypertensive Dahl genetically salt-sensitive rats. Hypertension 3 (suppl. I), I135-I141
28. Howe, P. R. C., Rogers, P. F. and Head, G. A. (1989) Limited baroreflex control of heart rate in young stroke-prone spontaneously hypertensive rats. J. Hypertens. 7, 69-75
29. Head, G. A. and Adams, M. A. (1992) Characterisation of the baroreceptor heart rate reflex during development in spontaneously hypertensive rats. Clin. Exp. Pharmacol. Physiol. 19, 587-597