Fetal renal and blood pressure responses to steroid infusion after early prenatal treatment with dexamethasone

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 288, Issue 1 57-1, 2005, Pages

  Moritz, Karen M ^a,b   Jefferies, Andrew ^a,b   Wintour, E Marelyn ^a,b   Dodic, Miodrag ^a,b  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b MONASH UNIVERSITY   (Australia)

Author keywords

Aldosterone; Cortisol; Fetal programming

Indexed keywords

ALDOSTERONE; ANGIOTENSIN 2 RECEPTOR; DEXAMETHASONE; GLUCOCORTICOID RECEPTOR; HYDROCORTISONE; MESSENGER RNA; MINERALOCORTICOID RECEPTOR; POTASSIUM; SODIUM; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ARTICLE; BLOOD PRESSURE; CONTROLLED STUDY; FETUS; FETUS DEVELOPMENT; GLOMERULUS FILTRATION RATE; KIDNEY FUNCTION; MICTURITION; NONHUMAN; POTASSIUM EXCRETION; PRENATAL DRUG EXPOSURE; PRIORITY JOURNAL; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; SHEEP; THIRD TRIMESTER PREGNANCY;

ALDOSTERONE; ANIMALS; BLOOD PRESSURE; DEXAMETHASONE; FEMALE; FETUS; GESTATIONAL AGE; GLOMERULAR FILTRATION RATE; GLUCOCORTICOIDS; HYDROCORTISONE; KIDNEY; POTASSIUM; PREGNANCY; SHEEP; SODIUM;

EID: 11144324902     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.00282.2004     Document Type: Article

References (27)

1. Barker DJ, Eriksson JG, Forsen T, and Osmond C. Fetal origins of adult disease: strength of effects and biological basis. Int J Epidemiol 31: 1235-1239, 2003.
2. Benson CA and Wintour EM. The effect of bilateral fetal adrenalectomy on fluid balance in the ovine fetus. J Physiol 489: 235-241, 1994.
3. Dodic M, Abouantoun T, O'Connor A, Wintour EM, and Moritz KM. Programming effects of short prenatal exposure to dexamethasone in sheep. Hypertension 40: 729-734, 2002.
4. Dodic M, Hantzis V, Duncan J, Rees S, Koukoulas I, Johnson K, Wintour EM, and Moritz KM. Programming effects of short prenatal exposure to cortisol. FASEB J 16: 1017-1026, 2002.
5. Dodic M, May CN, Wintour EM, and Coghlan JP. An early prenatal exposure to excess glucocorticoid leads to hypertensive offspring in sheep. Clin Sci (Lond) 94: 149-155, 1998.
6. Dodic M and Wintour EM. Effects of prolonged (48 h) infusion of cortisol on blood pressure, renal function and fetal fluids in the immature ovine foetus. Clin Exp Pharmacol Physiol 21: 971-980, 1994.
7. Gogerly RL, Coghlan JP, Morgenroth P, and McDougall JG. A compartmental model of acute stimulation of aldosterone secretion in vivo by potassium and ANG II. Am J Physiol Endocrinol Melab 265: E190-E196, 1993.
8. Hantzis V, Albiston A, Matsacos D, Wintour EM, Peers A, Koukoulas I, Myles K, Moritz K, and Dodic M. Ontogeny of mineralcorticoid and glucocorticoid receptors in the developing ovine kidney and the effect of early gluococorticoid treatment on their expression in the late gestation fetus. Kidney Int 61: 405-413, 2002.
9. Kairaitis K and Lumbers ER. The influence of endogenous mineralo-corticoids on the composition of fetal urine. J Dev Physiol 13: 347-351, 1990.
10. Kett MM and Bertram JF. Nephron endowment and blood pressure: what do we really know? Curr Hypertens Rep 6: 133-139, 2004.
11. Lingwood B, Hardy KJ, Coghlan JP, and Wintour EM. Effect of aldosterone on urine composition in the chronically cannulated ovine foetus. J Endocrinol 76: 553-554, 1978.
12. Mann SE, Nijland MJ, and Ross MG. Fetal absorption of intra-amniotic aldosterone: effects on urine composition. J Soc Gynecol Investig 6: 252-257, 1999.
13. Moritz KM, Dodic M, and Wintour EM. Kidney development and the fetal programming of adult disease. Bioessays 25: 212-220, 2003.
14. Moritz KM, Johnson K, Douglas-Denton R, Wintour EM, and Dodic M. Maternal glucocorticoid treatment programs alterations in the renin-angiotensin system of the ovine fetal kidney. Endocrinology 143: 4455-4463, 2002.
15. Moritz KM, Koukoulas I, Albiston A, and Wintour EM. Angiotensin II infusion to the midgestation ovine fetus: effects on the fetal kidney. Am J Physiol Regul Integr Comp Physiol 279: R1290-R1297, 2000.
16. Moritz KM, Tangalakis K, and Wintour EM. Renal, hormonal, and cardiovascular responses to chronic angiotensin I infusion in the ovine fetus. Am J Physiol Regul Integr Comp Physiol 272: R1912-R1917, 1997.
17. Moritz KM and Wintour EM. Functional development of the meso- and metanephros. Pediatr Nephrol 13: 171-178, 1999.
18. Ortiz LA, Quan A, Weinberg A, and Baum M. Effect of prenatal dexamethasone on rat renal development. Kidney Int 59: 1663-1669, 2001.
19. Ortiz LA, Quan A, Zarzar F, Weinberg A, and Baum M. Prenatal dexamethasone programs hypertension and renal injury in the rat. Hypertension 41: 328-334, 2003.
20. Robillard JE, Ramberg E, Sessions C, Consamus B, Van Orden D, Weismann D, and Smith FG Jr. Role of aldosterone on renal sodium and potassium excretion during fetal life and newborn period. Dev Pharmacol Ther 1: 201-206, 1980.
21. Siegel SR, Oakes G, and Palmer S. Transplacental transfer of aldosterone and its effects on renal function in the fetal lamb. Pediatr Res 15: 163-165, 1981.
22. Tangalakis K, Lumbers ER, Moritz KM, Towstoless MK, and Wintour EM. Effect of cortisol on blood pressure and vascular reactivity in the ovine fetus. Exp Physiol 77: 709-717, 1992.
23. Towstoless MK, McDougall JG, and Wintour EM. Gestational changes in renal responsiveness to cortisol in the ovine fetus. Pediatr Res 26: 6-10, 1989.
24. Welham SJ, Wade A, and Woolf AS. Protein restriction in pregnancy is associated with increased apoptosis of mesenchymal cells at the start of rat metanephrogenesis. Kidney Int 61: 1231-1242, 2002.
25. Whorwood CB, Firth KM, Budge H, and Symonds ME. Maternal undernutrition during early to midgestation programs tissue-specific alterations in the expression of the glucocorticoid receptor, IIβ-hydroxysteroid dehydrogenase isoforms, and type 1 angiotensin II receptor in neonatal sheep. Endocrinology 142: 2854-2864, 2001.
26. Wintour EM, Moritz KM, Johnson K, Samuel CS, and Dodic M. Reduced nephron number in adult sheep hypertensive as a result of prenatal glucocorticoid treatment. J Physiol 549: 929-935, 2003.
27. Woods LL, Weeks DA, and Rasch R. Programming of adult blood pressure by maternal protein restriction: role of nephrogenesis. Kidney Int 65: 1339-1348, 2004.