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Volumn 8, Issue 1, 2007, Pages 23-36

Illuminating the silence: Understanding the structure and function of small RNAs

Author keywords

[No Author keywords available]

Indexed keywords

DNA; MICRORNA; RNA INDUCED SILENCING COMPLEX; SMALL INTERFERING RNA;

EID: 33845755467     PISSN: 14710072     EISSN: 14710080     Source Type: Journal    
DOI: 10.1038/nrm2085     Document Type: Review
Times cited : (884)

References (135)
  • 1
    • 0032545933 scopus 로고    scopus 로고
    • Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
    • Fire, A. et al. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391, 806-811 (1998). First report showing that dsRNA can silence specific genes in animals.
    • (1998) Nature , vol.391 , pp. 806-811
    • Fire, A.1
  • 2
    • 0030996469 scopus 로고    scopus 로고
    • Role of the double-stranded RNA-activated protein kinase (PKR) in cell regulation
    • Williams, B. R. Role of the double-stranded RNA-activated protein kinase (PKR) in cell regulation. Biochem. Soc. Trans. 25, 509-513 (1997).
    • (1997) Biochem. Soc. Trans. , vol.25 , pp. 509-513
    • Williams, B.R.1
  • 3
    • 0035905766 scopus 로고    scopus 로고
    • Role for a bidentate ribonuclease in the initiation step of RNA interference
    • Bernstein, E., Caudy, A. A., Hammond, S. M. & Hannon, G. J. Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature 409, 363-366 (2001).
    • (2001) Nature , vol.409 , pp. 363-366
    • Bernstein, E.1    Caudy, A.A.2    Hammond, S.M.3    Hannon, G.J.4
  • 4
    • 0035839109 scopus 로고    scopus 로고
    • Argonaute2, a link between genetic and biochemical analyses of RNAi
    • Hammond, S. M., Boettcher, S., Caudy, A. A., Kobayashi, R. & Hannon, G. J. Argonaute2, a link between genetic and biochemical analyses of RNAi. Science 293, 1146-1150 (2001).
    • (2001) Science , vol.293 , pp. 1146-1150
    • Hammond, S.M.1    Boettcher, S.2    Caudy, A.A.3    Kobayashi, R.4    Hannon, G.J.5
  • 5
    • 0033572660 scopus 로고    scopus 로고
    • Targeted mRNA degradation by double-stranded RNA in vitro
    • Tuschl, T., Zamore, P. D., Lehmann, R., Bartel, D. P. & Sharp, P. A. Targeted mRNA degradation by double-stranded RNA in vitro. Genes Dev. 13, 3191-3197 (1999).
    • (1999) Genes Dev. , vol.13 , pp. 3191-3197
    • Tuschl, T.1    Zamore, P.D.2    Lehmann, R.3    Bartel, D.P.4    Sharp, P.A.5
  • 6
    • 0034737298 scopus 로고    scopus 로고
    • RNAi: Double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals
    • Zamore, P. D., Tuschl, T., Sharp, P. A. & Bartel, D. P. RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals. Cell 101, 25-33 (2000).
    • (2000) Cell , vol.101 , pp. 25-33
    • Zamore, P.D.1    Tuschl, T.2    Sharp, P.A.3    Bartel, D.P.4
  • 7
    • 0035859929 scopus 로고    scopus 로고
    • Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems
    • Caplen, N. J., Parrish, S., Imani, F., Fire, A. & Morgan, R. A. Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems. Proc. Natl Acad. Sci. USA 98, 9742-9747 (2001).
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 9742-9747
    • Caplen, N.J.1    Parrish, S.2    Imani, F.3    Fire, A.4    Morgan, R.A.5
  • 8
    • 0035942736 scopus 로고    scopus 로고
    • Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
    • Elbashir, S. M. et al. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411, 494-498 (2001). This paper, together with reference 7, showed that siRNA can trigger RNAi in mammalian cells.
    • (2001) Nature , vol.411 , pp. 494-498
    • Elbashir, S.M.1
  • 9
    • 0027751663 scopus 로고
    • The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
    • Lee, R. C., Feinbaum, R. L. & Ambros, V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 75, 843-854 (1993). Discovery of the first miRNA.
    • (1993) Cell , vol.75 , pp. 843-854
    • Lee, R.C.1    Feinbaum, R.L.2    Ambros, V.3
  • 11
    • 0041691111 scopus 로고    scopus 로고
    • MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms
    • Zeng, Y., Yi, R. & Cullen, B. R. MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms. Proc. Natl Acad. Sci. USA 100, 9779-9784 (2003).
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 9779-9784
    • Zeng, Y.1    Yi, R.2    Cullen, B.R.3
  • 12
    • 23944514849 scopus 로고    scopus 로고
    • Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation
    • Bagga, S. et al. Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation. Cell 122, 553-563 (2005).
    • (2005) Cell , vol.122 , pp. 553-563
    • Bagga, S.1
  • 13
    • 4644312235 scopus 로고    scopus 로고
    • The role of RNA interference in heterochromatic silencing
    • Lippman, Z. & Martienssen, R. The role of RNA interference in heterochromatic silencing. Nature 431, 364-370 (2004).
    • (2004) Nature , vol.431 , pp. 364-370
    • Lippman, Z.1    Martienssen, R.2
  • 14
    • 0032506226 scopus 로고    scopus 로고
    • Virus resistance and gene silencing in plants can be induced by simultaneous expression of sense and antisense RNA
    • Waterhouse, P. M., Graham, M. W. & Wang, M. B. Virus resistance and gene silencing in plants can be induced by simultaneous expression of sense and antisense RNA. Proc. Natl Acad. Sci. USA 95, 13959-13964 (1998).
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 13959-13964
    • Waterhouse, P.M.1    Graham, M.W.2    Wang, M.B.3
  • 15
    • 4644350944 scopus 로고    scopus 로고
    • Unlocking the potential of the human genome with RNA interference
    • Hannon, G. J. & Rossi, J. J. Unlocking the potential of the human genome with RNA interference. Nature 431, 371-378 (2004).
    • (2004) Nature , vol.431 , pp. 371-378
    • Hannon, G.J.1    Rossi, J.J.2
  • 16
    • 4644223259 scopus 로고    scopus 로고
    • Mechanisms of gene silencing by double-stranded RNA
    • Meister, G. & Tuschl, T. Mechanisms of gene silencing by double-stranded RNA. Nature 431, 343-349 (2004).
    • (2004) Nature , vol.431 , pp. 343-349
    • Meister, G.1    Tuschl, T.2
  • 17
    • 1442360415 scopus 로고    scopus 로고
    • RNase III enzymes and the initiation of gene silencing
    • Carmell, M. A. & Hannon, G. J. RNase III enzymes and the initiation of gene silencing. Nature Struct. Mol. Biol. 11, 214-218 (2004).
    • (2004) Nature Struct. Mol. Biol. , vol.11 , pp. 214-218
    • Carmell, M.A.1    Hannon, G.J.2
  • 18
    • 27744537851 scopus 로고    scopus 로고
    • Human RISC couples microRNA biogenesis and posttranscriptional gene silencing
    • Gregory, R. I., Chendrimada, T. P., Cooch, N. & Shiekhattar, R. Human RISC couples microRNA biogenesis and posttranscriptional gene silencing. Cell 123, 631-640 (2005).
    • (2005) Cell , vol.123 , pp. 631-640
    • Gregory, R.I.1    Chendrimada, T.P.2    Cooch, N.3    Shiekhattar, R.4
  • 19
    • 13844281898 scopus 로고    scopus 로고
    • Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy
    • Kim, D. H. et al. Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy. Nature Biotechnol. 23, 222-226 (2005).
    • (2005) Nature Biotechnol. , vol.23 , pp. 222-226
    • Kim, D.H.1
  • 20
    • 13844280638 scopus 로고    scopus 로고
    • Synthetic shRNAs as potent RNAi triggers
    • Siolas, D. et al. Synthetic shRNAs as potent RNAi triggers. Nature Biotechnol. 23, 227-231 (2005).
    • (2005) Nature Biotechnol. , vol.23 , pp. 227-231
    • Siolas, D.1
  • 21
    • 26944495173 scopus 로고    scopus 로고
    • MicroRNA function in animal development
    • Wienholds, E. & Plasterk, R. H. MicroRNA function in animal development. FEBS Lett. 579, 5911-5922 (2005).
    • (2005) FEBS Lett. , vol.579 , pp. 5911-5922
    • Wienholds, E.1    Plasterk, R.H.2
  • 22
    • 4644309196 scopus 로고    scopus 로고
    • The functions of animal microRNAs
    • Ambros, V. The functions of animal microRNAs. Nature 431, 350-355 (2004).
    • (2004) Nature , vol.431 , pp. 350-355
    • Ambros, V.1
  • 23
    • 0347444723 scopus 로고    scopus 로고
    • MicroRNAs: Genomics, biogenesis, mechanism, and function
    • Bartel, D. P. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116, 281-297 (2004).
    • (2004) Cell , vol.116 , pp. 281-297
    • Bartel, D.P.1
  • 24
    • 4644242349 scopus 로고    scopus 로고
    • RNA silencing in plants
    • Baulcombe, D. RNA silencing in plants. Nature 431, 356-363 (2004).
    • (2004) Nature , vol.431 , pp. 356-363
    • Baulcombe, D.1
  • 25
    • 26944480096 scopus 로고    scopus 로고
    • Small RNAs and Arabidopsis. A fast forward look
    • Carrington, J. C. Small RNAs and Arabidopsis. A fast forward look. Plant Physiol. 138, 565-566 (2005).
    • (2005) Plant Physiol. , vol.138 , pp. 565-566
    • Carrington, J.C.1
  • 26
    • 0035955374 scopus 로고    scopus 로고
    • Identification of novel genes coding for small expressed RNAs
    • Lagos-Quintana, M., Rauhut, R., Lendeckel, W. & Tuschl, T. Identification of novel genes coding for small expressed RNAs. Science 294, 853-858 (2001).
    • (2001) Science , vol.294 , pp. 853-858
    • Lagos-Quintana, M.1    Rauhut, R.2    Lendeckel, W.3    Tuschl, T.4
  • 27
    • 0035955361 scopus 로고    scopus 로고
    • An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans
    • Lau, N. C., Lim, L. P., Weinstein, E. G. & Bartel, D. P. An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans. Science 294, 858-862 (2001).
    • (2001) Science , vol.294 , pp. 858-862
    • Lau, N.C.1    Lim, L.P.2    Weinstein, E.G.3    Bartel, D.P.4
  • 28
    • 0037087780 scopus 로고    scopus 로고
    • miRNPs: A novel class of ribonucleoproteins containing numerous microRNAs
    • Mourelatos, Z. et al. miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs. Genes Dev. 16, 720-728 (2002).
    • (2002) Genes Dev. , vol.16 , pp. 720-728
    • Mourelatos, Z.1
  • 29
    • 18344369543 scopus 로고    scopus 로고
    • MicroRNA biogenesis: Coordinated cropping and dicing
    • Kim, V. N. MicroRNA biogenesis: coordinated cropping and dicing. Nature Rev. Mol. Cell Biol. 6, 376-385 (2005).
    • (2005) Nature Rev. Mol. Cell Biol. , vol.6 , pp. 376-385
    • Kim, V.N.1
  • 30
    • 10344248903 scopus 로고    scopus 로고
    • The human DiGeorge syndrome critical region gene 8 and its D. melanogaster homolog are required for miRNA biogenesis
    • Landthaler, M., Yalcin, A. & Tuschl, T. The human DiGeorge syndrome critical region gene 8 and its D. melanogaster homolog are required for miRNA biogenesis. Curr. Biol. 14, 2162-2167 (2004).
    • (2004) Curr. Biol. , vol.14 , pp. 2162-2167
    • Landthaler, M.1    Yalcin, A.2    Tuschl, T.3
  • 31
    • 9144225636 scopus 로고    scopus 로고
    • The microprocessor complex mediates the genesis of microRNAs
    • Gregory, R. I. et al. The microprocessor complex mediates the genesis of microRNAs. Nature 432, 235-240 (2004).
    • (2004) Nature , vol.432 , pp. 235-240
    • Gregory, R.I.1
  • 32
    • 9144224451 scopus 로고    scopus 로고
    • Processing of primary microRNAs by the microprocessor complex
    • Denli, A. M., Tops, B. B., Plasterk, R. H., Ketting, R. F. & Hannon, G. J. Processing of primary microRNAs by the microprocessor complex. Nature 432, 231-235 (2004).
    • (2004) Nature , vol.432 , pp. 231-235
    • Denli, A.M.1    Tops, B.B.2    Plasterk, R.H.3    Ketting, R.F.4    Hannon, G.J.5
  • 33
    • 10644234841 scopus 로고    scopus 로고
    • The Drosha-DGCR8 complex in primary microRNA processing
    • Han, J. et al. The Drosha-DGCR8 complex in primary microRNA processing. Genes Dev. 18, 3016-3027 (2004).
    • (2004) Genes Dev. , vol.18 , pp. 3016-3027
    • Han, J.1
  • 34
    • 33744520104 scopus 로고    scopus 로고
    • Molecular basis for the recognition of primary microRNAs by the Drosha-DGCR8 complex
    • Han, J. et al. Molecular basis for the recognition of primary microRNAs by the Drosha-DGCR8 complex. Cell 125, 887-901 (2006). Elegant study showing the molecular mechanism of the first step involved in pri-miRNA processing.
    • (2006) Cell , vol.125 , pp. 887-901
    • Han, J.1
  • 36
    • 1642499415 scopus 로고    scopus 로고
    • Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs
    • Bohnsack, M. T., Czaplinski, K. & Gorlich, D. Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs. RNA 10, 185-191 (2004).
    • (2004) RNA , vol.10 , pp. 185-191
    • Bohnsack, M.T.1    Czaplinski, K.2    Gorlich, D.3
  • 37
    • 0347361541 scopus 로고    scopus 로고
    • Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs
    • Yi, R., Qin, Y., Macara, I. G. & Cullen, B. R. Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs. Genes Dev. 17, 3011-3016 (2003).
    • (2003) Genes Dev. , vol.17 , pp. 3011-3016
    • Yi, R.1    Qin, Y.2    Macara, I.G.3    Cullen, B.R.4
  • 38
    • 33745894330 scopus 로고    scopus 로고
    • Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54
    • Chu, C. & Rana, T. M. Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54. PLoS Biol. 4, e210 (2006).
    • (2006) PLoS Biol. , vol.4
    • Chu, C.1    Rana, T.M.2
  • 39
    • 20444427566 scopus 로고    scopus 로고
    • Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies
    • Sen, G. L. & Blau, H. M. Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies. Nature Cell Biol. 7, 633-636 (2005).
    • (2005) Nature Cell Biol. , vol.7 , pp. 633-636
    • Sen, G.L.1    Blau, H.M.2
  • 40
    • 24644480213 scopus 로고    scopus 로고
    • Inhibition of translational initiation by let-7 microRNA in human cells
    • Pillai, R. S. et al. Inhibition of translational initiation by let-7 microRNA in human cells. Science 309, 1573-1576 (2005).
    • (2005) Science , vol.309 , pp. 1573-1576
    • Pillai, R.S.1
  • 41
    • 22144478256 scopus 로고    scopus 로고
    • MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies
    • Liu, J., Valencia-Sanchez, M. A., Hannon, G. J. & Parker, R. MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies. Nature Cell Biol. 7, 719-723 (2005). This paper, combined with references 38-40, showed that Argonaute proteins localize to mRNA-processing bodies, or P-bodies.
    • (2005) Nature Cell Biol. , vol.7 , pp. 719-723
    • Liu, J.1    Valencia-Sanchez, M.A.2    Hannon, G.J.3    Parker, R.4
  • 42
    • 33644768174 scopus 로고    scopus 로고
    • Control of translation and mRNA degradation by miRNAs and siRNAs
    • Valencia-Sanchez, M. A., Liu, J., Hannon, G. J. & Parker, R. Control of translation and mRNA degradation by miRNAs and siRNAs. Genes Dev. 20, 515-524 (2006).
    • (2006) Genes Dev. , vol.20 , pp. 515-524
    • Valencia-Sanchez, M.A.1    Liu, J.2    Hannon, G.J.3    Parker, R.4
  • 43
    • 22344455246 scopus 로고    scopus 로고
    • Stress granules and processing bodies are dynamically linked sites of mRNP remodeling
    • Kedersha, N. et al. Stress granules and processing bodies are dynamically linked sites of mRNP remodeling. J. Cell Biol. 169, 871-884 (2005).
    • (2005) J. Cell Biol. , vol.169 , pp. 871-884
    • Kedersha, N.1
  • 44
    • 0036752785 scopus 로고    scopus 로고
    • RNAi in human cells: Basic structural and functional features of small interfering RNA
    • Chiu, Y. L. & Rana, T. M. RNAi in human cells: basic structural and functional features of small interfering RNA. Mol. Cell 10, 549-561 (2002).
    • (2002) Mol. Cell , vol.10 , pp. 549-561
    • Chiu, Y.L.1    Rana, T.M.2
  • 45
    • 0041331496 scopus 로고    scopus 로고
    • siRNA function in RNAi: A chemical modification analysis
    • Chiu, Y. L. & Rana, T. M. siRNA function in RNAi: a chemical modification analysis. RNA 9, 1034-1048 (2003).
    • (2003) RNA , vol.9 , pp. 1034-1048
    • Chiu, Y.L.1    Rana, T.M.2
  • 46
    • 3042602447 scopus 로고    scopus 로고
    • Kinetic analysis of the RNAi enzyme complex
    • Haley, B. & Zamore, P. D. Kinetic analysis of the RNAi enzyme complex. Nature Struct. Mol. Biol. 11, 599-606 (2004). This article, together with references 44 and 45, showed that RNA helical geometry is the major determinant in RNAi.
    • (2004) Nature Struct. Mol. Biol. , vol.11 , pp. 599-606
    • Haley, B.1    Zamore, P.D.2
  • 47
    • 0037440005 scopus 로고    scopus 로고
    • Tolerance for mutations and chemical modifications in a siRNA
    • Amarzguioui, M., Holen, T., Babaie, E. & Prydz, H. Tolerance for mutations and chemical modifications in a siRNA. Nucleic Acids Res. 31, 589-595 (2003).
    • (2003) Nucleic Acids Res. , vol.31 , pp. 589-595
    • Amarzguioui, M.1    Holen, T.2    Babaie, E.3    Prydz, H.4
  • 48
    • 0029069266 scopus 로고
    • Major groove opening at the HIV-1 Tat binding site of TAR RNA evidenced by a rhodium probe
    • Neenhold, H. R. & Rana, T. M. Major groove opening at the HIV-1 Tat binding site of TAR RNA evidenced by a rhodium probe. Biochemistry 34, 6303-6309 (1995).
    • (1995) Biochemistry , vol.34 , pp. 6303-6309
    • Neenhold, H.R.1    Rana, T.M.2
  • 49
    • 0027370486 scopus 로고
    • Major groove accessibility of RNA
    • Weeks, K. M. & Crothers, D. M. Major groove accessibility of RNA. Science 261, 1574-1577 (1993).
    • (1993) Science , vol.261 , pp. 1574-1577
    • Weeks, K.M.1    Crothers, D.M.2
  • 50
    • 0038074374 scopus 로고    scopus 로고
    • Similar behaviour of single-strand and double-strand siRNAs suggests they act through a common RNAi pathway
    • Holen, T., Amarzguioui, M., Babaie, E. & Prydz, H. Similar behaviour of single-strand and double-strand siRNAs suggests they act through a common RNAi pathway. Nucleic Acids Res. 31, 2401-2407 (2003).
    • (2003) Nucleic Acids Res. , vol.31 , pp. 2401-2407
    • Holen, T.1    Amarzguioui, M.2    Babaie, E.3    Prydz, H.4
  • 51
    • 2142654329 scopus 로고    scopus 로고
    • MicroRNA-directed cleavage of HOXB8 mRNA
    • Yekta, S., Shih, I. H. & Bartel, D. P. MicroRNA-directed cleavage of HOXB8 mRNA. Science 304, 594-596 (2004).
    • (2004) Science , vol.304 , pp. 594-596
    • Yekta, S.1    Shih, I.H.2    Bartel, D.P.3
  • 52
    • 0037144546 scopus 로고    scopus 로고
    • A microRNA in a multiple-turnover RNAi enzyme complex
    • Hutvagner, G. & Zamore, P. D. A microRNA in a multiple-turnover RNAi enzyme complex. Science 297, 2056-2060 (2002).
    • (2002) Science , vol.297 , pp. 2056-2060
    • Hutvagner, G.1    Zamore, P.D.2
  • 53
    • 0142173075 scopus 로고    scopus 로고
    • Small RNAs with imperfect match to endogenous mRNA repress translation. Implications for off-target activity of small inhibitory RNA in mammalian cells
    • Saxena, S., Jonsson, Z. O. & Dutta, A. Small RNAs with imperfect match to endogenous mRNA repress translation. Implications for off-target activity of small inhibitory RNA in mammalian cells. J. Biol. Chem. 278, 44312-44319 (2003).
    • (2003) J. Biol. Chem. , vol.278 , pp. 44312-44319
    • Saxena, S.1    Jonsson, Z.O.2    Dutta, A.3
  • 54
    • 4644336023 scopus 로고    scopus 로고
    • Revealing the world of RNA interference
    • Mello, C. C. & Conte, D. Revealing the world of RNA interference. Nature 431, 338-342 (2004).
    • (2004) Nature , vol.431 , pp. 338-342
    • Mello, C.C.1    Conte, D.2
  • 55
    • 0033551328 scopus 로고    scopus 로고
    • Gene silencing in Neurospora crassa requires a protein homologous to RNA-dependent RNA polymerase
    • Cogoni, C. & Macino, G. Gene silencing in Neurospora crassa requires a protein homologous to RNA-dependent RNA polymerase. Nature 399, 166-169 (1999).
    • (1999) Nature , vol.399 , pp. 166-169
    • Cogoni, C.1    Macino, G.2
  • 56
    • 0034716924 scopus 로고    scopus 로고
    • An RNA-dependent RNA polymerase gene in Arabidopsis is required for posttranscriptional gene silencing mediated by a transgene but not by a virus
    • Dalmay, T., Hamilton, A., Rudd, S., Angell, S. & Baulcombe, D. C. An RNA-dependent RNA polymerase gene in Arabidopsis is required for posttranscriptional gene silencing mediated by a transgene but not by a virus. Cell 101, 543-553 (2000).
    • (2000) Cell , vol.101 , pp. 543-553
    • Dalmay, T.1    Hamilton, A.2    Rudd, S.3    Angell, S.4    Baulcombe, D.C.5
  • 57
    • 0035798399 scopus 로고    scopus 로고
    • RNAi as random degradative PCR: siRNA primers convert mRNA into dsRNAs that are degraded to generate new siRNAs
    • Lipardi, C., Wei, Q. & Paterson, B. M. RNAi as random degradative PCR: siRNA primers convert mRNA into dsRNAs that are degraded to generate new siRNAs. Cell 107, 297-307 (2001).
    • (2001) Cell , vol.107 , pp. 297-307
    • Lipardi, C.1    Wei, Q.2    Paterson, B.M.3
  • 58
    • 0034716907 scopus 로고    scopus 로고
    • Arabidopsis SGS2 and SGS3 genes are required for posttranscriptional gene silencing and natural virus resistance
    • Mourrain, P. et al. Arabidopsis SGS2 and SGS3 genes are required for posttranscriptional gene silencing and natural virus resistance. Cell 101, 533-542 (2000).
    • (2000) Cell , vol.101 , pp. 533-542
    • Mourrain, P.1
  • 59
    • 0035900651 scopus 로고    scopus 로고
    • On the role of RNA amplification in dsRNA-triggered gene silencing
    • Sijen, T. et al. On the role of RNA amplification in dsRNA-triggered gene silencing. Cell 107, 465-476 (2001).
    • (2001) Cell , vol.107 , pp. 465-476
    • Sijen, T.1
  • 60
    • 0035798399 scopus 로고    scopus 로고
    • RNAi as random degradative PCR: siRNA primers convert mRNA into dsRNAs that are degraded to generate new siRNAs
    • Lipardi, C., Wei, Q. & Paterson, B. M. RNAi as random degradative PCR: siRNA primers convert mRNA into dsRNAs that are degraded to generate new siRNAs. Cell 107, 297-307 (2001).
    • (2001) Cell , vol.107 , pp. 297-307
    • Lipardi, C.1    Wei, Q.2    Paterson, B.M.3
  • 61
    • 0035900635 scopus 로고    scopus 로고
    • A short primer on RNAi: RNA-directed RNA polymerase acts as a key catalyst
    • Nishikura, K. A short primer on RNAi: RNA-directed RNA polymerase acts as a key catalyst. Cell 107, 415-418 (2001).
    • (2001) Cell , vol.107 , pp. 415-418
    • Nishikura, K.1
  • 62
    • 0038606999 scopus 로고    scopus 로고
    • Structural variations and stabilising modifications of synthetic siRNAs in mammalian cells
    • Czauderna, F. et al. Structural variations and stabilising modifications of synthetic siRNAs in mammalian cells. Nucleic Acids Res. 31, 2705-2716 (2003).
    • (2003) Nucleic Acids Res. , vol.31 , pp. 2705-2716
    • Czauderna, F.1
  • 63
    • 0036752955 scopus 로고    scopus 로고
    • Evidence that siRNAs function as guides, not primers, in the Drosophila and human RNAi pathways
    • Schwarz, D. S., Hutvagner, G., Haley, B. & Zamore, P. D. Evidence that siRNAs function as guides, not primers, in the Drosophila and human RNAi pathways. Mol. Cell 10, 537-548 (2002).
    • (2002) Mol. Cell , vol.10 , pp. 537-548
    • Schwarz, D.S.1    Hutvagner, G.2    Haley, B.3    Zamore, P.D.4
  • 64
    • 0037373298 scopus 로고    scopus 로고
    • Absence of transitive and systemic pathways allows cell-specific and isoform-specific RNAi in Drosophila
    • Roignant, J. Y. et al. Absence of transitive and systemic pathways allows cell-specific and isoform-specific RNAi in Drosophila. RNA 9, 299-308 (2003).
    • (2003) RNA , vol.9 , pp. 299-308
    • Roignant, J.Y.1
  • 65
    • 15844371219 scopus 로고    scopus 로고
    • Structural basis for 5′-end-specific recognition of guide RNA by the A. fulgidus Piwi protein
    • Ma, J. B. et al. Structural basis for 5′-end-specific recognition of guide RNA by the A. fulgidus Piwi protein. Nature 434, 666-670 (2005).
    • (2005) Nature , vol.434 , pp. 666-670
    • Ma, J.B.1
  • 66
    • 15844402005 scopus 로고    scopus 로고
    • Structural insights into mRNA recognition from a PIWI domain-siRNA guide complex
    • Parker, J. S., Roe, S. M. & Barford, D. Structural insights into mRNA recognition from a PIWI domain-siRNA guide complex. Nature 434, 663-666 (2005).
    • (2005) Nature , vol.434 , pp. 663-666
    • Parker, J.S.1    Roe, S.M.2    Barford, D.3
  • 67
    • 33745612464 scopus 로고    scopus 로고
    • Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity
    • Jackson, A. L. et al. Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity. RNA 12, 1179-1187 (2006).
    • (2006) RNA , vol.12 , pp. 1179-1187
    • Jackson, A.L.1
  • 68
    • 0037685280 scopus 로고    scopus 로고
    • Expression profiling reveals off-target gene regulation by RNAi
    • Jackson, A. L. et al. Expression profiling reveals off-target gene regulation by RNAi. Nature Biotechnol. 21, 635-637 (2003).
    • (2003) Nature Biotechnol. , vol.21 , pp. 635-637
    • Jackson, A.L.1
  • 69
    • 33646185371 scopus 로고    scopus 로고
    • RNAi-mediated gene silencing in non-human primates
    • Zimmermann, T. S. et al. RNAi-mediated gene silencing in non-human primates. Nature 441, 111-114 (2006).
    • (2006) Nature , vol.441 , pp. 111-114
    • Zimmermann, T.S.1
  • 70
    • 23444445660 scopus 로고    scopus 로고
    • Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs
    • Morrissey, D. V. et al. Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs. Nature Biotechnol. 23, 1002-1007 (2005).
    • (2005) Nature Biotechnol. , vol.23 , pp. 1002-1007
    • Morrissey, D.V.1
  • 71
    • 9144247189 scopus 로고    scopus 로고
    • Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs
    • Soutschek, J. et al. Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs. Nature 432, 173-178 (2004).
    • (2004) Nature , vol.432 , pp. 173-178
    • Soutschek, J.1
  • 72
    • 33745614074 scopus 로고    scopus 로고
    • Position-specific chemical modification of siRNAs reduces "off-target" transcript silencing
    • Jackson, A. L. et al. Position-specific chemical modification of siRNAs reduces "off-target" transcript silencing. RNA 12, 1197-1205 (2006).
    • (2006) RNA , vol.12 , pp. 1197-1205
    • Jackson, A.L.1
  • 73
    • 22144489833 scopus 로고    scopus 로고
    • RNAi: The nuts and bolts of the RISC machine
    • Filipowicz, W. RNAi: the nuts and bolts of the RISC machine. Cell 122, 17-20 (2005).
    • (2005) Cell , vol.122 , pp. 17-20
    • Filipowicz, W.1
  • 74
    • 24644446398 scopus 로고    scopus 로고
    • Ribo-gnome: The big world of small RNAs
    • Zamore, P. D. & Haley, B. Ribo-gnome: the big world of small RNAs. Science 309, 1519-1524 (2005).
    • (2005) Science , vol.309 , pp. 1519-1524
    • Zamore, P.D.1    Haley, B.2
  • 75
    • 3242736704 scopus 로고    scopus 로고
    • Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs
    • Meister, G. et al. Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs. Mol. Cell 15, 185-197 (2004).
    • (2004) Mol. Cell , vol.15 , pp. 185-197
    • Meister, G.1
  • 76
    • 4444368187 scopus 로고    scopus 로고
    • Argonaute2 is the catalytic engine of mammalian RNAi
    • Liu, J. et al. Argonaute2 is the catalytic engine of mammalian RNAi. Science 305, 1437-1441 (2004).
    • (2004) Science , vol.305 , pp. 1437-1441
    • Liu, J.1
  • 77
    • 4444302947 scopus 로고    scopus 로고
    • Crystal structure of Argonaute and its implications for RISC slicer activity
    • Song, J. J., Smith, S. K., Hannon, G. J. & Joshua-Tor, L. Crystal structure of Argonaute and its implications for RISC slicer activity. Science 305, 1434-1437 (2004).
    • (2004) Science , vol.305 , pp. 1434-1437
    • Song, J.J.1    Smith, S.K.2    Hannon, G.J.3    Joshua-Tor, L.4
  • 78
    • 0035803583 scopus 로고    scopus 로고
    • Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate
    • Elbashir, S. M., Martinez, J., Patkaniowska, A., Lendeckel, W. & Tuschl, T. Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate. EMBO J. 20, 6877-6888 (2001).
    • (2001) EMBO J. , vol.20 , pp. 6877-6888
    • Elbashir, S.M.1    Martinez, J.2    Patkaniowska, A.3    Lendeckel, W.4    Tuschl, T.5
  • 79
    • 10744225153 scopus 로고    scopus 로고
    • Asymmetry in the assembly of the RNAi enzyme complex
    • Schwarz, D. S. et al. Asymmetry in the assembly of the RNAi enzyme complex. Cell 115, 199-208 (2003).
    • (2003) Cell , vol.115 , pp. 199-208
    • Schwarz, D.S.1
  • 80
    • 0142165224 scopus 로고    scopus 로고
    • Functional siRNAs and miRNAs exhibit strand bias
    • Khvorova, A., Reynolds, A. & Jayasena, S. D. Functional siRNAs and miRNAs exhibit strand bias. Cell 115, 209-216 (2003). This paper, together with reference 79, showed the influence of siRNA thermodynamic stability on RISC formation.
    • (2003) Cell , vol.115 , pp. 209-216
    • Khvorova, A.1    Reynolds, A.2    Jayasena, S.D.3
  • 81
    • 33645763485 scopus 로고    scopus 로고
    • Cleavage of the siRNA passenger strand during RISC assembly in human cells
    • Leuschner, P. J., Ameres, S. L., Kueng, S. & Martinez, J. Cleavage of the siRNA passenger strand during RISC assembly in human cells. EMBO Rep. 7, 314-320 (2006).
    • (2006) EMBO Rep. , vol.7 , pp. 314-320
    • Leuschner, P.J.1    Ameres, S.L.2    Kueng, S.3    Martinez, J.4
  • 82
    • 27744590896 scopus 로고    scopus 로고
    • Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes
    • Matranga, C., Tomari, Y., Shin, C., Bartel, D. P. & Zamore, P. D. Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes. Cell 123, 607-620 (2005).
    • (2005) Cell , vol.123 , pp. 607-620
    • Matranga, C.1    Tomari, Y.2    Shin, C.3    Bartel, D.P.4    Zamore, P.D.5
  • 83
    • 27744506761 scopus 로고    scopus 로고
    • Argonaute2 cleaves the anti-guide strand of siRNA during RISC activation
    • Rand, T. A., Petersen, S., Du, F. & Wang, X. Argonaute2 cleaves the anti-guide strand of siRNA during RISC activation. Cell 123, 621-629 (2005).
    • (2005) Cell , vol.123 , pp. 621-629
    • Rand, T.A.1    Petersen, S.2    Du, F.3    Wang, X.4
  • 84
    • 1642273831 scopus 로고    scopus 로고
    • An algorithm for selection of functional siRNA sequences
    • Amarzguioui, M. & Prydz, H. An algorithm for selection of functional siRNA sequences. Biochem. Biophys. Res. Commun. 316, 1050-1058 (2004).
    • (2004) Biochem. Biophys. Res. Commun. , vol.316 , pp. 1050-1058
    • Amarzguioui, M.1    Prydz, H.2
  • 85
    • 1642491747 scopus 로고    scopus 로고
    • Enhancement of RNAi activity by improved siRNA duplexes
    • Hohjoh, H. Enhancement of RNAi activity by improved siRNA duplexes. FEBS Lett. 557, 193-198 (2004).
    • (2004) FEBS Lett. , vol.557 , pp. 193-198
    • Hohjoh, H.1
  • 86
    • 3242889236 scopus 로고    scopus 로고
    • siDirect: Highly effective, target-specific siRNA design software for mammalian RNA interference
    • Naito, Y., Yamada, T., Ui-Tei, K., Morishita, S. & Saigo, K. siDirect: highly effective, target-specific siRNA design software for mammalian RNA interference. Nucleic Acids Res. 32, W124-W129 (2004).
    • (2004) Nucleic Acids Res. , vol.32
    • Naito, Y.1    Yamada, T.2    Ui-Tei, K.3    Morishita, S.4    Saigo, K.5
  • 87
    • 1542336952 scopus 로고    scopus 로고
    • Rational siRNA design for RNA interference
    • Reynolds, A. et al. Rational siRNA design for RNA interference. Nature Biotechnol. 22, 326-330 (2004).
    • (2004) Nature Biotechnol. , vol.22 , pp. 326-330
    • Reynolds, A.1
  • 88
    • 1642346273 scopus 로고    scopus 로고
    • Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference
    • Ui-Tei, K. et al. Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference. Nucleic Acids Res. 32, 936-948 (2004).
    • (2004) Nucleic Acids Res. , vol.32 , pp. 936-948
    • Ui-Tei, K.1
  • 89
    • 13444282536 scopus 로고    scopus 로고
    • Filtering of ineffective siRNAs and improved siRNA design yool
    • Yiu, S. M. et al. Filtering of ineffective siRNAs and improved siRNA design yool. Bioinformatics 21, 144-151 (2005).
    • (2005) Bioinformatics , vol.21 , pp. 144-151
    • Yiu, S.M.1
  • 90
    • 2442495329 scopus 로고    scopus 로고
    • RISC is a 5′ phosphomonoester-producing RNA endonuclease
    • Martinez, J. & Tuschl, T. RISC is a 5′ phosphomonoester- producing RNA endonuclease. Genes Dev. 18, 975-980 (2004).
    • (2004) Genes Dev. , vol.18 , pp. 975-980
    • Martinez, J.1    Tuschl, T.2
  • 91
    • 13444287967 scopus 로고    scopus 로고
    • Assembly and function of RNA silencing complexes
    • Sontheimer, E. J. Assembly and function of RNA silencing complexes. Nature Rev. Mol. Cell Biol. 6, 127-138 (2005).
    • (2005) Nature Rev. Mol. Cell Biol. , vol.6 , pp. 127-138
    • Sontheimer, E.J.1
  • 92
    • 20444455464 scopus 로고    scopus 로고
    • Target accessibility dictates the potency of human RISC
    • Brown, K. M., Chu, C. Y. & Rana, T. M. Target accessibility dictates the potency of human RISC. Nature Struct. Mol. Biol. 12, 469-470 (2005).
    • (2005) Nature Struct. Mol. Biol. , vol.12 , pp. 469-470
    • Brown, K.M.1    Chu, C.Y.2    Rana, T.M.3
  • 93
    • 1242318826 scopus 로고    scopus 로고
    • Sequence-specific inhibition of microRNA- and siRNA-induced RNA silencing
    • Meister, G., Landthaler, M., Dorsett, Y. & Tuschl, T. Sequence-specific inhibition of microRNA- and siRNA-induced RNA silencing. RNA 10, 544-550 (2004).
    • (2004) RNA , vol.10 , pp. 544-550
    • Meister, G.1    Landthaler, M.2    Dorsett, Y.3    Tuschl, T.4
  • 94
    • 1242342082 scopus 로고    scopus 로고
    • Inhibition of human immunodeficiency virus type 1 replication by RNA interference directed against human transcription elongation factor P-TEFb (CDK9/CyclinT1)
    • Chiu, Y. L., Cao, H., Jacque, J. M., Stevenson, M. & Rana, T. M. Inhibition of human immunodeficiency virus type 1 replication by RNA interference directed against human transcription elongation factor P-TEFb (CDK9/CyclinT1). J. Virol. 78, 2517-2529 (2004).
    • (2004) J. Virol. , vol.78 , pp. 2517-2529
    • Chiu, Y.L.1    Cao, H.2    Jacque, J.M.3    Stevenson, M.4    Rana, T.M.5
  • 95
    • 23644433363 scopus 로고    scopus 로고
    • TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing
    • Chendrimada, T. P. et al. TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing. Nature 436, 740-744 (2005).
    • (2005) Nature , vol.436 , pp. 740-744
    • Chendrimada, T.P.1
  • 96
    • 22744433240 scopus 로고    scopus 로고
    • Normal microRNA maturation and germ-line stem cell maintenance requires Loquacious, a double-stranded RNA-binding domain protein
    • Forstemann, K. et al. Normal microRNA maturation and germ-line stem cell maintenance requires Loquacious, a double-stranded RNA-binding domain protein. PLoS Biol. 3, e236 (2005).
    • (2005) PLoS Biol. , vol.3
    • Forstemann, K.1
  • 97
    • 27144550559 scopus 로고    scopus 로고
    • TRBP, a regulator of cellular PKR and HIV-1 virus expression, interacts with Dicer and functions in RNA silencing
    • Haase, A. D. et al. TRBP, a regulator of cellular PKR and HIV-1 virus expression, interacts with Dicer and functions in RNA silencing. EMBO Rep. 6, 961-967 (2005).
    • (2005) EMBO Rep. , vol.6 , pp. 961-967
    • Haase, A.D.1
  • 98
    • 0036792769 scopus 로고    scopus 로고
    • Fragile X-related protein and VIG associate with the RNA interference machinery
    • Caudy, A. A., Myers, M., Hannon, G. J. & Hammond, S. M. Fragile X-related protein and VIG associate with the RNA interference machinery. Genes Dev. 16, 2491-2496 (2002).
    • (2002) Genes Dev. , vol.16 , pp. 2491-2496
    • Caudy, A.A.1    Myers, M.2    Hannon, G.J.3    Hammond, S.M.4
  • 99
    • 1642374097 scopus 로고    scopus 로고
    • Specificity of microRNA target selection in translational repression
    • Doench, J. G. & Sharp, P. A. Specificity of microRNA target selection in translational repression. Genes Dev. 18, 504-511 (2004).
    • (2004) Genes Dev. , vol.18 , pp. 504-511
    • Doench, J.G.1    Sharp, P.A.2
  • 100
    • 13944282215 scopus 로고    scopus 로고
    • Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs
    • Lim, L. P. et al. Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature 433, 769-773 (2005).
    • (2005) Nature , vol.433 , pp. 769-773
    • Lim, L.P.1
  • 101
    • 3142729150 scopus 로고    scopus 로고
    • Distinct roles for Argonaute proteins in small RNA-directed RNA cleavage pathways
    • Okamura, K., Ishizuka, A., Siomi, H. & Siomi, M. C. Distinct roles for Argonaute proteins in small RNA-directed RNA cleavage pathways. Genes Dev. 18, 1655-1666 (2004).
    • (2004) Genes Dev. , vol.18 , pp. 1655-1666
    • Okamura, K.1    Ishizuka, A.2    Siomi, H.3    Siomi, M.C.4
  • 103
    • 17444412299 scopus 로고    scopus 로고
    • Local RNA target structure influences siRNA efficacy: Systematic analysis of intentionally designed binding regions
    • Schubert, S., Grunweller, A., Erdmann, V. A. & Kurreck, J. Local RNA target structure influences siRNA efficacy: systematic analysis of intentionally designed binding regions. J. Mol. Biol. 348, 883-893 (2005).
    • (2005) J. Mol. Biol. , vol.348 , pp. 883-893
    • Schubert, S.1    Grunweller, A.2    Erdmann, V.A.3    Kurreck, J.4
  • 104
    • 17444365809 scopus 로고    scopus 로고
    • Local RNA target structure influences siRNA efficacy: A systematic global analysis
    • Overhoff, M. et al. Local RNA target structure influences siRNA efficacy: a systematic global analysis. J. Mol. Biol. 348, 871-881 (2005). This article, together with references 92 and 103, showed the effect of target accessibility on RNAi function.
    • (2005) J. Mol. Biol. , vol.348 , pp. 871-881
    • Overhoff, M.1
  • 105
    • 0033562094 scopus 로고    scopus 로고
    • Biochemical and functional interactions between HIV-1 Tat protein and TAR RNA
    • Rana, T. M. & Jeang, K. T. Biochemical and functional interactions between HIV-1 Tat protein and TAR RNA. Arch. Biochem. Biophys. 365, 175-185 (1999).
    • (1999) Arch. Biochem. Biophys. , vol.365 , pp. 175-185
    • Rana, T.M.1    Jeang, K.T.2
  • 106
    • 0033061571 scopus 로고    scopus 로고
    • Initiation of translation in prokaryotes and eukaryotes
    • Kozak, M. Initiation of translation in prokaryotes and eukaryotes. Gene 234, 187-208 (1999).
    • (1999) Gene , vol.234 , pp. 187-208
    • Kozak, M.1
  • 107
    • 28444469246 scopus 로고    scopus 로고
    • Silencing of microRNAs in vivo with 'antagomirs'
    • Krutzfeldt, J. et al. Silencing of microRNAs in vivo with 'antagomirs'. Nature 438, 685-689 (2005).
    • (2005) Nature , vol.438 , pp. 685-689
    • Krutzfeldt, J.1
  • 108
    • 14544280255 scopus 로고    scopus 로고
    • The silent revolution: RNA interference as basic biology, research tool, and therapeutic
    • Dykxhoorn, D. M. & Lieberman, J. The silent revolution: RNA interference as basic biology, research tool, and therapeutic. Annu. Rev. Med. 56, 401-423 (2005).
    • (2005) Annu. Rev. Med. , vol.56 , pp. 401-423
    • Dykxhoorn, D.M.1    Lieberman, J.2
  • 109
    • 30144434185 scopus 로고    scopus 로고
    • An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection
    • Palliser, D. et al. An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection. Nature 439, 89-94 (2006).
    • (2006) Nature , vol.439 , pp. 89-94
    • Palliser, D.1
  • 110
    • 4944225347 scopus 로고    scopus 로고
    • Endogenous trans-acting siRNAs regulate the accumulation of Arabidopsis mRNAs
    • Vazquez, F. et al. Endogenous trans-acting siRNAs regulate the accumulation of Arabidopsis mRNAs. Mol. Cell 16, 69-79 (2004).
    • (2004) Mol. Cell , vol.16 , pp. 69-79
    • Vazquez, F.1
  • 111
    • 4644286235 scopus 로고    scopus 로고
    • SGS3 and SGS2/SDE1/RDR6 are required for juvenile development and the production of trans-acting siRNAs in Arabidopsis
    • Peragine, A., Yoshikawa, M., Wu, G., Albrecht, H. L. & Poethig, R. S. SGS3 and SGS2/SDE1/RDR6 are required for juvenile development and the production of trans-acting siRNAs in Arabidopsis. Genes Dev. 18, 2368-2379 (2004).
    • (2004) Genes Dev. , vol.18 , pp. 2368-2379
    • Peragine, A.1    Yoshikawa, M.2    Wu, G.3    Albrecht, H.L.4    Poethig, R.S.5
  • 112
    • 0037072661 scopus 로고    scopus 로고
    • Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi
    • Volpe, T. A. et al. Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi. Science 297, 1833-1837 (2002).
    • (2002) Science , vol.297 , pp. 1833-1837
    • Volpe, T.A.1
  • 113
    • 0037072660 scopus 로고    scopus 로고
    • Small RNAs correspond to centromere heterochromatic repeats
    • Reinhart, B. J. & Bartel, D. P. Small RNAs correspond to centromere heterochromatic repeats. Science 297, 1831 (2002).
    • (2002) Science , vol.297 , pp. 1831
    • Reinhart, B.J.1    Bartel, D.P.2
  • 114
    • 0035838369 scopus 로고    scopus 로고
    • Double-stranded RNA-mediated silencing of genomic tandem repeats and transposable elements in the D. melanogaster germline
    • Aravin, A. A. et al. Double-stranded RNA-mediated silencing of genomic tandem repeats and transposable elements in the D. melanogaster germline. Curr. Biol. 11, 1017-1027 (2001).
    • (2001) Curr. Biol. , vol.11 , pp. 1017-1027
    • Aravin, A.A.1
  • 115
    • 1942535718 scopus 로고    scopus 로고
    • Small RNAs in genome rearrangement in Tetrahymena
    • Mochizuki, K. & Gorovsky, M. A. Small RNAs in genome rearrangement in Tetrahymena. Curr. Opin. Genet. Dev. 14, 181-187 (2004).
    • (2004) Curr. Opin. Genet. Dev. , vol.14 , pp. 181-187
    • Mochizuki, K.1    Gorovsky, M.A.2
  • 116
    • 33745402414 scopus 로고    scopus 로고
    • A novel class of small RNAs bind to MILI protein in mouse testes
    • Aravin, A. et al. A novel class of small RNAs bind to MILI protein in mouse testes. Nature 442, 203-207 (2006).
    • (2006) Nature , vol.442 , pp. 203-207
    • Aravin, A.1
  • 117
    • 33745336617 scopus 로고    scopus 로고
    • A germline-specific class of small RNAs binds mammalian Piwi proteins
    • Girard, A., Sachidanandam, R., Hannon, G. J. & Carmell, M. A. A germline-specific class of small RNAs binds mammalian Piwi proteins. Nature 442, 199-202 (2006).
    • (2006) Nature , vol.442 , pp. 199-202
    • Girard, A.1    Sachidanandam, R.2    Hannon, G.J.3    Carmell, M.A.4
  • 118
    • 33745621037 scopus 로고    scopus 로고
    • A novel class of small RNAs in mouse spermatogenic cells
    • Grivna, S. T., Beyret, E., Wang, Z. & Lin, H. A novel class of small RNAs in mouse spermatogenic cells. Genes Dev. 20, 1709-1714 (2006).
    • (2006) Genes Dev. , vol.20 , pp. 1709-1714
    • Grivna, S.T.1    Beyret, E.2    Wang, Z.3    Lin, H.4
  • 119
    • 33745599586 scopus 로고    scopus 로고
    • Identification and characterization of two novel classes of small RNAs in the mouse germline: Retrotransposon-derived siRNAs in oocytes and germline small RNAs in testes
    • Watanabe, T. et al. Identification and characterization of two novel classes of small RNAs in the mouse germline: retrotransposon-derived siRNAs in oocytes and germline small RNAs in testes. Genes Dev. 20, 1732-1743 (2006).
    • (2006) Genes Dev. , vol.20 , pp. 1732-1743
    • Watanabe, T.1
  • 120
    • 33746527679 scopus 로고    scopus 로고
    • Characterization of the piRNA complex from rat testes
    • Lau, N. C. et al. Characterization of the piRNA complex from rat testes. Science 313, 363-367 (2006).
    • (2006) Science , vol.313 , pp. 363-367
    • Lau, N.C.1
  • 121
    • 0034829922 scopus 로고    scopus 로고
    • Two mouse piwi-related genes: Miwi and mili
    • Kuramochi-Miyagawa, S. et al. Two mouse piwi-related genes: miwi and mili. Mech. Dev. 108, 121-133 (2001).
    • (2001) Mech. Dev. , vol.108 , pp. 121-133
    • Kuramochi-Miyagawa, S.1
  • 122
    • 1842816517 scopus 로고    scopus 로고
    • Distinct roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA silencing pathways
    • Lee, Y. S. et al. Distinct roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA silencing pathways. Cell 117, 69-81 (2004).
    • (2004) Cell , vol.117 , pp. 69-81
    • Lee, Y.S.1
  • 123
    • 3142613181 scopus 로고    scopus 로고
    • Single processing center models for human Dicer and bacterial RNase III
    • Zhang, H., Kolb, F. A., Jaskiewicz, L., Westhof, E. & Filipowicz, W. Single processing center models for human Dicer and bacterial RNase III. Cell 118, 57-68 (2004).
    • (2004) Cell , vol.118 , pp. 57-68
    • Zhang, H.1    Kolb, F.A.2    Jaskiewicz, L.3    Westhof, E.4    Filipowicz, W.5
  • 124
    • 28444437427 scopus 로고    scopus 로고
    • Slicer function of Drosophila Argonautes and its involvement in RISC formation
    • Miyoshi, K., Tsukumo, H., Nagami, T., Siomi, H. & Siomi, M. C. Slicer function of Drosophila Argonautes and its involvement in RISC formation. Genes Dev. 19, 2837-2848 (2005). This paper, together with references 75 and 76, provided evidence that AGO2 is the catalytic enzyme that cleaves target mRNA during RNAi.
    • (2005) Genes Dev. , vol.19 , pp. 2837-2848
    • Miyoshi, K.1    Tsukumo, H.2    Nagami, T.3    Siomi, H.4    Siomi, M.C.5
  • 125
    • 22744454230 scopus 로고    scopus 로고
    • Processing of pre-microRNAs by the Dicer-1-Loquacious complex in Drosophila cells
    • Saito, K., Ishizuka, A., Siomi, H. & Siomi, M. C. Processing of pre-microRNAs by the Dicer-1-Loquacious complex in Drosophila cells. PLoS Biol. 3, e235 (2005).
    • (2005) PLoS Biol. , vol.3
    • Saito, K.1    Ishizuka, A.2    Siomi, H.3    Siomi, M.C.4
  • 126
    • 23044462450 scopus 로고    scopus 로고
    • Dicer-1 and R3D1-L catalyze microRNA maturation in Drosophila
    • Jiang, F. et al. Dicer-1 and R3D1-L catalyze microRNA maturation in Drosophila. Genes Dev. 19, 1674-1679 (2005).
    • (2005) Genes Dev. , vol.19 , pp. 1674-1679
    • Jiang, F.1
  • 127
    • 32544460452 scopus 로고    scopus 로고
    • The role of PACT in the RNA silencing pathway
    • Lee, Y. et al. The role of PACT in the RNA silencing pathway. EMBO J. 25, 522-532 (2006).
    • (2006) EMBO J. , vol.25 , pp. 522-532
    • Lee, Y.1
  • 128
    • 11244279683 scopus 로고    scopus 로고
    • Crystal structure of a PIWI protein suggests mechanisms for siRNA recognition and slicer activity
    • Parker, J. S., Roe, S. M. & Barford, D. Crystal structure of a PIWI protein suggests mechanisms for siRNA recognition and slicer activity. EMBO J. 23, 4727-4737 (2004).
    • (2004) EMBO J. , vol.23 , pp. 4727-4737
    • Parker, J.S.1    Roe, S.M.2    Barford, D.3
  • 129
    • 12544255524 scopus 로고    scopus 로고
    • Maintaining inhibition: siRNA double expression vectors against coxsackieviral RNAs
    • Schubert, S. et al. Maintaining inhibition: siRNA double expression vectors against coxsackieviral RNAs. J. Mol. Biol. 346, 457-465 (2005).
    • (2005) J. Mol. Biol. , vol.346 , pp. 457-465
    • Schubert, S.1
  • 130
    • 0037089135 scopus 로고    scopus 로고
    • Positional effects of short interfering RNAs targeting the human coagulation trigger tissue factor
    • Holen, T., Amarzguioui, M., Wiiger, M. T., Babaie, E. & Prydz, H. Positional effects of short interfering RNAs targeting the human coagulation trigger tissue factor. Nucleic Acids Res. 30, 1757-1766 (2002).
    • (2002) Nucleic Acids Res. , vol.30 , pp. 1757-1766
    • Holen, T.1    Amarzguioui, M.2    Wiiger, M.T.3    Babaie, E.4    Prydz, H.5
  • 131
    • 21244497878 scopus 로고    scopus 로고
    • Positional effect of chemical modifications on short interference RNA activity in mammalian cells
    • Prakash, T. P. et al. Positional effect of chemical modifications on short interference RNA activity in mammalian cells. J. Med. Chem. 48, 4247-4253 (2005).
    • (2005) J. Med. Chem. , vol.48 , pp. 4247-4253
    • Prakash, T.P.1
  • 132
    • 0038385504 scopus 로고    scopus 로고
    • RNA interference in mammalian cells by chemically-modified RNA
    • Braasch, D. A. et al. RNA interference in mammalian cells by chemically-modified RNA. Biochemistry 42, 7967-7975 (2003).
    • (2003) Biochemistry , vol.42 , pp. 7967-7975
    • Braasch, D.A.1
  • 133
    • 29844452007 scopus 로고    scopus 로고
    • Small interfering RNAs containing full 2′-O-methylribonucleotide- modified sense strands display Argonaute2/eIF2C2-dependent activity
    • Kraynack, B. A. & Baker, B. F. Small interfering RNAs containing full 2′-O-methylribonucleotide-modified sense strands display Argonaute2/eIF2C2-dependent activity. RNA 12, 163-176 (2006).
    • (2006) RNA , vol.12 , pp. 163-176
    • Kraynack, B.A.1    Baker, B.F.2
  • 134
    • 18744407284 scopus 로고    scopus 로고
    • Purified Argonaute2 and an siRNA form recombinant human RISC
    • Rivas, F. V. et al. Purified Argonaute2 and an siRNA form recombinant human RISC. Nature Struct. Mol. Biol. 12, 340-349 (2005).
    • (2005) Nature Struct. Mol. Biol. , vol.12 , pp. 340-349
    • Rivas, F.V.1
  • 135
    • 0035968282 scopus 로고    scopus 로고
    • Investigating the structure of human RNase H1 by site-directed mutagenesis
    • Wu, H., Lima, W. F. & Crooke, S. T. Investigating the structure of human RNase H1 by site-directed mutagenesis. J. Biol. Chem. 276, 23547-23553 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 23547-23553
    • Wu, H.1    Lima, W.F.2    Crooke, S.T.3


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