Crystal structure of argonaute and its implications for RISC slicer activity

Science

Volumn 305, Issue 5689, 2004, Pages 1434-1437

  Song, Ji Joon ^a   Smith, Stephanie K ^a   Hannon, Gregory J ^a   Joshua Tor, Leemor ^a  

^a Howard Hughes Medical Institute Cold Spring Harbor Laboratory Cold Spring Harbor   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGONAUTE PROTEINS; RNA-INDUCED SILENCING COMPLEXES (RISC); SMALL INTERFERING RNAS (SIRNA);

COMPLEXATION; CRYSTAL STRUCTURE; ENZYMES; PROTEINS; SUBSTRATES;

RNA;

ARABINOSE; ASPARTIC ACID; BINDING PROTEIN; GALACTOSE; GLUCOSE; MESSENGER RNA; NUCLEASE; OLIGONUCLEOTIDE; OLIGOSACCHARIDE; PROTEIN; RIBONUCLEASE H; RIBOSE; RNA INDUCED SILENCING COMPLEX; SMALL INTERFERING RNA; TRANSPOSASE;

BIOLOGY; RNA;

AMINO TERMINAL SEQUENCE; ARTICLE; CATALYSIS; CRYSTAL STRUCTURE; NONHUMAN; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ARCHAEAL PROTEINS; BINDING SITES; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PYROCOCCUS FURIOSUS; RIBONUCLEASE H, CALF THYMUS; RNA INTERFERENCE; RNA, MESSENGER; RNA, SMALL INTERFERING; RNA-INDUCED SILENCING COMPLEX;

BACTERIA (MICROORGANISMS); EUKARYOTA; PYROCOCCUS; PYROCOCCUS FURIOSUS;

EID: 4444302947     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1102514     Document Type: Article

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31. We thank E. Enemark for help with data collection, R. Martienssen and members of the Joshua-Tor laboratory for helpful discussions, and M. Becker (beamline X25) for support with data collection at the National Synchrotron Light Source (NSLS). The NSLS is supported by the U.S. Department of Energy, Division of Material Sciences and Division of Chemical Sciences. J.-J.S. is a Bristol-Myers Squibb Predoctoral Fellow. Coordinates have been deposited in the Protein Data Bank (accession code 1U04).