A germline-specific class of small RNAs binds mammalian Piwi proteins

Nature

Volumn 442, Issue 7099, 2006, Pages 199-202

  Girard, Angélique ^a,b   Sachidanandam, Ravi ^a   Hannon, Gregory J ^a   Carmell, Michelle A ^a  

^a Howard Hughes Medical Institute Cold Spring Harbor Laboratory Cold Spring Harbor   (United States)

^b PSL RESEARCH UNIVERSITY   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; GENETIC ENGINEERING; MUTAGENESIS; RNA; SYNTHESIS (CHEMICAL);

GENOMES; MICRORNA; PIWI PROTEINS; PROTEIN SYNTHESIS;

PROTEINS;

PIWI PROTEIN; PROTEIN; RNA; RNA BINDING PROTEIN; UNCLASSIFIED DRUG;

GENOME; MAMMAL; PROTEIN; RNA;

ARTICLE; COMPARATIVE GENE MAPPING; GAMETOGENESIS; GENETIC SIMILARITY; GENOME; GERM LINE; HUMAN; HUMAN VERSUS ANIMAL COMPARISON; MALE STERILITY; MAMMAL; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FAMILY; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN RNA BINDING; RNA SEQUENCE; RNA STRUCTURE; STEM CELL;

ANIMALIA; MAMMALIA; MURINAE;

EID: 33745336617     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature04917     Document Type: Article

References (25)

1. Hannon, G. J. RNA interference. Nature 418, 244-251 (2002).
2. Meister, G. & Tuschl, T. Mechanisms of gene silencing by double-stranded RNA. Nature 431, 343-349 (2004).
3. Bartel, D. P. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116, 281-297 (2004).
4. Carmell, M. A., Xuan, Z., Zhang, M. Q. & Hannon, G. J. The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis. Genes Dev. 16, 2733-2742 (2002).
5. Cox, D. N. et al. A novel class of evolutionary conserved genes defined by piwi are essential for stem cell self-renewal. Genes Dev. 12, 3715-3727 (1998).
6. Lin, H. & Spradling, A. C. A novel group of pumilio mutations affects the asymmetric division of germline stem cells in the Drosophila ovary. Development 124, 2463-2476 (1997).
7. Cox, D. N., Chao, A. & Lin, H. piwi encodes a nucleoplasmic factor whose activity modulates the number and division rate of germline stem cells. Development 127, 503-514 (2000).
8. Pal-Bhadra, M., Bhadra, U. & Birchler, J. A. RNAi related mechanisms affect both transcriptional and posttranscriptional transgene silencing in Drosophila. Mol. Cell 9, 315-327 (2002).
9. Pal-Bhadra, M. et al. Heterochromatic silencing and HP1 localization in Drosophila are dependent on the RNAi machinery. Science 303, 669-672 (2004).
10. Aravin, A. A. et al. Dissection of a natural RNA silencing process in the Drosophila melanogaster germ line. Mol. Cell. Biol. 24, 6742-6750 (2004).
11. Aravin, A. A. et al. Double-stranded RNA-mediated silencing of genomic tandem repeats and transposable elements in the D. melanogoster germline. Curr. Biol. 11, 1017-1027 (2001).
12. Kalmykova, A. I., Klenov, M. S. & Gvozdev, V. A. Argonaute protein PIWI controls mobilization of retrotransposons in the Drosophila male germline. Nucleic Acids Res. 33, 2052-2059 (2005).
13. Savitsky, M., Kwon, D., Georgiev, P., Kalmykova, A. & Gvozdev, V. Telomere elongation is under the control of the RNAi-based mechanism in the Drosophila germline. Genes Dev. 20, 345-354 (2006).
14. Vagin, V. V. et al. The RNA interference proteins and vasa locus are involved in the silencing of retrotransposons in the female germline of Drosophila melanogaster. RNA Biol. 1, 51-55 (2004).
15. Sarot, E., Payen-Groschene, G., Bucheton, A. & Pelisson, A. Evidence for a piwi-dependent RNA silencing of the gypsy endogenous retrovirus by the Drosophila melanogaster flamenco gene. Genetics 166, 1313-1321 (2004).
16. Deng, W. & Lin, H. miwi, a murine homolog of piwi, encodes a cytoplasmic protein essential for spermatogenesis. Dev. Cell 2, 819-830 (2002).
17. Kuramochi-Miyagawa, S. et al. Mili, a mammalian member of piwi family gene, is essential for spermatogenesis. Development 131, 839-849 (2004).
18. Ambros, V. & Lee, R. C. Identification of microRNAs and other tiny noncoding RNAs by cDNA cloning. Methods Mol. Biol. 265, 131-158 (2004).
19. Margulies, M. et al. Genome sequencing in microfabricated high-density picolitre reactors. Nature 437, 376-380 (2005).
20. Aravin, A. A. et al. The small RNA profile during Drosophila melanogaster development. Dev. Cell 5, 337-350 (2003).
21. Sijen, T. et al. On the role of RNA amplification in dsRNA-triggered gene silencing. Cell 107, 465-476 (2001).
22. Bourc'his, D. & Bestor, T. H. Meiotic catastrophe and retrotransposon reactivation in male germ cells lacking Dnmt3L. Nature 431, 96-99 (2004).
23. Webster, K. E. et al. Meiotic and epigenetic defects in Dnmt3L-knockout mouse spermatogenesis. Proc. Natl Acad. Sci. USA 102, 4068-4073 (2005).
24. Peters, A. H. et al. Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability. Cell 107, 323-337 (2001).
25. Caudy, A. A., Myers, M., Hannon, G. J. & Hammond, S. M. Fragile X-related protein and VIG associate with the RNA interference machinery. Genes Dev. 16, 2491-2496 (2002).