메뉴 건너뛰기




Volumn 6, Issue 2, 2005, Pages 127-138

Assembly and function of RNA silencing complexes

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED RNA; MESSENGER RNA; RNA BINDING PROTEIN; RNA INDUCED SILENCING COMPLEX;

EID: 13444287967     PISSN: 14710072     EISSN: None     Source Type: Journal    
DOI: 10.1038/nrm1568     Document Type: Review
Times cited : (360)

References (96)
  • 1
    • 0032545933 scopus 로고    scopus 로고
    • Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
    • Fire, A. et al. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391, 806-811 (1998).
    • (1998) Nature , vol.391 , pp. 806-811
    • Fire, A.1
  • 3
    • 19344365307 scopus 로고    scopus 로고
    • Planting the seeds of a new paradigm
    • Matzke, M. A. & Matzke, A. J. M. Planting the seeds of a new paradigm. PLoS Biol. 2, 582-586 (2004).
    • (2004) PLoS Biol. , vol.2 , pp. 582-586
    • Matzke, M.A.1    Matzke, A.J.M.2
  • 5
    • 0037686295 scopus 로고    scopus 로고
    • Killing the messenger: Short RNAs that silence gene expression
    • Dykxhoorn, D. M., Novina, C. D. & Sharp, P. A. Killing the messenger: short RNAs that silence gene expression. Nature Rev. Mol. Cell Biol. 4, 457-167 (2003).
    • (2003) Nature Rev. Mol. Cell Biol. , vol.4 , pp. 457-1167
    • Dykxhoorn, D.M.1    Novina, C.D.2    Sharp, P.A.3
  • 6
    • 0035942736 scopus 로고    scopus 로고
    • Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
    • Elbashir, S. M. et al. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411, 494-498 (2001).
    • (2001) Nature , vol.411 , pp. 494-498
    • Elbashir, S.M.1
  • 7
    • 0034673638 scopus 로고    scopus 로고
    • An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells
    • Hammond, S. M., Bernstein, E., Beach, D. & Hannon, G. J. An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells. Nature 404, 293-296 (2000).
    • (2000) Nature , vol.404 , pp. 293-296
    • Hammond, S.M.1    Bernstein, E.2    Beach, D.3    Hannon, G.J.4
  • 8
    • 0034737298 scopus 로고    scopus 로고
    • RNAi: Double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals
    • Zamcre, P. D., Tuschl, T., Sharp, P. A. & Bartel, D. P. RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals. Cell 101, 25-33 (2000).
    • (2000) Cell , vol.101 , pp. 25-33
    • Zamcre, P.D.1    Tuschl, T.2    Sharp, P.A.3    Bartel, D.P.4
  • 9
    • 0037031576 scopus 로고    scopus 로고
    • Single-stranded antisense siRNAs guide target RNA cleavage in RNAi
    • Martinez, J., Patkaniowska, A., Urlaub, H., Luhmann, R. & Tuschl, T. Single-stranded antisense siRNAs guide target RNA cleavage in RNAi. Cell 110, 563-574 (2002).
    • (2002) Cell , vol.110 , pp. 563-574
    • Martinez, J.1    Patkaniowska, A.2    Urlaub, H.3    Luhmann, R.4    Tuschl, T.5
  • 10
    • 0037224921 scopus 로고    scopus 로고
    • A biochemical framework for RNA silencing in plants
    • Tang, G., Reinhart, B. J., Bartel, D. P. & Zamore, P. D. A biochemical framework for RNA silencing in plants. Genes Dev. 17, 49-63 (2003).
    • (2003) Genes Dev. , vol.17 , pp. 49-63
    • Tang, G.1    Reinhart, B.J.2    Bartel, D.P.3    Zamore, P.D.4
  • 12
    • 0033615491 scopus 로고    scopus 로고
    • A species of small antisense RNA in posttranscriptional gene silencing in plants
    • Hamilton, A. J. & Baulcombe, D. C. A species of small antisense RNA in posttranscriptional gene silencing in plants. Science 288, 950-952 (1999).
    • (1999) Science , vol.288 , pp. 950-952
    • Hamilton, A.J.1    Baulcombe, D.C.2
  • 13
    • 0035863097 scopus 로고    scopus 로고
    • RNA interference is mediated by 21- And 22-nucleotide RNAs
    • Elbashir, S. M., Lendeckel, W. & Tuschl, T. RNA interference is mediated by 21- and 22-nucleotide RNAs. Genes Dev. 15, 188-200 (2001).
    • (2001) Genes Dev. , vol.15 , pp. 188-200
    • Elbashir, S.M.1    Lendeckel, W.2    Tuschl, T.3
  • 14
    • 0034609759 scopus 로고    scopus 로고
    • Evidence that processed small dsRNAs may mediate sequence-specific mRNA degradation during RNAi in Drosophila embryos
    • Yang, D., Lu, H. & Erickson, J. W. Evidence that processed small dsRNAs may mediate sequence-specific mRNA degradation during RNAi in Drosophila embryos. Curr. Biol. 10, 1191-1200 (2000).
    • (2000) Curr. Biol. , vol.10 , pp. 1191-1200
    • Yang, D.1    Lu, H.2    Erickson, J.W.3
  • 15
    • 0035905766 scopus 로고    scopus 로고
    • Role for a bidentate ribonuclease in the initiation step of RNA interference
    • Bernstein, E., Caudy, A. A., Hammond, S. M. & Hannon, G. J. Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature 409, 363-366 (2001).
    • (2001) Nature , vol.409 , pp. 363-366
    • Bernstein, E.1    Caudy, A.A.2    Hammond, S.M.3    Hannon, G.J.4
  • 16
    • 0035839109 scopus 로고    scopus 로고
    • Argonaute2, a link between genetic and biochemical analyses of RNAi
    • Hammond, S. M., Boettcher, S., Caudy, A. A., Kobayashi, R. & Hannon, G. J. Argonaute2, a link between genetic and biochemical analyses of RNAi. Science 293, 1146-1150 (2001).
    • (2001) Science , vol.293 , pp. 1146-1150
    • Hammond, S.M.1    Boettcher, S.2    Caudy, A.A.3    Kobayashi, R.4    Hannon, G.J.5
  • 17
    • 0035798415 scopus 로고    scopus 로고
    • ATP requirements and small interfering RNA structure in the RNA interference pathway
    • Nykanen, A., Haley, B. & Zamore, P. D. ATP requirements and small interfering RNA structure in the RNA interference pathway. Cell 107, 309-321 (2001). Delineated some of the roles of ATP during discrete phases of the RNAi pathway.
    • (2001) Cell , vol.107 , pp. 309-321
    • Nykanen, A.1    Haley, B.2    Zamore, P.D.3
  • 18
    • 0037087780 scopus 로고    scopus 로고
    • MiRNPs: A novel class of ribonucleoproteins containing numerous microRNAs
    • Mourelatos, Z. et al. miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs. Genes Dev. 18, 720-728 (2002).
    • (2002) Genes Dev. , vol.18 , pp. 720-728
    • Mourelatos, Z.1
  • 19
    • 0037144546 scopus 로고    scopus 로고
    • A microRNA in a multiple-turnover RNAi enzyme complex
    • Hutvagner, G. & Zamore, P. D. A microRNA in a multiple-turnover RNAi enzyme complex. Science 297, 2056-2060 (2002).
    • (2002) Science , vol.297 , pp. 2056-2060
    • Hutvagner, G.1    Zamore, P.D.2
  • 20
    • 1842766252 scopus 로고    scopus 로고
    • A Dicer-2-dependent 80S complex cleaves targeted mRNAs during RNAi in Drosophila
    • Pham, J. W., Pellino, J. L., Lee, Y. S., Carthew, R. W. & Sontheimer, E. J. A Dicer-2-dependent 80S complex cleaves targeted mRNAs during RNAi in Drosophila. Cell 117, 83-94 (2004). This paper, together with reference 25, showed that Dcr is important for RISC function as well as for dsRNA processing, and provided an initial framework for the RISC-assembly pathway.
    • (2004) Cell , vol.117 , pp. 83-94
    • Pham, J.W.1    Pellino, J.L.2    Lee, Y.S.3    Carthew, R.W.4    Sontheimer, E.J.5
  • 21
    • 0036828639 scopus 로고    scopus 로고
    • The Argonaute family: Tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis
    • Carmell, M. A., Xuan, Z., Zhang, M. Q. & Hannon, G. J. The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis. Genes Dev. 16, 2733-2742 (2002).
    • (2002) Genes Dev. , vol.16 , pp. 2733-2742
    • Carmell, M.A.1    Xuan, Z.2    Zhang, M.Q.3    Hannon, G.J.4
  • 22
    • 0037188904 scopus 로고    scopus 로고
    • The dsRNA binding protein RDE-4 interacts with RDE-1, DCR-1, and a DExH-box helicase to direct RNAi in C. elegans
    • Tabara, H., Yigit, E., Siomi, H. & Mello, C. C. The dsRNA binding protein RDE-4 interacts with RDE-1, DCR-1, and a DExH-box helicase to direct RNAi in C. elegans. Cell 109, 861-871 (2002).
    • (2002) Cell , vol.109 , pp. 861-871
    • Tabara, H.1    Yigit, E.2    Siomi, H.3    Mello, C.C.4
  • 23
    • 1642487115 scopus 로고    scopus 로고
    • Characterization of the interactions between mammalian PAZ PIWI domain proteins and Dicer
    • Tahbaz, N. et al. Characterization of the interactions between mammalian PAZ PIWI domain proteins and Dicer. EMBO Rep. 5, 189-194 (2004).
    • (2004) EMBO Rep. , vol.5 , pp. 189-194
    • Tahbaz, N.1
  • 24
    • 0141868916 scopus 로고    scopus 로고
    • R2D2, a bridge between the initiation and effector steps of the Drosophila RNAi pathway
    • Liu, Q. et al. R2D2, a bridge between the initiation and effector steps of the Drosophila RNAi pathway. Science 301, 1921-1925 (2003). Identified the R2D2 protein and documented its role in the incorporation of siRNAs into RISC.
    • (2003) Science , vol.301 , pp. 1921-1925
    • Liu, Q.1
  • 25
    • 1842816517 scopus 로고    scopus 로고
    • Distinct roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA silencing pathways
    • Lee, Y. S. et al. Distinct roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA silencing pathways. Cell 117, 69-81 (2004).
    • (2004) Cell , vol.117 , pp. 69-81
    • Lee, Y.S.1
  • 26
    • 0035803583 scopus 로고    scopus 로고
    • Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate
    • Elbashir, S. M., Martinez, J., Patkaniowska, A., Lendeckel, W. & Tuschl, T. Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate. EMBO J. 20, 6877-6888 (2001).
    • (2001) EMBO J. , vol.20 , pp. 6877-6888
    • Elbashir, S.M.1    Martinez, J.2    Patkaniowska, A.3    Lendeckel, W.4    Tuschl, T.5
  • 27
    • 0035859929 scopus 로고    scopus 로고
    • Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems
    • Caplen, N. J., Parrish, S., Imani, F., Fire, A. & Morgan, R. A. Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems. Proc. Natl Acad. Sci. USA 98, 9742-9747 (2001).
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 9742-9747
    • Caplen, N.J.1    Parrish, S.2    Imani, F.3    Fire, A.4    Morgan, R.A.5
  • 28
    • 0037425583 scopus 로고    scopus 로고
    • Short-interfering-RNA-mediated gene silencing in mammalian cells requires Dicer and elF2C translation initiation factors
    • Doi, N. et al. Short-interfering-RNA-mediated gene silencing in mammalian cells requires Dicer and elF2C translation initiation factors. Curr. Biol. 13, 41-46 (2003).
    • (2003) Curr. Biol. , vol.13 , pp. 41-46
    • Doi, N.1
  • 29
    • 4444368187 scopus 로고    scopus 로고
    • Argonaute2 is the catalytic engine of mammalian RNAi
    • Liu, J. et al. Argonaute2 is the catalytic engine of mammalian RNAi. Science 305, 1437-1441 (2004).
    • (2004) Science , vol.305 , pp. 1437-1441
    • Liu, J.1
  • 30
    • 13844280638 scopus 로고    scopus 로고
    • Synthetic shRNAs as potent RNAi triggers
    • 26 Dec doi:10.1038/nbt1052
    • Siolas, D. et al. Synthetic shRNAs as potent RNAi triggers. Nature Biotechnol. 26 Dec 2004 (doi:10.1038/nbt1052).
    • (2004) Nature Biotechnol.
    • Siolas, D.1
  • 31
    • 13444282783 scopus 로고    scopus 로고
    • Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy
    • 26 Dec doi:10-1038/nb11051
    • Kim, D.-H. et al. Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy. Nature Biotechnol. 26 Dec 2004 (doi:10-1038/nb11051).
    • (2004) Nature Biotechnol.
    • Kim, D.-H.1
  • 32
    • 1642603943 scopus 로고    scopus 로고
    • RISC assembly defects in the Drosophila RNAi mutant armitage
    • Tomari, Y. et al. RISC assembly defects in the Drosophila RNAi mutant armitage. Cell 116, 831-841 (2004). Demonstrated the requirement for D. melanogaster Armitage in RNAi, and provided an initial framework for the RISC-assembly pathway.
    • (2004) Cell , vol.116 , pp. 831-841
    • Tomari, Y.1
  • 33
    • 8844271740 scopus 로고    scopus 로고
    • A protein sensor for siRNA asymmetry
    • Tomari, Y., Matranga, C., Haley, B., Martinez, N. & Zamore, P. D. A protein sensor for siRNA asymmetry. Science 306, 1377-1380 (2004). Described the roles of Dcr2 and R2D2 in interacting with opposite ends of asymmetrical siRNAs.
    • (2004) Science , vol.306 , pp. 1377-1380
    • Tomari, Y.1    Matranga, C.2    Haley, B.3    Martinez, N.4    Zamore, P.D.5
  • 34
    • 3142729150 scopus 로고    scopus 로고
    • Distinct roles for Argonaute proteins in small RNA-directed RNA cleavage pathways
    • Okamura, K., Ishizuka, A., Siomi, H. & Siomi, M. C. Distinct roles for Argonaute proteins in small RNA-directed RNA cleavage pathways. Genes Dev. 18, 1655-1666 (2004). Showed that D. melanogaster Ago1 and Ago2 are specific to the miRNA and siRNA pathways, respectively, and that Ago2 is required for the unwinding of siRNA and for the later stages of siRISC assembly.
    • (2004) Genes Dev. , vol.18 , pp. 1655-1666
    • Okamura, K.1    Ishizuka, A.2    Siomi, H.3    Siomi, M.C.4
  • 35
    • 0344232733 scopus 로고    scopus 로고
    • MicroRNAs: Runts of the genome assert themselves
    • Lai, E. C. MicroRNAs: runts of the genome assert themselves. Curr. Biol. 13, R925-R936 (2003).
    • (2003) Curr. Biol. , vol.13
    • Lai, E.C.1
  • 36
    • 0347444723 scopus 로고    scopus 로고
    • MicroRNAs: Genomics, biogenesis, mechanism, and function
    • Bartel, D. P. MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell 118, 281-297 (2004).
    • (2004) Cell , vol.118 , pp. 281-297
    • Bartel, D.P.1
  • 37
    • 3042767202 scopus 로고    scopus 로고
    • MicroRNAs: Small RNAs with a big role in gene regulation
    • He, L. & Hannon, G. J. MicroRNAs: small RNAs with a big role in gene regulation. Nature Rev. Genet. 5, 522-531 (2004).
    • (2004) Nature Rev. Genet. , vol.5 , pp. 522-531
    • He, L.1    Hannon, G.J.2
  • 38
    • 0037144457 scopus 로고    scopus 로고
    • Cleavage of Scarecrow-like mRNA targets directed by a class of Arabidopsis miRNA
    • Llave, C., Xie, Z., Kasschau, K. D. & Carrington, J. C. Cleavage of Scarecrow-like mRNA targets directed by a class of Arabidopsis miRNA. Science 297, 2053-2056 (2002).
    • (2002) Science , vol.297 , pp. 2053-2056
    • Llave, C.1    Xie, Z.2    Kasschau, K.D.3    Carrington, J.C.4
  • 39
    • 19344374219 scopus 로고    scopus 로고
    • Genetic and functional diversification of small RNA pathways in plants
    • Xie, Z. et al. Genetic and functional diversification of small RNA pathways in plants. PLoS Biol. 2, 642-652 (2004).
    • (2004) PLoS Biol. , vol.2 , pp. 642-652
    • Xie, Z.1
  • 40
    • 4644312235 scopus 로고    scopus 로고
    • The role of RNA interference in heterochromatic silencing
    • Lippman, Z. & Martienssen, R. The role of RNA interference in heterochromatic silencing. Nature 431, 364-370 (2004).
    • (2004) Nature , vol.431 , pp. 364-370
    • Lippman, Z.1    Martienssen, R.2
  • 42
    • 1642586497 scopus 로고    scopus 로고
    • ed. Hannon, G. J. Cold Spring Harbor Laboratory Press, New York
    • Jorgensen, R. in RNAi: A Guide to Gene Silencing (ed. Hannon, G. J.) 5-22 (Cold Spring Harbor Laboratory Press, New York, 2003).
    • (2003) RNAi: A Guide to Gene Silencing , pp. 5-22
    • Jorgensen, R.1
  • 44
    • 0942279635 scopus 로고    scopus 로고
    • RNAi-mediated targeting of heterochromatin by the RITS complex
    • Verdel, A. et al. RNAi-mediated targeting of heterochromatin by the RITS complex. Science 303, 672-676 (2004).
    • (2004) Science , vol.303 , pp. 672-676
    • Verdel, A.1
  • 45
    • 0036752955 scopus 로고    scopus 로고
    • SiRNAs function as guides, not primers, in the RNAi pathway in Drosophila and human cells
    • Schwarz, D., Hutvagner, G., Haley, G. & Zamore, P. D. siRNAs function as guides, not primers, in the RNAi pathway in Drosophila and human cells. Mol. Cell 10, 537-548 (2002).
    • (2002) Mol. Cell , vol.10 , pp. 537-548
    • Schwarz, D.1    Hutvagner, G.2    Haley, G.3    Zamore, P.D.4
  • 46
    • 1542344429 scopus 로고    scopus 로고
    • DEAD-box proteins: The driving forces behind RNA metabolism
    • Rocak, S. & Linder, P. DEAD-box proteins: the driving forces behind RNA metabolism. Nature Rev. Mol. Cell Biol. 5, 232-241 (2004).
    • (2004) Nature Rev. Mol. Cell Biol. , vol.5 , pp. 232-241
    • Rocak, S.1    Linder, P.2
  • 47
    • 0036682990 scopus 로고    scopus 로고
    • RNAi is activated during Drosophila oocyte maturation in a manner dependent on aubergine and spindle-E
    • Kennerdell, J. R., Yamaguchi, S. & Carthew, R. W. RNAi is activated during Drosophila oocyte maturation in a manner dependent on aubergine and spindle-E. Genes Dev. 16, 1884-1889 (2002).
    • (2002) Genes Dev. , vol.16 , pp. 1884-1889
    • Kennerdell, J.R.1    Yamaguchi, S.2    Carthew, R.W.3
  • 48
    • 0036791671 scopus 로고    scopus 로고
    • A Drosophila fragile X protein interacts with components of RNAi and ribosomal proteins
    • Ishizuka, A., Siomi, M. C. & Siomi, H. A Drosophila fragile X protein interacts with components of RNAi and ribosomal proteins. Genes Dev. 16, 2497-2508 (2002).
    • (2002) Genes Dev. , vol.16 , pp. 2497-2508
    • Ishizuka, A.1    Siomi, M.C.2    Siomi, H.3
  • 49
    • 0142165224 scopus 로고    scopus 로고
    • Functional siRNAs and miRNAs exhibit strand bias
    • Khvorova, A., Reynolds, A. & Jayasena, S. D. Functional siRNAs and miRNAs exhibit strand bias. Cell 115, 209-216 (2003).
    • (2003) Cell , vol.115 , pp. 209-216
    • Khvorova, A.1    Reynolds, A.2    Jayasena, S.D.3
  • 50
    • 10744225153 scopus 로고    scopus 로고
    • Asymmetry in the assembly of the RNAi enzyme complex
    • Schwarz, D. S. et al. Asymmetry in the assembly of the RNAi enzyme complex. Cell 115, 199-208 (2003). This paper, together with reference 49, showed that selection of the siRNA guide strand is specified by the relative strength of base pairing at each end of an siRNA duplex.
    • (2003) Cell , vol.115 , pp. 199-208
    • Schwarz, D.S.1
  • 51
    • 1542336952 scopus 로고    scopus 로고
    • Rational siRNA design for RNA interference
    • Reynolds, A. et al. Rational siRNA design for RNA interference. Nature Biotechnol. 22, 326-330 (2004).
    • (2004) Nature Biotechnol. , vol.22 , pp. 326-330
    • Reynolds, A.1
  • 52
    • 1942499451 scopus 로고    scopus 로고
    • Improving the efficiency of RNA interference in mammals
    • Mittal, V. Improving the efficiency of RNA interference in mammals. Nature Rev. Genet. 5, 355-365 (2004).
    • (2004) Nature Rev. Genet. , vol.5 , pp. 355-365
    • Mittal, V.1
  • 53
    • 2442679207 scopus 로고    scopus 로고
    • Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain
    • Ma, J.-B., Ye, K. & Patel, D. J. Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain. Nature 429, 318-322 (2004).
    • (2004) Nature , vol.429 , pp. 318-322
    • Ma, J.-B.1    Ye, K.2    Patel, D.J.3
  • 55
    • 0036845374 scopus 로고    scopus 로고
    • Human Dicer preferentially cleaves dsRNAs at their termini without a requirement for ATP
    • Zhang, H., Kolb, F. A., Brondani, V., Billy, E. & Filipowicz, W. Human Dicer preferentially cleaves dsRNAs at their termini without a requirement for ATP. EMBO J. 21, 5875-5885 (2002).
    • (2002) EMBO J. , vol.21 , pp. 5875-5885
    • Zhang, H.1    Kolb, F.A.2    Brondani, V.3    Billy, E.4    Filipowicz, W.5
  • 56
    • 3142613181 scopus 로고    scopus 로고
    • Single processing center models for human Dicer and bacterial RNase III
    • Zhang, H., Kolb, F. A., Jaskiewicz, L., Westhot, E. & Filipowicz, W. Single processing center models for human Dicer and bacterial RNase III. Cell 118, 57-68 (2004). Described the roles of different domains of DCR in the dsRNA processing reaction.
    • (2004) Cell , vol.118 , pp. 57-68
    • Zhang, H.1    Kolb, F.A.2    Jaskiewicz, L.3    Westhot, E.4    Filipowicz, W.5
  • 57
    • 4944225347 scopus 로고    scopus 로고
    • Endogenous trans-acting siRNAs regulate the accumulation of Arabidopsis mRNAs
    • Vazquez, F. et al. Endogenous trans-acting siRNAs regulate the accumulation of Arabidopsis mRNAs. Mol. Cell 18, 69-79 (2004).
    • (2004) Mol. Cell , vol.18 , pp. 69-79
    • Vazquez, F.1
  • 58
    • 5144225452 scopus 로고    scopus 로고
    • Biochemical identification of Argonaute 2 as the sole protein required for RNA-induced silencing complex activity
    • Rand, T. A., Ginalski, K., Grishin, N. V. & Wang, X. Biochemical identification of Argonaute 2 as the sole protein required for RNA-induced silencing complex activity. Proc. Natl Acad. Sci. USA 101, 14385-14339 (2004).
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 14385-114339
    • Rand, T.A.1    Ginalski, K.2    Grishin, N.V.3    Wang, X.4
  • 59
    • 0036792769 scopus 로고    scopus 로고
    • Fragile X-related protein and VIG associate with the RNA interference machinery
    • Caudy, A. A., Myers, M., Hannon, G. J. & Hammond, S. M. Fragile X-related protein and VIG associate with the RNA interference machinery. Genes Dev. 16, 2491-2496 (2002).
    • (2002) Genes Dev. , vol.16 , pp. 2491-2496
    • Caudy, A.A.1    Myers, M.2    Hannon, G.J.3    Hammond, S.M.4
  • 60
    • 0141843655 scopus 로고    scopus 로고
    • A micrococcal nuclease homologue in RNAi effector complexes
    • Caudy, A. A. et al. A micrococcal nuclease homologue in RNAi effector complexes. Nature 425, 411-414 (2003).
    • (2003) Nature , vol.425 , pp. 411-414
    • Caudy, A.A.1
  • 61
    • 2442495329 scopus 로고    scopus 로고
    • RISC is a 5′ phosphomonoester-producing RNA endonuclease
    • Martinez, J. & Tuschl, T. RISC is a 5′ phosphomonoester- producing RNA endonuclease. Genes Dev. 18, 975-980 (2004). This paper, together with references 67 and 71, described the endonucleolytic reaction that is catalysed by RISC, and provided initial mechanistic analyses of the reaction.
    • (2004) Genes Dev. , vol.18 , pp. 975-980
    • Martinez, J.1    Tuschl, T.2
  • 62
    • 1242318826 scopus 로고    scopus 로고
    • Sequence-specific inhibition of microRNA- And siRNA-induced RNA silencing
    • Meister, G., Landthaler, M., Dorsett, Y. & Tuschl, T. Sequence-specific inhibition of microRNA- and siRNA-induced RNA silencing. RNA 10, 544-550 (2004).
    • (2004) RNA , vol.10 , pp. 544-550
    • Meister, G.1    Landthaler, M.2    Dorsett, Y.3    Tuschl, T.4
  • 63
    • 0642345790 scopus 로고    scopus 로고
    • Structure and conserved RNA binding of the PAZ domain
    • Yan, K. S. et al. Structure and conserved RNA binding of the PAZ domain. Nature 426, 468-174 (2003).
    • (2003) Nature , vol.426 , pp. 468-1174
    • Yan, K.S.1
  • 64
    • 0345490960 scopus 로고    scopus 로고
    • The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi effector complexes
    • Song, J. J. et al. The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi effector complexes. Nature Struct. Biol. 10, 1026-1032 (2003).
    • (2003) Nature Struct. Biol. , vol.10 , pp. 1026-1032
    • Song, J.J.1
  • 65
    • 0345359925 scopus 로고    scopus 로고
    • Structure and nucleic-acid binding of the Drosophila Argonaute 2 PAZ domain
    • Lingel, A., Simon, B., Izaurralde, E. & Sattler, M. Structure and nucleic-acid binding of the Drosophila Argonaute 2 PAZ domain. Nature 426, 465-469 (2003).
    • (2003) Nature , vol.426 , pp. 465-469
    • Lingel, A.1    Simon, B.2    Izaurralde, E.3    Sattler, M.4
  • 66
    • 4444302947 scopus 로고    scopus 로고
    • Crystal structure of Argonaute and its implications for RISC Slicer activity
    • Song, J. J., Smith, S. K., Hannon, G. J. & Joshua-Tor, L. Crystal structure of Argonaute and its implications for RISC Slicer activity. Science 305, 1434-1437 (2004). This paper, combined with reference 29, provided strong evidence that the PIWI domains of certain Ago proteins provide RISC with target-mRNA endonuclease activity.
    • (2004) Science , vol.305 , pp. 1434-1437
    • Song, J.J.1    Smith, S.K.2    Hannon, G.J.3    Joshua-Tor, L.4
  • 68
    • 0033766888 scopus 로고    scopus 로고
    • Selective reduction of dormant maternal mRNAs in mouse oocytes by RNA interference
    • Svoboda, P., Stein, P., Hayashi, H. & Schultz, R. M. Selective reduction of dormant maternal mRNAs in mouse oocytes by RNA interference. Development 127, 4147-4156 (2000).
    • (2000) Development , vol.127 , pp. 4147-4156
    • Svoboda, P.1    Stein, P.2    Hayashi, H.3    Schultz, R.M.4
  • 69
    • 0038721055 scopus 로고    scopus 로고
    • An siRNA ribonucleoprotein is found associated with polyribosomes in Trypanosoma brucei
    • Djikeng, A., Shi, H., Tschudi, C., Shen, S. & Ullu, E. An siRNA ribonucleoprotein is found associated with polyribosomes in Trypanosoma brucei. RNA 9, 802-808 (2003).
    • (2003) RNA , vol.9 , pp. 802-808
    • Djikeng, A.1    Shi, H.2    Tschudi, C.3    Shen, S.4    Ullu, E.5
  • 70
    • 0033572284 scopus 로고    scopus 로고
    • The lin-4 regulatory RNA controls developmental timing in Caenorhabditis elegans by blocking LIN-14 protein synthesis after the initiation of translation
    • Olsen, P. H. & Ambros, V. The lin-4 regulatory RNA controls developmental timing in Caenorhabditis elegans by blocking LIN-14 protein synthesis after the initiation of translation. Dev. Biol. 216, 671-680 (1999).
    • (1999) Dev. Biol. , vol.216 , pp. 671-680
    • Olsen, P.H.1    Ambros, V.2
  • 71
    • 3042602447 scopus 로고    scopus 로고
    • Kinetic analysis of the RNAi enzyme complex
    • Haley, B. & Zamore, P. D. Kinetic analysis of the RNAi enzyme complex. Nature Struct. Mol. Biol. 11, 599-606 (2004).
    • (2004) Nature Struct. Mol. Biol. , vol.11 , pp. 599-606
    • Haley, B.1    Zamore, P.D.2
  • 72
    • 19344378192 scopus 로고    scopus 로고
    • Sequence-specific inhibition of small RNA function
    • Hutvagner, G., Simard, M. J., Mello, C. & Zamore, P. D. Sequence-specific inhibition of small RNA function. PLoS Biol. 2, 1-11 (2004).
    • (2004) PLoS Biol. , vol.2 , pp. 1-11
    • Hutvagner, G.1    Simard, M.J.2    Mello, C.3    Zamore, P.D.4
  • 73
    • 0027209722 scopus 로고
    • The importance of being ribose at the cleavage site in the Tetrahymena ribozyme reaction
    • Herschlag, D., Eckstein, F. & Cech, T. R. The importance of being ribose at the cleavage site in the Tetrahymena ribozyme reaction. Biochemistry 32, 8312-8321 (1993).
    • (1993) Biochemistry , vol.32 , pp. 8312-8321
    • Herschlag, D.1    Eckstein, F.2    Cech, T.R.3
  • 75
    • 3242736704 scopus 로고    scopus 로고
    • Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs
    • Meister, G. et al. Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs. Mol. Cell 15, 185-197 (2004).
    • (2004) Mol. Cell , vol.15 , pp. 185-197
    • Meister, G.1
  • 76
    • 4644350944 scopus 로고    scopus 로고
    • Unlocking the potential of the human genome with RNA interference
    • Hannon, G. J. & Rossi, J. J. Unlocking the potential of the human genome with RNA interference. Nature 431, 371-378 (2004).
    • (2004) Nature , vol.431 , pp. 371-378
    • Hannon, G.J.1    Rossi, J.J.2
  • 77
    • 0035887005 scopus 로고    scopus 로고
    • Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans
    • Ketting, R. F. et al. Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans. Genes Dev. 15, 2654-2659 (2001).
    • (2001) Genes Dev. , vol.15 , pp. 2654-2659
    • Ketting, R.F.1
  • 78
    • 17844364875 scopus 로고    scopus 로고
    • Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing
    • Grishok, A. et al. Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing. Cell 106, 23-34 (2001).
    • (2001) Cell , vol.106 , pp. 23-34
    • Grishok, A.1
  • 79
    • 0035800521 scopus 로고    scopus 로고
    • A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA
    • Hutvagner, G. et al. A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA. Science 293, 834-838 (2001).
    • (2001) Science , vol.293 , pp. 834-838
    • Hutvagner, G.1
  • 80
    • 2142654329 scopus 로고    scopus 로고
    • MicroRNA-directed cleavage of HOXB8 mRNA
    • Yekta, S., Shih, I. H. & Bartel, D. P. MicroRNA-directed cleavage of HOXB8 mRNA. Science 304, 594-596 (2004).
    • (2004) Science , vol.304 , pp. 594-596
    • Yekta, S.1    Shih, I.H.2    Bartel, D.P.3
  • 81
    • 0032717319 scopus 로고    scopus 로고
    • The rde-1 gene, RNA interference, and transposon silencing in C. elegans
    • Tabara, H. et al. The rde-1 gene, RNA interference, and transposon silencing in C. elegans. Cell 99, 123-132 (1999).
    • (1999) Cell , vol.99 , pp. 123-132
    • Tabara, H.1
  • 82
    • 4644310115 scopus 로고    scopus 로고
    • Tethering of human Ago proteins to mRNA mimics the miRNA-mediated repression of protein synthesis
    • Pillai, R. S., Artus, C. G. & Filipowicz, W. Tethering of human Ago proteins to mRNA mimics the miRNA-mediated repression of protein synthesis. RNA 10, 1518-1525 (2004).
    • (2004) RNA , vol.10 , pp. 1518-1525
    • Pillai, R.S.1    Artus, C.G.2    Filipowicz, W.3
  • 83
    • 0037145031 scopus 로고    scopus 로고
    • Analysis of a piwi-related gene implicates small RNAs in genome rearrangement in Tetrahymena
    • Mochizuki, K., Fine, N. A., Fujisawa, T. & Gorovsky, M. A. Analysis of a piwi-related gene implicates small RNAs in genome rearrangement in Tetrahymena. Cell 110, 689-699 (2002).
    • (2002) Cell , vol.110 , pp. 689-699
    • Mochizuki, K.1    Fine, N.A.2    Fujisawa, T.3    Gorovsky, M.A.4
  • 84
    • 1442305898 scopus 로고    scopus 로고
    • RNA silencing genes control de novo DNA methylation
    • Chan, S. W. et al. RNA silencing genes control de novo DNA methylation. Science 303, 1336 (2004).
    • (2004) Science , vol.303 , pp. 1336
    • Chan, S.W.1
  • 85
    • 0942279615 scopus 로고    scopus 로고
    • Heterochromatic silencing and HP1 localization in Drosophila are dependent on the RNAi machinery
    • Pal-Bhadra, M. et al. Heterochromatic silencing and HP1 localization in Drosophila are dependent on the RNAi machinery. Science 303, 669-672 (2004).
    • (2004) Science , vol.303 , pp. 669-672
    • Pal-Bhadra, M.1
  • 86
    • 0036184188 scopus 로고    scopus 로고
    • RNAi related mechanisms affect both transcriptional and posttranscriptional transgene silencing in Drosophila
    • Pal-Bhadra, M., Bhadra, U. & Birchler, J. A. RNAi related mechanisms affect both transcriptional and posttranscriptional transgene silencing in Drosophila. Mol. Cell 9, 315-327 (2002).
    • (2002) Mol. Cell , vol.9 , pp. 315-327
    • Pal-Bhadra, M.1    Bhadra, U.2    Birchler, J.A.3
  • 87
    • 4143149753 scopus 로고    scopus 로고
    • Dicer is essential for formation of the heterochromatin structure in vertebrate cells
    • Fukagawa, T. et al. Dicer is essential for formation of the heterochromatin structure in vertebrate cells. Nature Cell Biol. 6, 784-791 (2004).
    • (2004) Nature Cell Biol. , vol.6 , pp. 784-791
    • Fukagawa, T.1
  • 88
    • 4544242851 scopus 로고    scopus 로고
    • Induction of DNA methylation and gene silencing by short interfering RNAs in human cells
    • Kawasaki, H. & Taira, K. Induction of DNA methylation and gene silencing by short interfering RNAs in human cells. Nature 431, 211-217 (2004).
    • (2004) Nature , vol.431 , pp. 211-217
    • Kawasaki, H.1    Taira, K.2
  • 89
    • 4344705410 scopus 로고    scopus 로고
    • Small interfering RNA-induced transcriptional gene silencing in human cells
    • Morris, K. V., Chan, S. W., Jacobsen, S. E. & Looney, D. J. Small interfering RNA-induced transcriptional gene silencing in human cells. Science 305, 1289-1292 (2004).
    • (2004) Science , vol.305 , pp. 1289-1292
    • Morris, K.V.1    Chan, S.W.2    Jacobsen, S.E.3    Looney, D.J.4
  • 90
    • 0037183856 scopus 로고    scopus 로고
    • Establishment and maintenance of a heterochromatin domain
    • Hall, I. M. et al. Establishment and maintenance of a heterochromatin domain. Science 297, 2232-2237 (2002).
    • (2002) Science , vol.297 , pp. 2232-2237
    • Hall, I.M.1
  • 91
    • 0037072661 scopus 로고    scopus 로고
    • Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi
    • Volpe, T. A. et al. Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi. Science 297, 1833-1837 (2002).
    • (2002) Science , vol.297 , pp. 1833-1837
    • Volpe, T.A.1
  • 92
    • 0042831010 scopus 로고    scopus 로고
    • Hairpin RNAs and retrotransposon LTRs effect RNAi and chromatin-based gene silencing
    • Schramke, V. & Allshire, R. Hairpin RNAs and retrotransposon LTRs effect RNAi and chromatin-based gene silencing. Science 301, 1069-1074 (2003).
    • (2003) Science , vol.301 , pp. 1069-1074
    • Schramke, V.1    Allshire, R.2
  • 93
    • 10644221797 scopus 로고    scopus 로고
    • RITS acts in cis to promote RNA interference-mediated transcriptional and posttranscriptional silencing
    • Noma, K. et al. RITS acts in cis to promote RNA interference-mediated transcriptional and posttranscriptional silencing. Nature Genet. 36, 1174-1180 (2004).
    • (2004) Nature Genet. , vol.36 , pp. 1174-1180
    • Noma, K.1
  • 94
    • 1442360415 scopus 로고    scopus 로고
    • RNase III enzymes and the initiation of gene silencing
    • Carmell, M. A. & Hannon, G. J. RNase III enzymes and the initiation of gene silencing. Nature Struct. Mol. Biol. 11, 214-218 (2004).
    • (2004) Nature Struct. Mol. Biol. , vol.11 , pp. 214-218
    • Carmell, M.A.1    Hannon, G.J.2
  • 95
    • 4644223259 scopus 로고    scopus 로고
    • Mechanisms of gene silencing by double-stranded RNA
    • Meister, G. & Tuschl, T. Mechanisms of gene silencing by double-stranded RNA. Nature 431, 343-349 (2004).
    • (2004) Nature , vol.431 , pp. 343-349
    • Meister, G.1    Tuschl, T.2
  • 96
    • 0037076320 scopus 로고    scopus 로고
    • ARGONAUTE1 is required for efficient RNA interference in Drosophila embryos
    • Williams, R. W. & Rubin, G. M. ARGONAUTE1 is required for efficient RNA interference in Drosophila embryos. Proc. Natl Acad. Sci. USA 99, 6889-6894 (2002).
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 6889-6894
    • Williams, R.W.1    Rubin, G.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.