Molecular biology: Inhibition of translational initiation by let-7 microRNA in human cells

Science

Volumn 309, Issue 5740, 2005, Pages 1573-1576

  Pillai, Ramesh S ^a   Bhattacharyya, Suvendra N ^a   Artus, Caroline G ^a   Zoller, Tabea ^a   Cougot, Nicolas ^b   Basyuk, Eugenia ^b   Bertrand, Edouard ^b   Filipowicz, Witold ^a  

^a FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH   (Switzerland)

^b INSTITUT DE GÉNÉTIQUE MOLÉCULAIRE DE MONTPELLIER   (France)

Author keywords

[No Author keywords available]

Indexed keywords

GENES; MOLECULAR BIOLOGY; PROTEINS;

MESSENGER RNA (MRNA); METAZOA; MULTICELLULAR EUKARYOTES; TRANSLATIONAL INITIATION;

RNA;

CAPPED RNA; LET 7 MICRORIBONUCLEOPROTEIN; MESSENGER RNA; MICRORNA; RIBONUCLEOPROTEIN; UNCLASSIFIED DRUG; EUKARYOTIC INITIATION FACTOR 2C 2, HUMAN; EUKARYOTIC INITIATION FACTOR 2C-2, HUMAN; INITIATION FACTOR;

RNA;

3' UNTRANSLATED REGION; ARTICLE; ENCEPHALOMYOCARDITIS VIRUS; GENE REPRESSION; HELA CELL; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; INTERNAL RIBOSOME ENTRY SITE; PRIORITY JOURNAL; RNA TRANSLATION; TRANSLATION INITIATION; TRANSLATION REGULATION; METABOLISM; PHYSIOLOGY;

ENCEPHALOMYOCARDITIS VIRUS; EUKARYOTA; HEPATITIS C VIRUS; METAZOA;

HELA CELLS; HUMANS; MICRORNAS; PEPTIDE CHAIN INITIATION, TRANSLATIONAL; PEPTIDE INITIATION FACTORS; RIBONUCLEOPROTEINS; RNA CAPS; RNA, MESSENGER;

EID: 24644480213     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1115079     Document Type: Article

References (27)

1. P. H. Olsen, V. Ambros, Dev. Biol. 216, 671 (1999).
2. K. Seggerson, L. Tang, E. G. Moss, Dev. Biol. 243, 215 (2002).
3. J. G. Doench, C. P. Petersen, P. A. Sharp, Genes Dev. 17, 438 (2003).
4. Y. Zeng, R. Yi, B. R. Cullen, Proc. Natl. Acad. Sci. U.S.A. 100, 9779 (2003).
5. J. Brennecke, D. R. Hipfner, A. Stark, R. B. Russell, S. M. Cohen, Cell 113, 25 (2003).
6. D. P. Bartel, Cell 116, 281 (2004).
7. Q. Jing et al., Cell 120, 623 (2005).
8. R. S. Pillai, C. G. Artus, W. Filipowicz, RNA 10, 1518 (2004).
9. R. S. Pillai et al., data not shown.
10. R. S. Pillai et al., unpublished results.
11. C. U. Hellen, P. Sarnow, Genes Dev. 15, 1593 (2001).
12. E. De Gregorio, J. Baron, T. Preiss, M. W. Hentze, RNA 7, 106 (2001).
13. G. Seydoux, S. Strome, Development 126, 3275 (1999).
14. P. Anderson, N. Kedersha J. Cell Sci. 115, 3227 (2002).
15. U. Sheth, R. Parker, Science 300, 805 (2003).
16. S. M. Johnson et al., Cell 120, 635 (2005).
17. J. Chang et al., RNA Biol. 1, 2 (2004).
18. F. Gebauer, M. W. Hentze, Nat. Rev. Mol. Cell Biol. 5, 827 (2004).
19. J. D. Richter, N. Sonenberg, Nature 433, 477 (2005).
20. P. F. Cho et al., Cell 121, 411 (2005).
21. G. L. Sen, H. M. Blau, Nat. Cell Biol. 7, 633 (2005).
22. J. Liu, M. A. Valencia-Sanchez, G. J. Hannon, R. Parker, Nat. Cell Biol. 7, 719(2005).
23. D. Teixeira, U. Sheth, M. A. Valencia-Sanchez, M. Brengues, R. Parker, RNA 11, 371 (2005).
24. M. A. Andrei et al., RNA 11, 717 (2005).
25. L. P. Lim et al., Nature 433, 769 (2005).
26. F. A. Kolb et al., Methods Enzymol. 392, 316 (2005).
27. We thank T. Hobman, R. Luhrmann, J. Lykke-Andersen, A. Prats, B. Seraphin, and N. Sonnenberg for providing plasmids and antibodies and F. Rage, S. Fumagalli, N. Sonenberg, and members of the Filipowicz group for help and discussions. This work was supported by grant 3109 of l'Association de la Recherche Contre le Cancer to E.B. S.N.B, is a recipient of a long-term fellowship from the Human Frontier Science Program. The Friedrich Miescher Institute is supported by Novartis Research Foundation.