Proteinaceous protease inhibitors: Structural features and multiple functional faces

Current Enzyme Inhibition

Volumn 2, Issue 3, 2006, Pages 199-217

  Joanitti, Graziella A ^a   Freitas, Sonia M ^a   Silva, Luciano Paulino ^a,b  

^a UNIVERSITY OF BRASILIA   (Brazil)

^b EMBRAPA RECURSOS GENÉTICOS E BIOTECNOLOGIA   (Brazil)

Author keywords

Aspartic protease; Bowman Birk; Cysteine protease; Kunitz; Metallo protease; Protease inhibitor; Serine protease

Indexed keywords

ALPHA 1 ANTITRYPSIN; ALPHA 2 MACROGLOBULIN; ANTICOAGULANT AGENT; ANTISTATIN; ANTITHROMBIN; APROTININ; BUFUDIN; ELAFIN; GRANULIN LIKE PEPTIDE; HAEMADIN; HIRUDIN; INSECTICIDE; LEUKOCYTE ELASTASE INHIBITOR; METALLOPROTEINASE INHIBITOR; PLASMINOGEN ACTIVATOR INHIBITOR; PROTEINASE INHIBITOR; SECRETORY LEUKOCYTE PROTEINASE INHIBITOR; SERINE PROTEINASE INHIBITOR; THROMBIN INHIBITOR; TRYPSIN INHIBITOR; UNCLASSIFIED DRUG;

AGRICULTURE; ALZHEIMER DISEASE; AMEBIASIS; ANTHRAX; ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIVIRAL ACTIVITY; ARTERY THROMBOSIS; ASTHMA; BACILLUS ANTHRACIS; BACTERIAL MENINGITIS; CANDIDA; CANDIDIASIS; CARDIOPULMONARY BYPASS; CHAGAS DISEASE; CORNEA ULCER; CRYPTOSPORIDIOSIS; CRYPTOSPORIDIUM; CYSTIC FIBROSIS; DEEP VEIN THROMBOSIS; DENGUE; DENGUE VIRUS; DEVELOPMENTAL STAGE; DRUG DESIGN; DRUG HYPERSENSITIVITY; ENTAMOEBA HISTOLYTICA; ENZYME STRUCTURE; GASTRITIS; HEART INFARCTION; HELICOBACTER PYLORI; HEMOSTASIS; HEPATITIS C; HEPATITIS C VIRUS; HOST RESISTANCE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE SYSTEM; INSECTICIDAL ACTIVITY; INSECTICIDE RESISTANCE; KIDNEY DISEASE; LUNG INJURY; MALARIA; MALIGNANT NEOPLASTIC DISEASE; MOLECULAR MODEL; MULTIPLE SCLEROSIS; MYCOBACTERIUM TUBERCULOSIS; NEISSERIA MENINGITIDIS; ORTHOPEDIC SURGERY; OSTEOARTHRITIS; PANCREATITIS; PEPTIC ULCER; PEST CONTROL; PLASMODIUM MALARIAE; POSTOPERATIVE HEMORRHAGE; PROTEIN DEGRADATION; PROTEIN FUNCTION; PSEUDOMONAS AERUGINOSA; REGULATORY MECHANISM; REPERFUSION INJURY; RESTENOSIS; REVIEW; RHEUMATOID ARTHRITIS; SARS CORONAVIRUS; SCHISTOSOMA; SCHISTOSOMIASIS; SEVERE ACUTE RESPIRATORY SYNDROME; SHOCK; THROMBOSIS; TRYPANOSOMA CRUZI; TUBERCULOSIS; UNSTABLE ANGINA PECTORIS; VEIN THROMBOSIS;

ANIMALIA; BACTERIA (MICROORGANISMS);

EID: 33746929944     PISSN: 15734080     EISSN: None     Source Type: Journal    
DOI: 10.2174/157340806777934801     Document Type: Review

References (305)

1. Carlini, C.R.; Grossi-de-Sa, M.F. Toxicon., 2002, 40, 1515-1539.
2. Denison, F.C.; Kelly, R.W.; Calder, A.A.; Riley, S.C. J. Endocrinol., 1999, 161, 299-306.
3. Mammen, E.F. Turk. J. Haematol., 2002, 19, 97-102.
4. Andreasen, P.A.; Egelund, R.; Petersen, H.H. Cell. Mol. Life Sci., 2000, 57, 25-40.
5. Leung, D.; Abbenante, G.; Fairlie, D.P. J. Med. Chem., 2000, 43, 305-341.
6. Lüthi, A.; Putten, H.; Botteri, F.M.; Mansuy, I.M.; Meins, M.; Frey, U.; Sansig, G.; Portet, C.; Schmutz. M.; Schröder, M.; Nitsch, C.; Laurent, J.; Monard, D. J. Neurosci., 1997, 17, 4688-4699.
7. Greenberg, J.T. Proc. Natl. Acad. Sci. USA, 1996, 93, 12094-12097.
8. Solomon, M.; Belenghi, B.; Delledonne, M.; Menachem, E.; Levine, A. Plant Cell, 1999, 11, 431-444.
9. Ashton-Rickardt, P.G. Crit. Rev. Immunol., 2005, 25, 161-182.
10. Schimmer, A.D. Cancer Res., 2004, 64, 7183-7190.
11. Fassina, G.; Ferrari, N.; Brigati, C.; Benelli, R.; Santi, L.; Noonan, D.M.; Albini, A. Clin. Exp. Metastasis, 2000, 18, 111-20.
12. Iwanaga, S. Curr. Opin. Immunol., 1993, 5, 74-82.
13. Imler, L.; Hoffmann, J.A. Curr. Opin. Microbiol., 2000, 3, 16-22.
14. Kanost, M.R. Dev. Comp. Immunol., 1999, 23, 291-301.
15. Simonet, G.; Claeys, I.; Broeck, J.V. Comp. Biochem. Physiol. B. Biochem. Mol. Biol., 2002, 132, 247-255.
16. Mottram, J.C.; Coombs, G.H.; Alexander, J. Curr. Opin. Microbiol., 2004, 7, 375-381.
17. Naglik, J.; Albrecht, A.; Bader, O.; Hube, B. Cell Microbiol., 2004, 6, 915-926.
18. Matsumoto, K. Biol. Chem., 2004, 385, 1007-1016.
19. Laskowski Jr., M.; Qasim, M.A. Biochem. Biophys. Acta, 2000, 1477, 324-337.
20. Qi, R.F.; Song, Z.W.; Chi, C.W. Acta Biochim. Biophys., 2005, 37, 283-292.
21. Losso, J.N.; Munene, C.N.; Bansode, R.R.; Bawadi, H.A. Biotechnol. Lett., 2004, 26, 901-905.
22. Ware, J.H.; Wan, X.S.; Rubin, H.; Schechter, N.M.; Kennedy, A.R. Arch. Biochem. Biophys., 1997, 344, 133-138.
23. Larionova, N.I.; Balabushevitch, N.G.; Zhatikov, P.A. Biochemistry, 1998, 63, 1078-1082.
24. Deshimaru, M.; Hanamoto, R.; Kusano, C.; Yoshimi, S.; Terada S. Biosci. Biotechnol. Biochem., 2002, 66, 1897-1903.
25. Silva, L.P.; Leite, J.R.S.A.; Bloch, C.; de-Freitas, S.M. Prot. Pept. Lett., 2000, 7, 397-401.
26. Ventura, M.M.; Filho, J.X. An. Acad. Bras. Cienc., 1966, 38, 553.
27. Teles, R.C.L.; Calderon, L.D.A.; Medrano, F.J.; Barbosa, J.A.R.G.; Guimaraes, B.G.; Santoro, M.M.; de Freitas, S.M. Bioph. J., 2005, 88, 3509-3517.
28. Capasso, C.; Rizzi, M.; Menegatti, E.; Ascenzi, P.; Bolognesi, M. J. Mol. Recognit., 1997, 10, 26-35.
29. Pritchard, L.; Dufton, M.J. J. Mol. Biol., 1999, 285, 1589-1607.
30. Waxler, B.; Rabito, S.F. Curr. Pharma. Des., 2003, 9, 777-787.
31. Asimakopoulos, G.; Thompson, R.; Nourshargh, S.; Lidington, E.A.; Mason, J.C.; Ratnatunga, C.P.; Haskard, D.O.; Taylor, K.M.; Landis, R.C. J. Thorac. Cardiovasc. Surg., 2000, 120, 361-369.
32. Levy, J.H.; Sypniewski, E. Orthopedics., 2004, 27, 653-658.
33. Stemlicht, M.D.; Werb, Z. Annu. Rev. Cell Dev. Biol., 2001, 17, 463-516.
34. Jiang, Y.; Goldberg, I.D.; Shi, Y.E. Oncogene, 2002, 21, 2245-2252.
35. Krane, S.M. Ann. N. Y. Acad. Sci., 1994, 732, 1-10.
36. Maskos, K.; Bode, W. Mol. Biotechnol., 2003, 25, 241-266.
37. Grzonka, Z.; Jankowska, E.; Kasprzykowski, F.; Kasprzykowska, R.; Lankiewicz, L.; Wiczk, W.; Wieczerzak, E.; Ciarkowski, J.; Drabik, P.; Janowski, R.; Kozak M.; Jaskolski, M.; Grubb, A. Acta Biochim. Pol., 2001, 48, 1-20.
38. Rzychon, M.; Sabat, A.; Kosowska, K.; Potempa, J.; Dubin, A. Mol. Microbiol., 2003, 49, 1051-1066.
39. Christeller, J.T.; Farley, P.C.; Ramsay, R.J.; Sullivan, P.A.; Laing, W.A. Eur. J. Biochem., 1998, 254, 160-167.
40. Umezawa, H.; Aoyagi, T.; Morishima, H.; Matsuzaki, M.; Hamada, M. J. Antibiot., 1970, 23, 259-262.
41. Seppala, U.; Majamaa, H.; Turjanmaa, K.; Helin, J.; Reunala, T.; Kalkkinen, N.; Palosuo, T. Allergy, 2001, 56, 619-626.
42. Pierce, M.M.; Raman, C.S.; Nall, B.T. Methods, 1999, 19, 213-221.
43. Otlewski, J.; Jelen, F.; Zakrzewska, M.; Oleksy, A. EMBO J., 2005, 24, 1303-1310.
44. Otlewski, J.; Jaskolski, M.; Buczek. O.; Cierpicki, T.; Czapinska, H.; Krowarsch, D.; Smalas, A.O.; Stachowiak D.; Szpineta, A.; Dadlez, M. Acta Biochim. Pol., 2001, 48, 419-428.
45. Schechter, I.; Berger, A. Biochem. Biophys. Res. Commun., 1967, 27, 157-162.
46. Bode, W.; Huber, R. Biochim. Biophys. Acta, 2000, 1477, 241-252.
47. Liu, J.; Gong, Y.; Prakash, O.; Wen, L.; Lee, I.; Huang, J.K.; Krishnamoorthi, R. Protein Sci., 1998, 7, 132-141.
48. Karplus, M.; McCammon, J.A. Sci. Am., 1986, 254, 42-51.
49. Louis, J.M.; Dyda, F.; Nashed, N.T.; Kimmel, A.R.; Davies, D.R. Biochemistry, 1998, 37, 2105-2110.
50. Kim, E.E.; Baker, C.T.; Dwyer, M.D.; Murcko, M.A.; Rao, B.G.; Tung, R.D.; Navia, M.A. J. Am. Chem. Soc., 1995, 17, 1181-1182
51. Rawlings, N.D.; Tolle, D.P.; Barrett, A.J. Biochem. J., 2004, 378, 705-716.
52. Buczek, O.; Krowarsch, D.; Otlewski, J. Protein. Sci., 2002, 11, 924-932.
53. Krokoszynska, I.; Otlewski, J. J. Mol. Biol., 1996, 256, 793-802.
54. Bode, W.; Huber, R. Eur. J. Biochem., 1992, 204, 433-451.
55. Blow, D.M.; Janin, J.; Sweet, R.M. Nature, 1974, 249, 54-57.
56. Kaslik, G.; Kardos, J.; Szabo, E.; Szilagyi, L.; Zavodszky, P.; Westler, W.M.; Markley, J.L.; Graf, L. Biochemistry, 1997, 36, 5455-5464.
57. Jackson, R. M.; Russel, R. B. J. Mol. Biol., 2000, 296, 325-334.
58. Brauer, A.B.E.; Kelly, G.; McBride, J.D.; Cooke, R.M.; Mathews, S.J.; Leatherbarrow, R.J. J. Mol. Biol., 2001, 306, 799-807.
59. Otzen, D.E.; Fersht, A.R. Protein Eng., 1999, 12, 41-45.
60. Oda, M.; Tamura, A.; Kanaori, K.; Kojima, S.; Miura, K.; Momma, K.; Tonomura, B.; Akasaka, K. J. Biochem., 2002, 132, 991-995.
61. Cai, M.; Gong, Y.; Wen, L.; Krishnamoorthi, R. Biochem., 2002, 41, 9572-9579.
62. Czapinska, H; Otlewski, J. Eur. J. Biochem., 1999, 260, 571-595.
63. Bousquet, J.A.; Duranton, J.; Mely, Y.; Bieth, J.G. Biochem. J., 2003, 370, 345-349.
64. van de Locht, A.; Bode, W.; Huber, R.; Le Bonniec, B.F.; Stone, S.R.; Esmon, C.T.; Stubbs, M.T. EMBO J., 1997, 16, 2977-2984.
65. Gomez, J.; Freire, E. J. Mol. Biol., 1995, 252, 337-350.
66. Baker, B.M.; Murphy, K.P. J. Mol. Biol., 1997, 268, 557-569.
67. Bryant, R.G. Annu. Rev. Biophys. Biomol. Struct., 1996, 25, 29-53.
68. Filfil, R.; Ratavosi, A.; Chalikian, T.V. Biochemistry, 2004, 43, 1315-1322.
69. Skinner, R.; Chang, W.S.; Jin, L.; Pei, X.; Huntington, J.A.; Abrahams, J.P.; Carrell, R.W.; Lomas, D.A. J. Mol. Biol., 1998, 283, 9-14.
70. Liang, J.; McGee, M.P. Biophys. J., 1995, 75, 573-582.
71. Vincent, J.P.; Lazdunski, M. Biochem., 1972, 11, 2967-2977
72. Snyder, G.H. Biochemistry, 1987, 26, 688-694.
73. Rosenthal, P.J.; Sijwali, P.S.; Singh, A.; Shenai, B.K. Curr. Pharm. Des., 2002, 8, 1659-1672.
74. McBride, J.D.; Watson, E.M.; Brauer, A.B.; Jaulent, A.M.; Leatherbarrow, R.J. Biopolymers, 2002, 66, 79-92.
75. McBride, J.D.; Freeman, H.N.; Leatherbarrow, R.J. J. Pept. Sci., 2000, 6, 446-452.
76. McBride, J.D.; Freeman, H.N.; Leatherbarrow, R.J. Eur. J. Biochem., 1999, 266, 403-412.
77. Vakser, I.A.; Matar, O.G.; Lam, C.F., Proc. Natl. Acad. Sci. USA, 1999, 96, 8477-8482.
78. Treptow, W.; Maigret, B.; Chipot, C.; Tarek, M. Bioph. J., 2004, 87, 2365-2379.
79. Claussen, H.; Buning, C.; Rarey, M.; Lengauer, T. J. Mol. Biol., 2001, 308, 377-395.
80. de Freitas, S.M.; de-Mello, L.V.; da Silva, M.C.; Vriend, G.; Neshich, G.; Ventura, M.M. FEBS Lett., 1997, 409, 121-127.
81. Xavier-Filho, J. Plant Physiol., 1992, 4, 1-6.
82. Haq, S.K.; Atif, S.M.; Khan, R.H. Arch. Biochem. Biophys., 2004, 431, 145-59.
83. Oerke, E.C.; Dehne, H.W.; Schonbeck F.; Weber, A. Crop Production and Crop Protection: Estimated Losses in Major Food and Cash Crops, Elsevier: Amsterdam, 1994.
84. Roy, I.; Gupta, M.N. Bioseparation, 2000, 9, 239-245.
85. Tiffin, P.; Gaut, B.S. Mol. Biol. Evol., 2001, 18, 2092-2101.
86. Falco, M.C.; Marbach, P.A.S.; Pompermayer, P.; Lopes, F.C.C.; Silva-Filho, M.C. Genet. Mol. Biol., 2001, 24, 113-122.
87. Franco, O.L.; dos Santo, R.C.; Batista, J.A.N.; Mendes, A.C.M.; de Araujo, M.A.M.; Monnerat, R.G.; Grossi-de-As, M.F.; de Freitas, S.M. Phytochemistry, 2003, 63, 343-349.
88. De Leo, F.; Bonadé-Bottino, M.; Ceci, L.R.; Gallerani, R.; Jouanin, L. Insect. Biochem. Mol. Biol., 2001, 31, 593-602.
89. Reed, B.J.; Chandler, D.S.; Samdeman, R.M. Int. J. Parasitol., 1999, 29, 839-850.
90. Franco, O.L.; Dias, S.C.; Magalhaes, C.P.; Monteiro, A.C.S.; Bloch, C.; Melo, F.R.; Otiveira-Neto, O.B.; Monnerat, R.G.; Grossi-de-Sá, M.F. Phytochemistry, 2004, 65, 81-89.
91. Burgess, E.P.J.; Stevens, P.S.; Keen, G.K.; Laing, W.A.; Christeller, J.T. Entomol. Exp. Appl., 1991, 61, 123-130.
92. Patankar, A.G.; Giri, A.P.; Harsulkar, A.M.; Sainani, M.N.; Deshpande, V.V.; Ranjekar, P.K.; Gupta, V.S. Insect Biochem. Mol. Biol., 2001, 31, 453-464.
93. Johnston, K.A.; Lee, M.; Brough, C.; Hilder, V.A.; Gatehouse, A.M.R.; Gatehouse, J.A. Insect Biochem. Mol. Biol., 1995, 25, 375-383.
94. Jongsma, M.A.; Peters, J.; Stiekema, W.J.; Bosch, D. Insect Biochem. Mol. Biol., 1996, 26, 185-193.
95. Elden, T.C. J. Entomol. Sci., 2000, 35, 70-76.
96. Murdock, L.L.; Shade, R.E.; Pomeroy, M.A. Environ. Entomol., 1988, 17, 467-469.
97. Gatehouse, A.M.R.; Gatehouse, J.A. Pest Sci., 1998, 52, 165-175.
98. Ryan, C.A. Annu. Rev. Phytopathol., 1990, 28, 425-449.
99. Boulter, D. Biochemistry, 1993, 34, 1453-1466.
100. Hilder, V.A.; Gatehouse, A.M.R.; Sheerman, S.E.; Barker, R.F.; Boulter, D. Nature, 1987, 330, 160-163.
101. Hilder, V.A.; Boulter, D. Crop Prot., 1999, 18, 177-191.
102. Atkinsen, H.J.; Urwin, P.E.; Hansen, E.; McPherson, M.J. Trends Biotechnol., 1995, 13, 369-374.
103. Soares-Costa, A.; Beltramini, L.; Thieman, O.; Henrique-Silva, F. Biochem. Biophys. Res. Commun., 2002, 296, 1194-1199.
104. Chen, P.; Buss, G.R.; Tolin, S.A. Heredity, 1993, 84, 25-28.
105. Jouanin, L.; Bonade-Bottino, M.; Girard, C.; Morrot, G.; Giband, M. Plant Sci., 1998, 131, 1-11.
106. Schuler, T.H.; Poppy, G.M.; Kerry, B.R.; Denholm, I. Trends Biotech., 1998, 16, 168-175.
107. Cowgill, S.E.; Atkinson, H.J. Transgenic Res., 2003, 12, 439-449.
108. Mello, M.O.; Silva-Filho, M.C. Braz. J. Plant Physiol., 2002, 14, 71-81.
109. Paulillo, L.C.M.S.; Lopes, A.R.; Cristofoletti, P.T.; Parra, J.R.P.; Terra, W.R.; Silva-Filho, M.C. J. Econ. Entomol., 2000, 93, 892-896.
110. Patankar, A.G.; Giri, A.P.; Harsulkar, A.M.; Sainani, M.N.; Deshpande, V.V.; Ranjekar, P.K.; Gupta, V.S. Insect Biochem. Mol. Biol., 2001, 31, 453-464.
111. Brito, L.O.; Lopes, A.R.; Parra, J.R.P.; Terra, W.R.; Silva-Filho, M.C. Comp. Biochem. Physiol., 2001, 128, 365-375.
112. Girard, C.; Le Métayer, M.; Bonadé-Bottino, M.; Pham- Delègue, M.H.; Jouanin, L. Insect Biochem. Mol. Biol., 1998, 28, 229-237.
113. Vaday, G.G.; Lider, O. J. Leukoc. Biol., 2000, 67, 149-159.
114. McGeer, P.L.; McGeer, E.G. Brain Res. Rev., 1995, 21, 195-218.
115. Walker, D.G.; Yasuhara, O.; Patston, P.A.; McGeer, E.G.; McGeer, P.L. Brain Res., 1995, 675, 75-82.
116. Simoni, M.G.; Rossi, E.; Storini, C.; Pizzimenti, S.; Echart C.; Bergamaschini, L. Am. J. Pathol., 2004, 164, 1857-1863.
117. Liu, D.; Zhang, D.; Scafidi, J.; Wu, X.; Cramer, C.C.; Davis, A.E. Blood, 2005, 105, 2350-2355.
118. Liu, D.; Cai, S.; Gu, X.; Scafidi, J.; Wu, X.; Davis, A.E. J. Immunol., 2003, 171, 2594-2601.
119. Davis, A.E. Drug News Perspec., 2004, 17, 439-446.
120. Lee, K.S.; Jin, S.M.; Lee, H.; Lee, Y.C. Clin. Exp. Allergy, 2004, 34, 276-84.
121. Mott, J.D.; Werb, Z. Curr. Opin. Cell Biol., 2004, 16, 558-64.
122. Tchetverikov, I.; Lohmander, L.S.; Verzijl, N.; Huizinga, T.W.; TeKoppele, J.M.; Hanemaaijer, R.; DeGroot, J. Ann. Rheum. Dis., 2005, 64, 694-698.
123. Bergin, P.J.; Anders, E.; Sicheng, W.; Erk, J.; Jennie, A.; Hans, L.; Pierre, M.; Qiang, P.H.; Marianne, Q.J. Helicobacter., 2004, 9, 201-210.
124. He, S.H.; Xie, H. World J. Gastroenterol., 2004, 10, 332-336.
125. He, S.; Walls, A.F. Br. J. Pharmacol., 1998, 125, 1491-1500.
126. He, S.; Aslam, A.; Gaca, M.D.; He, Y.; Buckley, M.G.; Hollenberg, M.D.; Walls, A.F. J. Pharmacol. Exp. Ther., 2004, 309, 119-26.
127. He, S.; Gaca, M.D.; Walls, A.F. Eur. J. Pharmacol., 2001, 412, 223-229.
128. Draper, D.L.; Landers, D.V.; Krohn, M.A.; Hillier, S.L.; Wiesenfeld, H.C.; Heine, R.P. Am. J. Obstet. Gynecol., 2000, 183, 1243-1248.
129. Forteza, R.M.; Ahmed, A.; Lee, T.; Abraham, W.M. Pulm. Pharmacol. Ther., 2001, 14, 107-110.
130. Pemberton, A.D.; Huntley, J.F.; Miller, H.R. Biochim. Biophys. Acta, 1998, 1379, 29-34.
131. Song, X.; Zeng, L.; Jin, W.; Thompson, J.; Mizel, D.E.; Lei, K.; Billinghurst, R.C.; Poole, A.R.; Wahl, S.M. J. Exp. Med., 1999, 190, 535-542.
132. Wright, C.D.; Havill, A.M.; Middleton, S.C.; Kashem, M.A.; Lee, P.A.; Dripps, D.J.; O'Riordan, T.G.; Bevilacqua, M.P.; Abraham, W.M. J. Pharmacol. Exp. Ther., 1999, 289, 1007-1014.
133. Oh, S.W.; Pae, C.I.; Lee, D.K.; Jones, F.; Chiang, G.K.; Kim, H.O.; Moon, S.H.; Cao, B.; Ogbu, C.; Jeong, K.W.; Kozu, G.; Nakanishi, H.; Kahn, M.; Chi, E.Y.; Henderson, W.R. Jr. J. Immunol., 2002, 168, 1992-2000.
134. Kucharewicz, I.; Kowal, K.; Buczko, W.; Bodzenta-Lukaszyk, A. Thromb. Res., 2003, 112, 1-7.
135. Stefansson, S.; Yepes, M.; Gorlatova, N.; Day, D.E.; Moore, E.G.; Zabaleta, A.; McMahon, G.A.; Lawrence, D.A. J. Biol. Chem., 2004, 279, 29981-29987.
136. Konstan, M.W.; Davis, P.B. Adv. Drug. Deliv. Rev., 2002, 54, 1409-1423.
137. Rees, D.D.; Rogers, R.A.; Cooley, J.; Mandle, R.J.; Kenney, D.M.; Remold-O'Donnell, E. Am. J. Respir. Cell Mol. Biol., 1999, 20, 69-78.
138. McElvaney, N.G.; Hubbard, R.C.; Birrer, P.; Chernick, M.S.; Caplan, D.B.; Frank, M.M.; Crystal, R.G. Lancet, 1991, 16, 337, 392-394.
139. McElvaney, N.G.; Doujaiji, B.; Moan, M.J.; Burnham, M.R.; Wu, M.C.; Crystal, R.G. Am. Rev. Respir. Dis., 1993, 148, 1056-1060.
140. Frenkel, K. Pharmacol. Ther., 1992, 53, 127-166.
141. Wan, X.S.; Koch, C.J.; Lord, E.M.; Manzone, H.; Billings, P.C.; Donahue, J.J.; Odell, C.S.; Miller, J.H.; Schmidt, N.A.; Kennedy, A.R. J. Immnol. Methods, 1995, 180, 117-130.
142. Ware, J.H.; Wan, X.S.; Kennedy, A.R. Nutrit. Cancer Int. J., 1999, 33, 174-177.
143. Hill, G.E.; Springall, D.R.; Robbins, R.A. Surgery, 1997, 121, 449-455.
144. Englberger, L.; Kipfer, B.; Berdat, P.A.; Nydegger, U.E.; Carrel, T.P. Ann. Thorac. Surg., 2002, 73, 1897-1904.
145. Goldsack, R.N.; Chambers, R.C.; Dabbagh, K.; Laurent, G.J. Int. J. Biochem. Cell Biol., 1998, 30, 641-646.
146. Roemisch, J.; Gray, E.; Hoffmann, J.N.; Wiedermann, C.J. Blood Coagul. Fibrinolysis., 2002, 13, 657-670.
147. Loskutoff, D.J.; Quigley, J.P. J. Clin. Invest., 2000, 106, 1441-1443.
148. Keck, T. Pancreatology, 2001, 1, 656-661.
149. Inoue, K.; Takano, H.; Shimada, A.; Yanagisawa, R.; Sakurai, M.; Yoshino, S.; Sato, H.; Yoshikawa, T. Mol. Pharmacol., 2005, 67, 673-680.
150. Inoue, K.; Takano, H.; Yanagisawa, R.; Sakurai, M.; Shimada, A.; Yoshino, S.; Sato, H.; Yoshikawa, T. Exp. Biol. Med., 2005, 230, 281-287.
151. Ibrahim, M.Z.; Reder, A.T.; Lawand, R.; Takash, W.; Sallouh-Khatib, S. J. Neuroimmunol., 1996, 70, 131-138.
152. Murphy, G.; Atkinson, S.; Ward, R.; Gavrilovic, J.; Reynolds, J.J. Ann. N. Y. Acad. Sci., 1992, 667, 1b-12b.
153. Welss, T.; Basketter, D.A.; Schroder, K.R. Toxicol. In Vitro, 2004, 18, 231-243.
154. Schalkwijk, J.; Chang, A.; Janssen, P.; De Jongh, G.J.; Mier, P.D. Br. J. Dermatol., 1990, 122, 631-641.
155. Wiedow, O.; Luademann, J.; Utrecht, B. Biochem. Biophys. Res. Com., 1991, 174, 6-10.
156. Welss, T.; Sun, J.; Irving, J.A.; Blum, R.; Smith, I.; Whisstock, J.C.; Pike, R.N.; von-Mikecz, A.; Ruzicka, T.; Bird, P.I.; Abts, H.F. Biochemistry, 2003, 42, 7381-7389.
157. Maki, P.; Paterson, Y.; Kennedy, A.R. Nutr. Cancer, 1994, 22, 185-193.
158. Fung, S.K.; Lok, A.S. Curr. Opin. Gastroenterol., 2005, 21, 300-307.
159. Chung, V.; Carroll, A.R.; Gray, N.M.; Parry, N.R.; Thommes, P.A.; Viner, K.C.; D'Souza, E.A. Antimicrob. Agents Chemother., 2005, 49, 1381-1390.
160. Surleraux, D.L.; de Kock, H.A.; Verschueren, W.G.; Pille, G.M.; Maes, L.J.; Peeters, A.; Vendeville, S.; De Meyer, S.; Azijn, H.; Pauwels, R.; de Bethune, M.P.; King, N.M.; Prabu-Jeyabalan, M.; Schiffer, C.A.; Wigerinck, P.B. J. Med. Chem., 2005, 48, 1965-7193.
161. Boyle, B.A.; Elion, R.A.; Moyle, G.J.; Cohen, C.J. AIDS Rev., 2004, 6, 218-225.
162. Bukrinskaya, A.G. Arch. Virol., 2004, 149, 1067-1082.
163. Kiso, Y. Biopolymers, 1996, 40, 235-244.
164. Fowler, K. STEP Perspect., 1997, 9, 15-16.
165. Hruz, P.W.; Murata, H.; Mueckler, M. Am. J. Physiol. Endocrinol. Metab., 2001, 280, E549-553.
166. Valero, N.; Larreal, Y.; Mosqueray, J.; Rincón, E. Invest. Clin., 2005, 46, 75-95.
167. Zhang, X.W.; Yap, Y.L. Bioorg. Med. Chem., 2004, 12, 2219-2223.
168. Hui, D.S.; Wong, G.W. Exp. Opin. Pharmacother., 2004, 5, 1687-1693.
169. Fujii, T.; Nakamura, T.; Iwamoto, A. J. Infect. Chemother., 2004, 10, 1-7.
170. Anand, K.; Ziebuhr, J.; Wadhwani, P.; Mesters, J.R.; Hilgenfeld, R. Science, 2003, 300, 1763-1767.
171. Blanchard, J.E.; Elowe, N.H.; Huitema, C.; Fortin, P.D.; Cechetto, J.D.; Eltis, L.D.; Brown, E.D. Chem. Biol., 2004, 11, 1445-1453.
172. Jenwitheesuk, E.; Samudrala, R. Bioorg. Med. Chem. Lett., 2003, 13, 3989-3992.
173. Choo, Q.L.; Kuo, G.; Weiner, A.J.; Overby, L.R.; Bradley, D.W.; Houghton, M. Science, 1989, 244, 359-362.
174. Strauss, E. Rev. Soc. Bras. Med. Trop., 2001, 34, 69-82.
175. Lauer, G.M.; Walker, B.D. New Engl. J. Med., 2001, 345, 41-52.
176. Pawlotsky, J.M. Trends Microbiol., 2004, 12, 96-102.
177. Foster, G.R. Semin. Liver Dis., 2004, 24, 97-104.
178. Lamarre, D.; Anderson, P.C.; Bailey, M.; Beaulieu, P.; Bolger, G.; Bonneau, P.; Bos, M.; Cameron, D.R.; Cartier, M.; Cordingley, M.G.; Faucher, A.M.; Goudreau, N.; Kawai, S.H.; Kukolj, G.; Lagace, L.; LaPlante, S.R.; Narjes, H.; Poupart, M.A.; Rancourt, J.; Sentjens, R.E.; St. George, R.; Simoneau, B.; Steinmann, G.; Thibeault, D.; Tsantrizos, Y.S.; Weldon, S.M.; Yong, C.L.; Llinas-Brunet, M. Nature, 2003, 426, 186-189.
179. Bailey, M.D.; Halmos, T.; Goudreau, N.; Lescop, E.; Llinas-Brunet, M. J. Med. Chem., 2004, 47, 3788-3799.
180. Sun, J.; Li, K.; Shata, M.T.; Chan, T.S. Curr. Opin. Gastroenterol., 2004, 20, 598-602.
181. Siqueira, J.B. Jr.; Martelli, C.M.; Coelho, G.E.; Simplicio, A.C.; Hatch, D.L. Emerg. Infect. Dis., 2005, 11, 48-53.
182. Stephenson, J.R. Bull World Health Organ., 2005, 83, 308-314.
183. Mukhopadhyay, S.; Kuhn, R-J.; Rossmann, M.G. Nat. Rev. Microbiol., 2005, 3, 13-22.
184. Zhang, L.; Mohan, P.M.; Padmanabhan, R. J. Virol., 1992, 66, 7549-7554.
185. Murthy, H.M.; Clum, S.; Padmanabhan, R. J. Biol. Chem., 1999, 274, 5573-5580.
186. Leung, D.; Schroder, K.; White, H.; Fang, N.X.; Stoermer, M.J.; Abbenante, G.; Martin, J.L.; Young, P.R.; Fairlie, D.P. J. Biol. Chem., 2001, 276, 45762-45771.
187. Markland, F.S. Jr. Thromb. Haemost., 1998, 79, 668-674.
188. Ljungberg, K.B.; Marelius, J.; Musil, D.; Svensson, P.; Norden, B.; Aqvist, J. Eur. J. Pharm. Sci., 2001, 12, 441-446.
189. Al-Obeidi, F.; Ostrem, J.A. DDT, 1998, 3, 223-231.
190. Franzeck, U.K.; Schalch, I.; Jager, K.A.; Schneider, E.; Grimm, J.; Bollinger, A. Circulation, 1996, 93, 74-79.
191. Prandoni, P.; Lensing, A.W.; Cogo, A.; Cuppini, S.; Villalta, S.; Carta, M.; Cattelan, A.M.; Polistena, P.; Bernardi, E.; Prins, M.H. Ann. Intern. Med, 1996, 125, 1-7.
192. Fowkes, F.J.; Price, J.F.; Fowkes, F.G. Eur. J. Vasc. Endovasc. Surg., 2003, 25, 1-5.
193. Milkovich, G.; Gibson, G. Am. J. Health. Syst. Pharm, 2003, 60, S15-21.
194. Ansell, J.E.; Weitz, J.I.; Comerota, A.J. Hematology (Am. Soc. Hematol. Educ. Program), 2000, 2000, 266-284.
195. Macfarlane, S.R.; Seatter, M.J.; Kanke, T.; Hunter, G.D.; Plevin R. Pharmacol. Rev., 2001, 53, 245-282.
196. Selwyn, A.P. Am. J. Cardiol., 2003, 91, 3H-11H.
197. Gruber, A.; Hanson, S.R. Curr. Pharm. Des., 2003, 9, 2367-2374.
198. Hauptmann, J.; Markwardt, F. Semin. Thromb. Hemost., 1992, 18, 200-217.
199. Strube, K.H.; Kroger, B.; Bialojan, S.; Otte, M.; Dodt, J. J. Biol. Chem., 1993, 268, 8590-8595.
200. Vacca, J.P. Curr. Opin. Chem. Biol., 2000, 4, 394-400.
201. Kikelj, D. Pathophysiol. Haemost. Thromb., 2003/2004, 33, 487-491.
202. Quinsey, N.S.; Greedy, A.L.; Bottomley, S.P.; Whisstock, J.C.; Pike, R.N. Int. J. Biochem. Cell Biol., 2004, 36, 386-389.
203. Bishop, P.; Lawson, J. Nat. Rev. Drug Discov., 2004, 3, 684-694.
204. Frumento, R.J.; O'Malley, C.M.; Bennett-Guerrero, E. Ann. Thorac. Surg., 2003, 75, 479-483.
205. Wegner, J. J. Extra. Corpor. Technol., 2003, 35, 326-338.
206. Golanski, R.; Golanski, J.; Chizynski, K.; Iwaszkiewicz, A.; Zaslonka, J.; Pietrucha, T.; Chrul, S.; Watala, C. Med. Sci. Monit., 2000, 6, 722-728.
207. Salzet, M. FEBS Lett., 2001, 492, 187-92.
208. Harvey, R.P.; Degryse, E.; Stefani, L.; Schamber, F.; Cazenave, J.P.; Courtney, M.; Tolstoshev, P.; Lecocq, J.P. Proc. Natl. Acad. Sci. USA, 1986, 83, 1084-1088.
209. Pineo, G.F.; Hull, R.D. Curr. Opin, Hematol., 1999, 6, 298-303.
210. Buller, H.R. Z. Kardiol., 1993, 82, 81-82.
211. Stark, K.R.; James, A.A. Exp. Parasitol., 1995, 81, 321-331.
212. Valenzuela, J.G.; Francischetti, I.M.; Ribeiro, J.M. Biochemistry, 1999, 38, 11209-11215.
213. Markwardt, F. Thromb. Haemostasis, 1994, 72, 477-480.
214. Dodt, J.; Otte, M.; Strube, K.H.; Friedrich, T. Semin. Thromb. Hemostasis, 1996, 22, 203-208.
215. Perez, J.C.; Sanchez, E.E. Toxicon, 1999, 37, 703-728.
216. Ilies, M.; Banciu, M.D.; Scozzafava, A.; Ilies, M.A.; Caproiu, M.T.; Supuran, C.T. Bioorg. Med. Chem. 2003, 11, 2227-2239.
217. Supuran, C.T.; Scozzafava, A. In Proteinase and Peptidase Inhibition: Recent Potential Targets for Drug Development; Smith, H.J., Simons, C., Eds.; Taylor & Francis: London and New York, 2002, pp. 35.
218. Rosenthal, P.J. Int. J. Parasitol., 2004, 34, 1489-1499.
219. Nitz, N.; Gomes, C.; de Cássia Rosa, A.; D'Souza-Ault, M.R.; Moreno, F.; Lauria-Pires, L.; Nascimento, R.J.; Teixeira, A.R. Cell, 2004, 118, 175-186.
220. Lima, A.P.C.A.; Reis, F.C.G.; Serveau, C.; Lalmanach, G.; Juliano, L.; Ménard, R.; Vernet, T.; Thomas, D.Y.; Storer, A.C.; Scharfstein, J. Mol. Biochem. Parasitol., 2001, 114, 41-52.
221. Monteiro, A.C.; Abrahamson, M.; Lima, A.P.; Vannier-Santos, M.A.; Scharfstein, J. J. Cell Sci., 2001, 114, 3933-3942.
222. Stoka, V.; Nycander, M.; Lenarcic, B.; Labriola, C.; Cazzulo, J.J.; Björk, I.; Turk, V. FEBS Lett., 1995, 370, 101-104.
223. Bastos, I.M.; Grellier, P.; Martins, N.F.; Cadavid-Restrepo, G.; de Souza-Ault, M.R.; Augustyns, K.; Teixeira, A.R.; Schrevel, J.; Maigret, B.; da Silveira, J.F.; Santana, J.M. Biochem. J., 2005, 388, 29-38.
224. Caffrey, C.R.; Scory, S.; Steverding, D. Curr. Drug Targets, 2000, 1, 155-162.
225. Cazzulo, J.; Stoka, V.; Turk, V. Curr. Pharm. Des., 2001, 7, 1143-1156.
226. Dalton, J.P.; Smith, A.M.; Clough, K.A.; Brindley, P.J. Parasitol. Today, 1995, 11, 299-303.
227. Fallon, P.G.; Teixeira, M.M.; Neice, C.M.; Williams, T.J.; Hellewell, P.G.; Doenboff, M.J. J. Infect. Dis., 1996, 173, 1460-1466.
228. Lim, K.C.; Sun, E.; Bahgat, M.; Bucks, D.; Guy, R.; Hinz, R.S.; Cullander, C.; McKerrow, J.H. Am. J. Trop. Med Hyg., 1999, 60, 487-492.
229. Wasilewski, M.M.; Lim, K.C.; Phillips, J.; McKerrow, J.H. Mol. Biochem. Parasitol., 1996, 81, 179-189.
230. Selitrennikoff, C.P. Appl. Environ. Microbiol., 2001, 67, 2883-2894.
231. Shao, F.; Hu, Z.; Xiong, Y.M.; Huang, Q.Z.; Wang, C.G.; Zhu, R.H.; Wang, D.C. Biochim. Biophys. Acta, 1999, 1430, 262-268.
232. Ng, T.B. Peptides, 2004, 25, 1215-1222.
233. Pernas, M.; López-Solanilla, E.; Sánchez-Monge,R.; Salcedo, G.; Rodríguez-Palenzuela, P. Mol. Plant-Microbe. Interact., 1999, 12, 624-627.
234. Singh, D.; Naik, S.R.; Naik, S. Parasitol., 2004, 129, 127-135.
235. Stewart, K.; Abad-Zapatero, C. Curr. Med. Chem., 2001, 8, 941-948.
236. Forney, J.R.; Yang, S.; Do, C.; Healey, M.C. J. Parasitol., 1996, 82, 638-640.
237. Krutzik, S.R.; Modlin, R.L. Semin. Immunol., 2004, 16, 35-41.
238. Schorey, J.S.; Carroll, M.C.; Brown, E.J. Science, 1997, 277, 1091-1093.
239. McKinney, J.C.; Bentrup, K.H.; Munõz-Elías, E.J.; Miczak, A.; Chen, B.; Chan, W.T.; Swenson, D.; Sacchettini, J.C.; Jacobs, W.R.; Russell, D.G. Nature, 2000, 406, 735-738.
240. Kheradmand, F.; Kiss, A.; Xu, J.; Lee, S.H.; Kolattukudy, P.E.; Corry, D.B. J. Immunol., 2002, 169, 5904-5911.
241. Fattorini, L.; Orefici, G.; Jin, S.H.; Scardaci, G.; Amicosante, G.; Franceschini, N.; Chopra, I. Antimicrob. Agents Chemother., 1992, 36, 1068-1072.
242. Antalis, T.M.; La Linn, M.; Donnan, K.; Mateo, L.; Gardner, J.; Dickinson, J.L.; Buttigieg, K.; Suhrbier, A. J. Exp. Med., 1998, 187, 1799-1811.
243. Grimwood, K.; Anderson, P.; Anderson, V.; Tan, L.; Nolan, T. Arch. Dis. Child., 2000, 83, 111-116.
244. Tauber, M.G.; Moser, B. Clin. Infect. Dis., 1999, 28, 1-11.
245. Lahrtz, F.; Piali, L.; Spanaus, K.S.; Seebach, J.; Fontana, A. J. Neuroimmunol., 1998, 85, 33-43.
246. Azeh, I.; Mader, M.; Smimov, A.; Beuche, W.; Nau, R.; Weber, F. Neurosci. Lett., 1998, 256, 127-1230.
247. Leib, S.L.; Leppert, D.; Clements, J.; Tauber, M.G. Infect. Immun., 2000, 68, 615-620.
248. Nau, R.; Bruck, W. Trends Neurosci. 2002, 25, 38-45.
249. Popov, S.G.; Popova, T.G.; Hopkins, S.; Weinstein, R.S.; Macafee, R.; Fryxell, K.J.; Chandhoke, V.; Bailey, C.; Alibek, K. BMC Infect. Dis., 2005, 5, 25.
250. Kernacki, K.A.; Chunta, J.L.; Barrett, R.P.; Hazlett, L.D. Exp. Eye Res., 2004, 78, 1155-1162.
251. Pozio, E.; Morales, M.A. Trends Parasitol., 2005, 21, 58-63.
252. Kennedy, A.R. Carcinogenesis, 1985, 6, 1441-1446.
253. Chang, J.D.; Billings, P.; Kennedy, A.R. Mol. Carcinog., 1990, 3, 226-232.
254. Li, J.H.; Billings, P.C.; Kennedy, A.R. Cancer. J., 1992, 5, 354-358.
255. Gerl, R.; Vaux, D.L. Carcinogenesis, 2005, 26, 263-270.
256. Kennedy, A.R.; Pharmacol. Ther., 1999, 78, 167-209.
257. Messina, M.J.; Persky, V.; Setchell, K.D.; Barnes, S. Nutr. Cancer., 1994, 21, 113-131.
258. Blondell, J.M. Cancer Detect. Prev., 1988, 11, 209-223.
259. Chen, M.S.; Chen, D.; Dou, Q.P. In vivo, 2004, 18, 73-80.
260. Winn, D.M.; Ziegler, R.G.; Pickle, L.W.; Gridley, G.; Blot, W.J.; Hoover, R.N. Cancer Res., 1984, 44, 1216-1222.
261. Koepke, J.; Ermler, U.; Warkentin, E.; Wenzl, G.; Flecker, P. J. Mol. Biol., 2000, 298, 477-491.
262. Rush, T.S.; Powers, R. Curr. Top. Med. Chem., 2004, 4, 1311-1327.
263. Gettins, P.G. Chem. Rev., 2002, 102, 4751-4804.
264. Burton, E.; Prados, M. Curr. Opin. Oncol., 1999, 11, 157-161.
265. Gottesman, M.N. In Escherichia coli and Salmonella typhimurium; Neidhardt, D, Ed.; American Society for Microbiology: Washington, DC, 1987, pp. 1308-1312.
266. Kennedy, A.R. Cancer Res., 1994, 54, 1999-2005.
267. Yoshiji, H.; Harris, S.R.; Raso, E.; Gomez, D.E.; Lindsay, C.K.; Shibuya, M.; Sinha, C.C.; Thorgeirsson, U.P. Int. J. Cancer, 1998, 75, 81-87.
268. St. Clair, W.H.; St. Clair, D.K.; Kennedy, A.R. Cancer J., 1991, 4, 278-282.
269. Dittmann, K.H.; Mayer, C.; Rodemann, H.P. Curr. Med. Chem. Anti-Cancer Agents, 2003, 3, 360-363.
270. Hu, E.; Mueller, E.; Oliviero, S.; Papaioannou, V.E.; Johnson, A. Spiegelman, B.M. EMBO J., 1994, 13, 3094-3103.
271. Kennedy, A.R.; Billings, P.C. In Anticarcinogenesis and Radiation Protection; Cerutti, P.A.; Nygaard, O.F.; Siomic, M.G., Eds.; Plenum Press: New York, 1997, pp. 285-295.
272. Gueven, N.; Dittmann, K.; Mayer, C.; Rodemann, H.P. Cancer Lett., 1998, 125, 77-82.
273. Kennedy, A.R. In Adjuvant Nutrition in Cancer Treatment; Quillin, P.; Williams, R.M., Eds.; Cancer Treatment Research Foundation: Arlington Heights, 1993, pp. 129-144.
274. Dittman, K.; Loffler, H.; Bamberg, M.; Rodemann, H.P. Radiother. Oncol., 1995, 34, 137-143.
275. Fox, S.B.; Gasparini, G.; Harris, A.L. Lancet Oncol., 2001, 2, 278-289.
276. Pepper, M.S. Arterioscler. Thromb. Vasc. Biol., 2001, 21, 1104-1107.
277. Noel, A.; Maillard, C.; Rocks, N.; Jost, M.; Chabottaux, V.; Sounni, N.E.; Maquoi, E.; Cataldo, D.; Foidart, J.M. J. Clin. Pathol., 2004, 57, 577-584.
278. Schneider, B.P.; Miller, K.D. J. Chn. Oncol., 2005, 23, 1782-1790.
279. Jonhson, M.D.; Kim, H.R.; Chesler, L.; Tsao Wu, G.; Bouck, N.; Polverini, P.J.J. Cell. Physiol., 1994, 160, 194-202.
280. Luttun, A.; Carmeliet, P. Ann. N. Y. Acad. Sci., 2001, 947, 124-132.
281. Rakic, J.M.; Maillard, C.; Jost, M.; Bajou, K.; Masson, V.; Devy, L.; Lambert, V.; Foidart J.M.; Noel, A. Cell Mol. Life Sci., 2003, 60, 463-473.
282. Rifkin, D.B.; Mazzieri, R.; Munger, J.S.; Noguera, I.; Sung, J. APMIS, 1999, 107, 80-85.
283. Montesano, R.; Pepper, M.S.; Mohlesteinlein, U.; Risau, W.; Wagner, E.F.; Orci, L. Cell, 1990, 32, 435-445.
284. Varner, J.A.; Cheresh, D.A. Curr. Opin. Cell Biol., 1996, 8, 724-730.
285. Mueller, B.M.; Yu, Y.B.; Laug, W.E. Proc. Natl. Acad. Sci USA, 1995, 92, 205-209.
286. Zucker, S.; Pei, D.Q.; Cao, J.; Lopez-Otin, C. Curr. Top. Dev. Biol., 2003, 54, 1-74.
287. Sounni, N.E.; Baramova, E.N.; Munaut C.; Maquoi, E.; Frankenne, F.; Foidart, J.M.; Noel, A. Int. J. Cancer, 2002, 98, 23-28.
288. Sounni, N.E.; Devy, L.; Hajitou, A.; Frankenne, F.; Munaut, C.; Gilles, C.; Deroanne, C.; Thompson, E.W.; Foidart, J.M.; Noel, A. FASEB J., 2002, 16, 555-564.
289. Behen, A.T.; Paganetti, P.A.; Schwab, M.E. J. Cell Biol., 1999, 144, 373-84.
290. Deryugina, E.I.; Soroceanu, L.; Strongin, A.Y.; Cancer Res., 2002, 62, 580-588.
291. Hotary, K.B.; Allen, E.D.; Brooks, P.C.; Datta, N.S.; Long, M.W.; Weiss, S.J. Cell, 2003, 114, 34-45.
292. Hotary, K.; Allen, E.; Punturieri, A.; Yana, I.; Weiss, S.J. J. Cell. Biol., 2000, 149, 1309-1323.
293. Hotary, K.B.; Yana, I.; Sabeh, F.; Li, X.Y.; Holmbeck, K.; Birkedal-Hansen, H.; Allen, E.D.; Hiraoka, N.; Weiss, S.J. J. Exp. Med., 2002, 195, 295-308.
294. Deryugina, E.I.; Bourdon, M.A.; Jungwirth, K.; Smith, J.W.; Strongin, A.Y. Int. J. Cancer, 2000, 86, 15-23.
295. Parfyonova, Y.V.; Plekhanova, O.S.; Tkachuk, V.A. Biochemistry Mosc., 2002, 67, 119-134.
296. Kahari, V.M.; Saarialho-Kere, U. Ann. Med., 1999, 31, 34-45.
297. Noel, A.; Hajitou, A.; L'Hoir, C.; Maquoi, E.; Baramova, E.; Lewalle, J.M.; Remacle, A.; Kebers, F.; Brown, P.; Calberg-Bacq, C. M.; Foidart J.M. Int. J. Cancer, 1998, 76, 267-273.
298. Khokha, R.; Zimmer, M.J.; Wilson, S.M.; Chambers, A.F. Clin. Exp. Metastasis, 1992, 10, 365-370.
299. Aozuka, Y.; Koizumi, K.; Saitoh, Y.; Ueda, Y.; Sakurai, H.; Saiki, I. Cancer Lett., 2004, 216, 35-42.
300. Guedez, L.; McMarlin, A.J.; Kingma, D.W.; Bennett, T.A.; Stetler-Stevenson, M.; Stetler-Stevenson, W.G. Am. J. Pathol., 2001, 158, 1207-1215.
301. Rhee, J.; Diaz, R.; Korets, L.; Hodgson, J.G.; Coussens, L.M. Cancer Res., 2004, 64, 952-961.
302. Joyce, J.A.; Baruch, A.; Chehade, K.; Meyer-Morse, N.; Giraudo, E.; Tsai, F.Y.; Greenbaum, D.C.; Hager, J.H.; Bogyo, M.; Hanahan, D. Cancer Cell, 2004, 5, 443-453.
303. Ossowik, L. Cancer Res., 1992, 52, 6754-6760.
304. DeClerck, Y.A.; Imren, S. Eur. J. Cancer, 1994, 14, 2170-2180.
305. Oreffo, V.I.C.; Billings, P.C.; Kennedy, A.R.; Witschi, H. Toxicology, 1991, 69, 165-176.