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Volumn 12, Issue 2, 2004, Pages 96-102

Pathophysiology of hepatitis C virus infection and related liver disease

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; ASIALOGLYCOPROTEIN RECEPTOR; CD209 ANTIGEN; CD81 ANTIGEN; HYBRID PROTEIN; INTERFERON; L SIGN PROTEIN; LECTIN; LOW DENSITY LIPOPROTEIN RECEPTOR; MEMBRANE PROTEIN; POLYPROTEIN; RNA POLYMERASE; UNCLASSIFIED DRUG; VIRUS ENVELOPE PROTEIN; VIRUS RECEPTOR; VIRUS RNA;

EID: 0842303291     PISSN: 0966842X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tim.2003.12.005     Document Type: Review
Times cited : (187)

References (83)
  • 1
    • 0036829649 scopus 로고    scopus 로고
    • National institutes of health consensus development conference statement: Management of hepatitis C: 2002-June 10-12, 2002
    • National institutes of health consensus development conference statement: Management of hepatitis C: 2002-June 10-12, 2002. Hepatology. 36:2002;S3-S20.
    • (2002) Hepatology , vol.36
  • 2
    • 85030909594 scopus 로고    scopus 로고
    • Structural biology of hepatitis C virus
    • in press
    • Penin, F. et al. Structural biology of hepatitis C virus. Hepatology (in press).
    • Hepatology
    • Penin, F.1
  • 3
    • 0027138643 scopus 로고
    • Density heterogeneities of hepatitis C virus in human sera due to the binding of beta-lipoproteins and immunoglobulins
    • Thomssen R., et al. Density heterogeneities of hepatitis C virus in human sera due to the binding of beta-lipoproteins and immunoglobulins. Med. Microbiol. Immunol. (Berl.). 182:1993;329-334.
    • (1993) Med. Microbiol. Immunol. (Berl.) , vol.182 , pp. 329-334
    • Thomssen, R.1
  • 4
    • 0000163169 scopus 로고    scopus 로고
    • Flaviviridae: The viruses and their replication
    • D.M. Knipe, Howley P.M. Lippincott Williams and Wilkins
    • Lindenbach B.D., Rice C.M. Flaviviridae: the viruses and their replication. Knipe D.M., Howley P.M. Fields Virology. Vol. 1:2001;991-1041 Lippincott Williams and Wilkins.
    • (2001) Fields Virology , vol.1 , pp. 991-1041
    • Lindenbach, B.D.1    Rice, C.M.2
  • 5
    • 0034775964 scopus 로고    scopus 로고
    • Biogenesis of hepatitis C virus envelope glycoproteins
    • Op De Beeck A., et al. Biogenesis of hepatitis C virus envelope glycoproteins. J. Gen. Virol. 82:2001;2589-2595.
    • (2001) J. Gen. Virol. , vol.82 , pp. 2589-2595
    • Op De Beeck, A.1
  • 6
    • 0035000935 scopus 로고    scopus 로고
    • Conservation of the conformation and positive charges of hepatitis C virus E2 envelope glycoprotein hypervariable region 1 points to a role in cell attachment
    • Penin F., et al. Conservation of the conformation and positive charges of hepatitis C virus E2 envelope glycoprotein hypervariable region 1 points to a role in cell attachment. J. Virol. 75:2001;5703-5710.
    • (2001) J. Virol. , vol.75 , pp. 5703-5710
    • Penin, F.1
  • 7
    • 17044457135 scopus 로고    scopus 로고
    • Cellular binding of hepatitis C virus envelope glycoprotein E2 requires cell surface heparan sulfate
    • Barth H., et al. Cellular binding of hepatitis C virus envelope glycoprotein E2 requires cell surface heparan sulfate. J. Biol. Chem. 278:2003;41003-41012.
    • (2003) J. Biol. Chem. , vol.278 , pp. 41003-41012
    • Barth, H.1
  • 8
    • 0033607281 scopus 로고    scopus 로고
    • Hepatitis C virus and other Flaviviridae viruses enter cells via low density lipoprotein receptor
    • Agnello V., et al. Hepatitis C virus and other Flaviviridae viruses enter cells via low density lipoprotein receptor. Proc. Natl. Acad. Sci. U. S. A. 96:1999;12766-12771.
    • (1999) Proc. Natl. Acad. Sci. U. S. A. , vol.96 , pp. 12766-12771
    • Agnello, V.1
  • 9
    • 0032582538 scopus 로고    scopus 로고
    • Binding of hepatitis C virus to CD81
    • Pileri P., et al. Binding of hepatitis C virus to CD81. Science. 282:1998;938-941.
    • (1998) Science , vol.282 , pp. 938-941
    • Pileri, P.1
  • 10
    • 0142242265 scopus 로고    scopus 로고
    • Cell entry of hepatitis C virus requires a set of co-receptors that include the CD81 tetraspanin and the SR-B1 scavenger receptor
    • Bartosch B., et al. Cell entry of hepatitis C virus requires a set of co-receptors that include the CD81 tetraspanin and the SR-B1 scavenger receptor. J. Biol. Chem. 278:2003;41624-41630.
    • (2003) J. Biol. Chem. , vol.278 , pp. 41624-41630
    • Bartosch, B.1
  • 11
    • 0038471344 scopus 로고    scopus 로고
    • Hepatitis C virus glycoproteins mediate pH-dependent cell entry of pseudotyped retroviral particles
    • Hsu M., et al. Hepatitis C virus glycoproteins mediate pH-dependent cell entry of pseudotyped retroviral particles. Proc. Natl. Acad. Sci. U. S. A. 100:2003;7271-7276.
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , pp. 7271-7276
    • Hsu, M.1
  • 12
    • 18644378971 scopus 로고    scopus 로고
    • The human scavenger receptor class B type I is a novel candidate receptor for the hepatitis C virus
    • Scarselli E., et al. The human scavenger receptor class B type I is a novel candidate receptor for the hepatitis C virus. EMBO J. 21:2002;5017-5025.
    • (2002) EMBO J. , vol.21 , pp. 5017-5025
    • Scarselli, E.1
  • 13
    • 0038165533 scopus 로고    scopus 로고
    • DC-SIGN and L-SIGN are high affinity binding receptors for hepatitis C virus glycoprotein E2
    • Lozach P.Y., et al. DC-SIGN and L-SIGN are high affinity binding receptors for hepatitis C virus glycoprotein E2. J. Biol. Chem. 278:2003;20358-20366.
    • (2003) J. Biol. Chem. , vol.278 , pp. 20358-20366
    • Lozach, P.Y.1
  • 14
    • 0037379186 scopus 로고    scopus 로고
    • Hepatitis C virus glycoproteins interact with DC-SIGN and DC-SIGNR
    • Pohlmann S., et al. Hepatitis C virus glycoproteins interact with DC-SIGN and DC-SIGNR. J. Virol. 77:2003;4070-4080.
    • (2003) J. Virol. , vol.77 , pp. 4070-4080
    • Pohlmann, S.1
  • 15
    • 0037213932 scopus 로고    scopus 로고
    • Role of the asialoglycoprotein receptor in binding and entry of hepatitis C virus structural proteins in cultured human hepatocytes
    • Saunier B., et al. Role of the asialoglycoprotein receptor in binding and entry of hepatitis C virus structural proteins in cultured human hepatocytes. J. Virol. 77:2003;546-559.
    • (2003) J. Virol. , vol.77 , pp. 546-559
    • Saunier, B.1
  • 16
    • 0026513651 scopus 로고
    • Internal ribosome entry site within hepatitis C virus RNA
    • Tsukiyama-Kohara K., et al. Internal ribosome entry site within hepatitis C virus RNA. J. Virol. 66:1992;1476-1483.
    • (1992) J. Virol. , vol.66 , pp. 1476-1483
    • Tsukiyama-Kohara, K.1
  • 17
    • 0035831269 scopus 로고    scopus 로고
    • Hepatitis C virus IRES RNA-induced changes in the conformation of the 40S ribosomal subunit
    • Spahn C.M., et al. Hepatitis C virus IRES RNA-induced changes in the conformation of the 40S ribosomal subunit. Science. 291:2001;1959-1962.
    • (2001) Science , vol.291 , pp. 1959-1962
    • Spahn, C.M.1
  • 18
    • 0036237981 scopus 로고    scopus 로고
    • Crystal structure of an RNA tertiary domain essential to HCV IRES-mediated translation initiation
    • Kieft J.S., et al. Crystal structure of an RNA tertiary domain essential to HCV IRES-mediated translation initiation. Nat. Struct. Biol. 9:2002;370-374.
    • (2002) Nat. Struct. Biol. , vol.9 , pp. 370-374
    • Kieft, J.S.1
  • 19
    • 0027476809 scopus 로고
    • Expression and identification of hepatitis C virus polyprotein cleavage products
    • Grakoui A., et al. Expression and identification of hepatitis C virus polyprotein cleavage products. J. Virol. 67:1993;1385-1395.
    • (1993) J. Virol. , vol.67 , pp. 1385-1395
    • Grakoui, A.1
  • 20
    • 0037472806 scopus 로고    scopus 로고
    • The p7 protein of hepatitis C virus forms an ion channel that is blocked by the antiviral drug, Amantadine
    • Griffin S.D., et al. The p7 protein of hepatitis C virus forms an ion channel that is blocked by the antiviral drug, Amantadine. FEBS Lett. 535:2003;34-38.
    • (2003) FEBS Lett. , vol.535 , pp. 34-38
    • Griffin, S.D.1
  • 21
    • 0038284830 scopus 로고    scopus 로고
    • The hepatitis C virus p7 protein forms an ion channel that is inhibited by long-alkyl-chain iminosugar derivatives
    • Pavlovic D., et al. The hepatitis C virus p7 protein forms an ion channel that is inhibited by long-alkyl-chain iminosugar derivatives. Proc. Natl. Acad. Sci. U. S. A. 100:2003;6104-6108.
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , pp. 6104-6108
    • Pavlovic, D.1
  • 22
    • 0037223688 scopus 로고    scopus 로고
    • Hepatitis C virus F protein is a short-lived protein associated with the endoplasmic reticulum
    • Xu Z., et al. Hepatitis C virus F protein is a short-lived protein associated with the endoplasmic reticulum. J. Virol. 77:2003;1578-1583.
    • (2003) J. Virol. , vol.77 , pp. 1578-1583
    • Xu, Z.1
  • 23
    • 0038158179 scopus 로고    scopus 로고
    • Characterization of the expression of the hepatitis C virus F protein
    • Roussel J., et al. Characterization of the expression of the hepatitis C virus F protein. J. Gen. Virol. 84:2003;1751-1759.
    • (2003) J. Gen. Virol. , vol.84 , pp. 1751-1759
    • Roussel, J.1
  • 24
    • 0032885602 scopus 로고    scopus 로고
    • The non-structural 5A protein of hepatitis C virus
    • Pawlotsky J.M., Germanidis G. The non-structural 5A protein of hepatitis C virus. J. Viral Hepat. 6:1999;343-356.
    • (1999) J. Viral Hepat. , vol.6 , pp. 343-356
    • Pawlotsky, J.M.1    Germanidis, G.2
  • 25
    • 0036715591 scopus 로고    scopus 로고
    • Viruses and interferon: A fight for supremacy
    • Katze M.G., et al. Viruses and interferon: a fight for supremacy. Nat. Rev. Immunol. 2:2002;675-687.
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 675-687
    • Katze, M.G.1
  • 26
    • 0034969251 scopus 로고    scopus 로고
    • Hepatitis C virus nonstructural 5A protein induces interleukin-8, leading to partial inhibition of the interferon-induced antiviral response
    • Polyak S.J., et al. Hepatitis C virus nonstructural 5A protein induces interleukin-8, leading to partial inhibition of the interferon-induced antiviral response. J. Virol. 75:2001;6095-6106.
    • (2001) J. Virol. , vol.75 , pp. 6095-6106
    • Polyak, S.J.1
  • 27
    • 0036100578 scopus 로고    scopus 로고
    • Expression of hepatitis C virus proteins induces distinct membrane alterations including a candidate viral replication complex
    • Egger D., et al. Expression of hepatitis C virus proteins induces distinct membrane alterations including a candidate viral replication complex. J. Virol. 76:2002;5974-5984.
    • (2002) J. Virol. , vol.76 , pp. 5974-5984
    • Egger, D.1
  • 28
    • 0035914925 scopus 로고    scopus 로고
    • Determinants of viral clearance and persistence during acute hepatitis C virus infection
    • Thimme R., et al. Determinants of viral clearance and persistence during acute hepatitis C virus infection. J. Exp. Med. 194:2001;1395-1406.
    • (2001) J. Exp. Med. , vol.194 , pp. 1395-1406
    • Thimme, R.1
  • 29
    • 0037180506 scopus 로고    scopus 로고
    • Viral and immunological determinants of hepatitis C virus clearance, persistence, and disease
    • Thimme R., et al. Viral and immunological determinants of hepatitis C virus clearance, persistence, and disease. Proc. Natl. Acad. Sci. U. S. A. 99:2002;15661-15668.
    • (2002) Proc. Natl. Acad. Sci. U. S. A. , vol.99 , pp. 15661-15668
    • Thimme, R.1
  • 30
    • 0037180553 scopus 로고    scopus 로고
    • Genomic analysis of the host response to hepatitis C virus infection
    • Su A.I., et al. Genomic analysis of the host response to hepatitis C virus infection. Proc. Natl. Acad. Sci. U. S. A. 99:2002;15669-15674.
    • (2002) Proc. Natl. Acad. Sci. U. S. A. , vol.99 , pp. 15669-15674
    • Su, A.I.1
  • 31
    • 0037310821 scopus 로고    scopus 로고
    • Critical role of MHC class I-related chain a and B expression on IFN-alpha-stimulated dendritic cells in NK cell activation: Impairment in chronic hepatitis C virus infection
    • Jinushi M., et al. Critical role of MHC class I-related chain A and B expression on IFN-alpha-stimulated dendritic cells in NK cell activation: impairment in chronic hepatitis C virus infection. J. Immunol. 170:2003;1249-1256.
    • (2003) J. Immunol. , vol.170 , pp. 1249-1256
    • Jinushi, M.1
  • 32
    • 0037033363 scopus 로고    scopus 로고
    • Binding of the hepatitis C virus envelope protein E2 to CD81 inhibits natural killer cell functions
    • Tseng C.T., Klimpel G.R. Binding of the hepatitis C virus envelope protein E2 to CD81 inhibits natural killer cell functions. J. Exp. Med. 195:2002;43-49.
    • (2002) J. Exp. Med. , vol.195 , pp. 43-49
    • Tseng, C.T.1    Klimpel, G.R.2
  • 33
    • 0037033359 scopus 로고    scopus 로고
    • Inhibition of natural killer cells through engagement of CD81 by the major hepatitis C virus envelope protein
    • Crotta S., et al. Inhibition of natural killer cells through engagement of CD81 by the major hepatitis C virus envelope protein. J. Exp. Med. 195:2002;35-41.
    • (2002) J. Exp. Med. , vol.195 , pp. 35-41
    • Crotta, S.1
  • 34
    • 0037687422 scopus 로고    scopus 로고
    • Regulation of interferon regulatory factor-3 by the hepatitis C virus serine protease
    • Foy E., et al. Regulation of interferon regulatory factor-3 by the hepatitis C virus serine protease. Science. 300:2003;1145-1148.
    • (2003) Science , vol.300 , pp. 1145-1148
    • Foy, E.1
  • 35
    • 0037621934 scopus 로고    scopus 로고
    • Expression of hepatitis C virus proteins inhibits interferon alpha signaling in the liver of transgenic mice
    • Blindenbacher A., et al. Expression of hepatitis C virus proteins inhibits interferon alpha signaling in the liver of transgenic mice. Gastroenterology. 124:2003;1465-1475.
    • (2003) Gastroenterology , vol.124 , pp. 1465-1475
    • Blindenbacher, A.1
  • 36
    • 0028087985 scopus 로고
    • Prevention of hepatitis C virus infection in chimpanzees after antibody-mediated in vitro neutralization
    • Farci P., et al. Prevention of hepatitis C virus infection in chimpanzees after antibody-mediated in vitro neutralization. Proc. Natl. Acad. Sci. U. S. A. 91:1994;7792-7796.
    • (1994) Proc. Natl. Acad. Sci. U. S. A. , vol.91 , pp. 7792-7796
    • Farci, P.1
  • 37
    • 0030587469 scopus 로고    scopus 로고
    • A hyperimmune serum against a synthetic peptide corresponding to the hypervariable region 1 of hepatitis C virus can prevent viral infection in cell cultures
    • Shimizu Y.K., et al. A hyperimmune serum against a synthetic peptide corresponding to the hypervariable region 1 of hepatitis C virus can prevent viral infection in cell cultures. Virology. 223:1996;409-412.
    • (1996) Virology , vol.223 , pp. 409-412
    • Shimizu, Y.K.1
  • 38
    • 0037416146 scopus 로고    scopus 로고
    • Infectious hepatitis C virus pseudo-particles containing functional E1-E2 envelope protein complexes
    • Bartosch B., et al. Infectious hepatitis C virus pseudo-particles containing functional E1-E2 envelope protein complexes. J. Exp. Med. 197:2003;633-642.
    • (2003) J. Exp. Med. , vol.197 , pp. 633-642
    • Bartosch, B.1
  • 39
    • 0032125798 scopus 로고    scopus 로고
    • Towards a solution for hepatitis C virus hypervariability: Mimotopes of the hypervariable region 1 can induce antibodies cross-reacting with a large number of viral variants
    • Puntoriero G., et al. Towards a solution for hepatitis C virus hypervariability: mimotopes of the hypervariable region 1 can induce antibodies cross-reacting with a large number of viral variants. EMBO J. 17:1998;3521-3533.
    • (1998) EMBO J. , vol.17 , pp. 3521-3533
    • Puntoriero, G.1
  • 40
    • 0035478694 scopus 로고    scopus 로고
    • Monoclonal antibodies with broad specificity for hepatitis C virus hypervariable region 1 variants can recognize viral particles
    • Cerino A., et al. Monoclonal antibodies with broad specificity for hepatitis C virus hypervariable region 1 variants can recognize viral particles. J. Immunol. 167:2001;3878-3886.
    • (2001) J. Immunol. , vol.167 , pp. 3878-3886
    • Cerino, A.1
  • 41
    • 0038461904 scopus 로고    scopus 로고
    • Kinetics of the immune response during HBV and HCV infection
    • Bertoletti A., Ferrari C. Kinetics of the immune response during HBV and HCV infection. Hepatology. 38:2003;4-13.
    • (2003) Hepatology , vol.38 , pp. 4-13
    • Bertoletti, A.1    Ferrari, C.2
  • 42
    • 0035121503 scopus 로고    scopus 로고
    • Impaired allostimulatory function of dendritic cells in chronic hepatitis C infection
    • Bain C., et al. Impaired allostimulatory function of dendritic cells in chronic hepatitis C infection. Gastroenterology. 120:2001;512-524.
    • (2001) Gastroenterology , vol.120 , pp. 512-524
    • Bain, C.1
  • 43
    • 0037324198 scopus 로고    scopus 로고
    • Immune responses in hepatitis C virus infection: The role of dendritic cells
    • Fowler N.L., et al. Immune responses in hepatitis C virus infection: the role of dendritic cells. Immunol. Cell Biol. 81:2003;63-66.
    • (2003) Immunol. Cell Biol. , vol.81 , pp. 63-66
    • Fowler, N.L.1
  • 44
    • 0037105567 scopus 로고    scopus 로고
    • Impaired effector function of hepatitis C virus-specific CD8+ T cells in chronic hepatitis C virus infection
    • Wedemeyer H., et al. Impaired effector function of hepatitis C virus-specific CD8+ T cells in chronic hepatitis C virus infection. J. Immunol. 169:2002;3447-3458.
    • (2002) J. Immunol. , vol.169 , pp. 3447-3458
    • Wedemeyer, H.1
  • 45
    • 0036109159 scopus 로고    scopus 로고
    • Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections
    • Appay V., et al. Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections. Nat. Med. 8:2002;379-385.
    • (2002) Nat. Med. , vol.8 , pp. 379-385
    • Appay, V.1
  • 46
    • 17644444485 scopus 로고    scopus 로고
    • Analysis of successful immune responses in persons infected with hepatitis C virus
    • Lechner F., et al. Analysis of successful immune responses in persons infected with hepatitis C virus. J. Exp. Med. 191:2000;1499-1512.
    • (2000) J. Exp. Med. , vol.191 , pp. 1499-1512
    • Lechner, F.1
  • 47
    • 0033690901 scopus 로고    scopus 로고
    • Interaction between complement receptor gC1qR and hepatitis C virus core protein inhibits T-lymphocyte proliferation
    • Kittlesen D.J., et al. Interaction between complement receptor gC1qR and hepatitis C virus core protein inhibits T-lymphocyte proliferation. J. Clin. Invest. 106:2000;1239-1249.
    • (2000) J. Clin. Invest. , vol.106 , pp. 1239-1249
    • Kittlesen, D.J.1
  • 48
    • 0030671121 scopus 로고    scopus 로고
    • Immunological significance of cytotoxic T lymphocyte epitope variants in patients chronically infected by the hepatitis C virus
    • Chang K.M., et al. Immunological significance of cytotoxic T lymphocyte epitope variants in patients chronically infected by the hepatitis C virus. J. Clin. Invest. 100:1997;2376-2385.
    • (1997) J. Clin. Invest. , vol.100 , pp. 2376-2385
    • Chang, K.M.1
  • 49
    • 18244397979 scopus 로고    scopus 로고
    • The outcome of hepatitis C virus infection is predicted by escape mutations in epitopes targeted by cytotoxic T lymphocytes
    • Erickson A.L., et al. The outcome of hepatitis C virus infection is predicted by escape mutations in epitopes targeted by cytotoxic T lymphocytes. Immunity. 15:2001;883-895.
    • (2001) Immunity , vol.15 , pp. 883-895
    • Erickson, A.L.1
  • 50
    • 0036094158 scopus 로고    scopus 로고
    • Molecular diagnosis of viral hepatitis
    • Pawlotsky J.M. Molecular diagnosis of viral hepatitis. Gastroenterology. 122:2002;1554-1568.
    • (2002) Gastroenterology , vol.122 , pp. 1554-1568
    • Pawlotsky, J.M.1
  • 51
    • 0032475822 scopus 로고    scopus 로고
    • Hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon-alpha therapy
    • Neumann A.U., et al. Hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon-alpha therapy. Science. 282:1998;103-107.
    • (1998) Science , vol.282 , pp. 103-107
    • Neumann, A.U.1
  • 52
    • 0037299166 scopus 로고    scopus 로고
    • Mathematical modeling of viral kinetics: A tool to understand and optimize therapy
    • Layden T.J., et al. Mathematical modeling of viral kinetics: a tool to understand and optimize therapy. Clin. Liver Dis. 7:2003;163-178.
    • (2003) Clin. Liver Dis. , vol.7 , pp. 163-178
    • Layden, T.J.1
  • 53
    • 0038122773 scopus 로고    scopus 로고
    • Effect of treatment with peginterferon or interferon alfa-2b and ribavirin on steatosis in patients infected with hepatitis C
    • Poynard T., et al. Effect of treatment with peginterferon or interferon alfa-2b and ribavirin on steatosis in patients infected with hepatitis C. Hepatology. 38:2003;75-85.
    • (2003) Hepatology , vol.38 , pp. 75-85
    • Poynard, T.1
  • 54
    • 18244365866 scopus 로고    scopus 로고
    • Hepatitis C virus core protein inhibits microsomal triglyceride transfer protein activity and very low density lipoprotein secretion: A model of viral-related steatosis
    • Perlemuter G., et al. Hepatitis C virus core protein inhibits microsomal triglyceride transfer protein activity and very low density lipoprotein secretion: a model of viral-related steatosis. FASEB J. 16:2002;185-194.
    • (2002) FASEB J. , vol.16 , pp. 185-194
    • Perlemuter, G.1
  • 55
    • 11144357274 scopus 로고    scopus 로고
    • Hepatitis C virus core protein shows a cytoplasmic localization and associates to cellular lipid storage droplets
    • Barba G., et al. Hepatitis C virus core protein shows a cytoplasmic localization and associates to cellular lipid storage droplets. Proc. Natl. Acad. Sci. U. S. A. 94:1997;1200-1205.
    • (1997) Proc. Natl. Acad. Sci. U. S. A. , vol.94 , pp. 1200-1205
    • Barba, G.1
  • 56
    • 0033933140 scopus 로고    scopus 로고
    • Hepatocyte steatosis is a cytopathic effect of hepatitis C virus genotype 3
    • Rubbia-Brandt L., et al. Hepatocyte steatosis is a cytopathic effect of hepatitis C virus genotype 3. J. Hepatol. 33:2000;106-115.
    • (2000) J. Hepatol. , vol.33 , pp. 106-115
    • Rubbia-Brandt, L.1
  • 57
    • 0035068318 scopus 로고    scopus 로고
    • Hepatitis C virus induced hypobetalipoproteinemia: A possible mechanism for steatosis in chronic hepatitis C
    • Serfaty L., et al. Hepatitis C virus induced hypobetalipoproteinemia: a possible mechanism for steatosis in chronic hepatitis C. J. Hepatol. 34:2001;428-434.
    • (2001) J. Hepatol. , vol.34 , pp. 428-434
    • Serfaty, L.1
  • 58
    • 0037301686 scopus 로고    scopus 로고
    • Worsening of steatosis is an independent factor of fibrosis progression in untreated patients with chronic hepatitis C and paired liver biopsies
    • Castera L., et al. Worsening of steatosis is an independent factor of fibrosis progression in untreated patients with chronic hepatitis C and paired liver biopsies. Gut. 52:2003;288-292.
    • (2003) Gut , vol.52 , pp. 288-292
    • Castera, L.1
  • 59
    • 0037418113 scopus 로고    scopus 로고
    • Hepatitis C in the HIV-infected Person
    • Sulkowski M.S., Thomas D.L. Hepatitis C in the HIV-infected Person. Ann. Intern. Med. 138:2003;197-207.
    • (2003) Ann. Intern. Med. , vol.138 , pp. 197-207
    • Sulkowski, M.S.1    Thomas, D.L.2
  • 60
    • 0036078576 scopus 로고    scopus 로고
    • HCV infection and hemodialysis
    • Pol S., et al. HCV infection and hemodialysis. Semin. Nephrol. 22:2002;331-339.
    • (2002) Semin. Nephrol. , vol.22 , pp. 331-339
    • Pol, S.1
  • 61
    • 0030946207 scopus 로고    scopus 로고
    • In-situ immunophenotyping study of hepatic-infiltrating cytotoxic cells in chronic active hepatitis C
    • Fiore G., et al. In-situ immunophenotyping study of hepatic-infiltrating cytotoxic cells in chronic active hepatitis C. Eur. J. Gastroenterol. Hepatol. 9:1997;491-496.
    • (1997) Eur. J. Gastroenterol. Hepatol. , vol.9 , pp. 491-496
    • Fiore, G.1
  • 62
    • 0031024723 scopus 로고    scopus 로고
    • Different cytokine profiles of intraphepatic T cells in chronic hepatitis B and hepatitis C virus infections
    • Bertoletti A., et al. Different cytokine profiles of intraphepatic T cells in chronic hepatitis B and hepatitis C virus infections. Gastroenterology. 112:1997;193-199.
    • (1997) Gastroenterology , vol.112 , pp. 193-199
    • Bertoletti, A.1
  • 63
    • 0029810790 scopus 로고    scopus 로고
    • Progressive liver injury in chronic hepatitis C infection correlates with increased intra-hepatic expression of Th1-associated cytokines
    • Napoli J., et al. Progressive liver injury in chronic hepatitis C infection correlates with increased intra-hepatic expression of Th1-associated cytokines. Hepatology. 24:1996;759-765.
    • (1996) Hepatology , vol.24 , pp. 759-765
    • Napoli, J.1
  • 64
    • 0034087136 scopus 로고    scopus 로고
    • Relationship between interferon-gamma, interleukin-10, and interleukin-12 production in chronic hepatitis C and in vitro effects of interferon-alpha
    • Piazzolla G., et al. Relationship between interferon-gamma, interleukin-10, and interleukin-12 production in chronic hepatitis C and in vitro effects of interferon-alpha. J. Clin. Immunol. 20:2000;54-61.
    • (2000) J. Clin. Immunol. , vol.20 , pp. 54-61
    • Piazzolla, G.1
  • 65
    • 0031155385 scopus 로고    scopus 로고
    • Perforin, Fas/Fas ligand, and TNF-alpha pathways as specific and bystander killing mechanisms of hepatitis C virus-specific human CTL
    • Ando K., et al. Perforin, Fas/Fas ligand, and TNF-alpha pathways as specific and bystander killing mechanisms of hepatitis C virus-specific human CTL. J. Immunol. 158:1997;5283-5291.
    • (1997) J. Immunol. , vol.158 , pp. 5283-5291
    • Ando, K.1
  • 66
    • 0031002790 scopus 로고    scopus 로고
    • Essential roles of the Fas ligand in the development of hepatitis
    • Kondo T., et al. Essential roles of the Fas ligand in the development of hepatitis. Nat. Med. 3:1997;409-413.
    • (1997) Nat. Med. , vol.3 , pp. 409-413
    • Kondo, T.1
  • 67
    • 0037300152 scopus 로고    scopus 로고
    • Approaches for treatment of liver fibrosis in chronic hepatitis C
    • Bedossa P., Paradis V. Approaches for treatment of liver fibrosis in chronic hepatitis C. Clin. Liver Dis. 7:2003;195-210.
    • (2003) Clin. Liver Dis. , vol.7 , pp. 195-210
    • Bedossa, P.1    Paradis, V.2
  • 68
    • 0034098165 scopus 로고    scopus 로고
    • Hepatic fibrogenesis and hepatitis C
    • Rockey D.C. Hepatic fibrogenesis and hepatitis C. Semin. Gastrointest. Dis. 11:2000;69-83.
    • (2000) Semin. Gastrointest. Dis. , vol.11 , pp. 69-83
    • Rockey, D.C.1
  • 69
    • 0029801255 scopus 로고    scopus 로고
    • Hepatic stellate cells
    • Friedman S.L. Hepatic stellate cells. Prog. Liver Dis. 14:1996;101-130.
    • (1996) Prog. Liver Dis. , vol.14 , pp. 101-130
    • Friedman, S.L.1
  • 70
    • 0034723290 scopus 로고    scopus 로고
    • Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury
    • Friedman S.L. Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. J. Biol. Chem. 275:2000;2247-2250.
    • (2000) J. Biol. Chem. , vol.275 , pp. 2247-2250
    • Friedman, S.L.1
  • 71
    • 0037220482 scopus 로고    scopus 로고
    • Liver fibrosis - From bench to bedside
    • Friedman S.L. Liver fibrosis - from bench to bedside. J. Hepatol. 38:(Suppl 1):2003;S38-S53.
    • (2003) J. Hepatol. , vol.38 , Issue.SUPPL. 1
    • Friedman, S.L.1
  • 73
    • 0038707215 scopus 로고    scopus 로고
    • Impact of moderate alcohol consumption on histological activity and fibrosis in patients with chronic hepatitis C, and specific influence of steatosis: A prospective study
    • Hezode C., et al. Impact of moderate alcohol consumption on histological activity and fibrosis in patients with chronic hepatitis C, and specific influence of steatosis: a prospective study. Aliment. Pharmacol. Ther. 17:2003;1031-1037.
    • (2003) Aliment. Pharmacol. Ther. , vol.17 , pp. 1031-1037
    • Hezode, C.1
  • 74
    • 0036242165 scopus 로고    scopus 로고
    • Impact of pegylated interferon alfa-2b and ribavirin on liver fibrosis in patients with chronic hepatitis C
    • Poynard T., et al. Impact of pegylated interferon alfa-2b and ribavirin on liver fibrosis in patients with chronic hepatitis C. Gastroenterology. 122:2002;1303-1313.
    • (2002) Gastroenterology , vol.122 , pp. 1303-1313
    • Poynard, T.1
  • 75
    • 0036829856 scopus 로고    scopus 로고
    • Hepatocellular carcinoma and hepatitis C in the United States
    • El-Serag H.B. Hepatocellular carcinoma and hepatitis C in the United States. Hepatology. 36:2002;S74-S83.
    • (2002) Hepatology , vol.36
    • El-Serag, H.B.1
  • 76
    • 8944262349 scopus 로고    scopus 로고
    • Hepatitis C virus core protein cooperates with ras and transforms primary rat embryo fibroblasts to tumorigenic phenotype
    • Ray R.B., et al. Hepatitis C virus core protein cooperates with ras and transforms primary rat embryo fibroblasts to tumorigenic phenotype. J. Virol. 70:1996;4438-4443.
    • (1996) J. Virol. , vol.70 , pp. 4438-4443
    • Ray, R.B.1
  • 77
    • 0034713462 scopus 로고    scopus 로고
    • Hepatitis C virus core protein promotes immortalization of primary human hepatocytes
    • Ray R.B., et al. Hepatitis C virus core protein promotes immortalization of primary human hepatocytes. Virology. 271:2000;197-204.
    • (2000) Virology , vol.271 , pp. 197-204
    • Ray, R.B.1
  • 78
    • 0029063640 scopus 로고
    • Hepatitis C virus nonstructural protein NS3 transforms NIH 3T3 cells
    • Sakamuro D., et al. Hepatitis C virus nonstructural protein NS3 transforms NIH 3T3 cells. J. Virol. 69:1995;3893-3896.
    • (1995) J. Virol. , vol.69 , pp. 3893-3896
    • Sakamuro, D.1
  • 79
    • 0034684968 scopus 로고    scopus 로고
    • Hepatitis C virus nonstructural protein NS4B transforms NIH3T3 cells in cooperation with the Ha-ras oncogene
    • Park J.S., et al. Hepatitis C virus nonstructural protein NS4B transforms NIH3T3 cells in cooperation with the Ha-ras oncogene. Biochem. Biophys. Res. Commun. 267:2000;581-587.
    • (2000) Biochem. Biophys. Res. Commun. , vol.267 , pp. 581-587
    • Park, J.S.1
  • 80
    • 0032938224 scopus 로고    scopus 로고
    • Hepatitis C virus NS5A protein modulates cell cycle regulatory genes and promotes cell growth
    • Ghosh A.K., et al. Hepatitis C virus NS5A protein modulates cell cycle regulatory genes and promotes cell growth. J. Gen. Virol. 80:1999;1179-1183.
    • (1999) J. Gen. Virol. , vol.80 , pp. 1179-1183
    • Ghosh, A.K.1
  • 81
    • 0031712813 scopus 로고    scopus 로고
    • The core protein of hepatitis C virus induces hepatocellular carcinoma in transgenic mice
    • Moriya K., et al. The core protein of hepatitis C virus induces hepatocellular carcinoma in transgenic mice. Nat. Med. 4:1998;1065-1067.
    • (1998) Nat. Med. , vol.4 , pp. 1065-1067
    • Moriya, K.1
  • 82
    • 0036158719 scopus 로고    scopus 로고
    • Steatosis and liver cancer in transgenic mice expressing the structural and nonstructural proteins of hepatitis C virus
    • Lerat H., et al. Steatosis and liver cancer in transgenic mice expressing the structural and nonstructural proteins of hepatitis C virus. Gastroenterology. 122:2002;352-365.
    • (2002) Gastroenterology , vol.122 , pp. 352-365
    • Lerat, H.1
  • 83
    • 0037299135 scopus 로고    scopus 로고
    • Tissue culture and animal models for hepatitis C virus
    • Pietschmann T., Bartenschlager R. Tissue culture and animal models for hepatitis C virus. Clin. Liver Dis. 7:2003;23-43.
    • (2003) Clin. Liver Dis. , vol.7 , pp. 23-43
    • Pietschmann, T.1    Bartenschlager, R.2


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