Tissue inhibitors of metalloproteases: Regulation and biological activities

Clinical and Experimental Metastasis

Volumn 18, Issue 2, 2000, Pages 111-120

  Fassina, Gianfranco ^a   Ferrari, Nicoletta ^a   Brigati, Claudio ^a   Benelli, Roberto ^a   Santi, Leonardo ^b   Noonan, Douglas ^a   Albini, Adriana ^a  

^a UNIVERSITY OF GENOA   (Italy)

^b UNIVERSITY OF GENOA   (Italy)

Author keywords

Basement membrane; Invasion; Metalloproteases; TIMPs

Indexed keywords

PROTEINASE; TISSUE INHIBITOR OF METALLOPROTEINASE 1;

ANGIOGENESIS; ENZYME INHIBITION; ENZYME REGULATION; ENZYME SPECIFICITY; EXTRACELLULAR MATRIX; GENE EXPRESSION; REVIEW; TATA BOX; TUMOR CELL;

AMINO ACID SEQUENCE; ANIMALS; APOPTOSIS; GENE THERAPY; HUMANS; MOLECULAR SEQUENCE DATA; SEQUENCE HOMOLOGY, AMINO ACID; TISSUE INHIBITOR OF METALLOPROTEINASES;

EID: 0035116631     PISSN: 02620898     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1006797522521     Document Type: Review

References (94)

1. General mechanisms of metastasis
2. The biochemistry of cancer dissemination
3. Matrix metalloproteinases and metastasis
4. Proteolytic enzymes in cancer invasion. Introduction
5. Tumor and endothelial cell invasion of basement membranes
6. Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation
7. The role of urokinase-type plasminogen activator in aggressive tumor cell behaviour
8. Urokinase-type plasminogen activator overexpression enhances the invasive capacity of endothelial cells
9. Inhibition of tumor cell invasion by a highly conserved peptide sequence from the matrix metalloproteinase enzyme prosegment
10. Inhibition of human type IV collagenase by a highly conserved peptide sequence derived from its prosegment
11. Regional localization of the TIMP gene on the human X chromosome. Extension of a conserved synteny and linkage group on proximal Xp
12. The gene for tissue inhibitor of metalloproteinases-2 (TIMP2) is localized on human chromosome arm 17q25
13. Domain structure of human 72-kDa gelatinase/type collagenase. Characterization of proteolytic activity and identification of the tissue inhibitor of metalloproteinase-2 (T1MP-2) binding regions
14. Tissue inhibitor of matrix metalloproteinase-2 regulates matrix metalloproteinase-2 activation by modulation of membrane-type 1 matrix metalloproteinase activity in high and low invasive melanoma cell lines
15. TIMP-2 promotes activation of progelatinase A by membrane-type I matrix metalloproteinase immobilized on agarose beads
16. Cloning of the cDNA encoding human tissue inhibitor of metalloproteinases-3 (TIMP-3) and mapping of the TIMP3 gene to chromosome 22
17. Tissue inhibitor of metalloproteinases-3 (T1MP-3) is an extracellular matrix-associated protein with a distinctive pattern of expression in mouse cells and tissues
18. Cloning of the human tissue inhibitor of metalloproteinase-4 gene (TIMP4) and localization of the TIMP4 and Timp4 genes to human chromosome 3p25 and mouse chromosome 6, respectively
19. Tissue inhibitors of metalloproteinases: Structure, regulation and biological functions
20. Tumor cell invasion inhibited by TIMP-2
21. Angiogenic potential in vivo by Kaposi sarcoma cell-free supernatants and HIV1-tat product: Inhibition of KS-like lesions by TIMP-2
22. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
23. Angiogenesis in cancer, vascular, rheumatoid and other disease
24. Inhibition of AIDS-Kaposi's sarcoma cell induced endothelial cell invasion by TIMP-2 and a synthetic peptide from the metalloproteinase propeptide: Implications for an anti-angiogenic therapy
25. Reduced angiogenesis and tumor progression in gelatinase A-deficient mice
26. MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes
27. MTI-MMP-deficient mice develop dwarfism, osteopenia, arthritis and connective tissue disease due to inadequate collagen turnover
28. Angiogenesis at the interface between basic and clinical research
29. Bi-directional induction of matrix metalloproteinase-9 and tissue inhibitor of matrix metalloproteinase-1 during T lymphome/endothelial cell contact: Implication of ICAM-1
30. Reprogramming of TIMP-1 and TIMP-3 expression profiles in brain microvascular endothelial cells and astrocytes in response to proinflammatory cytokines
31. Nafoxidine modulates the expression of matrix-metalloproteinase-2 (MMP-2) and tissue inhibitor of metalloproteinases-1 (TIMP-1) in endothelial cells
32. Vascular endothelial growth factor increases release of gelatinase A and decreases release of tissue inhibitor of metalloproteinases by microvascular endothelial cells in vitro
33. Relationship between matrix metalloproteinase expression and tumor angiogenesis in human breast carcinoma
34. Identification of angiogenic properties of insulin-like growth factor II in in vitro angiogenesis models
35. TIMP-2 over-expression reduces invasion and angiogenesis and protects B16F10 melanoma cells from apoptosis
36. Stimulation of angiogenesis through cathepsin B inactivation of the tissue inhibitors of matrix metalloproteinases
37. Differential expression of tissue inhibitors of metalloproteinases (TIMP-1,-2,-3,and-4) in normal and aberrant wound healing
38. Growth-promoting activity of tissue inhibitor of metalloproteinases-1 (TIMP-1) for a wide range of cells. A possible new growth factor in serum
39. Host TIMP-1 overexpression confers resistance to experimental brain metastasis of a fibrosarcoma cell line
40. Targeted distruption of the Tissue Inhibitor of Metalloproteinases gene increases the invasive behavior of primitive mesenchimal cells derived from embrionic stem cells in vitro
41. Control of the tissue inhibitor of metalloproteinases-1 promoter in culture-activated rat hepatic stellate cells: Regulation by activator protein-1 DNA binding proteins
42. Transgenic TIMP-1 inhibits simian virus 40 T antigen-reduced hepatocarcinogenesis by impairment of hepatocellular proliferation and tumor angiogenesis
43. Repression of tissue inhibitor of matrix metalloproteinase expression by all-trans-retinoic acid in rat bone cell populations: Comparison with transforming growth factor-beta 1
44. Identification of a serum and phorbol ester-responsive element in the murine tissue inhibitor of metalloproteinase gene
45. A growth-responsive gene (16C8) in normal mouse fibroblasts homologous to a human collagenase inhibitor with erythroid-potentiating activity: Evidence for inducible and constitutive transcripts
46. Synergistic transcriptional activation of the tissue inhibitor of metalloproteinases-1 promoter via functional interaction of AP-1 and Ets-1 transcription factors
47. Identification of the interleukin-6/oncostatin M response element in the rat tissue inhibitor of metalloproteinases-1 (TIMP-1) promoter
48. Upstream tissue inhibitor of metalloproteinases-1 (TIMP-1) element-1, a novel and essential regulatory DNA motif in the human TIMP-1 gene promoter, directly interacts with a 30-kDa nuclear protein
49. Tissue inhibitor of metalloproteinases-2 (TIMP-2) mRNA expression in tumor cell lines and human tumor tissues
50. Epidermal growth factor-like ligands differentially up-regulate matrix metalloproteinase 9 in head and neck squamous carcinoma cells
51. Identification of TIMP-2 in human alveolar macrophages. Regulation of biosynthesis is opposite to that of metalloproteinases and TIMP-1
52. Retinoids modulate endothelial cell production of matrix-degrading proteases and tissue inhibitors of metalloproteinases (TIMP)
53. Inhibition of invasion and metastasis in cells transfected with an inhibitor of metalloproteinases
54. Overexpression of Tissue Inhibitor of Metalloproteinases-2 by retroviral-mediated gene transfer in vivo inhibits tumor growth and invasion
55. Mechanism of cell surface activation of 72-kDa type IV collagenase. Isolation of the activated form of the membrane metalloprotease
56. Structure and characterization of the human tissue inhibitor of metalloproteinases-2 gene
57. Genes involved in tumor invasion and metastasis are differentially modulated by estradiol and progestin in human breast-cancer cells
58. Role of protein synthesis, prostaglandins, and estrogen in rat ovarian metalloproteinase inhibitor production
59. Hormonal regulation of collagenolysis in uterine cervical fibroblasts. Modulation of synthesis of procollagenase, prostromelysin and tissue inhibitor of metalloproteinases (TIMP) by progesterone and oestradiol-17 beta
60. Structure of the human TIMP-3 gene and its cell cycle-regulated promoter
61. Gene encoding a novel murine tissue inhibitor of metalloproteinases (TIMP), TIMP-3, is expressed in developing mouse epithelia, cartilage, and muscle, is located on mouse chromosome 10
62. Mutations in the tissue inhibitor of metalloproteinases-3 (TIMP3) in patients with Sorsby's fundus dystrophy
63. Molecular cloning of five messenger RNAs differentially expressed in preneoplastic or neoplastic JB6 mouse epidermal cells: One is homologous to human tissue inhibitor of metalloproteinases-3
64. Characterization and expression of a murine gene homologous to human EPA/TIMP: A virus-induced gene in the mouse
65. The tissue inhibitor of metalloproteinases-3 gene in breast carcinoma: Identification of multiple polyadenylation sites and a stromal pattern of expression
66. Temporal and spatial regulation of gene expression mediated by the promoter for the human tissue inhibitor of metalloproteinases-3 (TIMP-3)-encoding gene
67. A novel member of human tissue inhibitor of metalloproteinases (TIMP) gene family is regulated during G1 progression, mitogenic stimulation, differentiation and senescence
68. Tissue inhibitor of metalloproteinase-2 induces apoptosis in human T lymphocytes
69. Specific methylation events contribute to the transcriptional repression of the mouse tissue inhibitor of metalloproteinases-3 gene in neoplastic cells
70. Methylation-associated silencing of the tissue inhibitor of metalloproteinase-3 gene suggest a suppressor role in kidney, brain, other human cancers
71. Dibutyryl cyclic AMP-induced enhancement of tissue inhibitor of metalloproteinases-3 expression and its possible relation to the invasive activity of the human hepatoma cell line PLC/PRF/5
72. Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer
73. Therapeutic targeting of transcription in acute promyelocytic leukemia by use of an inhibitor of histone deacetylase
74. Inhibition of invasion and induction of apoptotic cell death of cancer cell lines by overexpression of TIMP-3
75. Molecular cloning and characterization of human tissue inhibitor of metalloproteinase 4
76. Inhibition of tumor growth and metastasis of human breast cancer cells transfected with tissue inhibitor of metalloproteinase 4
77. Specific. High affinity binding of tissue inhibitor of metalloproteinases-4 (TIMP-4) to the COOH-terminal hemopexin-like domain of human gelatinase A. TIMP-4 binds progelatinase A and the COOH-terminal domain in a similar manner to TIMP-2
78. Tissue inhibitor of metalloproteinase-1 inhibits apoptosis of human breast epithelial cells
79. In vitro suppression of programmed cell death of B cells by tissue inhibitor of metalloproteinases-1
80. Tissue inhibitor of metalloproteinase-2 stimulates mesenchymal growth and regulates epithelial branching during morphogenesis of the rat metanephros
81. TIMP-3 induces cell death by stabilizing TNF-alpha receptors on the surface of human colon carcinoma cells
82. Adenovirus-mediated gene delivery of tissue inhibitor of metalloproteinases-3 inhibits invasion and induces apoptosis in melanoma cells
83. Divergent effects of tissue inhibitor of metalloproteinase-1, -2, or -3 overexpression on rat vascular smooth muscle cell invasion, proliferation, and death in vitro. TIMP-3 promotes apoptosis
84. Inhibition of late vein graft neointima formation in human and porcine models by adenovirus-mediated overexpression of tissue inhibitor of metalloproteinase-3
85. Inhibition of the putative tumor suppressor gene TIMP-3 by tumor-derived p53 mutants and wild type p53
86. Antiangiogenic gene therapy
87. Generation of expression plasmids for angiostatin, endostatin and TIMP-2 for cancer gene therapy
88. Role of interleukin 10 and transforming growth factor beta1 in the angiogenesis and metastasis of human prostate primary tumor lines from orthotopic implants in severe combined immunodeficiency mice
89. Inhibition of Endothelial Cell Migration by Gene Transfer of Tissue Inhibitor of Metalloproteinases-1
90. Effect of tissue inhibitor of the matrix metalloproteinases-2 expression on the growth and spontaneous metastasis of a human melanoma cell line
91. Gelatinase A activity directly modulates melanoma cell adhesion and spreading
92. Gene transfer of tissue inhibitor of metalloproteinase-2 inhibits metalloproteinase activity and neointima formation in human saphenous veins
93. Adenovirus-mediated gene transfer of the human TIMP-1 gene inhibits smooth muscle cell migration and neointimal formation in human saphenous vein
94. Inhibition of osteolytic bone metastasis of breast cancer by combined treatment with the bisphosphonate ibandronate and tissue inhibitor of the matrix metalloproteinase-2