Molecules in focus thrombin

International Journal of Biochemistry and Cell Biology

Volumn 30, Issue 6, 1998, Pages 641-646

  Goldsack, Neil R ^a   Chambers, Rachel C ^a   Dabbagh, Karim ^a   Laurent, Geoffrey J ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Receptors; Serine protease; Therapies; Thrombin

Indexed keywords

CELL SURFACE RECEPTOR; COMPLEMENTARY DNA; CYTOKINE; FIBRIN; FIBRINOGEN; HEPARIN; HIRUDIN; SERINE PROTEINASE; THROMBIN; THROMBIN INHIBITOR; THROMBIN RECEPTOR; WARFARIN;

ALZHEIMER DISEASE; ATHEROSCLEROSIS; CELL PROLIFERATION; CHEMOTAXIS; EXTRACELLULAR MATRIX; HEMOSTASIS; HUMAN; LUNG FIBROSIS; PATHOGENESIS; REVIEW; THROMBOSIS; TISSUE REPAIR; ANIMAL; BIOSYNTHESIS; CHEMISTRY; METABOLISM; PHYSIOLOGY;

ANIMALS; HUMANS; THROMBIN;

EID: 0032087893     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1357-2725(98)00011-9     Document Type: Article

References (16)

1. Choi B.H., Kim R.C., Vaughan P.J., Lau A., Van-Nostrand W.E., Cotman C.W., Cunningham D.D. Decreases in protease nexins in Alzheimer's disease brain. Neurobiol. Aging. 16(4):1995;557-562.
2. Connolly A.J., Ishihara H., Kahn M.L., Farese R.V. Jr., Coughlin S.R. Role of the thrombin receptor in development and evidence for a second receptor. Nature. 381(6582):1996;516-519.
3. Cook J.J., Sitko G.R., Bednar B., Condra C., Mellott M.J., Feng D.M., Nutt R.F., Shafer J.A., Gould R.J., Connolly T.M. An antibody against the exosite of the cloned thrombin receptor inhibits experimental arterial thrombosis in the African green monkey. Circulation. 91(12):1995;2961-2971.
4. Degen S.J., MacGillivray R.T., Davie E.W. Characterization of the complementary deoxyribonucleic acid and gene coding for human prothrombin. Biochemistry. 22(9):1983;2087-2097.
5. Darrow A.L., Fung-Leung W.P., Ye R.D., Santulli R.J., Cheung W.M., Derian C.K., Burns C.L., Damiano B.P., Zhou L., Keenan C.M., Peterson P.A., Andrade-Gordon P. Biological consequences of thrombin receptor deficiency in mice. Thromb. Haemost. 76(6):1996;860-866.
6. Grand R.J., Turnell A.S., Grabham P.W. Cellular consequences of thrombin-receptor activation. Biochem. J. 313(2):1996;353-368.
7. Herbert J.M., Guy A.F., Lamarche I., Mares A.M., Savi P., Dol F. Intimal hyperplasia following vascular injury is not inhibited by an antisense thrombin receptor oligodeoxynucleotide. J. Cell. Physiol. 170(2):1997;106-114.
8. Hernandez-Rodriguez N.A., Cambrey A.D., Harrison N.K., Chambers R.C., Gray A.J., Southcott A.M., duBois R.M., Black C.M., Scully M.F., McAnulty R.J., Laurent G.J. Role of thrombin in pulmonary fibrosis. Lancet. 346(8982):1995;1071-1073.
9. Hewett P.W., Murray C. Modulation of human endothelial cell procoagulant activity in tumour models in vitro. Int. J. Cancer. 66(6):1996;784-789.
10. Ishihara H., Connolly A.J., Zeng D., Kahn M.L., Zheng Y.W., Timmons C., Tram T., Coughlin S.R. Protease-activated receptor 3 is a second thrombin receptor in humans. Nature. 386(6624):1997;502-506.
11. Magazine H.I., Srivastava K.D. Thrombin-induced vascular reactivity is modulated by ETB receptor-coupled nitric oxide release in rat aorta. Am. J. Physiol. 271(3):1996;C923-928.
12. Nierodzik M.L., Kajumo F., Karpatkin S. Effect of thrombin treatment of tumor cells on adhesion of tumor cells to platelets in vitro and tumor metastasis in vivo. Cancer Res. 52(12):1992;3267-3272.
13. Rade J.J., Schulick A.H., Virmani R., Dichek D.A. Local adenoviral-mediated expression of recombinant hirudin reduces neointima formation after arterial injury. Nat. Med. 2(3):1996;293-298.
14. Rasmussen U.B., Gachet C., Schlesinger Y., Hanau D., Ohlmann P., Van-Obberghen-Schilling E., Pouyssegur J., Cazenave J.P., Pavirani A. A peptide ligand of the human thrombin receptor antagonizes alpha-thrombin and partially activates platelets. J. Biol. Chem. 268(19):1993;14322-14328.
15. Vu T.K., Hung D.T., Wheaton V.I., Coughlin S.R. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell. 64(6):1991;1057-1068.
16. Zeymer U., Mateblowski M., Neuhaus K.L. Recombinant hirudin (HBW 023) produces stable anticoagulation unaffected by circadian variation in patients with thrombolysis for acute myocardial infarction. Eur. Heart J. 17(12):1996;1836-1840.