-
1
-
-
0034648765
-
Angiogenesis in cancer and other diseases
-
Carmeliet P. and Jain R. K. (2000) Angiogenesis in cancer and other diseases. Nature 407: 249-257
-
(2000)
Nature
, vol.407
, pp. 249-257
-
-
Carmeliet, P.1
Jain, R.K.2
-
2
-
-
0033986273
-
Circulating endothelial precursors: Mystery, reality, and promise
-
Rafii S. (2000) Circulating endothelial precursors: mystery, reality, and promise. J. Clin. Invest 105: 17-19
-
(2000)
J. Clin. Invest.
, vol.105
, pp. 17-19
-
-
Rafii, S.1
-
3
-
-
0034648793
-
Vascular-specific growth factors and blood vessel formation
-
Yancopoulos G. D., Davis S., Gale N. W., Rudge J. S., Wiegand S. J. and Holash J. (2000) Vascular-specific growth factors and blood vessel formation. Nature 407: 242-248
-
(2000)
Nature
, vol.407
, pp. 242-248
-
-
Yancopoulos, G.D.1
Davis, S.2
Gale, N.W.3
Rudge, J.S.4
Wiegand, S.J.5
Holash, J.6
-
4
-
-
0035254648
-
Angiogenesis: Regulators and clinical applications
-
Liekens S., De Clercq E. and Neyts J. (2001) Angiogenesis: regulators and clinical applications. Biochem. Pharmacol. 61: 253-270
-
(2001)
Biochem. Pharmacol.
, vol.61
, pp. 253-270
-
-
Liekens, S.1
De Clercq, E.2
Neyts, J.3
-
5
-
-
0030576517
-
Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
-
Hanahan D. and Folkman J. (1996) Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 86: 353-364
-
(1996)
Cell
, vol.86
, pp. 353-364
-
-
Hanahan, D.1
Folkman, J.2
-
6
-
-
0032952010
-
Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal
-
Benjamin L. E., Golijanin D., Itin A., Pode D. and Keshet E. (1999) Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal. J. Clin. Invest. 103:159-165
-
(1999)
J. Clin. Invest.
, vol.103
, pp. 159-165
-
-
Benjamin, L.E.1
Golijanin, D.2
Itin, A.3
Pode, D.4
Keshet, E.5
-
8
-
-
0030020131
-
Tumor angiogenesis and tissue factor
-
Folkman J. (1996) Tumor angiogenesis and tissue factor. Nat. Med. 2: 167-168
-
(1996)
Nat. Med.
, vol.2
, pp. 167-168
-
-
Folkman, J.1
-
9
-
-
0029004025
-
Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis
-
Dvorak H. F., Brown L. F., Detmar M. and Dvorak A. M. (1995) Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. Am. J. Pathol. 146: 1029-1039
-
(1995)
Am. J. Pathol.
, vol.146
, pp. 1029-1039
-
-
Dvorak, H.F.1
Brown, L.F.2
Detmar, M.3
Dvorak, A.M.4
-
10
-
-
0033121275
-
The role of alphav integrins during angiogenesis: Insights into potential mechanisms of action and clinical development
-
Eliceiri B. P. and Cheresh D. A. (1999) The role of alphav integrins during angiogenesis: insights into potential mechanisms of action and clinical development. J. Clin. Invest. 103: 1227-1230
-
(1999)
J. Clin. Invest.
, vol.103
, pp. 1227-1230
-
-
Eliceiri, B.P.1
Cheresh, D.A.2
-
11
-
-
0030484702
-
Role of integrins in angiogenesis
-
Brooks P. C. (1996) Role of integrins in angiogenesis. Eur. J. Cancer 32A: 2423-2429
-
(1996)
Eur. J. Cancer
, vol.32 A
, pp. 2423-2429
-
-
Brooks, P.C.1
-
12
-
-
0036007964
-
The alpha(v)beta3 integrin, NF-kappaB, osteoprotegerin endothelial cell survival pathway: Potential role in angiogenesis
-
Scatena M. and Giachelli C. (2002) The alpha(v)beta3 integrin, NF-kappaB, osteoprotegerin endothelial cell survival pathway: potential role in angiogenesis. Trends Cardiovasc. Med. 12: 83-88
-
(2002)
Trends Cardiovasc. Med.
, vol.12
, pp. 83-88
-
-
Scatena, M.1
Giachelli, C.2
-
13
-
-
0028670833
-
Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels
-
Brooks P. C., Montgomery A. M., Rosenfeld M., Reisfeld R. A., Hu T., Klier G. et al. (1994) Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels. Cell 79: 1157-1164
-
(1994)
Cell
, vol.79
, pp. 1157-1164
-
-
Brooks, P.C.1
Montgomery, A.M.2
Rosenfeld, M.3
Reisfeld, R.A.4
Hu, T.5
Klier, G.6
-
14
-
-
0036152857
-
Enhanced pathological angiogenesis in mice lacking beta3 integrin or beta3 and beta5 integrins
-
Reynolds L. E., Wyder L., Lively J. C., Taverna D., Robinson D., Huang X. et al. (2002) Enhanced pathological angiogenesis in mice lacking beta3 integrin or beta3 and beta5 integrins. Nat. Med. 8: 27-34
-
(2002)
Nat. Med.
, vol.8
, pp. 27-34
-
-
Reynolds, L.E.1
Wyder, L.2
Lively, J.C.3
Taverna, D.4
Robinson, D.5
Huang, X.6
-
15
-
-
0036130826
-
Integrin-mediated death: An explanation of the integrin-knockout phenotype?
-
Cheresh D. A. and Stupack D. G. (2002) Integrin-mediated death: an explanation of the integrin-knockout phenotype? Nat. Med. 8: 193-194
-
(2002)
Nat. Med.
, vol.8
, pp. 193-194
-
-
Cheresh, D.A.1
Stupack, D.G.2
-
16
-
-
0037134486
-
Loss of p53 compensates for alpha v-integrin function in retinal neovascularization
-
Stromblad S., Fotedar A., Brickner H., Theesfeld C., Aguilar D. D., Friedlander M. et al. (2002) Loss of p53 compensates for alpha v-integrin function in retinal neovascularization. J. Biol. Chem. 277: 13371-13374
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 13371-13374
-
-
Stromblad, S.1
Fotedar, A.2
Brickner, H.3
Theesfeld, C.4
Aguilar, D.D.5
Friedlander, M.6
-
17
-
-
0037655672
-
Emerging roles for proteinases in cancer
-
Noel A., Gilles C., Bajou K., Devy L., Kebers F., Lewalle J. M. et al. (1997) Emerging roles for proteinases in cancer. Invasion Metastasis 17: 221-239
-
(1997)
Invasion Metastasis
, vol.17
, pp. 221-239
-
-
Noel, A.1
Gilles, C.2
Bajou, K.3
Devy, L.4
Kebers, F.5
Lewalle, J.M.6
-
18
-
-
0032998208
-
Proteolytic control of growth factor availability
-
Rifkin D. B., Mazzieri R., Munger J. S., Noguera I. and Sung J. (1999) Proteolytic control of growth factor availability. APMIS 107: 80-85
-
(1999)
APMIS
, vol.107
, pp. 80-85
-
-
Rifkin, D.B.1
Mazzieri, R.2
Munger, J.S.3
Noguera, I.4
Sung, J.5
-
19
-
-
0036512208
-
New functions for the matrix metalloproteinases in cancer progression
-
Egeblad M. and Werb Z. (2002) New functions for the matrix metalloproteinases in cancer progression. Nat. Rev. 2: 163-176
-
(2002)
Nat. Rev.
, vol.2
, pp. 163-176
-
-
Egeblad, M.1
Werb, Z.2
-
20
-
-
0027992766
-
Regulation of proteolytic activity in tissues
-
Twining S. S. (1994) Regulation of proteolytic activity in tissues. Crit Rev. Biochem. Mol. Biol. 29: 315-383
-
(1994)
Crit Rev. Biochem. Mol. Biol.
, vol.29
, pp. 315-383
-
-
Twining, S.S.1
-
21
-
-
0027144754
-
Plasminogen activator inhibitor-1 gene-deficient mice. I. Generation by homologous recombination and characterization
-
Carmeliet P., Kieckens L., Schoonjans L., Ream B., Nuffelen A. van, Prendergast G. et al. (1993) Plasminogen activator inhibitor-1 gene-deficient mice. I. Generation by homologous recombination and characterization. J. Clin. Invest. 92: 2746-2755
-
(1993)
J. Clin. Invest.
, vol.92
, pp. 2746-2755
-
-
Carmeliet, P.1
Kieckens, L.2
Schoonjans, L.3
Ream, B.4
Van Nuffelen, A.5
Prendergast, G.6
-
22
-
-
0027135792
-
Plasminogen activator inhibitor-1 gene-deficient mice. II. Effects on hemostasis, thrombosis, and thrombolysis
-
Carmeliet P., Stassen J. M., Schoonjans L., Ream B., Oord J. J. van den, De Mol M. et al. (1993) Plasminogen activator inhibitor-1 gene-deficient mice. II. Effects on hemostasis, thrombosis, and thrombolysis. J. Clin. Invest. 92: 2756-2760
-
(1993)
J. Clin. Invest.
, vol.92
, pp. 2756-2760
-
-
Carmeliet, P.1
Stassen, J.M.2
Schoonjans, L.3
Ream, B.4
Van Den Oord, J.J.5
De Mol, M.6
-
23
-
-
0028295979
-
Physiological consequences of loss of plasminogen activator gene function in mice
-
Carmeliet P., Schoonjans L., Kieckens L., Ream B., Degen J., Bronson R. et al. (1994) Physiological consequences of loss of plasminogen activator gene function in mice. Nature 368: 419-424
-
(1994)
Nature
, vol.368
, pp. 419-424
-
-
Carmeliet, P.1
Schoonjans, L.2
Kieckens, L.3
Ream, B.4
Degen, J.5
Bronson, R.6
-
24
-
-
0030045209
-
Generation and characterization of urokinase receptor-deficient mice
-
Dewerchin M., Nuffelen A. V., Wallays G., Bouche A., Moons L., Carmeliet P. et al. (1996) Generation and characterization of urokinase receptor-deficient mice. J. Clin. Invest. 97: 870-878
-
(1996)
J. Clin. Invest.
, vol.97
, pp. 870-878
-
-
Dewerchin, M.1
Nuffelen, A.V.2
Wallays, G.3
Bouche, A.4
Moons, L.5
Carmeliet, P.6
-
25
-
-
0033106507
-
Alpha2-antiplasmin gene deficiency in mice is associated with enhanced fibrinolytic potential without overt bleeding
-
Lijnen H. R., Okada K., Matsuo O., Collen D. and Dewerchin M. (1999) Alpha2-antiplasmin gene deficiency in mice is associated with enhanced fibrinolytic potential without overt bleeding. Blood 93: 2274-2281
-
(1999)
Blood
, vol.93
, pp. 2274-2281
-
-
Lijnen, H.R.1
Okada, K.2
Matsuo, O.3
Collen, D.4
Dewerchin, M.5
-
26
-
-
0028894880
-
Effects of disruption of the plasminogen gene on thrombosis, growth, and health in mice
-
Ploplis V. A., Carmeliet P., Vazirzadeh S., Van V. I, Moons L. and Plow E. F. (1995) Effects of disruption of the plasminogen gene on thrombosis, growth, and health in mice. Circulation 92: 2585-2593
-
(1995)
Circulation
, vol.92
, pp. 2585-2593
-
-
Ploplis, V.A.1
Carmeliet, P.2
Vazirzadeh, S.3
Van, V.I.4
Moons, L.5
Plow, E.F.6
-
27
-
-
0034493782
-
A total fibrinogen deficiency is compatible with the development of pulmonary fibrosis in mice
-
Ploplis V. A., Wilberding J., McLennan L., Liang Z., Cornelissen I., DeFord M. E. et al. (2000) A total fibrinogen deficiency is compatible with the development of pulmonary fibrosis in mice. Am. J. Pathol. 157: 703-708
-
(2000)
Am. J. Pathol.
, vol.157
, pp. 703-708
-
-
Ploplis, V.A.1
Wilberding, J.2
McLennan, L.3
Liang, Z.4
Cornelissen, I.5
DeFord, M.E.6
-
28
-
-
0026331304
-
Basic and clinical aspects of fibrinolysis and thrombolysis
-
Collen D. and Lijnen H. R. (1991) Basic and clinical aspects of fibrinolysis and thrombolysis. Blood 78: 3114-3124
-
(1991)
Blood
, vol.78
, pp. 3114-3124
-
-
Collen, D.1
Lijnen, H.R.2
-
29
-
-
0030788411
-
The urokinase-type plasminogen activator system in cancer metastasis: A review
-
Andreasen P. A., Kjoller L., Christensen L. and Duffy M. J. (1997) The urokinase-type plasminogen activator system in cancer metastasis: a review. Int. J. Cancer 72: 1-22
-
(1997)
Int. J. Cancer
, vol.72
, pp. 1-22
-
-
Andreasen, P.A.1
Kjoller, L.2
Christensen, L.3
Duffy, M.J.4
-
30
-
-
0034095038
-
Transgenic mouse models in angiogenesis and cardiovascular disease
-
Carmeliet P. and Collen D. (2000) Transgenic mouse models in angiogenesis and cardiovascular disease. J. Pathol. 190: 387-405
-
(2000)
J. Pathol.
, vol.190
, pp. 387-405
-
-
Carmeliet, P.1
Collen, D.2
-
31
-
-
0030759096
-
uPA, uPAR, PAI-1: Key intersection of proteolytic, adhesive and chemotactic highways?
-
Blasi F. (1997) uPA, uPAR, PAI-1: key intersection of proteolytic, adhesive and chemotactic highways? Immunol. Today 18: 415-417
-
(1997)
Immunol. Today
, vol.18
, pp. 415-417
-
-
Blasi, F.1
-
32
-
-
0034711244
-
Activation of hepatocyte growth factor and urokinase/plasminogen activator by matriptase, an epithelial membrane serine protease
-
Lee S. L., Dickson R. B. and Lin C. Y. (2000) Activation of hepatocyte growth factor and urokinase/plasminogen activator by matriptase, an epithelial membrane serine protease. J. Biol. Chem. 275: 36720-36725
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 36720-36725
-
-
Lee, S.L.1
Dickson, R.B.2
Lin, C.Y.3
-
33
-
-
0033883613
-
Plasma kallikrein/kinin system: A revised hypothesis for its activation and its physiologic contributions
-
Schmaier A. H. (2000) Plasma kallikrein/kinin system: a revised hypothesis for its activation and its physiologic contributions. Curr. Opin. Hematol. 7: 261-265
-
(2000)
Curr. Opin. Hematol.
, vol.7
, pp. 261-265
-
-
Schmaier, A.H.1
-
34
-
-
0026011893
-
An analysis of the activators of single-chain urokinase-type plasminogen activator (scu-PA) in the dextran sulphate euglobulin fraction of normal plasma and of plasmas deficient in factor XII and prekallikrein
-
Binnema D. J., Dooijewaard G. and Turion P. N. (1991) An analysis of the activators of single-chain urokinase-type plasminogen activator (scu-PA) in the dextran sulphate euglobulin fraction of normal plasma and of plasmas deficient in factor XII and prekallikrein. Thromb. Haemost. 65: 144-148
-
(1991)
Thromb. Haemost.
, vol.65
, pp. 144-148
-
-
Binnema, D.J.1
Dooijewaard, G.2
Turion, P.N.3
-
35
-
-
0025786961
-
Inhibition of cell surface receptor-bound plasmin by alpha 2-antiplasmin and alpha 2-macroglobulin
-
Hall S. W., Humphries J. E. and Gonias S. L. (1991) Inhibition of cell surface receptor-bound plasmin by alpha 2-antiplasmin and alpha 2-macroglobulin. J. Biol. Chem. 266: 12329-12336
-
(1991)
J. Biol. Chem.
, vol.266
, pp. 12329-12336
-
-
Hall, S.W.1
Humphries, J.E.2
Gonias, S.L.3
-
36
-
-
0029128394
-
The cell biology of the plasminogen system
-
Plow E. F., Herren T., Redlitz A., Miles L. A. and Hoover-Plow J. L. (1995) The cell biology of the plasminogen system. FASEB J. 9: 939-945
-
(1995)
FASEB J.
, vol.9
, pp. 939-945
-
-
Plow, E.F.1
Herren, T.2
Redlitz, A.3
Miles, L.A.4
Hoover-Plow, J.L.5
-
37
-
-
12944328659
-
The urokinase plasminogen activator system as a novel target for turnout therapy
-
Schmitt M., Wilhelm O., Reuning U., Kruger A. and Harbec N. et al. (2000) The urokinase plasminogen activator system as a novel target for turnout therapy. Fibrinolysis Proteolysis 14: 114-132
-
(2000)
Fibrinolysis Proteolysis
, vol.14
, pp. 114-132
-
-
Schmitt, M.1
Wilhelm, O.2
Reuning, U.3
Kruger, A.4
Harbec, N.5
-
38
-
-
0033066858
-
The urokinase receptor: A cell surface, regulated chemokine
-
Blasi F. (1999) The urokinase receptor: a cell surface, regulated chemokine. APMIS 107: 96-101
-
(1999)
APMIS
, vol.107
, pp. 96-101
-
-
Blasi, F.1
-
39
-
-
0032748523
-
Proteolysis, cell adhesion, chemotaxis, and invasiveness are regulated by the u-PA-u-PAR-PAI-1 system
-
Blasi F. (1999) Proteolysis, cell adhesion, chemotaxis, and invasiveness are regulated by the u-PA-u-PAR-PAI-1 system. Thromb. Haemost. 82: 298-304
-
(1999)
Thromb. Haemost.
, vol.82
, pp. 298-304
-
-
Blasi, F.1
-
40
-
-
0030842795
-
Plasminogen activators, integrins, and the coordinated regulation of cell adhesion and migration
-
Chapman H. A. (1997) Plasminogen activators, integrins, and the coordinated regulation of cell adhesion and migration. Curr. Opin. Cell Biol. 9: 714-724
-
(1997)
Curr. Opin. Cell Biol.
, vol.9
, pp. 714-724
-
-
Chapman, H.A.1
-
41
-
-
0030916129
-
Urokinase-type plasminogen activator receptors associate with β1 and β3 integrins of fibrosarcoma cells: Dependence on extracellular matrix components
-
Xue W., Mizukami I., Tod R. F. III and Petty H. R. (1997) Urokinase-type plasminogen activator receptors associate with β1 and β3 integrins of fibrosarcoma cells: dependence on extracellular matrix components. Cancer Res. 57: 1682-1689
-
(1997)
Cancer Res.
, vol.57
, pp. 1682-1689
-
-
Xue, W.1
Mizukami, I.2
Tod R.F. III3
Petty, H.R.4
-
42
-
-
0034933664
-
The urokinase plasminogen activator receptor (uPAR) as a target for the diagnosis and therapy of cancer
-
Mazar A. P. (2001) The urokinase plasminogen activator receptor (uPAR) as a target for the diagnosis and therapy of cancer. Anticancer Drugs 12: 387-400
-
(2001)
Anticancer Drugs
, vol.12
, pp. 387-400
-
-
Mazar, A.P.1
-
43
-
-
0028305433
-
Induction of cell migration by pro-urokinase binding to its receptor: Possible mechanism for signal transduction in human epithelial cells
-
Busso N., Masur S. K., Lazega D., Waxman S. and Ossowski L. (1994) Induction of cell migration by pro-urokinase binding to its receptor: possible mechanism for signal transduction in human epithelial cells. J. Cell Biol. 126: 259-270
-
(1994)
J. Cell Biol.
, vol.126
, pp. 259-270
-
-
Busso, N.1
Masur, S.K.2
Lazega, D.3
Waxman, S.4
Ossowski, L.5
-
44
-
-
0344507516
-
A role for caveolin and the urokinase receptor in integrin-mediated adhesion and signaling
-
Wei Y., Yang X., Liu Q., Wilkins J. A. and Chapman H. A. (1999) A role for caveolin and the urokinase receptor in integrin-mediated adhesion and signaling. J. Cell Biol. 144: 1285-1294
-
(1999)
J. Cell Biol.
, vol.144
, pp. 1285-1294
-
-
Wei, Y.1
Yang, X.2
Liu, Q.3
Wilkins, J.A.4
Chapman, H.A.5
-
45
-
-
0022243864
-
Endothelial cells produce a latent inhibitor of plasminogen activators that can be activated by denaturants
-
Hekman C. M. and Loskutoff D. J. (1985) Endothelial cells produce a latent inhibitor of plasminogen activators that can be activated by denaturants. J. Biol. Chem. 260: 11581-11587
-
(1985)
J. Biol. Chem.
, vol.260
, pp. 11581-11587
-
-
Hekman, C.M.1
Loskutoff, D.J.2
-
47
-
-
0024589959
-
Interaction of plasminogen activator inhibitor (PAI-1) with vitronectin
-
Salonen E. M., Vaheri A., Pollanen J., Stephens R., Andreasen P., Mayer M. et al. (1989) Interaction of plasminogen activator inhibitor (PAI-1) with vitronectin. J. Biol. Chem. 264: 6339-6343
-
(1989)
J. Biol. Chem.
, vol.264
, pp. 6339-6343
-
-
Salonen, E.M.1
Vaheri, A.2
Pollanen, J.3
Stephens, R.4
Andreasen, P.5
Mayer, M.6
-
48
-
-
0024213555
-
Plasminogen activator inhibitor 1 (PAI) is bound to vitronectin in plasma
-
Wiman B., Almquist A., Sigurdardottir O. and Lindahl T (1988) Plasminogen activator inhibitor 1 (PAI) is bound to vitronectin in plasma. FEBS Lett. 242: 125-128
-
(1988)
FEBS Lett.
, vol.242
, pp. 125-128
-
-
Wiman, B.1
Almquist, A.2
Sigurdardottir, O.3
Lindahl, T.4
-
49
-
-
0033559607
-
The plasminogen-plasminogen activator (PA) system in neuroblastoma: Role of PA inhibitor-1 in metastasis
-
Sugiura Y., Ma L., Sun B., Shimada H., Laug W. E., Seeger R. C. et al. (1999) The plasminogen-plasminogen activator (PA) system in neuroblastoma: role of PA inhibitor-1 in metastasis. Cancer Res. 59: 1327-1336
-
(1999)
Cancer Res.
, vol.59
, pp. 1327-1336
-
-
Sugiura, Y.1
Ma, L.2
Sun, B.3
Shimada, H.4
Laug, W.E.5
Seeger, R.C.6
-
50
-
-
0029745109
-
The serpin PAI-1 inhibits cell migration by blocking integrin alpha V beta 3 binding to vitronectin
-
Stefansson S. and Lawrence D. A. (1996) The serpin PAI-1 inhibits cell migration by blocking integrin alpha V beta 3 binding to vitronectin. Nature 383: 441-443
-
(1996)
Nature
, vol.383
, pp. 441-443
-
-
Stefansson, S.1
Lawrence, D.A.2
-
51
-
-
0000124642
-
Plasminogen activator inhibitor-1 represses integrin- and vitronectin-mediated cell migration independently of its function as an inhibitor of plasminogen activation
-
Kjoller L., Kanse S. M., Kirkegaard T., Rodenburg W., Ronne E., Goodman S. L. et al. (1997) Plasminogen activator inhibitor-1 represses integrin- and vitronectin-mediated cell migration independently of its function as an inhibitor of plasminogen activation. Exp. Cell Res. 232: 420-429
-
(1997)
Exp. Cell Res.
, vol.232
, pp. 420-429
-
-
Kjoller, L.1
Kanse, S.M.2
Kirkegaard, T.3
Rodenburg, W.4
Ronne, E.5
Goodman, S.L.6
-
52
-
-
0030757506
-
Plasmin and plasminogen activator inhibitor type 1 promote cellular motility by regulating the interaction between the urokinase receptor and vitronectin
-
Waltz D. A., Natkin L. R., Fujita R. M., Wei Y. and Chapman H. A. (1997) Plasmin and plasminogen activator inhibitor type 1 promote cellular motility by regulating the interaction between the urokinase receptor and vitronectin. J. Clin. Invest. 100: 58-67
-
(1997)
J. Clin. Invest.
, vol.100
, pp. 58-67
-
-
Waltz, D.A.1
Natkin, L.R.2
Fujita, R.M.3
Wei, Y.4
Chapman, H.A.5
-
53
-
-
0029816265
-
Is plasminogen activator inhibitor-1 the molecular switch that governs urokinase receptor-mediated cell adhesion and release?
-
Deng G., Curriden S. A., Wang S., Rosenberg S. and Loskutoff D. J. (1996) Is plasminogen activator inhibitor-1 the molecular switch that governs urokinase receptor-mediated cell adhesion and release? J. Cell Biol. 134: 1-9
-
(1996)
J. Cell Biol.
, vol.134
, pp. 1-9
-
-
Deng, G.1
Curriden, S.A.2
Wang, S.3
Rosenberg, S.4
Loskutoff, D.J.5
-
54
-
-
0026023061
-
Distribution of plasminogen activator inhibitor (PAI-1) in tissues
-
Simpson A. J., Booth N. A., Moore N. R. and Bennett B. (1991) Distribution of plasminogen activator inhibitor (PAI-1) in tissues. J. Clin. Pathol. 44: 139-143
-
(1991)
J. Clin. Pathol.
, vol.44
, pp. 139-143
-
-
Simpson, A.J.1
Booth, N.A.2
Moore, N.R.3
Bennett, B.4
-
55
-
-
0026443723
-
In vivo patterns of expression of urokinase and its inhibitor PAI-1 suggest a concerted role in regulating physiological angiogenesis
-
Bacharach E., Itin A. and Keshet E. (1992) In vivo patterns of expression of urokinase and its inhibitor PAI-1 suggest a concerted role in regulating physiological angiogenesis. Proc. Natl. Acad. Sci. USA 89: 10686-10690
-
(1992)
Proc. Natl. Acad. Sci. USA
, vol.89
, pp. 10686-10690
-
-
Bacharach, E.1
Itin, A.2
Keshet, E.3
-
56
-
-
0023576670
-
Urokinase-type plasminogen activator is induced in migrating capillary endothelial cells
-
Pepper M. S., Vassalli J. D., Montesano R. and Orci L. (1987) Urokinase-type plasminogen activator is induced in migrating capillary endothelial cells. J. Cell Biol. 105: 2535-2541
-
(1987)
J. Cell Biol.
, vol.105
, pp. 2535-2541
-
-
Pepper, M.S.1
Vassalli, J.D.2
Montesano, R.3
Orci, L.4
-
57
-
-
0026754460
-
Plasminogen activator inhibitor-1 is induced in migrating endothelial cells
-
Pepper M. S., Sappino A. P., Montesano R., Orcin L. and Vassalli J. D. (1992) Plasminogen activator inhibitor-1 is induced in migrating endothelial cells. J. Cell Physiol. 153: 129-139
-
(1992)
J. Cell Physiol.
, vol.153
, pp. 129-139
-
-
Pepper, M.S.1
Sappino, A.P.2
Montesano, R.3
Orcin, L.4
Vassalli, J.D.5
-
58
-
-
0027183188
-
Upregulation of urokinase receptor expression on migrating endothelial cells
-
Pepper M. S., Sappino A. P., Stocklin R., Montesano R., Orci L. and Vassalli J. D. (1993) Upregulation of urokinase receptor expression on migrating endothelial cells. J. Cell Biol. 122: 673-684
-
(1993)
J. Cell Biol.
, vol.122
, pp. 673-684
-
-
Pepper, M.S.1
Sappino, A.P.2
Stocklin, R.3
Montesano, R.4
Orci, L.5
Vassalli, J.D.6
-
59
-
-
0034032489
-
Hypoxia induces transcription of the plasminogen activator inhibitor-1 gene through genistein-sensitive tyrosine kinase pathways in vascular endothelial cells
-
Uchiyama T., Kurabayashi M., Ohyama Y., Utsugi T., Akuzawa N., Sato M. et al. (2000) Hypoxia induces transcription of the plasminogen activator inhibitor-1 gene through genistein-sensitive tyrosine kinase pathways in vascular endothelial cells. Arterioscler. Thromb. Vasc. Biol. 20: 1155-1161
-
(2000)
Arterioscler. Thromb. Vasc. Biol.
, vol.20
, pp. 1155-1161
-
-
Uchiyama, T.1
Kurabayashi, M.2
Ohyama, Y.3
Utsugi, T.4
Akuzawa, N.5
Sato, M.6
-
60
-
-
0032147026
-
Apposition-dependent induction of plasminogen activator inhibitor type 1 expression: A mechanism for balancing pericellular proteolysis during angiogenesis
-
Bacharach E., Itin A. and Keshet E. (1998) Apposition-dependent induction of plasminogen activator inhibitor type 1 expression: a mechanism for balancing pericellular proteolysis during angiogenesis. Blood 92: 939-945
-
(1998)
Blood
, vol.92
, pp. 939-945
-
-
Bacharach, E.1
Itin, A.2
Keshet, E.3
-
61
-
-
0029896690
-
Plasminogen and wound healing
-
Romer J., Bugge T. H., Pyke C., Lund L. R., Flick M. J., Degen J. L. et al. (1996) Plasminogen and wound healing. Nat. Med. 2: 725
-
(1996)
Nat. Med.
, vol.2
, pp. 725
-
-
Romer, J.1
Bugge, T.H.2
Pyke, C.3
Lund, L.R.4
Flick, M.J.5
Degen, J.L.6
-
62
-
-
0345251960
-
The urokinase plasminogen activator system as a target for prognostic studies in breast cancer
-
Stephens R. W., Brunner N., Janicke F. and Schmitt M. (1998) The urokinase plasminogen activator system as a target for prognostic studies in breast cancer. Breast Cancer Res. Treat. 52: 99-111
-
(1998)
Breast Cancer Res. Treat.
, vol.52
, pp. 99-111
-
-
Stephens, R.W.1
Brunner, N.2
Janicke, F.3
Schmitt, M.4
-
63
-
-
0028070859
-
Prognostic impact of urokinase, urokinase receptor, and type 1 plasminogen activator inhibitor in squamous and large cell lung cancer tissue
-
Pedersen H., Brunner N., Francis D., Osterlind K., Ronne E., Hansen H. H. et al. (1994) Prognostic impact of urokinase, urokinase receptor, and type 1 plasminogen activator inhibitor in squamous and large cell lung cancer tissue. Cancer Res. 54: 4671-4675
-
(1994)
Cancer Res.
, vol.54
, pp. 4671-4675
-
-
Pedersen, H.1
Brunner, N.2
Francis, D.3
Osterlind, K.4
Ronne, E.5
Hansen, H.H.6
-
64
-
-
0028812299
-
Localization of urokinase-type plasminogen activator, plasminogen activator inhibitor-1,2 and plasminogen in colon cancer
-
Naitoh H., Eguchi Y., Ueyama H., Kodama M. and Hattori T. (1995) Localization of urokinase-type plasminogen activator, plasminogen activator inhibitor-1,2 and plasminogen in colon cancer. Jpn. J. Cancer Res. 86: 48-56
-
(1995)
Jpn. J. Cancer Res.
, vol.86
, pp. 48-56
-
-
Naitoh, H.1
Eguchi, Y.2
Ueyama, H.3
Kodama, M.4
Hattori, T.5
-
65
-
-
0032833646
-
Demonstration of urokinase expression in cancer cells of colon adenocarcinomas by immunohistochemistry and in situ hybridization
-
Harvey S. R., Sait S. N., Xu Y., Bailey J. L., Penetrante R. M. and Markus G. (1999) Demonstration of urokinase expression in cancer cells of colon adenocarcinomas by immunohistochemistry and in situ hybridization. Am. J. Pathol. 155: 1115-1120
-
(1999)
Am. J. Pathol.
, vol.155
, pp. 1115-1120
-
-
Harvey, S.R.1
Sait, S.N.2
Xu, Y.3
Bailey, J.L.4
Penetrante, R.M.5
Markus, G.6
-
66
-
-
0030061754
-
Messenger RNA for urokinase plasminogen activator is expressed in myofibroblasts adjacent to cancer cells in human breast cancer
-
Nielsen B. S., Sehested M., Timshel M., Pyke C. and Dano K. (1996) Messenger RNA for urokinase plasminogen activator is expressed in myofibroblasts adjacent to cancer cells in human breast cancer. Lab. Invest. 74: 168-177
-
(1996)
Lab. Invest.
, vol.74
, pp. 168-177
-
-
Nielsen, B.S.1
Sehested, M.2
Timshel, M.3
Pyke, C.4
Dano, K.5
-
67
-
-
0030703165
-
Cellular localization of urokinase-type plasminogen activator, its inhibitors, and their mRNAs in breast cancer tissues
-
Umeda T., Eguchi Y., Okino K., Kodama M. and Hattori T. (1997) Cellular localization of urokinase-type plasminogen activator, its inhibitors, and their mRNAs in breast cancer tissues. J. Pathol. 183: 388-397
-
(1997)
J. Pathol.
, vol.183
, pp. 388-397
-
-
Umeda, T.1
Eguchi, Y.2
Okino, K.3
Kodama, M.4
Hattori, T.5
-
68
-
-
0035165524
-
Urokinase plasminogen activator is localized in stromal cells in ductal breast cancer
-
Nielsen B. S., Sehested M., Duun S., Rank F., Timshel S., Rygaard J. et al. (2001) Urokinase plasminogen activator is localized in stromal cells in ductal breast cancer. Lab. Invest. 81: 1485-1501
-
(2001)
Lab. Invest.
, vol.81
, pp. 1485-1501
-
-
Nielsen, B.S.1
Sehested, M.2
Duun, S.3
Rank, F.4
Timshel, S.5
Rygaard, J.6
-
69
-
-
0033820073
-
Immunohistochemical expression of uPA, uPAR, and PAI-1 in breast carcinoma
-
Dublin E., Hanby A., Patel N. K., Liebman R. and Barnes D. (2000) Immunohistochemical expression of uPA, uPAR, and PAI-1 in breast carcinoma. Am. J. Pathol. 157: 1219-1227
-
(2000)
Am. J. Pathol.
, vol.157
, pp. 1219-1227
-
-
Dublin, E.1
Hanby, A.2
Patel, N.K.3
Liebman, R.4
Barnes, D.5
-
70
-
-
0001453577
-
Urokinase receptor antagonists inhibit angiogenesis and primary tumor growth in syngeneic mice
-
Min HY., Doyle L. V., Vitt C. R., Zandonella C. L., Stratton-Thomas J. R., Shuman M. A. et al. (1996) Urokinase receptor antagonists inhibit angiogenesis and primary tumor growth in syngeneic mice. Cancer Res. 56: 2428-2433
-
(1996)
Cancer Res.
, vol.56
, pp. 2428-2433
-
-
Min, H.Y.1
Doyle, L.V.2
Vitt, C.R.3
Zandonella, C.L.4
Stratton-Thomas, J.R.5
Shuman, M.A.6
-
71
-
-
7344262560
-
Adenovirus-mediated delivery of a uPA/uPAR antagonist suppresses angiogenesis-dependent tumor growth and dissemination in mice
-
Li H., Lu H., Griscelli F., Opolon P., Sun L. Q., Ragot T. et al. (1998) Adenovirus-mediated delivery of a uPA/uPAR antagonist suppresses angiogenesis-dependent tumor growth and dissemination in mice. Gene Ther. 5: 1105-1113
-
(1998)
Gene Ther.
, vol.5
, pp. 1105-1113
-
-
Li, H.1
Lu, H.2
Griscelli, F.3
Opolon, P.4
Sun, L.Q.5
Ragot, T.6
-
72
-
-
0030812212
-
Inhibition of prostate cancer neovascularization and growth by urokinase-plasminogen activator receptor blockade
-
Evans C. P., Elfman F., Parangi S., Conn M., Cunha G. and Shuman M. A. (1997) Inhibition of prostate cancer neovascularization and growth by urokinase-plasminogen activator receptor blockade. Cancer Res. 57: 3594-3599
-
(1997)
Cancer Res.
, vol.57
, pp. 3594-3599
-
-
Evans, C.P.1
Elfman, F.2
Parangi, S.3
Conn, M.4
Cunha, G.5
Shuman, M.A.6
-
73
-
-
0035721955
-
Role of the matrix metalloproteinase and plasminogen activator-plasmin systems in angiogenesis
-
Pepper M. S. (2001) Role of the matrix metalloproteinase and plasminogen activator-plasmin systems in angiogenesis. Arterioscler. Thromb. Vasc. Biol. 21: 1104-1117
-
(2001)
Arterioscler. Thromb. Vasc. Biol.
, vol.21
, pp. 1104-1117
-
-
Pepper, M.S.1
-
74
-
-
0025063772
-
Increased proteolytic activity is responsible for the aberrant morphogenetic behavior of endothelial cells expressing the middle T oncogene
-
Montesano R., Pepper M. S., Mohle-Steinlein U., Risau W., Wagner E. F. and Orci L. (1990) Increased proteolytic activity is responsible for the aberrant morphogenetic behavior of endothelial cells expressing the middle T oncogene. Cell 62: 435-445
-
(1990)
Cell
, vol.62
, pp. 435-445
-
-
Montesano, R.1
Pepper, M.S.2
Mohle-Steinlein, U.3
Risau, W.4
Wagner, E.F.5
Orci, L.6
-
75
-
-
14444278730
-
Polyoma middle T-induced vascular tumor formation: The role of the plasminogen activator/plasmin system
-
Sabapathy K. T., Pepper M. S., Kiefer F., Möhle-Steinlein U., Tacchini-Cottier F., Fetka I. et al. (1997) Polyoma middle T-induced vascular tumor formation: the role of the plasminogen activator/plasmin system. J. Cell Biol. 137: 953-963
-
(1997)
J. Cell Biol.
, vol.137
, pp. 953-963
-
-
Sabapathy, K.T.1
Pepper, M.S.2
Kiefer, F.3
Möhle-Steinlein, U.4
Tacchini-Cottier, F.5
Fetka, I.6
-
76
-
-
0031045247
-
Plasminogen-dependent and -independent proteolytic activity of murine endothelioma cells with targeted inactivation of fibrinolytic genes
-
Lijnen H. R., Wagner E. F. and Collen D. (1997) Plasminogen-dependent and -independent proteolytic activity of murine endothelioma cells with targeted inactivation of fibrinolytic genes. Thromb. Haemost. 77: 362-367
-
(1997)
Thromb. Haemost.
, vol.77
, pp. 362-367
-
-
Lijnen, H.R.1
Wagner, E.F.2
Collen, D.3
-
77
-
-
0027970092
-
Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma
-
O'Reilly M. S., Holmgren L., Shing Y., Chen C., Rosenthal R A, Moses M. et al. (1994) Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma. Cell 79: 315-328
-
(1994)
Cell
, vol.79
, pp. 315-328
-
-
O'Reilly, M.S.1
Holmgren, L.2
Shing, Y.3
Chen, C.4
Rosenthal, R.A.5
Moses, M.6
-
78
-
-
0031454617
-
Endostatin: An endogenous inhibitor of angiogenesis and tumor growth
-
O'Reilly M. S., Boehm T., Shing Y., Fuka N., Vasios G., Lane W. S. et al. (1997) Endostatin: an endogenous inhibitor of angiogenesis and tumor growth. Cell 88: 277-285
-
(1997)
Cell
, vol.88
, pp. 277-285
-
-
O'Reilly, M.S.1
Boehm, T.2
Shing, Y.3
Fuka, N.4
Vasios, G.5
Lane, W.S.6
-
79
-
-
0033563107
-
Angiostatin inhibitits endothelial and melanoma cellular invasion by blocking matrix-enhanced plasminogen activation
-
Stack M. S., Gately S., Bafetti L. M., Enghild J. and Soff G. A. (1999) Angiostatin inhibitits endothelial and melanoma cellular invasion by blocking matrix-enhanced plasminogen activation. Biochem. J. 340: 77-84
-
(1999)
Biochem. J.
, vol.340
, pp. 77-84
-
-
Stack, M.S.1
Gately, S.2
Bafetti, L.M.3
Enghild, J.4
Soff, G.A.5
-
80
-
-
12644251975
-
The mechanism of cancer-mediated conversion of plasminogen to the angiogenesis inhibitor angiostatin
-
Gately S., Twardowski P., Stack M. S., Cundiff D. L., Grella D., Castellino F. J. et al. (1997) The mechanism of cancer-mediated conversion of plasminogen to the angiogenesis inhibitor angiostatin. Proc. Natl. Acad. Sci. USA 94: 10868-10872
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 10868-10872
-
-
Gately, S.1
Twardowski, P.2
Stack, M.S.3
Cundiff, D.L.4
Grella, D.5
Castellino, F.J.6
-
81
-
-
0033599308
-
Antiangiogenic activity of restin, NC10 domain of human collagen XV: Comparison to endostatin
-
Ramchandran R., Dhanabal M., Volk R., Waterman M. J., Segal M., Lu H. et al. (1999) Antiangiogenic activity of restin, NC10 domain of human collagen XV: comparison to endostatin. Biochem Biophys. Res. Commun. 255: 735-739
-
(1999)
Biochem. Biophys. Res. Commun.
, vol.255
, pp. 735-739
-
-
Ramchandran, R.1
Dhanabal, M.2
Volk, R.3
Waterman, M.J.4
Segal, M.5
Lu, H.6
-
82
-
-
0034194237
-
Anti-angiogenic cues from vascular basement membrane collagen
-
Colorado P. C., Torre A., Kamphaus G., Maeshima Y., Hopfer H., Takahashi K. et al. (2000) Anti-angiogenic cues from vascular basement membrane collagen. Cancer Res. 60: 2520-2526
-
(2000)
Cancer Res.
, vol.60
, pp. 2520-2526
-
-
Colorado, P.C.1
Torre, A.2
Kamphaus, G.3
Maeshima, Y.4
Hopfer, H.5
Takahashi, K.6
-
83
-
-
0033979905
-
Canstatin, a novel matrix-derived inhibitor of angiogenesis and tumor growth
-
Kamphaus G. D., Colorado P. C., Panka D. J., Hopfer H., Ram-chandran R., Torre A. et al. (2000) Canstatin, a novel matrix-derived inhibitor of angiogenesis and tumor growth. J. Biol. Chem. 275: 1209-1215
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 1209-1215
-
-
Kamphaus, G.D.1
Colorado, P.C.2
Panka, D.J.3
Hopfer, H.4
Ramchandran, R.5
Torre, A.6
-
84
-
-
0034604650
-
Two RGD-independent alpha vbeta 3 integrin binding sites on tumstatin regulate distinct anti-tumor properties
-
Maeshima Y., Colorado P. C. and Kalluri R. (2000) Two RGD-independent alpha vbeta 3 integrin binding sites on tumstatin regulate distinct anti-tumor properties. J. Biol. Chem. 275: 23745-23750
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 23745-23750
-
-
Maeshima, Y.1
Colorado, P.C.2
Kalluri, R.3
-
85
-
-
0035805614
-
Identification of the anti-angiogenic site within vascular basement membrane-derived tumstatin
-
Maeshima Y., Manfredi M., Reimer C., Holthaus K. A., Hopfer H., Chandamuri B. R. et al. (2001) Identification of the anti-angiogenic site within vascular basement membrane-derived tumstatin. J. Biol. Chem. 276: 15240-15248
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 15240-15248
-
-
Maeshima, Y.1
Manfredi, M.2
Reimer, C.3
Holthaus, K.A.4
Hopfer, H.5
Chandamuri, B.R.6
-
86
-
-
0035943604
-
Extracellular matrix-derived peptide binds to alpha(v)beta(3) integrin and inhibits angiogenesis
-
Maeshima Y., Yerramalla U. L., Dhanabal M., Holthaus K. A., Barbashov S., Kharbanda S. et al. (2001 ) Extracellular matrix-derived peptide binds to alpha(v)beta(3) integrin and inhibits angiogenesis. J. Biol. Chem. 276: 31959-31968
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 31959-31968
-
-
Maeshima, Y.1
Yerramalla, U.L.2
Dhanabal, M.3
Holthaus, K.A.4
Barbashov, S.5
Kharbanda, S.6
-
87
-
-
0033578910
-
Antiangiogenic activity of the cleaved conformation of the serpin antithrombin
-
O'Reilly M. S., Pirie-Shepherd S., Lane W. S. and Folkman J. (1999) Antiangiogenic activity of the cleaved conformation of the serpin antithrombin. Science 285: 1926-1928
-
(1999)
Science
, vol.285
, pp. 1926-1928
-
-
O'Reilly, M.S.1
Pirie-Shepherd, S.2
Lane, W.S.3
Folkman, J.4
-
88
-
-
0032445492
-
Vasostatin, a calreticulin fragment, inhibits angiogenesis and suppresses tumor growth
-
Pike S. E., Yao L., Jones K. D., Cherney B., Appella E., Sakaguchi K. et al. (1998) Vasostatin, a calreticulin fragment, inhibits angiogenesis and suppresses tumor growth. J. Exp. Med. 188: 2349-2356
-
(1998)
J. Exp. Med.
, vol.188
, pp. 2349-2356
-
-
Pike, S.E.1
Yao, L.2
Jones, K.D.3
Cherney, B.4
Appella, E.5
Sakaguchi, K.6
-
89
-
-
0034651013
-
Domain 5 of high molecular weight kininogen (kininostatin) down-regulates endothelial cell proliferation and migration and inhibits angiogenesis
-
Colman R. W., Jameson B. A., Lin Y., Johnson D. and Mousa S. A. (2000) Domain 5 of high molecular weight kininogen (kininostatin) down-regulates endothelial cell proliferation and migration and inhibits angiogenesis. Blood 95: 543-550
-
(2000)
Blood
, vol.95
, pp. 543-550
-
-
Colman, R.W.1
Jameson, B.A.2
Lin, Y.3
Johnson, D.4
Mousa, S.A.5
-
90
-
-
0029296140
-
The antibody to plasminogen activator inhibitor-1 suppresses pulmonary metastases of human fibrosarcoma in athymic mice
-
Tsuojiya H., Katsuo E., Sunayama C., Tomita K., Ueda Y. and Binder B. R. (1995) The antibody to plasminogen activator inhibitor-1 suppresses pulmonary metastases of human fibrosarcoma in athymic mice. Gen. Diagn. Pathol. 141: 41-48
-
(1995)
Gen. Diagn. Pathol.
, vol.141
, pp. 41-48
-
-
Tsuojiya, H.1
Katsuo, E.2
Sunayama, C.3
Tomita, K.4
Ueda, Y.5
Binder, B.R.6
-
91
-
-
0031902286
-
Absence of host plasminogen activator inhibitor 1 prevents cancer invasion and vascularization
-
Bajou K., Noel A., Gerard R. D., Masson V., Brunner N., Holst-Hansen C. et al. (1998) Absence of host plasminogen activator inhibitor 1 prevents cancer invasion and vascularization. Nat. Med 4: 923-928
-
(1998)
Nat. Med.
, vol.4
, pp. 923-928
-
-
Bajou, K.1
Noel, A.2
Gerard, R.D.3
Masson, V.4
Brunner, N.5
Holst-Hansen, C.6
-
92
-
-
0035911151
-
The plasminogen activator inhibitor PAI-1 controls in vivo tumor vascularization by interaction with proteases, not vitronectin: Implications for antiangiogenic strategies
-
Bajou K., Masson V., Gerard R. D., Schmitt P., Albert V., Praus M. et al. (2001) The plasminogen activator inhibitor PAI-1 controls in vivo tumor vascularization by interaction with proteases, not vitronectin: implications for antiangiogenic strategies. J. Cell Biol. 152: 777-784
-
(2001)
J. Cell Biol.
, vol.152
, pp. 777-784
-
-
Bajou, K.1
Masson, V.2
Gerard, R.D.3
Schmitt, P.4
Albert, V.5
Praus, M.6
-
93
-
-
0034667385
-
Tumor development is retarded in mice lacking the gene for urokinase-type plasminogen activator or its inhibitor, plasminogen activator inhibitor-1
-
Gutierrez L. S., Schulman A., Brito-Robinson T., Noria F., Ploplis V. A. and Castellino F. J. (2000) Tumor development is retarded in mice lacking the gene for urokinase-type plasminogen activator or its inhibitor, plasminogen activator inhibitor-1. Cancer Res. 60: 5839-5847
-
(2000)
Cancer Res.
, vol.60
, pp. 5839-5847
-
-
Gutierrez, L.S.1
Schulman, A.2
Brito-Robinson, T.3
Noria, F.4
Ploplis, V.A.5
Castellino, F.J.6
-
94
-
-
17744377410
-
Influence of plasminogen activator inhibitor type 1 on choroidal neovascularization
-
Lambert V., Munaut C., Noel A., Frankenne F., Bajou K., Gerard R. et al. (2001) Influence of plasminogen activator inhibitor type 1 on choroidal neovascularization. FASEB J. 15: 1021-1027
-
(2001)
FASEB J.
, vol.15
, pp. 1021-1027
-
-
Lambert, V.1
Munaut, C.2
Noel, A.3
Frankenne, F.4
Bajou, K.5
Gerard, R.6
-
95
-
-
0035823504
-
Plasminogen activator inhibitor-1 regulates tumor growth and angiogenesis
-
McMahon G. A., Petitclerc E., Stefansson S., Smith E., Wong M. K., Westrick R. J. et al. (2001) Plasminogen activator inhibitor-1 regulates tumor growth and angiogenesis. J. Biol. Chem. 276: 33964-33968
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 33964-33968
-
-
McMahon, G.A.1
Petitclerc, E.2
Stefansson, S.3
Smith, E.4
Wong, M.K.5
Westrick, R.J.6
-
96
-
-
18244389007
-
The pro- or antiangiogenic effect of plasminogen activator inhibitor 1 is dose dependent
-
Devy L., Blacher S., Grignet-Debrus C., Bajou K., Masson V., Gerard R. D. et al. (2002) The pro- or antiangiogenic effect of plasminogen activator inhibitor 1 is dose dependent. FASEB J. 16: 147-154
-
(2002)
FASEB J.
, vol.16
, pp. 147-154
-
-
Devy, L.1
Blacher, S.2
Grignet-Debrus, C.3
Bajou, K.4
Masson, V.5
Gerard, R.D.6
-
97
-
-
0025697078
-
Proteolytic balance and capillary morphogenesis
-
Pepper M. S. and Montesano R. (1990) Proteolytic balance and capillary morphogenesis. Cell Differ. Dev. 32: 319-327
-
(1990)
Cell Differ. Dev.
, vol.32
, pp. 319-327
-
-
Pepper, M.S.1
Montesano, R.2
-
98
-
-
0035896622
-
Inhibition of angiogenesis in vivo by plasminogen activator inhibitor-1
-
Stefansson S., Petitclerc E., Wong M. K., McMahon G. A., Brooks P. C. and Lawrence D. A. (2001) Inhibition of angiogenesis in vivo by plasminogen activator inhibitor-1. J. Biol. Chem. 276: 8135-8141
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 8135-8141
-
-
Stefansson, S.1
Petitclerc, E.2
Wong, M.K.3
McMahon, G.A.4
Brooks, P.C.5
Lawrence, D.A.6
-
99
-
-
0031733174
-
Multifunctional potential of the plasminogen activation system in tumor invasion and metastasis
-
Reuning U., Magdolen V., Wilhelm O., Fischer K., Lutz V., Graeff H. et al. (1998) Multifunctional potential of the plasminogen activation system in tumor invasion and metastasis. Int. J. Oncol. 13: 893-906
-
(1998)
Int. J. Oncol.
, vol.13
, pp. 893-906
-
-
Reuning, U.1
Magdolen, V.2
Wilhelm, O.3
Fischer, K.4
Lutz, V.5
Graeff, H.6
-
100
-
-
0035408087
-
Interference with the urokinase plasminogen activator system: A promising therapy concept for solid tumours
-
Muehlenweg B., Sperl S., Magdolen V., Schmitt M. and Harbeck N. (2001) Interference with the urokinase plasminogen activator system: a promising therapy concept for solid tumours. Expert. Opin. Biol. Ther. 1: 683-691
-
(2001)
Expert. Opin. Biol. Ther.
, vol.1
, pp. 683-691
-
-
Muehlenweg, B.1
Sperl, S.2
Magdolen, V.3
Schmitt, M.4
Harbeck, N.5
-
101
-
-
0035918882
-
Randomized adjuvant chemotherapy trial in high-risk, lymph node-negative breast cancer patients identified by urokinase-type plasminogen activator and plasminogen activator inhibitor type 1
-
Janicke F., Prechtl A., Thomssen C., Harbeck N., Meisner C., Untch M. et al. (2001) Randomized adjuvant chemotherapy trial in high-risk, lymph node-negative breast cancer patients identified by urokinase-type plasminogen activator and plasminogen activator inhibitor type 1. J. Natl. Cancer Inst. 93: 913-920
-
(2001)
J. Natl. Cancer Inst.
, vol.93
, pp. 913-920
-
-
Janicke, F.1
Prechtl, A.2
Thomssen, C.3
Harbeck, N.4
Meisner, C.5
Untch, M.6
-
102
-
-
0037192458
-
Matrix metalloproteinase inhibitors and cancer: Trials and tribulations
-
Cousssens L. M., Fingleton B. and Matrisian L. M. (2002) Matrix metalloproteinase inhibitors and cancer: trials and tribulations. Science 295: 2387-2392
-
(2002)
Science
, vol.295
, pp. 2387-2392
-
-
Cousssens, L.M.1
Fingleton, B.2
Matrisian, L.M.3
-
103
-
-
0029007784
-
Antisense inhibition of urokinase reduces spread of human ovarian cancer in mice
-
Wilhelm O., Schmitt M., Hohl S., Senekowitsch R. and Graeff H. (1995) Antisense inhibition of urokinase reduces spread of human ovarian cancer in mice. Clin. Exp. Metastasis 13: 296-302
-
(1995)
Clin. Exp. Metastasis
, vol.13
, pp. 296-302
-
-
Wilhelm, O.1
Schmitt, M.2
Hohl, S.3
Senekowitsch, R.4
Graeff, H.5
-
104
-
-
0032984011
-
Invasion by esophageal cancer cells: Functional contribution of the urokinase plasminogen activation system, and inhibition by antisense oligonucleotides to urokinase or urokinase receptor
-
Morrissey D., O'Connell J., Lynch D., O'Sullivan G. C., Shanahan F. and Collins J. K. (1999) Invasion by esophageal cancer cells: functional contribution of the urokinase plasminogen activation system, and inhibition by antisense oligonucleotides to urokinase or urokinase receptor. Clin. Exp. Metastasis 17: 77-85
-
(1999)
Clin. Exp. Metastasis
, vol.17
, pp. 77-85
-
-
Morrissey, D.1
O'Connell, J.2
Lynch, D.3
O'Sullivan, G.C.4
Shanahan, F.5
Collins, J.K.6
-
105
-
-
0033565613
-
Adenovirus-mediated delivery of antisense gene to urokinase-type plasminogen activator receptor suppresses glioma invasion and tumor growth
-
Moran P. M., Chintala S. K., Mohanam S., Gladson C. L., Kim E. S., Gokaslan Z. L. et al. (1999) Adenovirus-mediated delivery of antisense gene to urokinase-type plasminogen activator receptor suppresses glioma invasion and tumor growth. Cancer Res. 59: 3369-3373
-
(1999)
Cancer Res.
, vol.59
, pp. 3369-3373
-
-
Moran, P.M.1
Chintala, S.K.2
Mohanam, S.3
Gladson, C.L.4
Kim, E.S.5
Gokaslan, Z.L.6
-
106
-
-
0002460807
-
Tumor dormancy induced by downregulation of urokinase receptor in human carcinoma involves integrin and MAPK signaling
-
Aguirre Ghiso J. A., Kovalski K. and Ossowski L. (1999) Tumor dormancy induced by downregulation of urokinase receptor in human carcinoma involves integrin and MAPK signaling. J. Cell Biol. 147: 89-104
-
(1999)
J. Cell Biol.
, vol.147
, pp. 89-104
-
-
Aguirre Ghiso, J.A.1
Kovalski, K.2
Ossowski, L.3
-
107
-
-
0033129098
-
Angiostatic activity of synthetic inhibitors of urokinase type plasminogen activator
-
Swiercz R., Skrzypczak-Jankun E., Merrell M. M., Selman S. H. and Jankun J. (1999) Angiostatic activity of synthetic inhibitors of urokinase type plasminogen activator. Oncol. Rep. 6: 523-526
-
(1999)
Oncol. Rep.
, vol.6
, pp. 523-526
-
-
Swiercz, R.1
Skrzypczak-Jankun, E.2
Merrell, M.M.3
Selman, S.H.4
Jankun, J.5
-
108
-
-
17544363650
-
A peptide derived from the non-receptor binding region of urokinase plasminogen activator (uPA) inhibits tumor progression and angiogenesis and induces tumor cell death in vivo
-
Guo Y., Higazi A. A., Arakelian A., Sachais B. S., Cines D., Goldfarb R. H. et al. (2000) A peptide derived from the non-receptor binding region of urokinase plasminogen activator (uPA) inhibits tumor progression and angiogenesis and induces tumor cell death in vivo. FASEB J. 14: 1400-1410
-
(2000)
FASEB J.
, vol.14
, pp. 1400-1410
-
-
Guo, Y.1
Higazi, A.A.2
Arakelian, A.3
Sachais, B.S.4
Cines, D.5
Goldfarb, R.H.6
-
109
-
-
0034682473
-
A peptide derived from the non-receptor-binding region of urokinase plasminogen activator inhibits glioblastoma growth and angiogenesis in vivo in combination with cisplatin
-
Mishima K., Mazar A. P., Gown A., Skelly M., Ji X. D., Wang X. D. et al. (2000) A peptide derived from the non-receptor-binding region of urokinase plasminogen activator inhibits glioblastoma growth and angiogenesis in vivo in combination with cisplatin. Proc. Natl. Acad. Sci. USA 97: 8484-8489
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 8484-8489
-
-
Mishima, K.1
Mazar, A.P.2
Gown, A.3
Skelly, M.4
Ji, X.D.5
Wang, X.D.6
-
110
-
-
0028287392
-
Inhibition of metastasis of Lewis lung carcinoma by a synthetic peptide within growth factor-like domain of urokinase in the experimental and spontaneous metastasis model
-
Kobayashi H., Gotoh J., Fujie M., Shinohara H., Moniwa N. and Terao T. (1994) Inhibition of metastasis of Lewis lung carcinoma by a synthetic peptide within growth factor-like domain of urokinase in the experimental and spontaneous metastasis model. Int. J. Cancer 57: 727-733
-
(1994)
Int. J. Cancer
, vol.57
, pp. 727-733
-
-
Kobayashi, H.1
Gotoh, J.2
Fujie, M.3
Shinohara, H.4
Moniwa, N.5
Terao, T.6
-
111
-
-
1842296386
-
Inhibition of the interaction of urokinase-type plasminogen activator (uPA) with its receptor (uPAR) by synthetic peptides
-
Burgle M., Koppitz M., Riemer C., Kessler H., Konig B., Weidle U. H. et al. (1997) Inhibition of the interaction of urokinase-type plasminogen activator (uPA) with its receptor (uPAR) by synthetic peptides. Biol. Chem. 378: 231-237
-
(1997)
Biol. Chem.
, vol.378
, pp. 231-237
-
-
Burgle, M.1
Koppitz, M.2
Riemer, C.3
Kessler, H.4
Konig, B.5
Weidle, U.H.6
-
112
-
-
0028277928
-
High-affinity urokinase receptor antagonists identified with bacteriophage peptide display
-
Goodson R. J., Doyle M. V., Kaufman S. E. and Rosenberg S. (1994) High-affinity urokinase receptor antagonists identified with bacteriophage peptide display. Proc. Natl. Acad. Sci. USA 91: 7129-7133
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 7129-7133
-
-
Goodson, R.J.1
Doyle, M.V.2
Kaufman, S.E.3
Rosenberg, S.4
-
113
-
-
0036005967
-
Random peptide bacteriophage display as a probe for urokinase receptor ligands
-
Fong S., Doyle M. V., Goodson R. J., Drummond R. J., Stratton J. R., McGuire L. et al. (2002) Random peptide bacteriophage display as a probe for urokinase receptor ligands. Biol. Chem. 383: 149-158
-
(2002)
Biol. Chem.
, vol.383
, pp. 149-158
-
-
Fong, S.1
Doyle, M.V.2
Goodson, R.J.3
Drummond, R.J.4
Stratton, J.R.5
McGuire, L.6
-
114
-
-
0030945032
-
Epitope-mapped monoclonal antibodies as tools for functional and morphological analyses of the human urokinase receptor in tumor tissue
-
Luther T., Magdolen V., Albrecht S., Kasper M., Riemer C., Kessler H. et al. (1997) Epitope-mapped monoclonal antibodies as tools for functional and morphological analyses of the human urokinase receptor in tumor tissue. Am. J. Pathol. 150: 1231-1244
-
(1997)
Am. J. Pathol.
, vol.150
, pp. 1231-1244
-
-
Luther, T.1
Magdolen, V.2
Albrecht, S.3
Kasper, M.4
Riemer, C.5
Kessler, H.6
-
115
-
-
0027537957
-
Binding of the urokinase-type plasminogen activator to its cell surface receptor is inhibited by low doses of suramin
-
Behrendt N., Ronne E. and Dano K. (1993) Binding of the urokinase-type plasminogen activator to its cell surface receptor is inhibited by low doses of suramin. J. Biol. Chem. 268: 5985-5989
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 5985-5989
-
-
Behrendt, N.1
Ronne, E.2
Dano, K.3
-
116
-
-
0033662360
-
Fibroblast growth factors and their inhibitors
-
Botta M., Manetti F. and Corelli F. (2000) Fibroblast growth factors and their inhibitors. Curr. Pharm. Des. 6: 1897-1924
-
(2000)
Curr. Pharm. Des.
, vol.6
, pp. 1897-1924
-
-
Botta, M.1
Manetti, F.2
Corelli, F.3
-
117
-
-
0033427943
-
Polysulfated heparinoids selectively inactivate heparin-binding angiogenesis factors
-
Zugmaier G., Favoni R., Jaeger R., Rosen N. and Knabbe C. (1999) Polysulfated heparinoids selectively inactivate heparin-binding angiogenesis factors. Ann. N. Y. Acad. Sci. 886: 243-248
-
(1999)
Ann. N. Y. Acad. Sci.
, vol.886
, pp. 243-248
-
-
Zugmaier, G.1
Favoni, R.2
Jaeger, R.3
Rosen, N.4
Knabbe, C.5
-
118
-
-
0029764639
-
Regulation of integrin function by the urokinase receptor
-
Wei Y., Lukashev M., Simon D. I., Bodary S. C., Rosenberg S., Doyle M. V. et al. (1996) Regulation of integrin function by the urokinase receptor. Science 273: 1551-1555
-
(1996)
Science
, vol.273
, pp. 1551-1555
-
-
Wei, Y.1
Lukashev, M.2
Simon, D.I.3
Bodary, S.C.4
Rosenberg, S.5
Doyle, M.V.6
-
119
-
-
0034616388
-
Identification of a urokinase receptor-integrin interaction site: Promiscuous regulator of integrin function
-
Simon D. I., Wei Y., Zhang L., Rao N. K., Xu H., Chen Z. et al. (2000) Identification of a urokinase receptor-integrin interaction site: promiscuous regulator of integrin function. J. Biol. Chem. 275: 10228-10234
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 10228-10234
-
-
Simon, D.I.1
Wei, Y.2
Zhang, L.3
Rao, N.K.4
Xu, H.5
Chen, Z.6
-
120
-
-
0030815119
-
Inhibition of metastasis of intraocular melanomas by adenovirus-mediated gene transfer of plasminogen activator inhibitor type 1 (PAI-1) in an athymic mouse model
-
Ma D., Gerard R. D., Li X. Y., Alizadeh H. and Niederkorn J. Y. (1997) Inhibition of metastasis of intraocular melanomas by adenovirus-mediated gene transfer of plasminogen activator inhibitor type 1 (PAI-1) in an athymic mouse model. Blood 90: 2738-2746
-
(1997)
Blood
, vol.90
, pp. 2738-2746
-
-
Ma, D.1
Gerard, R.D.2
Li, X.Y.3
Alizadeh, H.4
Niederkorn, J.Y.5
-
121
-
-
0032993493
-
Reduction of tumor cell migration and metastasis by adenoviral gene transfer of plasminogen activator inhibitors
-
Praus M., Wauterickx K., Collen D. and Gerard R. D. (1999) Reduction of tumor cell migration and metastasis by adenoviral gene transfer of plasminogen activator inhibitors. Gene Ther. 6: 236
-
(1999)
Gene Ther.
, vol.6
, pp. 236
-
-
Praus, M.1
Wauterickx, K.2
Collen, D.3
Gerard, R.D.4
-
122
-
-
0032930364
-
Intraoperatively administered aprotinin increases one year survival after elective liver resection for colorectal metastasis
-
Lentschener C., Li H., Franco D., Mercier F. J., Lu H., Soria J. et al. (1999) Intraoperatively administered aprotinin increases one year survival after elective liver resection for colorectal metastasis. Proteolysis Fibrinolysis 13: 39-45
-
(1999)
Proteolysis Fibrinolysis
, vol.13
, pp. 39-45
-
-
Lentschener, C.1
Li, H.2
Franco, D.3
Mercier, F.J.4
Lu, H.5
Soria, J.6
-
123
-
-
0035947634
-
Targeting of tumor cells by cell surface urokinase plasminogen activator-dependent anthrax toxin
-
Liu S., Bugge T. H. and Leppla S. H. (2001) Targeting of tumor cells by cell surface urokinase plasminogen activator-dependent anthrax toxin. J. Biol. Chem. 276: 17976-17984
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 17976-17984
-
-
Liu, S.1
Bugge, T.H.2
Leppla, S.H.3
-
124
-
-
0020644940
-
Plasmin-activated prodrugs for cancer chemotherapy. 2. Synthesis and biological activity of peptidyl derivatives of doxorubicin
-
Chakravarty P. K., Carl P. L., Weber M. J. and Katzenellenbogen J. A. (1983) Plasmin-activated prodrugs for cancer chemotherapy. 2. Synthesis and biological activity of peptidyl derivatives of doxorubicin. J. Med. Chem. 26: 638-644
-
(1983)
J. Med. Chem.
, vol.26
, pp. 638-644
-
-
Chakravarty, P.K.1
Carl, P.L.2
Weber, M.J.3
Katzenellenbogen, J.A.4
-
125
-
-
0033843895
-
In vivo activity of a PSA-activated doxorubicin prodrug against PSA-producing human prostate cancer xenografts
-
Khan S. R. and Denmeade S. R. (2000) In vivo activity of a PSA-activated doxorubicin prodrug against PSA-producing human prostate cancer xenografts. Prostate 45: 80-83
-
(2000)
Prostate
, vol.45
, pp. 80-83
-
-
Khan, S.R.1
Denmeade, S.R.2
-
126
-
-
0036533873
-
Characterization of a novel prostate-specific antigen-activated peptide- doxorubicin conjugate in patients with prostate cancer
-
DiPaola R. S., Rinehart J., Nemunaitis J., Ebbinghaus S., Rubin E., Capanna T. et al. (2002) Characterization of a novel prostate-specific antigen-activated peptide- doxorubicin conjugate in patients with prostate cancer. J. Clin. Oncol. 20: 1874-1879
-
(2002)
J. Clin. Oncol.
, vol.20
, pp. 1874-1879
-
-
DiPaola, R.S.1
Rinehart, J.2
Nemunaitis, J.3
Ebbinghaus, S.4
Rubin, E.5
Capanna, T.6
-
127
-
-
0034090097
-
Angiogenesis: Potentials for pharmacologic intervention in the treatment of cancer, cardiovascular diseases, and chronic inflammation
-
Griffioen A. W. and Molema G. (2000) Angiogenesis: potentials for pharmacologic intervention in the treatment of cancer, cardiovascular diseases, and chronic inflammation. Pharmacol. Rev. 52: 237-268
-
(2000)
Pharmacol. Rev.
, vol.52
, pp. 237-268
-
-
Griffioen, A.W.1
Molema, G.2
-
128
-
-
0036158842
-
Lymphatic dissemination of tumour cells and the formation of micrometasrases
-
Van Trappen P. O. and Pepper M. S. (2002) Lymphatic dissemination of tumour cells and the formation of micrometasrases. Lancet Oncol. 3: 44-52
-
(2002)
Lancet Oncol.
, vol.3
, pp. 44-52
-
-
Van Trappen, P.O.1
Pepper, M.S.2
-
129
-
-
0031784561
-
Vascular endothelial growth factor (VEGF)-C synergizes with basic fibroblast growth factor and VEGF in the induction of angiogenesis in vitro and alters endothelial cell extracellular proteolytic activity
-
Pepper M. S., Mandriota S. J., Jeltsch M., Kumar V. and Alitalo K. (1998) Vascular endothelial growth factor (VEGF)-C synergizes with basic fibroblast growth factor and VEGF in the induction of angiogenesis in vitro and alters endothelial cell extracellular proteolytic activity. J. Cell Physiol. 177: 439-452
-
(1998)
J. Cell Physiol.
, vol.177
, pp. 439-452
-
-
Pepper, M.S.1
Mandriota, S.J.2
Jeltsch, M.3
Kumar, V.4
Alitalo, K.5
-
130
-
-
0033746825
-
Stimulation of plasminogen activator and inhibitor in the lymphatic endothelium
-
Leak L. V., Saunders M., Day A. A. and Jones M. (2000) Stimulation of plasminogen activator and inhibitor in the lymphatic endothelium. Microvasc. Res. 60: 201-211
-
(2000)
Microvasc. Res.
, vol.60
, pp. 201-211
-
-
Leak, L.V.1
Saunders, M.2
Day, A.A.3
Jones, M.4
|