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Volumn 25, Issue 1, 2002, Pages 38-45

Neuronal injury in bacterial meningitis: Mechanisms and implications for therapy

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; AMINO ACID RECEPTOR BLOCKING AGENT; ANTIBIOTIC AGENT; ANTIOXIDANT; BAY 11 7085; BB 1101; BETA LACTAM ANTIBIOTIC; BOSENTAN; CASPASE INHIBITOR; CEFTRIAXONE; CORTICOSTEROID DERIVATIVE; DEFEROXAMINE; DEXAMETHASONE; ENDOTHELIN RECEPTOR ANTAGONIST; ILOMASTAT; KYNURENIC ACID; MATRIX METALLOPROTEINASE INHIBITOR; PROTEINASE; REACTIVE OXYGEN METABOLITE; RIFAMPICIN; TIRILAZAD; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

EID: 0036155726     PISSN: 01662236     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-2236(00)02024-5     Document Type: Review
Times cited : (243)

References (80)
  • 1
    • 0033839838 scopus 로고    scopus 로고
    • Twelve-year outcomes following bacterial meningitis: Further evidence for persisting effects
    • (2000) Arch. Dis. Child. , vol.83 , pp. 111-116
    • Grimwood, K.1
  • 5
    • 0029992465 scopus 로고    scopus 로고
    • Anti-inflammatory treatment influences neuronal apoptotic cell death in the dentate gyrus in experimental pneumococcal meningitis
    • (1996) J. Neuropathol. Exp. Neurol. , vol.55 , pp. 722-728
    • Zysk, G.1
  • 6
    • 0034664821 scopus 로고    scopus 로고
    • The polymeric immunoglobulin receptor translocates pneumococci across human nasopharyngeal epithelial cells
    • (2000) Cell , vol.102 , pp. 827-837
    • Zhang, J.R.1
  • 8
    • 0033661176 scopus 로고    scopus 로고
    • E. coli invasion of brain microvascular endothelial cells as a pathogenetic basis of meningitis
    • (2000) Subcell. Biochem. , vol.33 , pp. 47-59
    • Kim, K.S.1
  • 9
    • 0032527622 scopus 로고    scopus 로고
    • Pneumococcal trafficking across the blood-brain barrier. Molecular analysis of a novel bi-directional pathway
    • (1998) J. Clin. Invest. , vol.102 , pp. 347-360
    • Ring, A.1
  • 10
    • 0031916112 scopus 로고    scopus 로고
    • Differential release of lipoteichoic and teichoic acids from Streptococcus pneumoniae as a result of exposure to β-lactam antibiotics, rifamycins, trovafloxacin, and quinupristin-dalfopristin
    • (1998) Antimicrob. Agents Chemother. , vol.42 , pp. 277-281
    • Stuertz, K.1
  • 11
    • 0032830919 scopus 로고    scopus 로고
    • Lower lipoteichoic and teichoic acid CSF concentrations during treatment of pneumococcal meningitis with non-bacteriolytic antibiotics than with ceftriaxone
    • (1999) Scand. J. Infect. Dis. , vol.31 , pp. 367-370
    • Stuertz, K.1
  • 12
    • 0343811704 scopus 로고    scopus 로고
    • Elimination of blood-derived macrophages inhibits the release of interleukin-1 and the entry of leukocytes into the cerebrospinal fluid in experimental pneumococcal meningitis
    • (1997) J. Neuroimmunol. , vol.73 , pp. 77-80
    • Zysk, G.1
  • 13
    • 0345035378 scopus 로고    scopus 로고
    • Reduction of meningeal macrophages does not decrease migration of granulocytes into the CSF and brain parenchyma in experimental pneumococcal meningitis
    • (1999) J. Neuroimmunol. , vol.99 , pp. 205-210
    • Trostdorf, F.1
  • 15
    • 0032825681 scopus 로고    scopus 로고
    • Cerebral endothelial cells release TNF-α after stimulation with cell walls of Streptococcus pneumoniae and regulate inducible nitric oxide synthase and ICAM-1 expression via autocrine loops
    • (1999) J. Immunol. , vol.163 , pp. 4308-4314
    • Freyer, D.1
  • 16
    • 0034043667 scopus 로고    scopus 로고
    • Inhibition of leukocyte entry into the brain by the selectin blocker fucoidin decreases interleukin-1 (IL-1) levels but increases IL-8 levels in cerebrospinal fluid during experimental pneumococcal meningitis in rabbits
    • (2000) Infect. Immun. , vol.68 , pp. 3153-3157
    • Ostergaard, C.1
  • 17
    • 0033623579 scopus 로고    scopus 로고
    • Treatment with a monoclonal antibody to IL-8 attenuates the pleocytosis in experimental pneumococcal meningitis in rabbits when given intravenously, but not intracisternally
    • (2000) Clin. Exp. Immunol. , vol.122 , pp. 207-211
    • Ostergaard, C.1
  • 18
    • 0032977353 scopus 로고    scopus 로고
    • Neuroprotection by a caspase inhibitor in acute bacterial meningitis
    • (1999) Nat. Med. , vol.5 , pp. 298-302
    • Braun, J.S.1
  • 20
    • 0029852720 scopus 로고    scopus 로고
    • Reactive oxygen intermediates contribute to necrotic and apoptotic neuronal injury in an infant rat model of bacterial meningitis due to group B streptococci
    • (1996) J. Clin. Invest. , vol.98 , pp. 2632-2639
    • Leib, S.L.1
  • 21
    • 0035863578 scopus 로고    scopus 로고
    • The free radical scavenger α-phenyl-tert-butyl nitrone aggravates hippocampal apoptosis and learning deficits in experimental pneumococcal meningitis
    • (2001) J. Infect. Dis. , vol.183 , pp. 247-252
    • Loeffler, J.M.1
  • 22
    • 0035255057 scopus 로고    scopus 로고
    • Organotypic hippocampal cultures - A model of brain tissue damage in Streptococcus pneumoniae meningitis
    • (2001) J. Neuroimmunol. , vol.113 , pp. 30-39
    • Schmidt, H.1
  • 23
    • 0034892892 scopus 로고    scopus 로고
    • Expression of death-related proteins in dentate granule cells in human bacterial meningitis
    • (2001) Brain Pathol. , vol.11 , pp. 422-431
    • Gerber, J.1
  • 24
    • 0034958369 scopus 로고    scopus 로고
    • A mouse model of Streptococcus pneumoniae meningitis mimicking several features of human disease
    • (2001) Acta Neuropathol. , vol.101 , pp. 499-508
    • Gerber, J.1
  • 25
    • 0032125488 scopus 로고    scopus 로고
    • Neurodegeneration in excitotoxicity, global cerebral ischemia, and target deprivation: A perspective on the contributions of apoptosis and necrosis
    • (1998) Brain Res. Bull. , vol.46 , pp. 281-309
    • Martin, L.J.1
  • 26
    • 0029962368 scopus 로고    scopus 로고
    • Bilateral hippocampal volume loss in patients with a history of encephalitis or meningitis
    • (1996) Epilepsia , vol.37 , pp. 400-405
    • Free, S.L.1
  • 27
    • 0031809152 scopus 로고    scopus 로고
    • Amnesia and the organization of the hippocampal system
    • (1998) Hippocampus , vol.8 , pp. 212-216
    • Mishkin, M.1
  • 28
    • 0033396242 scopus 로고    scopus 로고
    • Dentate gyrus-selective colchicine lesion and disruption of performance in spatial tasks: Difficulties in 'place strategy' because of a lack of flexibility in the use of environmental cues?
    • (1999) Hippocampus , vol.9 , pp. 668-681
    • Xavier, G.F.1
  • 29
    • 0034704377 scopus 로고    scopus 로고
    • Spatial memory and learning deficits after experimental pneumococcal meningitis in mice
    • (2000) Neurosci. Lett. , vol.296 , pp. 137-140
    • Wellmer, A.1
  • 31
    • 0033866076 scopus 로고    scopus 로고
    • Virulence factors and the pathogenesis of disease caused by Streptococcus pneumoniae
    • (2000) Res. Microbiol. , vol.151 , pp. 413-419
    • Mitchell, T.J.1
  • 32
    • 0035139915 scopus 로고    scopus 로고
    • Pneumolysin is the main inducer of cytotoxicity to brain microvascular endothelial cells caused by Streptococcus pneumoniae
    • (2001) Infect. Immun. , vol.69 , pp. 845-852
    • Zysk, G.1
  • 33
    • 0033976512 scopus 로고    scopus 로고
    • Relative roles of pneumolysin and hydrogen peroxide from Streptococcus pneumoniae in inhibition of ependymal ciliary beat frequency
    • (2000) Infect. Immun. , vol.68 , pp. 1557-1562
    • Hirst, R.A.1
  • 34
    • 0035118579 scopus 로고    scopus 로고
    • Regulation of matrix metalloproteinase expression in endothelial cells by heat-inactivated Streptococcus pneumoniae
    • (2001) Infect. Immun. , vol.69 , pp. 1914-1916
    • Michel, U.1
  • 35
    • 0030017211 scopus 로고    scopus 로고
    • Neurotoxicity of glia activated by gram-positive bacterial products depends on nitric oxide production
    • (1996) Infect. Immun. , vol.64 , pp. 3148-3153
    • Kim, Y.S.1
  • 36
    • 0034980448 scopus 로고    scopus 로고
    • Transcriptional regulation of caspases in experimental pneumococcal meningitis
    • (2001) Brain Pathol. , vol.11 , pp. 282-295
    • Von Mering, M.1
  • 37
    • 0033580949 scopus 로고    scopus 로고
    • Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by Toll-like receptor 2
    • (1999) J. Biol. Chem. , vol.274 , pp. 17406-17409
    • Schwandner, R.1
  • 38
    • 0033168728 scopus 로고    scopus 로고
    • Cutting edge: Recognition of gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2
    • (1999) J. Immunol. , vol.163 , pp. 1-5
    • Yoshimura, A.1
  • 39
    • 0035170282 scopus 로고    scopus 로고
    • Toll-like receptor 4: The missing link of the cerebral innate immune response triggered by circulating gram-negative bacterial cell wall components
    • (2001) FASEB J. , vol.15 , pp. 155-163
    • Laflamme, N.1    Rivest, S.2
  • 40
    • 0032866588 scopus 로고    scopus 로고
    • Microglial activation by components of gram-positive and -negative bacteria: Distinct and common routes to the induction of ion channels and cytokines
    • (1999) J. Neuropathol. Exp. Neurol. , vol.58 , pp. 1078-1089
    • Prinz, M.1
  • 42
    • 0034713932 scopus 로고    scopus 로고
    • Lipopolysaccharide inhibits long term potentiation in the rat dentate gyrus by activating caspase-1
    • (2000) J. Biol. Chem. , vol.275 , pp. 26252-26258
    • Vereker, E.1
  • 43
    • 0035064940 scopus 로고    scopus 로고
    • Bacterial endotoxin sensitises the immature brain to hypoxic-ischaemic injury
    • (2001) Eur. J. Neurosci. , vol.13 , pp. 1101-1106
    • Eklind, S.1
  • 44
    • 0032719350 scopus 로고    scopus 로고
    • Clinical outcome in pneumococcal meningitis correlates with CSF lipoteichoic acid concentrations
    • (1999) Neurology , vol.53 , pp. 1584-1587
    • Schneider, O.1
  • 46
    • 0032768658 scopus 로고    scopus 로고
    • Pneumolysin, a protein toxin of Streptococcus pneumoniae, induces nitric oxide production from macrophages
    • (1999) Infect. Immun. , vol.67 , pp. 3750-3756
    • Braun, J.S.1
  • 47
    • 0033928019 scopus 로고    scopus 로고
    • Group B streptococcal β-hemolysin induces nitric oxide production in murine macrophages
    • (2000) J. Infect. Dis. , vol.182 , pp. 150-157
    • Ring, A.1
  • 48
    • 0010528829 scopus 로고    scopus 로고
    • Cutting edge: Bacterial DNA and LPS act in synergy in inducing nitric oxide production in RAW 264.7 macrophages
    • (1999) J. Immunol. , vol.163 , pp. 4095-4099
    • Gao, J.J.1
  • 49
    • 0035877050 scopus 로고    scopus 로고
    • Differential expression of nitric oxide synthases in bacterial meningitis: Role of the inducible isoform for blood-brain barrier breakdown
    • (2001) J. Infect. Dis. , vol.183 , pp. 1749-1759
    • Winkler, F.1
  • 50
    • 0033790833 scopus 로고    scopus 로고
    • Pharmacologic interference with NF-κB activation attenuates central nervous system complications in experimental pneumococcal meningitis
    • (2000) J. Infect. Dis. , vol.182 , pp. 1437-1445
    • Koedel, U.1
  • 51
    • 0034773556 scopus 로고    scopus 로고
    • Pneumococcal meningitis: Decreased clearance of Streptococcus pneumoniae from the peritoneum and blood in mice deficient for tumor necrosis factor-α or both its receptors p55 and p75
    • (2001) Infect. Immun. , vol.69 , pp. 6881-6886
    • Wellmer, A.1
  • 52
    • 0030739695 scopus 로고    scopus 로고
    • Tumor necrosis factor-α contributes to apoptosis in hippocampal neurons during experimental group B streptococcal meningitis
    • (1997) J. Infect. Dis. , vol.176 , pp. 693-697
    • Bogdan, I.1
  • 53
    • 0034845846 scopus 로고    scopus 로고
    • Inhibition of matrix metalloproteinases and tumor necrosis factor-α converting enzyme as adjuvant therapy in pneumococcal meningitis
    • (2001) Brain , vol.124 , pp. 1734-1742
    • Leib, S.L.1
  • 54
    • 0035879340 scopus 로고    scopus 로고
    • FGF induces a switch in death receptor pathways in neuronal cells
    • (2001) J. Neurosci. , vol.21 , pp. 4996-5006
    • Eves, E.M.1
  • 55
    • 0032514934 scopus 로고    scopus 로고
    • Experimental pneumococcal meningitis in rabbits: The increase of matrix metalloproteinase-9 in cerebrospinal fluid correlates with leucocyte invasion
    • (1998) Neurosci. Lett. , vol.256 , pp. 127-130
    • Azeh, I.1
  • 56
    • 0033984374 scopus 로고    scopus 로고
    • Matrix metalloproteinases contribute to brain damage in experimental pneumococcal meningitis
    • (2000) Infect. Immun. , vol.68 , pp. 615-620
    • Leib, S.L.1
  • 57
    • 0026781559 scopus 로고
    • Cerebrovascular complications of bacterial meningitis in adults
    • (1992) Neurology , vol.42 , pp. 1497-1504
    • Pfister, H.W.1
  • 58
    • 0034009119 scopus 로고    scopus 로고
    • Endothelin inhibition improves cerebral blood flow and is neuroprotective in pneumococcal meningitis
    • (2000) Ann. Neurol. , vol.47 , pp. 329-335
    • Pfister, L.A.1
  • 60
    • 0033782296 scopus 로고    scopus 로고
    • Mitochondrial participation in ischemic and traumatic neuronal cell death
    • (2000) J. Neurotrauma , vol.17 , pp. 843-855
    • Fiskum, G.1
  • 61
    • 0027288536 scopus 로고
    • Amino acids in cerebrospinal and brain interstitial fluid during experimental pneumococcal meningitis
    • (1993) Pediatr. Res. , vol.33 , pp. 510-513
    • Guerra-Romero, L.1
  • 62
    • 0029798477 scopus 로고    scopus 로고
    • Excess glutamate levels in the cerebrospinal fluid predict clinical outcome of bacterial meningitis
    • (1996) Arch. Neurol. , vol.53 , pp. 992-996
    • Spranger, M.1
  • 63
    • 0030059740 scopus 로고    scopus 로고
    • Neuroprotective effect of excitatory amino acid antagonist kynurenic acid in experimental bacterial meningitis
    • (1996) J. Infect. Dis. , vol.173 , pp. 166-171
    • Leib, S.L.1
  • 65
    • 0034023717 scopus 로고    scopus 로고
    • Inhibition of glutamine synthetase in rabbit pneumococcal meningitis is associated with neuronal apoptosis in the dentate gyrus
    • (2000) Glia , vol.30 , pp. 11-18
    • Tumani, H.1
  • 67
    • 0032524150 scopus 로고    scopus 로고
    • The intracellular domain of p55 tumor necrosis factor receptor induces apoptosis which requires different caspases in naive and neuronal PC12 cells
    • (1998) J. Neurosci. Res. , vol.52 , pp. 380-389
    • Haviv, R.1    Stein, R.2
  • 68
    • 0033968517 scopus 로고    scopus 로고
    • Fas/CD95/APO-1 can function as a death receptor for neuronal cells in vitro and in vivo and is upregulated following cerebral hypoxic-ischemic injury to the developing rat brain
    • (2000) Brain Pathol. , vol.10 , pp. 17-29
    • Felderhoff-Mueser, U.1
  • 69
    • 0032545286 scopus 로고    scopus 로고
    • Granzyme B mimics apical caspases. Description of a unified pathway for trans-activation of executioner caspase-3 and -7
    • (1998) J. Biol. Chem. , vol.273 , pp. 34278-34283
    • Yang, X.1
  • 70
    • 0035971091 scopus 로고    scopus 로고
    • Synergistic activation of caspase-3 by m-calpain after neonatal hypoxia-ischemia: A mechanism of 'pathological apoptosis'?
    • (2001) J. Biol. Chem. , vol.276 , pp. 10191-10198
    • Blomgren, K.1
  • 71
    • 0035084329 scopus 로고    scopus 로고
    • Molecular consequences of activated microglia in the brain: Overactivation induces apoptosis
    • (2001) J. Neurochem. , vol.77 , pp. 182-189
    • Liu, B.1
  • 72
    • 0034711236 scopus 로고    scopus 로고
    • Cytochrome C is released from mitochondria in a reactive oxygen species (ROS)-dependent fashion and can operate as a ROS scavenger and as a respiratory substrate in cerebellar neurons undergoing excitotoxic death
    • (2000) J. Biol. Chem. , vol.275 , pp. 37159-37166
    • Atlante, A.1
  • 74
    • 0034595940 scopus 로고    scopus 로고
    • Activation of calpain I converts excitotoxic neuron death into a caspase-independent cell death
    • (2000) J. Biol. Chem. , vol.275 , pp. 17064-17071
    • Lankiewicz, S.1
  • 77
    • 0033065397 scopus 로고    scopus 로고
    • Rifampin reduces early mortality in experimental Streptococcus pneumoniae meningitis
    • (1999) J. Infect. Dis. , vol.179 , pp. 1557-1560
    • Nau, R.1
  • 78
    • 0034047547 scopus 로고    scopus 로고
    • Rifampin reduces production of reactive oxygen species of CSF phagocytes and hippocampal neuronal apoptosis in experimental Streptococcus pneumoniae meningitis
    • (2000) J. Infect. Dis. , vol.181 , pp. 2095-2098
    • Böttcher, T.1
  • 79
    • 0024421227 scopus 로고
    • Reduction of inflammation, tissue damage, and mortality in bacterial meningitis in rabbits treated with monoclonal antibodies against adhesion-promoting receptors of leukocytes
    • (1989) J. Exp. Med. , vol.170 , pp. 959-968
    • Tuomanen, E.1
  • 80
    • 0033931132 scopus 로고    scopus 로고
    • Effects of clinically used antioxidants in experimental pneumococcal meningitis
    • (2000) J. Infect. Dis. , vol.182 , pp. 347-350
    • Auer, M.1


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