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Cheresh, D.A.4
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52
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0028984231
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An anti-alpha v-integrin antibody that blocks integrin function inhibits the development of a human melanoma in nude mice
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Mitjans F, Sander D, Adan J, Sutter A, Martinez JM, Jaggle CS, Moyano JM, Kreysch HG, Piulats J, Goodman SL: An anti-alpha v-integrin antibody that blocks integrin function inhibits the development of a human melanoma in nude mice. J Cell Sci 1995,108:3067-3078.
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Mitjans, F.1
Sander, D.2
Adan, J.3
Sutter, A.4
Martinez, J.M.5
Jaggle, C.S.6
Moyano, J.M.7
Kreysch, H.G.8
Piulats, J.9
Goodman, S.L.10
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53
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0027933266
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Transformation and tumor progression are frequently associated with expression of the alpha 3/beta 1 heterodimer in solid tumors
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Bartolazzi A, Cerboni C, Nicotra MR, Mottolese M, Bigotti A, Natali PG: Transformation and tumor progression are frequently associated with expression of the alpha 3/beta 1 heterodimer in solid tumors. Int J Cancer 1994, 58:488-491.
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Bartolazzi, A.1
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Natali, P.G.6
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54
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Overexpression of the A9 antigen α6β4 in head and neck cancer
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Van Waes C, Carey TE: Overexpression of the A9 antigen α6β4 in head and neck cancer. Otolaryngol Clin North Am 1992, 25:1117-1139.
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Van Waes, C.1
Carey, T.E.2
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55
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0027179199
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The monoclonal antibody BQ16 identifies the α6β4 integrin on bladder cancer
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Liebert M, Wedemeyer G, Stein JA, Washington RW, Van Waes C, Carey T, Grossman HB: The monoclonal antibody BQ16 identifies the α6β4 integrin on bladder cancer. Hybridoma 1993, 12:67-80.
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Liebert, M.1
Wedemeyer, G.2
Stein, J.A.3
Washington, R.W.4
Van Waes, C.5
Carey, T.6
Grossman, H.B.7
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56
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0025012441
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Integrin α6β4 expression in human lung cancer as monitored by specific monoclonal antibodies
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Costatini RM, Falcioni R, Battista P, Zupi G, Kennel S, Colasante A, Venture I, Cucio C, Sacci A: Integrin α6β4 expression in human lung cancer as monitored by specific monoclonal antibodies. Cancer Res 1990, 50:6107-6112.
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Costatini, R.M.1
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Battista, P.3
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Kennel, S.5
Colasante, A.6
Venture, I.7
Cucio, C.8
Sacci, A.9
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57
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33646302350
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A novel, ankyrin repeat-containing serine/threonine protein kinase interacts with the β1 cytoplasmic domain
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Hannigan GE, Leung-Hagesteijn C, Fitz-Gibbon L, Coppolino M, Radeva G, Bell JC, Dedhar S: A novel, ankyrin repeat-containing serine/threonine protein kinase interacts with the β1 cytoplasmic domain. Nature 1995, 379:91-96. This paper describes a novel integrin-associated serine/threonine kinase that can induce anchorage-independent growth and that can directly phosphorylate the integrin β1 cytoplasmic tail in vitro. This kinase may play an essential role in integrin-mediated signal transduction that contributes to induction of cellular proliferation.
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Nature
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Hannigan, G.E.1
Leung-Hagesteijn, C.2
Fitz-Gibbon, L.3
Coppolino, M.4
Radeva, G.5
Bell, J.C.6
Dedhar, S.7
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58
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0028057613
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Disruption of epithelial cell-matrix interactions induces apoptosis
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Frisch SM, Francis H: Disruption of epithelial cell-matrix interactions induces apoptosis. J Cell Biol 1994, 124:619-626.
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J Cell Biol
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Frisch, S.M.1
Francis, H.2
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59
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0001322994
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The α5β1 integrin supports survival of cells on fibronectin and upregulates bcl-2 expression
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Zhang Z, Vuori K, Reed JC, Ruoslahti E: The α5β1 integrin supports survival of cells on fibronectin and upregulates bcl-2 expression. Mol Biol Cell 1995, 6:841-850. This paper is the first to document a regulation of the apoptosis suppressor Bcl-2 by integrin ligation. These studies demonstrate that integrins contribute to cell survival by transducing a signal that leads to Bcl-2 expression and function.
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(1995)
Mol Biol Cell
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Zhang, Z.1
Vuori, K.2
Reed, J.C.3
Ruoslahti, E.4
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60
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0030038229
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Suppression of p53 activity and p21 WAF1/CIP1 expression by vascular cell integrin αvβ3 during angiogenesis
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Stromblad S, Becker J, Yebra M, Brooks P, Cheresh DA: Suppression of p53 activity and p21 WAF1/CIP1 expression by vascular cell integrin αvβ3 during angiogenesis. J Clin Invest 1996, 98:426-433. This paper documents the molecular mechanism by which antagonists of integrin αvβ3 inhibit angiogenesis by promoting apoptosis of endothelial cells. These studies demonstrate a regulation of p53 activity and Bcl-2 expression by integrin ligation that is inhibited by αvβ3 antagonists.
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(1996)
J Clin Invest
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Stromblad, S.1
Becker, J.2
Yebra, M.3
Brooks, P.4
Cheresh, D.A.5
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61
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0029092648
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Activation of the p21 pathway of growth arrest and apoptosis by the beta (4) integrin cytoplasmic domain
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Clarke AS, Lotz MM, Chao C, Mercuric AM: Activation of the p21 pathway of growth arrest and apoptosis by the beta (4) integrin cytoplasmic domain. J Biol Chem 1995, 270:22673-22676. This paper demonstrates that the integrin β4 subunit induces cell cycle arrest in colon carcinoma cells by inducing the expression of the cell cycle inhibitor p21 WAF1/QP1, and that the cytoplasmic tail of integrin β4 is required for this activity.
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(1995)
J Biol Chem
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Clarke, A.S.1
Lotz, M.M.2
Chao, C.3
Mercuric, A.M.4
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62
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0025806141
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In vitro and in vivo consequences of VLA-2 expression on rhabdomyosarcoma cells
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Chan BM, Chan C, Matsuura, N, Takada Y, Zetter BR, Hemler ME: In vitro and in vivo consequences of VLA-2 expression on rhabdomyosarcoma cells. Science 1992, 251:1600-1602.
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Science
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Chan, B.M.1
Chan, C.2
Matsuura, N.3
Takada, Y.4
Zetter, B.R.5
Hemler, M.E.6
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63
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0005306564
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Human endothelial cells synthesize and express an Arg-Gly-Asp directed adhesion receptor involved in attachment to fibrinogen and von Willebrand factor
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Cheresh D: Human endothelial cells synthesize and express an Arg-Gly-Asp directed adhesion receptor involved in attachment to fibrinogen and von Willebrand factor. Proc Natl Acad Sci USA 1987, 84:6471-6475.
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(1987)
Proc Natl Acad Sci USA
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Cheresh, D.1
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64
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0026764576
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Requirement of integrin β3 subunit for carcinoma cell spreading or migration on vitronectin and fibrinogen
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Leavesley Dl, Ferguson GD, Wayner EA, Cheresh DA: Requirement of integrin β3 subunit for carcinoma cell spreading or migration on vitronectin and fibrinogen. J Cell Biol 1992, 117:1101-1107.
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(1992)
J Cell Biol
, vol.117
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Leavesley, D.1
Ferguson, G.D.2
Wayner, E.A.3
Cheresh, D.A.4
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65
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0027166647
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Integrins αvβ3 and αvβ5 promote adenovirus internalization but not virus attachment
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Wickham TJ, Mathias P, Cheresh DA, Nemerow GR: Integrins αvβ3 and αvβ5 promote adenovirus internalization but not virus attachment Cell 1993, 73:309-319.
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(1993)
Cell
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Wickham, T.J.1
Mathias, P.2
Cheresh, D.A.3
Nemerow, G.R.4
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66
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0029050683
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Requirement of the NPXY motif in the integrin β3 subunit cytoplasmic tail for melanoma cell migration in vitro and in vivo
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Filardo EJ, Brooks PC, Deming SL, Cheresh DA: Requirement of the NPXY motif in the integrin β3 subunit cytoplasmic tail for melanoma cell migration in vitro and in vivo. J Cell Biol 1995, 130:441-450.
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(1995)
J Cell Biol
, vol.130
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Filardo, E.J.1
Brooks, P.C.2
Deming, S.L.3
Cheresh, D.A.4
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67
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0026451947
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Human melanoma cells derived from lymphatic metastases use integrin αvβ3 to adhere to lymph node vitronectin
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Nip J, Shibata H, Loskutoff D, Cheresh D, Brodt P: Human melanoma cells derived from lymphatic metastases use integrin αvβ3 to adhere to lymph node vitronectin. J Clin Invest 1992, 90:1406-1413.
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(1992)
J Clin Invest
, vol.90
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Nip, J.1
Shibata, H.2
Loskutoff, D.3
Cheresh, D.4
Brodt, P.5
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68
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0028043735
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Receptor tyrosine kinase signaling required for integrin αvβ5 directed cell motility but not adhesion on vitronectin
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Klemke RL, Yebra M, Bayna EM, Cheresh DA: Receptor tyrosine kinase signaling required for integrin αvβ5 directed cell motility but not adhesion on vitronectin. J Cell Biol 1994, 127:859-866.
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(1994)
J Cell Biol
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Klemke, R.L.1
Yebra, M.2
Bayna, E.M.3
Cheresh, D.A.4
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69
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15844420283
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Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin αvβ3
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Brooks PC, Stromblad S, Sanders L, Von Schalscha T, Aimes RT, Stetler-Stevenson WG, Quigley JP, Cheresh D: Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin αvβ3. Cell 1996, 85:683-693. This paper is the first documentation that integrins and matrix metalloproteinases directly interact to influence tumor and endothelial cell invasion processes. These studies demonstrate that activated matrix metalloproteinase 2 binds to integrin αvβ3, and that this interaction promotes cellular invasion and contributes to angiogenesis.
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(1996)
Cell
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Brooks, P.C.1
Stromblad, S.2
Sanders, L.3
Von Schalscha, T.4
Aimes, R.T.5
Stetler-Stevenson, W.G.6
Quigley, J.P.7
Cheresh, D.8
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70
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0028979348
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J. Integrin alpha 2 beta 1 is a positive regulator of collagenase (MMP-1) and collagen alpha 1 (I) gene expression
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Riikonen T, Westermarck J, Koivisto L, Broberg A, Kahari VM, Heino, J. Integrin alpha 2 beta 1 is a positive regulator of collagenase (MMP-1) and collagen alpha 1 (I) gene expression. J Biol Chem 1995, 270:13548-13552.
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J Biol Chem
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Riikonen, T.1
Westermarck, J.2
Koivisto, L.3
Broberg, A.4
Kahari, V.M.5
Heino6
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71
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0028987190
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Cooperative signalling by alpha 5 beta 1 and alpha 4 beta 1 integrins regulates metalloproteinase gene expression in fibroblasts adhering to fibronectin
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Huhtala P, Humphries MJ, McCarthy JB, Tremble PM, Werb Z, Damsky CH: Cooperative signalling by alpha 5 beta 1 and alpha 4 beta 1 integrins regulates metalloproteinase gene expression in fibroblasts adhering to fibronectin. J Cell Biol 1995, 129:867-879.
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J Cell Biol
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Huhtala, P.1
Humphries, M.J.2
McCarthy, J.B.3
Tremble, P.M.4
Werb, Z.5
Damsky, C.H.6
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72
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0028362876
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Requirement of vascular integrin cxv3 for angiogenesis
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Brooks PC, Clark RAF, Cheresh DA: Requirement of vascular integrin cxv3 for angiogenesis. Science 1994, 264:569-571.
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(1994)
Science
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Brooks, P.C.1
Clark, R.A.F.2
Cheresh, D.A.3
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73
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0028130434
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Basic fibroblast growth factor increases expression of the αvβ3 complex on human microvessel endothelial cells
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Sepp NT, Li L-J, Lee KH, Brown EJ, Caughman SWW, Lawley TJ, Swerlick RA: Basic fibroblast growth factor increases expression of the αvβ3 complex on human microvessel endothelial cells. J Invest Dermatol 1994,103:295-299.
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J Invest Dermatol
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Sepp, N.T.1
Li, L.-J.2
Lee, K.H.3
Brown, E.J.4
Caughman, S.W.W.5
Lawley, T.J.6
Swerlick, R.A.7
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74
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0027008419
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Basic FGF and TGFβ differentially modulate integrin expression of human microvascular endothelial cells
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Enenstein J, Waleh NS, Kramer RH: Basic FGF and TGFβ differentially modulate integrin expression of human microvascular endothelial cells. Exp Cell Res 1992, 203:499-503.
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(1992)
Exp Cell Res
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Enenstein, J.1
Waleh, N.S.2
Kramer, R.H.3
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75
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0029610677
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Definition of two angiogenic pathways by distinct αv integrins
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Friedlander M, Brooks PC, Shaffer RW, Kincaid CM, Varner JA, Cheresh DA: Definition of two angiogenic pathways by distinct αv integrins. Science 1995, 27:1500-1502.
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(1995)
Science
, vol.27
, pp. 1500-1502
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Friedlander, M.1
Brooks, P.C.2
Shaffer, R.W.3
Kincaid, C.M.4
Varner, J.A.5
Cheresh, D.A.6
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76
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0028972105
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Antiintegrin αvβ3 blocks breast cancer growth and angiogenesis in human skin
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Brooks P, Stromblad S, Klemke R, Visscher D, Sarkar F, Cheresh D: Antiintegrin αvβ3 blocks breast cancer growth and angiogenesis in human skin. J Clin Invest 1995, 96:1815-1822.
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(1995)
J Clin Invest
, vol.96
, pp. 1815-1822
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Brooks, P.1
Stromblad, S.2
Klemke, R.3
Visscher, D.4
Sarkar, F.5
Cheresh, D.6
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77
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0028981497
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An antagonist of integrin αvβ3 prevents maturation of blood vessels during embryonic neovascularization
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Drake CJ, Cheresh DA, Little CD: An antagonist of integrin αvβ3 prevents maturation of blood vessels during embryonic neovascularization. J Cell Sci 1995, 108:2655-2661.
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(1995)
J Cell Sci
, vol.108
, pp. 2655-2661
-
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Drake, C.J.1
Cheresh, D.A.2
Little, C.D.3
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