What can the structures of enzyme-inhibitor complexes tell us about the structures of enzyme substrate complexes?

Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology

Volumn 1477, Issue 1-2, 2000, Pages 324-337

  Laskowski Jr , Michael ^a   Qasim, M A ^a  

^a PURDUE UNIVERSITY   (United States)

Author keywords

Chymotrypsin; Family of proteinase inhibitor; Reactive site peptide bond; Standard mechanism, canonical protein inhibitor of serine proteinase; Transition state complex; Turkey ovomucoid third domain

Indexed keywords

CHYMOTRYPSIN; SERINE PROTEINASE;

ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME KINETICS; ENZYME STRUCTURE, FUNCTION AND VARIABILITY; ENZYME SUBSTRATE COMPLEX; HUMAN; MOLECULE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; REVIEW; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; ENDOPEPTIDASES; ENZYME ACTIVATION; ENZYME PRECURSORS; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; OVOMUCIN; PROTEASE INHIBITORS; PROTEIN CONFORMATION; PROTEINS; SERINE PROTEINASE INHIBITORS; SUBSTRATE SPECIFICITY; THERMODYNAMICS;

BOVINAE;

EID: 0342445397     PISSN: 01674838     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-4838(99)00284-8     Document Type: Review

References (49)

1. N.M. Green, H. Neurath, in: H. Neurath, K. Bailey (Eds.), The Proteins, Academic Press, New York, 1954, pp. 1057-1171.
2. Kunitz M., Northrop J.H. J. Gen. Physiol. 19:1936;991-1007.
3. Kunitz M. Science. 101:1945;668-669.
4. Fraenckel-Conrat H., Bean R.C., Ducay E.D., Olcott H.S. Arch. Biochem. Biophys. 37:1952;393-407.
5. Jirgensons B., Ikenaka T., Gorguraki V. Makromol. Chem. 39:1960;149-165.
6. SriRam J., Terminiello L., Bier M., Nord F.F. Arch. Biochem. Biophys. 52:1954;451-453.
7. Kassell B., Laskowski M. Sr. Biochem. Biophys. Res. Commun. 17:1964;792-797.
8. Kassell B., Laskowski M. Sr. Biochem. Biophys. Res. Commun. 18:1965;255-258.
9. Anderer F.A., Hörnle S. Z. Naturforschg. 20b:1965;457-462.
10. Huber R., Kukla D., Rühlmann A., Epp O., Formanek H. Naturwissenschaften. 57:1970;389-392.
11. Rühlmann A., Kukla D., Schwager P., Bartels K., Huber R. J. Mol. Biol. 77:1973;417-436.
12. Sweet R.M., Wright H.T., Janin J., Chothia C.H., Blow D.M. Biochemistry. 13:1974;4212-4228.
13. Lebowitz J., Laskowski M. Jr. Biochemistry. 1:1962;1044-1055.
14. Finkenstadt W.R., Laskowski M. Jr. J. Biol. Chem. 240:1965;962-963.
15. Ozawa K., Laskowski M. Jr. J. Biol. Chem. 241:1966;3955-3961.
16. Sealock R.W., Laskowski M. Jr. Biochemistry. 8:1969;3703-3710.
17. Rhodes M.B., Bennett N., Feeney R.E. J. Biol. Chem. 235:1960;1686-1693.
18. T.R. Leary, M. Laskowski, Jr., Fed. Proc. 32 (1973) 465. See also: D. Kowalski, T. R. Leary, R. E. McKee, R. W. Sealock, D. Wang, M. Laskowski, Jr. in: H. Fritz, H. Tschesche, L. J. Greene, E. Truscheit (Eds.), Bayer Symposium V 'Proteinase Inhibitors' Springler Verlag, Berlin, Heidelberg, New York, 1974, pp. 311-324.
19. T.R. Leary, M. Laskowski, Jr., Fed. Proc. 32 (1973) 465. See also: D. Kowalski, T. R. Leary, R. E. McKee, R. W. Sealock, D. Wang, M. Laskowski, Jr. in: H. Fritz, H. Tschesche, L. J. Greene, E. Truscheit (Eds.), Bayer Symposium V 'Proteinase Inhibitors' Springler Verlag, Berlin, Heidelberg, New York, 1974, pp. 311-324.
20. Schecter I., Berger A. Biochem. Biophys. Res. Commun. 27:1967;157-162.
21. Ardelt W., Laskowski M. Jr. J. Mol. Biol. 220:1991;1041-1053.
22. Laskowski M. Jr., Kato I. Annu. Rev. Biochem. 49:1980;593-626.
23. Ardelt W., Laskowski M. Jr. Biochemistry. 24:1985;5313-5320.
24. McPhalen C.A., James M.N.G. Biochemistry. 27:1988;6582-6598.
25. Hipler K., Priestle J.P., Rahuel J., Grütter M.G. FEBS Lett. 309:1992;139-145.
26. Bode W., Huber R. Eur. J. Biochem. 204:1992;433-451.
27. Apostoluk W., Otlewski J. Proteins. 32:1998;459-474.
28. Jackson R.M. Protein Sci. 8:1999;603-613.
29. K.A. Wilson, in: B.A. Larkins, I.K. Vasil (Eds.), Cellular and Molecular Biology of Plant Seed Development, Kluwer Academic Publishers, Dordrecht, 1997, pp. 331-374.
30. Perona J.J., Craik C.S. Protein Sci. 4:1995;337-360.
31. M. Laskowski, Jr, M.A. Qasim, S.M. Lu, in: C. Kleanthous, (Ed.), Protein-Protein recognition: The Frontiers in Molecular Biology Series, Oxford University Press, Oxford, 2000, in press.
32. W. Lu (1994) Ph.D. thesis, Purdue University, West Lafayette, IN, USA.
33. Finkenstadt W.R., Laskowski M. Jr. J. Biol. Chem. 242:1967;771-772.
34. Bigler T.L., Lu W., Park S.J., Tashiro M., Wieczorek M., Wynn R., Laskowski M. Jr. Protein Sci. 2:1993;786-799.
35. Lu W., Apostol I., Qasim M.A., Warne N., Wynn R., Zhang W.L., Anderson S., Chiang Y.W., Ogin E., Rothberg I., Ryan K., Laskowski M. Jr. J. Mol. Biol. 266:1997;441-461.
36. Huang K., Lu W., Anderson S., Laskowski M. Jr., James M.N.G. Protein Sci. 4:1995;1985-1997.
37. Fujinaga M., Huang K., Bateman K.S., James M.N.G. J. Mol. Biol. 284:1998;1683-1694.
38. Helland R., Otlewski J., Sundheim O., Dadlez M., Smalås A.O. J. Mol. Biol. 287:1999;923-942.
39. Qasim M.A., Lu S.M., Ding J., Bateman K.S., James M.N.G., Anderson S., Song J., Markley J.L., Ganz P.J., Saunders C.W., Laskowski M. Jr. Biochemistry. 38:1999;7142-7150.
40. Qasim M.A., Ganz P.J., Saunders C.W., Bateman K.S., James M.N.G., Laskowski M. Jr. Biochemistry. 36:1997;1598-1607.
41. Krowarsch D., Dadlez M., Buczek O., Krokoszynska I., Smalås A.O., Otlewski J. J. Mol. Biol. 289:1999;175-186.
42. Fujinaga M., Sielecki A.R., Read R.J., Ardelt W., Laskowski M. Jr., James M.N.G. J. Mol. Biol. 195:1987;397-418.
43. Frigerio F., Coda A., Pugliese L., Lionetti C., Menegatti E., Amiconi G., Schnebli H.P., Ascenzi P., Bolognesi M. J. Mol. Biol. 225:1992;107-123.
44. Scheidig A.J., Hynes T.R., Pelletier L.A., Wells J.A., Kossiakoff A.A. Protein Sci. 6:1997;1806-1824.
45. Capasso C., Rizzi M., Menegatti E., Ascenzi P., Bolognesi M. J. Mol. Recognit. 10:1997;26-35.
46. S.J. Park (1985) Ph.D. Thesis, Purdue University, West Lafayette, IN, USA.
47. R. Wynn (1990) Ph.D. Thesis, Purdue University, West Lafayette, IN, USA.
48. Dorovska V.N., Varfolomeyev S.D., Kazanskaya N.F., Martinek K. FEBS Lett. 23:1972;122-124.
49. Bauer C.A. Biochemistry. 17:1978;375-380.