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Volumn 298, Issue 3, 2000, Pages 477-491

Crystal structure of cancer chemopreventive Bowman-Birk inhibitor in ternary complex with bovine trypsin at 2.3 Å resolution. Structural basis of Janus-faced serine protease inhibitor specificity

Author keywords

Bowman Birk inhibitor; Molecular recognition; Protease inhibitor; Serine protease; Specificity

Indexed keywords

BOWMAN BIRK INHIBITOR; CHYMOTRYPSIN; SERINE PROTEINASE INHIBITOR; TRYPSIN;

EID: 0034607547     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2000.3677     Document Type: Article
Times cited : (75)

References (62)
  • 8
    • 0037877123 scopus 로고
    • A system for X-ray crystallography and NMR
    • X-PLOR Manual, Version 3.1, Yale university, New Haven, CT
    • (1992)
    • Brunger, A.T.1
  • 9
    • 0026597444 scopus 로고
    • Free R value: A novel statistical quantity for assessing the accuracy of crystal structures
    • (1992) Nature , vol.335 , pp. 472-474
    • Brunger, A.T.1
  • 12
    • 0023195312 scopus 로고
    • Chemical synthesis, molecular cloning and expression of gene coding for a Bowman-Birk-type proteinase inhibitor
    • (1987) Eur. J. Biochem. , vol.166 , pp. 151-156
    • Flecker, P.1
  • 13
    • 0024364855 scopus 로고
    • A new and general procedure for refolding mutant Bowman-Birk-type proteinase inhibitors on trypsin-Sepharose as a matrix with complementary structure
    • (1989) FEBS Letters , vol.252 , pp. 153-157
    • Flecker, P.1
  • 14
    • 0000575176 scopus 로고
    • Analysis of structure activity relationships of the Bowman Birk inhibitor of serine proteinases - Towards a rational design of new cancer chemopreventive agents
    • Protease Inhibitors as Cancer Chemopreventive Agents (Troll, W. and Kennedy, A. R., eds), Plenum Publishing Corp., New York
    • (1993) , pp. 161-176
    • Flecker, P.1
  • 16
    • 0017302833 scopus 로고
    • Double-headed protease inhibitors from black-eyed peas. IV. Half-site reactivity in the formation of complexes with trypsin and chymotrypsin
    • (1976) J. Biol. Chem. , vol.251 , pp. 754-762
    • Gennis, L.S.1    Cantor, C.R.2
  • 19
    • 0029832603 scopus 로고    scopus 로고
    • Trypsin - A case study in the structural determinants of enzyme specificity
    • (1996) Biol. Chem. , vol.377 , pp. 465-470
    • Hedstrom, L.1
  • 20
    • 0002193613 scopus 로고
    • The processing and diffractional data taken on a screenless Weissenberg camera for macromolecular crystallography
    • (1989) J. Appl. Crystallog. , vol.22 , pp. 9-18
    • Higashi, T.1
  • 24
    • 0000946759 scopus 로고
    • Bowman-Birk family serine proteinase inhibitors
    • Proteinase Inhibitors (Barrett, A. J. and Salvesen, G., eds), Elsevier, Amsterdam
    • (1986) , pp. 361-374
    • Ikenaka, T.1    Norioka, S.2
  • 41
    • 0007944887 scopus 로고
    • Practical Protein Crystallography, Academic Press, Inc., New York
    • (1993)
    • McRee, D.E.1
  • 43
    • 0017839012 scopus 로고
    • Studies on soybean trypsin inhibitors. XIII. Preparation and characterisation of active fragments from Bowman-Birk proteinase inhibitor
    • (1978) J. Biochem. , vol.83 , pp. 747-753
    • Odani, S.1    Ikenaka, T.2
  • 49
    • 0000525517 scopus 로고
    • A focussing Weissenberg camera with multi-layer-line screens for macromolecular crystallography
    • (1983) J. Appl. Crystallog. , vol.16 , pp. 542-547
    • Sakabe, N.1
  • 50
  • 61
    • 0007901359 scopus 로고
    • Cell membrane enzymes containing chymotrypsin-like activity
    • Proteinase Inhibitors as Cancer Chemopreventive Agents (Troll, W. and Kennedy, A. R., eds), Plenum Press, New York
    • (1993) , pp. 217-225
    • Yavelow, J.1    Schepis, L.T.2    Nickels J., Jr.3    Ritchie, G.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.