Recombinant human monocyte/neutrophil elastase inhibitor protects rat lungs against injury from cystic fibrosis airway secretions

American Journal of Respiratory Cell and Molecular Biology

Volumn 20, Issue 1, 1999, Pages 69-78

  Rees, Dianne D ^b   Rogers, Rick A ^b   Cooley, Jessica ^b   Mandle, Robert J ^b   Kenney, Dianne M ^a   Remold O'Donnell, Eileen ^a  

^a CENTER FOR BLOOD RESEARCH   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

LEUKOCYTE ELASTASE; MONOCYTE NEUTROPHIL ELASTASE INHIBITOR, HUMAN; MONOCYTE-NEUTROPHIL ELASTASE INHIBITOR, HUMAN; PROTEIN; RECOMBINANT PROTEIN; SERINE PROTEINASE INHIBITOR;

ADULT; ANIMAL; ARTICLE; BLEEDING; CYSTIC FIBROSIS; DRUG ANTAGONISM; FEMALE; HUMAN; LUNG DISEASE; METABOLISM; RAT; SPRAGUE DAWLEY RAT; SPUTUM;

ADULT; ANIMALS; CYSTIC FIBROSIS; FEMALE; HEMORRHAGE; HUMANS; LEUKOCYTE ELASTASE; LUNG DISEASES; PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS; SERINE PROTEINASE INHIBITORS; SPUTUM;

EID: 0032608484     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/ajrcmb.20.1.3306     Document Type: Article

References (43)

1. Rees, D., R. Dowgiert, R. Rogers, R. Mandle, and E. Remold-O'Donnell. 1997. Recombinant human elastase inhibitor (rHEI) protects rats from lung injury induced by instilled CF sputum sol or neutrophil elastase. Pediatr. Pulmonol. 14:271A. (Abstr.)
2. Davis, P. B., M. Drumm, and M. W. Konstan. 1996. Cystic fibrosis. Am. J. Respir. Crit. Care Med. 154:1229-1256.
3. O'Connor, C. M., K. Gaffney, J. Keane, A. Southey, N. Bryne, S. O'Mahoney, and M. X. Fitzgerald. 1993. α1-proteinase inhibitor, elastase activity, and lung disease severity in cystic fibrosis. Am. Rev. Respir. Dis. 148: 1665-1670.
4. Konstan, M. W., K. A. Hilliard, T. M. Norvell, and M. Berger. 1994. Bronchoalveolar lavage findings in cystic fibrosis patients with stable, clinically mild lung disease suggest ongoing infection and inflammation. Am. J. Respir. Crit. Care Med. 150:448-454.
5. Birrer, P., N. G. McElvaney, A. Rudeberg, C. W. Sommer, S. Liechti-Gallati, R. Kraemer, R. Hubbard, and R. G. Crystal. 1994. Protease-antiprotease imbalance in the lungs of children with cystic fibrosis. Am. J. Respir. Crit. Care Med. 150:207-213.
6. Khan, T. Z., J. S. Wagener, T. Bost, J. Martinez, F. J. Accurso, and D. W. H. Riches. 1995. Early pulmonary inflammation in infants with cystic fibrosis. Am. J. Respir. Crit. Care Med. 151:1075-1082.
7. Kirchner, K. K., J. S. Wagener, T. Z. Khan, S. C. Copenhaver, and F. J. Accurso. 1996. Increased DNA levels in bronchoalveolar lavage fluid obtained from infants with cystic fibrosis. Am. J. Respir. Crit. Care Med. 154: 1426-1429.
8. Janoff, A. 1985. Elastase in tissue injury. Annu. Rev. Med. 36:207-216.
9. Fick, R. B., Jr., G. P. Naegel, S. U. Squier, R. E. Wood, J. Bernard, L. Gee, and H. Y. Reynolds. 1984. Proteins of the cystic fibrosis respiratory tract. J. Clin. Invest. 74:236-248.
10. Doering, G., W. Goldstein, K. Botzenhart, A. Kharazmi, P. O. Schiotz, N. Hoiby, and M. Dasgupta. 1986. Elastase from polymorphonuclear leucocytes: a regulatory enzyme in immune complex disease. Clin. Exp. Immunol. 64:597-605.
11. Tosi, M. F., H. Zakem, and M. Berger. 1990. Neutrophil elastase cleaves C3bi on opsonized Pseudomonas as well as CRI on neutrophils to create a functionally important opsonin receptor mismatch. J. Clin. Invest. 86:300-308.
12. Kim, K. C., K. Wasano, R. M. Niles, J. E. Schuster, P. J. Stone, and J. S. Brody. 1987. Human neutrophil elastase releases cell surface mucins from primary cultures of hamster tracheal epithelial cells. Proc. Natl. Acad. Sci. USA 84:9304-9308.
13. Sommerhoff, C. P., J. A. Nadel, C. B. Basbaum, and G. H. Caughey. 1990. Neutrophil elastase and cathepsin G stimulate secretion from cultured bovine airway gland serous cells. J. Clin. Invest. 85:682-689.
14. Schuster, A., J. V. Fahy, I. Ueki, and J. A. Nadel. 1995. Cystic fibrosis sputum induces a secretory response from airway gland serous cells that can be prevented by neutrophil protease inhibitors. Eur. Respir. J. 8:10-14.
15. Bedard, M., C. D. McClure, N. L. Schiller, C. Francoeur, A. Cantin, and M. Denis. 1993. Release of interleukin-8, interleukin-6 and colony-stimulating factors by upper airway epithelial cells: implication for cystic fibrosis. Am. J. Respir. Cell Mol. Biol. 9:455-462.
16. Rees, D. D., J. D. Brain, M. E. Wohl, J. L. Humes, and R. A. Mumford. 1997. Inhibition of neutrophil elastase in CF sputum by L-658,758. J. Pharmacol. Exp. Ther. 283:1201-1206.
17. Carrell, R. W., J.-O. Jeppsson, C.-B. Laurell, S. O. Brennan, M. C. Owen, L. Vaughan, and D. R. Boswell. 1982. Structure and variation of human α1-antitrypsin. Nature 298:329-334.
18. Seemuller, U., M. Arnhold, H. Fritz, K. Weidenmann, W. Machleidt, R. Heinzel, H. Appelhans, H.-G. Gassen, and F. Lottspeich. 1986. The acidstable proteinase inhibitor of human mucous secretions (HUSI-I, antileukoprotease). FEBS Lett. 199:43-48.
19. Thompson, R. C., and K. Ohlsson. 1986. Isolation, properties, and complete amino acid sequence of human secretory leukocyte protease inhibitor, a potent inhibitor of leukocyte elastase. Proc. Natl. Acad. Sci. USA 83:6692-6696.
20. Abe, T., N. Kobayashi, K. Yoshimura, B. C. Trapnell, H. Kim, R. C. Hubbard, M. T. Brewer, R. C. Thompson, and R. G. Crystal. 1991. Expression of the secretory leukoprotease inhibitor gene in epithelial cells. J. Clin. Invest. 87:2207-2215.
21. Sallenave, J.-M., M. Si-Ta har, G. Cox, M. Chignard, and J. Gauldie. 1997. Secretory leukocyte proteinase inhibitor is a major leukocyte elastase inhibitor in human neutrophils. J. Leukoc. Biol. 61:695-702.
22. Wiedow, O., J.-M. Schröder, H. Gregory, J. A. Young, and E. Christopher. 1990. Elafin: an elastase-specific inhibitor of human skin. J. Biol. Chem. 265:14791-14795.
23. Sallenave, J.-M., M. D. Marsden, and A. P. Ryle. 1992. Isolation of elafin and elastase-specific inhibitor (ESI) from bronchial secretions: evidence of sequence homology and immunological cross-reactivity. Biol. Chem. Hoppe-Seyler 373:27-33.
24. Remold-O'Donnell, E. 1985. A fast-acting elastase inhibitor in human monocytes. J. Exp. Med. 162:2142-2155.
25. Remold-O'Donnell, E., J. C. Nixon, and R. M. Rose. 1989. Elastase inhibitor: characterization of the human elastase inhibitor molecule associated with monocytes, macrophages and neutrophils. J. Exp. Med. 169:1071-1086.
26. Remold-O'Donnell, E., J. Chin, and M. Alberts. 1992. Sequence and molecular characterization of human monocyte/neutrophil elastase inhibitor. Proc. Natl. Acad. Sci. USA 89:5635-5639.
27. Sugimori, T., J. Cooley, J. R. Hoidal, and E. Remold O'Donnell. 1995. Inhibitory properties of recombinant human monocyte/neutrophil elastase inhibitor. Am. J. Respir. Cell Mol. Biol. 13:314-322.
28. Remold-O'Donnell, E., J. Cooley, and R. Mandle. 1998. MNEI is an efficient inhibitor of neutrophil proteases. Am. J. Respir. Crit. Care Med. 157:A606. (Abstr.)
29. Fletcher, D. S, D. G. Osinga, K. M. Hand, P. S. Dellea, B. M. Ashe, R. A. Mumford, P. Davies, W. Hagmann, P. E. Finke, J. B. Doherty, and R. J. Bonney. 1990. A comparison of α1-proteinase inhibitor methoxysuccinyl-ala-ala-pro-val-chlormethylketone and specific β-lactam inhibitors in an acute model of human polymorphonuclear leukocyte elastase-induced lung hemorrhage in the hamster. Am. Rev. Respir. Dis. 141:672-677.
30. Rees, D. D., and J. D. Brain. 1995. Effects of cystic fibrosis airway secretions on rat lung: role of neutrophil elastase. Am. J. Physiol. 269:L195-L202.
31. Lefevre, C., H. C. Kang, R. P. Haugland, N. Malekzadeh, S. Arttamangkul, and R. P. Haugland. 1996. Texas Red-X and rhodamine Red-X, new derivatives of sulforhodamine 101 and lissamine rhodamine B with improved labeling and fluorescence properties. Bioconj. Chem. 7:482-489.
32. Twumasi, D. Y., and I. E. Liener. 1977. Proteases from purulent sputum. J. Biol. Chem. 252:1917-1926.
33. Laemmli, U. K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685.
34. Beck, B. D., J. D. Brain, and D. E. Bohannon. 1982. An in vivo hamster bioassay to assess the toxicity of particulates for the lungs. Toxicol. Appl. Pharmacol. 66:9-29.
35. Doumas, B. T., and H. G. Biggs. 1972. Determination of serum albumin. In Standard Methods of Clinical Chemistry, Vol. 7. G. R. Cooper, editor. Academic Press, New York. 175-188.
36. Makarem, A. 1974. Hemoglobins, myoglobins, and haptoglobins. In Clinical Chemistry - Principles and Techniques. R. F. Henry, D. C. Canon, and J. W. Winkelman, editors. Harper & Row, Hagerstown, MD. 1128-1135.
37. Fouret, P., R. M. duBois, J.-F. Bernaudin, H. Takahashi, V. J. Ferrans, and R. G. Crystal. 1989. Expression of the neutrophil elastase gene during human bone marrow cell differentiation. J. Exp. Med. 169:833-845.
38. Senior, R. M., and E. J. Campbell. 1984. Cathepsin G in human mononuclear phagocytes: comparisons between monocytes and U937 monocyte-like cells. J. Immunol. 132:2547-2551.
39. Hanson, R. D., N. L. Connolly, D. Burnett, E. J. Campbell, R. M. Senior, and T. J. Ley. 1990. Developmental regulation of the human cathepsin G gene in myclomonocytic cells. J. Biol. Chem. 265:1524-1530.
40. Baggiolini, M., U. Bretz, B. Dewald, and M. E. Feigenson. 1978. The polymorphonuclear leukocyte. Agents Actions 8:3-10.
41. Kao, R. C., N. G. Wehner, K. M. Skubitz, B. H. Gray, and J. R. Hoidal. 1988. A distinct human polymorphonuclear leukocyte proteinase that produces emphysema in hamsters. J. Clin. Invest. 82:1963-1973.
42. Campanelli, D., M. Melchior, Y. Fu, M. Nakata, H. Shuman, C. Nathan, and J. E. Gabay. 1990. Cloning of cDNA for proteinase 3: a serine protease, antibiotic, and autoantigen from human neutrophils. J. Exp. Med. 172:1709-1715.
43. Kupfer, A., and S. J. Singer. 1989. Cell biology of cytotoxic and helper T cell functions: immunofluorescence microscopic studies of single cells and cell couples. Annu. Rev. Immunol. 7:309-337.