Blockage of skin invasion by schistosome cercariae by serine protease inhibitors

American Journal of Tropical Medicine and Hygiene

Volumn 60, Issue 3, 1999, Pages 487-492

  Lim, Kee Chong ^a   Sun, Eugene ^b   Bahgat, Mahmoud ^c   Bucks, Daniel ^d   Richard, Guy ^e   Hinz, Robert S ^f   Cullander, Chris ^f   McKerrow, James H ^g  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b ABBOTT LABORATORIES   (United States)

^c AIN SHAMS UNIVERSITY   (Egypt)

^d Penederm Inc   (United States)

^e Parc d'Affaires International   (France)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g SAN FRANCISCO VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SERINE PROTEINASE INHIBITOR; TOPICARE; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CERCARIA; CONTROLLED STUDY; DRUG FORMULATION; ENZYME INHIBITION; HUMAN; HUMAN TISSUE; MOUSE; NONHUMAN; PARASITE DEVELOPMENT; PARASITIC SKIN DISEASE; PATHOGENESIS; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS; TREATMENT OUTCOME;

ANIMALIA; PROTOZOA; SCHISTOSOMA; SCHISTOSOMA MANSONI;

EID: 0032958974     PISSN: 00029637     EISSN: None     Source Type: Journal    
DOI: 10.4269/ajtmh.1999.60.487     Document Type: Article

References (15)

1. Stirewalt MA, Dorsey CH, 1974. Schistosoma mansoni: cercarial penetration of host epidermis at the ultrastructural level. Exp Parasitol 35: 1-15.
2. McKerrow JH, Newport G, Fishelson Z, 1991. Recent insights into the structure and function of a larval proteinase involved in host infection by a multicellular parasite. Proc Soc Exp Biol Med 197: 119-124.
3. Pellegrino J, 1967. Protection against human schistosome cercariae. Exp Parasitol 21: 112-131.
4. Abu-Elyazeed RR, Podgore JK, Mansour NS, Kilpatrick ME, 1993. Field trial of 1% niclosamide as a topical antipenetrant to Schistosoma mansoni cercariae. Am J Trop Med Hyg 49: 403-409.
5. Podgore JK, Abu-Elyazeed RR, Mansour NS, Yousset FG, Hibbs RG, Gere JA, 1994. Evaluation of a twite-a-week application of 1% niclosamide lotion in preventing Schistosoma haematobium reinfection. Am J Trop Med Hyg 51: 875-879.
6. Cohen FE, Gregoret L M., Amiri P, Aldape K, Railey J Mc-Kerrow JH, 1991. Arresting tissue invasion of a parasite by protease inhibitors chosen with the aid of computer modeling. Biochemistry 30: 11221-11229.
7. Ring CS, Sun E, McKerrow JH, Lee GK, Rosenthal PJ, Kuntz ID, Cohen FE, 1993. Structure-based inhibitor design using protein models for the development of anti-parasitic agents. Proc Natl Acad Sci USA 90: 3583-3587.
8. Berti JJ, Lipsky JJ, 1995. Transcutaneous drug deliver: a practical review. Mayo Clin Proc 70: 581-586.
9. Misoire G, Bucks D. 1997. An unexpected finding in percutaneous absorption between haired and hairless guinea pig skin. J Pharm Sci 86: 398-400.
10. Niemiec SM, Wu H-L, Jayaraman S, Misoire G, Bucks D, Ramachandran C, Weiner N. 1997. Effect of polyolprepolymer on the deposition of retinoic acid in various strata of hamster ear following topical in vivo application of gel formulations: correlation with disposition in human skin. Drug Delivery 4: 33-36.
11. Goldenberg RL, 1996. Sunscreens and topical enzymes. Drug Cosmetic Industry 159: 94-96.
12. Fox C, 1996. Raw materials. Cosmetics Toiletries III: 18.
13. Lim HK, Heyneman D. 1972. Intramolluscan inter-trematode antagonism: a review of factors influencing the host-parasite system and its possible role in biological control. Adv Parasitol 10: 191-268.
14. McKerrow JH, Pino-Heiss S, Lindquist R, Werb Z. 1985. Purification and characterization of an elastinolytic proteinase secreted by cercariae of Schistosoma mansona. J Clin Chem 260: 3703-3707.
15. Amiri P, Locksley RM, Parslow TG, Sadick M, Rector E, Ritter D. McKerrow JH, 1992. Tumor necrosis factor restores granulomas and induces parasite egg laying in schistosome-infected scid mice. Nature 356: 604-607.