Design and synthesis of substrate-based peptidomimetic human immunodeficiency virus protease inhibitors containing the hydroxymethylcarbonyl isostere

Biopolymers

Volumn 40, Issue 2, 1996, Pages 235-244

  Kiso, Yoshiaki ^a  

^a KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BIOSYNTHESIS; CONFORMATIONS; DRUG PRODUCTS; ENZYMES; HYDROGEN BONDS; MOLECULAR STRUCTURE; TOXICITY; VIRUSES; X RAY CRYSTALLOGRAPHY;

ACQUIRED IMMUNODEFICIENCY SYNDROME; BIOAVAILABILITY; CYTOTOXICITY; HYDROMETHYLCARBONYL ISOSTERE; PEPTIDES; PEPTIDOMIMETIC HUMAN IMMUNODEFICIENCY VIRUS; PROTEASE INHIBITORS; RETROVIRAL MATURATION; RETROVIRAL REPLICATION; THIOESTER CHEMICAL LEGATION METHOD;

ENZYME INHIBITION;

3 AMINO 2 HYDROXY 4 PHENYLBUTYRIC ACID; ANTIVIRUS AGENT; ASPARTIC PROTEINASE; CARBONYL DERIVATIVE; KNI 102; KNI 93; KYNOSTATIN; KYNOSTATIN 272; PROTEINASE INHIBITOR; SERYLPHENYLALANYLASPARAGINYL ALLOPHENYLNORSTATINE PROLYLISOLEUCYLVALINE AMIDE; UNCLASSIFIED DRUG; ZIDOVUDINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2; HYDROGEN BOND; INTRADERMAL DRUG ADMINISTRATION; MOLECULAR MODEL; MONONUCLEAR CELL; MOUSE; NONHUMAN; RAT; STEREOCHEMISTRY; X RAY CRYSTALLOGRAPHY;

ACQUIRED IMMUNODEFICIENCY SYNDROME; AMINO ACID SEQUENCE; ANIMALS; ANTIVIRAL AGENTS; BINDING SITES; DRUG DESIGN; HIV PROTEASE; HIV PROTEASE INHIBITORS; HUMANS; MOLECULAR SEQUENCE DATA; OLIGOPEPTIDES; PHENYLBUTYRATES;

EID: 0029943637     PISSN: 00063525     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0282(1996)40:2<235::AID-BIP3>3.0.CO;2-X     Document Type: Article

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