Tryptase inhibition blocks airway inflammation in a mouse asthma model

Journal of Immunology

Volumn 168, Issue 4, 2002, Pages 1992-2000

  Oh, Se Woong ^a   Pae, Chong I ^a   Lee, Dong Keun ^a   Jones, Falaah ^a   Chiang, Gertrude K S ^a   Kim, Hwa Ok ^a   Moon, Sung Hwan ^a   Cao, Bolong ^a   Ogbu, Cyprian ^a   Jeong, Kwang Won ^a   Kozu, Geoffrey ^a   Nakanishi, Hiroshi ^a   Kahn, Michael ^a   Chi, Emil Y ^a   Henderson Jr , William R ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 11A; BLOOD CLOTTING FACTOR 7A; KALLIKREIN; MOL 6131; OVALBUMIN; SERINE PROTEINASE; THROMBIN; TRYPSIN; TRYPTASE; TRYPTASE INHIBITOR; UNCLASSIFIED DRUG; UROKINASE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTHMA; BRONCHUS HYPERREACTIVITY; CONTROLLED STUDY; DRUG TARGETING; ENZYME INHIBITION; EXPERIMENTAL MODEL; INFLAMMATION; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0037083293     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.168.4.1992     Document Type: Article

References (59)

1. Quantitation of histamine, tryptase, and chymase in dispersed human T and TC mast cells
2. Neutral proteases of mast cells
3. Time course of appearance and disappearance of human mast cell tryptase in the circulation after anaphylaxis
4. Immediate and late airway response of allergic rhinitis patients to segmental antigen challenge: Characterization of eosinophil and mast cell mediators
5. Of mites and men: Trypsin-like proteases in the lungs
6. Activation of pulmonary mast cells by bronchoalveolar allergen challenge: In vivo release of histamine and tryptase in atopic subjects with and without asthma
7. Elevated bronchoalveolar lavage fluid histamine levels in allergic asthmatics are associated with increased airway obstruction
8. Bronchoalveolar mast cells in extrinsic asthma: A mechanism for the initiation of antigen specific bronchoconstriction
9. Degradation of airway neuropeptides by human lung tryptase
10. Effects of chronic airway inflammation on the activity and enzymatic inactivation of neuropeptides in guinea pig lungs
11. Human mast cell tryptase attenuates the vasodilator activity of calcitonin gene-related peptide
12. A role for tryptase in the activation of human mast cells: Modulation of histamine release by tryptase and inhibitors of tryptase
13. Granulocyte recruitment by human mast cell tryptase
14. Mast cell tryptase is a mitogen for epithelial cells: Stimulation of IL-8 production and intercellular adhesion molecule-1 expression
15. Synovial procollagenase activation by human mast cell tryptase: Dependence upon matrix metalloproteinase 3 activation
16. Interactions of mast cell tryptase with thrombin receptors and PAR-2
17. Mast cell tryptase regulates rat colonic myocytes through proteinase-activated receptor 2
18. Rat proteinase-activated receptor-2 (PAR-2): cDNA sequence and activity of receptor-derived peptides in gastric and vascular tissue
19. Proteinase-activated receptors: A growing family of heptahelical receptors for thrombin, trypsin and tryptase
20. Inhaled tryptase causes bronchoconstriction in sheep via histamine release
21. Tryptase inhibitors block allergen-induced airway and inflammatory responses in allergic sheep
22. Inhibition of allergen-induced pulmonary responses by the selective tryptase inhibitor 1,5-bis-[4-[(3-carbamimidoyl-benzenesulfonylamino)-methyl]-phenoxy]-pentane (AMG-126737)
23. Potent selective nonpeptidic inhibitors of human lung tryptase
24. Highly efficient and versatile synthesis of libraries of constrained β-strand mimetics
25. Bivalent inhibition of human β-tryptase
26. Human β-tryptase is a ring-like tetramer with active sites facing a central pore
27. Structure of thrombin complexed with selective non-electrophilic inhibitors having cyclohexyl moieties at P1
28. Development of murine allergic asthma is dependent upon B7-2 costimulation
29. Noninvasive measurement of airway responsiveness in allergic mice using barometric plethysmography
30. The importance of leukotrienes in airway inflammation in a mouse model of asthma
31. Dimethylthiourea does not ameliorate reperfusion lung injury in dogs or rabbits
32. Soluble IL-4 receptor inhibits airway inflammation following allergen challenge in a mouse model of asthma
33. Natural protein proteinase inhibitors and their interaction with proteinases
34. The structure of a designed peptidomimetic inhibitor complex of α-thrombin
35. Secondary structure peptide mimetics: Design, synthesis, and evaluation of β-strand mimetic thrombin inhibitors
36. Bis(5-amidino-2-benzimidazolyl)methane and related amidines are potent, reversible inhibitors of mast cell tryptases
37. Lactoferrin, a potent tryptase inhibitor, abolishes late-phase airway responses in allergic sheep
38. Potent induction of a neutrophil and eosinophil-rich infiltrate in vivo by human mast cell tryptase: Selective enhancement of eosinophil recruitment by histamine
39. Neutrophil-activating protein 1/interleukin 8 stimulates the binding activity of the leukocyte adhesion receptor CDI1b/CDI8 on human neutrophils
40. Interleukin-8 is a potent mediator of eosinophil chemotaxis through endothelium and epithelium
41. Expression of macrophage inflammatory protein-2 and KC mRNA in pulmonary inflammation
42. Allergen exposure induces the expression of endothelial adhesion molecules in passively sensitized human bronchus: Time course and the role of cytokines
43. 4 integrin) on intrapulmonary but not circulating leukocytes inhibits airway inflammation and hyperresponsiveness in a mouse model of asthma
44. Requirement for IL-13 independently of IL-4 in experimental asthma
45. A novel role for murine IL-4 in vivo: Induction of MUC5AC gene expression and mucin hypersecretion
46. Interleukin-13: Central mediator of allergic asthma
47. Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production
48. Tryptase, the dominant secretory granular protein in human mast cells, is a potent mitogen for cultured dog tracheal smooth muscle cells
49. Mast cell tryptase causes airway smooth muscle hyperresponsiveness in dogs
50. Mast cell tryptase as a mediator of hyperresponsiveness in human isolated bronchi
51. Mast cell tryptase potentiates histamine-induced contraction in human sensitized bronchus
52. 2 generation in mouse bone marrow-derived mast cells
53. Dissociation of airway hyperresponsiveness from immunoglobulin E and airway eosinophilia in a murine model of allergic asthma
54. Cloning of the cDNA and gene of mouse mast cell protease-6: Transcription by progenitor mast cells and mast cells of the connective tissue subclass
55. Isolation, characterization, and transcription of the gene encoding mouse mast cell protease 7
56. Characterization of genes encoding known and novel human mast cell tryptases on chromosome 16p13.3
57. Influence of the route of allergen administration and genetic background on the murine allergic pulmonary response