Mutants of plasminogen activator inhibitor-1 designed to inhibit neutrophil elastase and cathepsin G are more effective in vivo than their endogenous inhibitors

Journal of Biological Chemistry

Volumn 279, Issue 29, 2004, Pages 29981-29987

  Stefansson, Steingrimur ^a   Yepes, Manuel ^a   Gorlatova, Natalia ^a   Day, Duane E ^b   Moore, Elisabeth G ^a   Zabaleta, Adriana ^a   McMahon, Grainne A ^a   Lawrence, Daniel A ^a  

^a HOLLAND LABORATORY   (United States)

^b Molecular Innovations Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL ORGANS; ENZYME KINETICS; ENZYMES; IMMUNOLOGY; MUTAGENESIS; PHYSIOLOGY;

CONNECTIVE TISSUE; NEUTROPHILS;

CELLS;

ALPHA 1 ANTICHYMOTRYPSIN; CATHEPSIN G; LEUKOCYTE ELASTASE; MUTANT PROTEIN; PLASMINOGEN ACTIVATOR INHIBITOR 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COMPLEX FORMATION; CONNECTIVE TISSUE; CONTROLLED STUDY; DEGRANULATION; ENDOCYTOSIS; ENZYME INHIBITION; HUMAN; IN VIVO STUDY; LUNG ALVEOLUS EPITHELIUM; MALE; NEUTROPHIL; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS; RAT; WILD TYPE;

ALPHA 1-ANTICHYMOTRYPSIN; ALPHA 1-ANTITRYPSIN; ANIMALS; ANIONS; CATHEPSINS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOCYTOSIS; ENDOTHELIAL CELLS; ENZYME INHIBITORS; HUMANS; INFLAMMATION; KINETICS; LEUKOCYTE ELASTASE; LUNG; MALE; MICE; MICE, INBRED C57BL; MUTATION; NEUTROPHILS; PANCREAS; PLASMINOGEN ACTIVATOR INHIBITOR 1; SERINE ENDOPEPTIDASES; TIME FACTORS;

ANIMALIA;

EID: 3242725914     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M401913200     Document Type: Article

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