Cytokines and chemokines in meningeal inflammation: Biology and clinical implications

Clinical Infectious Diseases

Volumn 28, Issue 1, 1999, Pages 1-12

  Täuber, Martin G ^a,b   Moser, Bernhard ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b Institute for Medical Microbiology   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE; CYTOKINE; FORMYLMETHIONYLLEUCYLPHENYLALANINE; GAMMA INTERFERON; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; LEUKOTRIENE DERIVATIVE; PROSTAGLANDIN DERIVATIVE; THROMBOCYTE ACTIVATING FACTOR; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; BACTERIAL MENINGITIS; BLOOD BRAIN BARRIER; BRAIN BLOOD FLOW; BRAIN METABOLISM; CENTRAL NERVOUS SYSTEM INFECTION; CEREBROSPINAL FLUID; DIFFERENTIAL DIAGNOSIS; FUNGAL MENINGITIS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; VIRUS MENINGITIS;

EID: 0032987950     PISSN: 10584838     EISSN: None     Source Type: Journal    
DOI: 10.1086/515079     Document Type: Article

References (109)

1. Tani M, Fuentes ME, Peterson JW, et al. Neutrophil infiltration, glial reaction, and neurological disease in transgenic mice expressing the chemokine N51/KC in oligodendrocytes. J Clin Invest 1996;98:529-39.
2. Waage A, Halstensen A, Shalaby R, Brandtz P, Kierule P, Espevik T. Local production of tumor necrosis factor α, interleukin 1, and interleukin 6 in meningococcal meningitis. J Exp Med 1989;170:1859-67.
3. Mustafa MM, Ramilo O, Olsen KD, et al. Tumor necrosis factor α in mediating experimental Haemophilus influenzae type b meningitis. J Clin Invest 1989;84:1253-9.
4. Tuomanen EI, Saukkonen K, Sande S, Cioffe C, Wright SD. Reduction of inflammation, tissue damage, and mortality in bacterial meningitis in rabbits treated with monoclonal antibodies against adhesion-promoting receptors of leukocytes. J Exp Med 1989;170:959-68.
5. Ramilio O, Saez-Llorens X, Mertsola J, et al. Tumor necrosis factor alpha/cachectin and interleukin 1 beta initiate meningeal inflammation. J Exp Med 1990;172:497-507.
6. Seebach J, Bartholdi D, Frei K, et al. Experimental listeria meningoencephalitis. Macrophage inflammatory protein-1 alpha and -2 are produced intrathecally and mediate chemotactic activity in cerebrospinal fluid of infected mice. J Immunol 1995;155:4367-75.
7. Tang T, Frenette PS, Hynes RO, Wagner DD, Mayadas TN. Cytokine-induced meningitis is dramatically attenuated in mice deficient in endothelial selectins. J Clin Invest 1996;97:2485-90.
8. Quagliarello V, Scheld WM. Bacterial meningitis: pathogenesis, pathophysiology, and progress. N Engl J Med 1992;327:864-72.
9. Fassbender K, Schminke U, Ries S, et al. Endothelial-derived adhesion molecules in bacterial meningitis: association to cytokine release and intrathecal leukocyte-recruitment. J Neuroimmunol 1997;74:130-4.
10. Kornelisse RF, Savelkoul HF, Mulder PH, et al. Interleukin-10 and soluble tumor necrosis factor receptors in cerebrospinal fluid of children with bacterial meningitis. J Infect Dis 1996;173:1498-502.
11. Raziuddin S, el-Awad ME, Telemesani AW, Bilal NE, al-Janadi M. CD4+ Th2 cell response cytokine production in bacterial meningitis. J Clin Immunol 1995;15:338-48.
12. Spanaus KS, Nadal D, Pfister HW, et al. C-X-C and C-C chemokines are expressed in the cerebrospinal fluid in bacterial meningitis and mediate chemotactic activity on peripheral blood-derived polymorphonuclear and mononuclear cells in vitro. J Immunol 1997;158:1956-64.
13. Inaba Y, Ishiguro A, Shimbo T. The production of macrophage inflammatory protein-1-alpha in the cerebrospinal fluid at the initial stage of meningitis in children. Pediatr Res 1997;42:788-93.
14. Paris MM, Hickey SM, Trujillo M, Ahmed A, Olsen K, McCracken GH Jr. The effect of interleukin-10 on meningeal inflammation in experimental bacterial meningitis. J Infect Dis 1997;176:1239-46.
15. van Furth AM, Seijmonsbergen FM, Langermans JA, Groeneveld PH, de Bel CE, van Furth R. High levels of interleukin 10 and tumor necrosis factor alpha in cerebrospinal fluid during onset of bacterial meningitis. Clin Infect Dis 1995;21:220-2.
16. Ishiguro A, Suzuki Y, Inaba Y, Komiyama A, Koeffler HP, Shimbo T. Production of interleukin-10 in the cerebrospinal fluid in aspetic meningitis of children. Pediatr Res 1996;40:610-4.
17. Kornelisse RF, Hack CE, Savelkoul HF, et al. Intrathecal production of interleukin-12 and gamma interferon in patients with bacterial meningitis. Infect Immun 1997;65:877-81.
18. Ossege LM, Voss B, Wiethege T, Sindern E, Malin JP. Detection of transforming growth factor beta 1 mRNA in cerebrospinal fluid cells of patients with meningitis by non-radioactive in situ hybridization. J Neurol 1994;242:14-9.
19. Frei K, Nadal D, Pfister HW, Fontana A. Listeria meningitis: identification of a cerebrospinal fluid inhibitor of macrophage listericidal function as interleukin 10. J Exp Med 1993;178:1255-61.
20. van Deuren M, van der Ven-Jongekrijg J, Vannier E, et al. The pattern of interleukin-1 beta (IL-1 beta) and its modulating agents IL-1 receptor antagonist and IL-1 soluble receptor type II in acute meningococcal infections. Blood 1997;90:1101-8.
21. Møller B, Mogensen BC, Wendelboe P, Bendtzen K, Petersen CM. Bioactive and inactive forms of tumor necrosis factor-alpha in spinal fluid from patients with meningitis. J Infect Dis 1991;163:886-9.
22. Moiler B, Ellermann-Eriksen S, Storgaard M, Obel N, Bendtzen K, Petersen CM. Soluble tumor necrosis factor (TNF) receptor conserves TNF bioactivity in meningitis patient spinal fluid. J Infect Dis 1996;174:557-63.
23. Ramilio O, Mustafa MM, Porter J, et al. Detection of interleukin 1 beta but not tumor necrosis factor-alpha in cerebrospinal fluid of children with aseptic meningitis. Am J Dis Child 1990;144:349-52.
24. Ohga S, Aoki T, Okada K, et al. Cerebrospinal fluid concentrations of interleukin-1 beta, and tumor necrosis factor alpha, interferon gamma in bacterial meningitis. Arch Dis Child 1994;70:123-5.
25. Chavanet P, Bonnotte B, Guiguet M, et al. High concentrations of intrathecal interleukin-6 in human bacterial and non-bacterial meningitis. J Infect Dis 1992;166:428-31.
26. Torre D, Zeroli C, Ferraro G, et al. Cerebrospinal fluid levels of IL-6 in patients with acute infections of the central nervous system. Scand J Infect Dis 1992;24:787-91.
27. Gallo P, Sivieri S, Rinaldi L, et al. Intrathecal synthesis of interleukin-10 (IL-10) in viral and inflammatory diseases of the central nervous system. J Neurol Sci 1994;126:49-53.
28. Ossege LM, Sindern E, Voss B, Malin JP. Expression of tumor necrosis factor-alpha and transforming growth factor-beta-1 in cerebrospinal fluid cells in meningitis. J Neurol Sci 1996;144:1-13.
29. Sprenger H, Rosler A, Tonn P, Braune HJ, Huffmann G, Gemsa D. Chemokines in the cerebrospinal fluid of patients with meningitis. Clin Immunol Immunopathol 1996;80:155-61.
30. Lopez-Cortez LF, Cruz-Ruiz M, Gomez-Mateos J, Viciana-Fernandez P, Martinez-Marcos FJ, Pachon J. Interleukin-8 in cerebrospinal fluid from patients with meningitis of different etiologies: its possible role as neutrophil chemotactic factor. J Infect Dis 1995;172:581-4.
31. Yokoyama T, Oda M, Ogura S, Horiuchi T, Seino Y. Relationship of interleukin-8 and colony-stimulating factors to neutrophil migration in aspetic meningitis. Acta Paediatr 1996;85:303-7.
32. Gallo P, Frei K, Rordorf C, Lazdins J, Tavolato B, Fontana A. Human immunodeficiency virus type 1 (HIV-1) infection of the central nervous system: an evaluation of cytokines in cerebrospinal fluid. J Neuroimmunol 1989;23:109-16.
33. Perrella O, Carrieri PB, Guarnaccia D, Soscia M. Cerebrospinal fluid cytokines in AIDS dementia complex. J Neurol 1992;239:387-8.
34. Bernasconi S, Cinque P, Peri G, et al. Selective elevation of monocyte chemotactic protein-1 in the cerebrospinal fluid of AIDS patients with cytomegalovirus encephalitis. J Infect Dis 1996;174:1098-101.
35. Donald PR, Schoeman JF, Beyers N, et al. Concentrations of interferon gamma, tumor necrosis factor alpha, and interleukin-1 beta in the cerebrospinal fluid of children treated for tuberculous meningitis. Clin Infect Dis 1995;21:924-9.
36. Mastroianni CM, Paoletti F, Lichtner M, D'Agostino C, Vullo V, Delia S. Cerebrospinal fluid cytokines in patients with tuberculous meningitis. Clin Immunol Immunopathol 1997;84:171-6.
37. Rydberg J, Miorner H, Chandramuki A, Lantz M. Assessment of a possible imbalance between tumor necrosis factor (TNF) and soluble TNF receptor forms in tuberculous infection of the central nervous system. J Infect Dis 1995;172:301-4.
38. Mastroianni CM, Paoletti F, Rivosecchi RM, et al. Cerebrospinal fluid interleukin 8 in children with purulent bacterial and tuberculous meningitis. Pediatr Infect Dis J 1994;13:1008-10.
39. Ampel NM, Ahmann DR, Delgado KL, Galgiani JN, Cloud GA, National Institute of Allergy and Infectious Diseases Mycosis Study Group. Tumor necrosis factor-α and interleukin-β in cerebrospinal fluid of patients with coccidioidal meningitis during therapy with fluconazole. J Infect Dis 1995;171:1675-8.
40. Chaka WS, Heyderman R, Gangaidzo I, et al. Cytokine profiles in cerebrospinal fluid of human immunodeficiency virus-infected patients with cryptococcal meningitis: no leukocytosis despite high interleukin-8 levels. J Infect Dis 1997;176:1633-6.
41. Leist TP, Frei K, Kam-Hansen S, Zinkernagel RM, Fontana A. Tumor necrosis factor alpha in cerebrospinal fluid during bacterial, but not viral, meningitis. Evaluation in murine model infections and patients. J Exp Med 1988;167:1743-8.
42. van Deuren M, van der Ven-Jongekrijg J, Bartelink AK, van Dalen R, Sauerwein RW, van der Meer JW. Correlation between proinflammatory cytokines and antiinflammatory mediators and the severity of disease in meningococcal infections. J Infect Dis 1995;172:433-9.
43. Banks WA, Kastin AJ, Broadwell RD. Passage of cytokines across the blood-brain barrier. Neuroimmunomodulation 1995;2:241-8.
44. Medana IM, Hunt NH, Chaudhri G. Tumor necrosis factor alpha expression in the brain during fatal murine cerebral malaria: evidence for production by microglia and astrocytes. Am J Pathol 1997;150:1473-86.
45. Chao CC, Hu S, Close K, et al. Cytokine release from microglia: differential inhibition by pentoxifylline and dexamethasone. J Infect Dis 1993;166:847-53.
46. Hunter CA, Roberts CW, Murray M, Alexander J. Detection of cytokine mRNA in the brains of mice with toxoplasma encephalitis. Parasite Immunol 1992;14:405-13.
47. Diab A, Zhu J, Linquist L, Wretlind B, Bakhiet M, Link H. Haemophilus influenzae and Streptococcus pneumoniae induce different intracerebral mRNA cytokine patterns during the course of experimental bacterial meningitis. Clin Exp Immunol 1997;109:233-41.
48. Tarlow MJ, Jenkins R, Comis SD, et al. Ependymal cells of the choroid plexus express tumor necrosis factor-alpha. Neuropathol Appl Neurobiol 1993;19:324-8.
49. Bitsch A, Trostdorf F, Bruck W, Schmidt H, Fischer FR, Nau R. Central nervous system TNF-alpha-mRNA expression during rabbit experimental pneumococcal meningitis. Neurosci Lett 1997;237:105-8.
50. Zysk G, Bruck W, Huitinga I, et al. Elimination of blood-derived macrophages inhibits the release of interleukin-1 and the entry of leukocytes into the cerebrospinal fluid in experimental pneumococcal meningitis. J Neuroimmunol 1997;73:77-80.
51. Navika V, Haglund M, Link J, et al. Cytokine mRNA profile in mononuclear cells in acute aseptic meningoencephalitis. Infect Immun 1995;63:1581-6.
52. Quagliarello VJ, Wispelwey B, Long WJ, Scheld WM. Recombinant human interleukin-1 induces meningitis and blood-brain barrier injury in the rat. J Clin Invest 1991;87:1360-6.
53. Kim KS, Wass CA, Cross AS, Opal SM. Modulation of blood-brain barrier permeability by tumor necrosis factor and antibody to tumor necrosis factor in the rat. Lymphokine Cytokine Res 1992;11:293-8.
54. Saukkonen K, Sande S, Cioffe C, et al. The role of cytokines in the generation of inflammation and tissue damage in experimental gram-positive meningitis. J Exp Med 1990;171:439-48.
55. Sharief MK, Ciardi M, Thompson EJ. Blood-brain barrier damage in patients with bacterial meningitis: association with tumor necrosis factor-α but not interleukin-1β. J Infect Dis 1992;166:350-8.
56. Täuber MG. Brain edema, intracranial pressure and cerebral blood flow in bacterial meningitis. Pediatr Infect Dis J 1989;8:915-7.
57. Thomas VH, Hopkins IJ. Arteriographic demonstration of vascular lesions in the study of neurologic deficit in advanced Haemophilus influenzae meningitis. Dev Med Child Neurol 1972;14:783-7.
58. Pfister HW, Borasio GD, Dirnagl U, Bauer M, Einhäupl KM. Cerebrovascular complications of bacterial meningitis in adults. Neurology 1992;42:1497-504.
59. Leib SL, Kim YS, Chow LL, Sheldon RA, Täuber MG. Reactive oxygen intermediates contribute to necrotic and apoptotic neuronal injury in an infant rat model of bacterial meningitis due to group B streptococci. J Clin Invest 1996;98:2632-9.
60. Leib SL, Kim YS, Black SM, Tureen JH, Täuber MG. Inducible nitric oxide synthase and the effect of aminoguanidine in experimental neonatal meningitis. J Infect Dis 1998;177:692-700.
61. Cairns H, Russell DS. Cerebral arteritis and phlebitis in pneumococcal meningitis. J Pathol Bacteriol 1946;58:649-65.
62. Tureen JH, Dworkin RJ, Kennedy SL, Sachdeva M, Sande MA. Loss of cerebrovascular autoregulation in experimental meningitis in rabbits. J Clin Invest 1990;85:577-81.
63. Tureen JH, Tauber MG, Sande MA. Effect of hydration status on cerebral blood flow and cerebrospinal fluid lactic acidosis in rabbits with experimental meningitis. J Clin Invest 1992;89:947-53.
64. Fassbender K, Ries S, Schminke U, Schneider S, Hennerici M. Inflammatory cytokines in CSF in bacterial meningitis: association with altered blood flow velocity in basal cerebral arteries. J Neurol Neurosurg Psychiatry 1996;61:57-61.
65. Tureen J. Effect of recombinant human tumor necrosis factor-alpha on cerebral oxygen uptake, cerebrospinal fluid lactate, and cerebral blood flow in the rabbit: role of nitric oxide. J Clin Invest 1995;95:1086-91.
66. van Furth AM, Seijmonsbergen EM, Groeneveld PH, van Furth R, Langermans JA. Levels of nitric oxide correlate with high levels of tumor necrosis factor alpha in cerebrospinal fluid samples from children with bacterial meningitis. Clin Infect Dis 1996;22:876-8.
67. Kim YS, Kennedy S, Täuber MG. Toxicity of Streptococcus pneumoniae in neurons, astrocytes, and microglia in vitro. J Infect Dis 1995;171:1363-9.
68. Hu S, Martella A, Anderson R, Chao CC. Role of cytokines in lipopolysaccharide-induced functional and structural abnormalities of astrocytes. Glia 1994;10:227-34.
69. 2+ and induces a depolarization in cultured astroglial cells. Brain 1996;119:2021-7.
70. Koller H. TNF alpha in cerebrospinal fluid of meningitis patients reduces astrocyte membrane potential. J Neuroimmunol 1997;76:185-8.
71. Bogdan I, Leib SL, Chow L, Täuber MG. Tumor necrosis factor-α contributes to apoptosis of hippocampal neurons in experimental meningitis due to group B streptococcus. J Infect Dis 1997;176:693-7.
72. Free SL, Li LM, Fish DR, Shorvon SD, Stevens JM. Bilateral hippocampal volume loss in patients with a history of encephalitis or meningitis. Epilepsia 1996;37:400-5.
73. Akalin H, Akdis AC, Mistik R, Helvaci S, Kilicturgay K. Cerebrospinal fluid interleukin 1β/interleukin-1 receptor antagonist balance and tumor necrosis factor-alpha concentrations in tuberculous, viral, and acute bacterial meningitis. Scand J Infect Dis 1994;26:667-4.
74. Lopez-Cortez LF, Cruz-Ruiz M, Gomez-Mateos J, Jimenez-Hernandez D, Palomino J, Jimenez E. Measurement of levels of tumor necrosis factor-alpha and interleukin-1 beta in the CSF of patients with meningitis of different etiologies: utility in the differential diagnosis. Clin Infect Dis 1993;16:534-9.
75. Gilmaker M, Krasbjerg P, Forsgren M, Olcen P. Tumor necrosis factor-alpha in cerebrospinal fluid from patients with meningitis of different etiologies: high levels of TNF alpha predict bacterial meningitis. J Infect Dis 1993;167:882-9.
76. Dulkerian SJ, Kilpatrick L, Costarino AT, et al. Cytokine elevations in infants with bacterial and aseptic meningitis. J Pediatr 1995;126:872-6.
77. Hashim IA, Walsh A, Hart CA, Shenkin A. Cerebrospinal fluid interleukin-6 and its diagnostic value in the investigation of meningitis. Ann Clin Biochem 1995;32:289-96.
78. Lopez-Cortes LF, Cruz-Ruiz M, Gomez-Mateos J, Jimenez-Hernandez D, Viciana-Fernandez P, Jemenez-Menjias E. Interleukin-6 in cerebro-spinal fluid of patients with meningitis is not a useful diagnostic marker in the differential diagnosis of meningitis. Ann Clin Biochem 1997;34(part 2):165-9.
79. Seki T, Joh K, Oh-ishi T. Augmented production of interleukin-8 in cerebrospinal fluid in bacterial meningitis. Immunology 1993;80:333-5.
80. Ostergaard C, Benefield TL, Sellerbjerg F, Kronborg G, Lohse N, Lundgren JD. Interleukin-8 in cerebrospinal fluid from patients with septic and aspetic meningitis. Eur J Clin Microbiol Infect Dis 1996;15:166-9.
81. Spanos A, Harrell FE, Durack DT. Differential diagnosis of acute meningitis - an analysis of the predictive value of initial observation. JAMA 1989;262:2700-7.
82. Hoen B, Viel JF, Paquot C, Gerard A, Canton P. Multivariate approach to differential diagnosis of acute meningitis. Eur J Clin Microbiol Infect Dis 1995;14:267-74.
83. Mustafa MM, Lebel MH, Ramilo O, et al. Correlation of interleukin-1β and cachectin concentrations in cerebrospinal fluid and outcome from bacterial meningitis. J Pediatr 1989;115:208-13.
84. Mustafa MM, Mertsola J, Ramilo O, Saez-Llorens X, Risser RC, McCracken GH Jr. Increased endotoxin and interleukin 1β concentrations in cerebrospinal fluid of infants with coliform meningitis and ventriculitis associated with intraventricular gentamicin therapy. J Infect Dis 1989;160:891-5.
85. Arditi M, Manogue KR, Caplan M, Yogev R. Cerebrospinal fluid cachectin/tumor necrosis factor-α and platelet-activating factor concentrations and severity of bacterial meningitis in children. J Infect Dis 1990;162:139-47.
86. Ichiyama T, Hayashi T, Furukawa S. Cerebrospinal fluid concentrations of soluble tumor necrosis factor receptor in bacterial and aseptic meningitis. Neurology 1996;46:837-8.
87. Ichiyama T, Hayashi T, Nishikawa M, Furuka S. Levels of transforming growth factor β1, tumor necrosis factor α, and interleukin 6 in cerebrospinal fluid: association with clinical outcome for children with bacterial meningitis. Clin Infect Dis 1997;25:328-9.
88. Westendorp RG, Langermans JA, Huizinga TW, et al. Genetic influence on cytokine production and fatal meningococcal disease. Lancet 1997;349:170-3.
89. van Furth AM, Roord JJ, van Furth R. Roles of proinflammatory and antiinflammatory cytokines in pathophysiology of bacterial meningitis and effect of adjunctive therapy. Infect Immun 1996;64:4883-90.
90. Velasco S, Tarlow M, Olsen K, Shay JW, McCracken GH Jr, Nisen PD. Temperature-dependent modulation of lipopolysaccharide-induced interleukin-1β and tumor necrosis factor α expression in cultured human astroglial cells by dexamethasone and indomethacin. J Clin Invest 1991;87:1674-80.
91. Täuber MG, Khayam-Bashi H, Sande MA. Effects of ampicillin and corticosteroids on brain water content, CSF pressure, and CSF lactate in experimental pneumococcal meningitis. J Infect Dis 1985;151:528-34.
92. Syrogiannopoulos GA, Olsen KD, Reisch JS, McCracken GH Jr. Dexamethasone in the treatment of experimental Haemophilus influenzae type b meningitis. J Infect Dis 1987;155:213-9.
93. Saez-Llorens X, Jafari HS, Severien C, et al. Enhanced attenuation of meningeal inflammation and brain edema by concomitant administration of anti-CD18 monoclonal antibodies and dexamethasone in experimental Haemophilus influenzae meningitis. J Clin Invest 1991;88:2003-11.
94. Lebel MH, Freij BJ, Syrogiannopoulos GA, et al. Dexamethasone therapy for bacterial meningitis. Results of two double-blind, placebo-controlled trials. N Engl J Med 1988;319:364-71.
95. Lebel MH, Hoyt MJ, Waagner DC, Rollins NK, Finitzo T, McCracken GH Jr. Magnetic resonance imaging and dexamethasone therapy for bacterial meningitis. Am J Dis Child 1989;143:301-6.
96. Schaad UB, Lips U, Gnehm HE, Blumberg A, Heinzer I, Wedgwood J. Dexamethasone therapy for bacterial meningitis in children. Lancet 1993;342:457-61.
97. Odio CM, Faingezicht I, Paris M, et al. The beneficial effects of early dexamethasone administration in infants and children with bacterial meningitis. N Engl J Med 1991;324:1525-31.
98. King SM, Law B, Langley JM, Heurter H. Dexamethasone for bacterial meningitis: better never than late? Can J Infect Dis 1994;5:1-7.
99. Wald ER, Kaplan SL, Mason EO, et al. Dexamethasone therapy for children with bacterial meningitis. Pediatrics 1995;95:21-8.
100. Kilpi T, Peltola H, Jauhiainen T, Kallio MJT. Oral glycerol and intravenous dexamethasone in preventing hearing impairment due to childhood bacterial meningitis. Pediatr Infect Dis J 1995;14:270-8.
101. Girgis NI, Farid Z, Mikhail IA, Farrag I, Sultan Y, Kilpatrick ME. Dexamethasone treatment for bacterial meningitis in children and adults. Pediatr Infect Dis J 1989;8:848-51.
102. Kanra GY, Ozen H, Secmeer G, Ceyhan M, Ecevit Z, Belgin E. The beneficial effect of dexamethasone in children with pneumococcal meningitis. Pediatr Infect Dis J 1995;14:490-4.
103. Ciana G, Parmar N, Antonio C, Pivetta S, Tamburlini G, Cuttini M. Effectiveness of adjunctive treatment with steroids in reducing short-term mortality in a high-risk population of children with bacterial meningitis. J Trop Paediatr 1995;41:164-8.
104. McIntyre PB, Berkey CS, King SM, et al. Dexamethasone as adjunctive therapy in bacterial meningitis. A meta-analysis of randomized clinical trials since 1988. JAMA 1997;278:925-31.
105. Saez-Llorens X, Ramilo O, Mustafa MM, et al. Pentoxifylline modulates meningeal inflammation in experimental bacterial meningitis. Antimicrob Agents Chemother 1990;34:837-43.
106. Burroughs M, Tsenova-Berkova L, Sokol K, Ossig J, Tuomanen E, Kaplan G. Effect of thalidomide on the inflammatory response in cerebrospinal fluid in experimental bacterial meningitis. Microb Pathog 1995;19:245-55.
107. Paris MM, Friedland IR, Ehrett S, et al. Effect of interleukin-1 receptor antagonist and soluble tumor necrosis factor receptor in animal models of infection. J Infect Dis 1995;171:161-9.
108. Leib SL, Kim SY, Ferriero DM, Täuber MG. Neuroprotective effect of excitatory amino acid antagonist kynurenic acid in experimental bacterial meningitis. J Infect Dis 1996;173:166-71.
109. Quagliarello VJ, Scheld WM. Treatment of bacterial meningitis. N Engl J Med 1997;336:708-16.