Endogenous serine protease inhibitor modulates epileptic activity and hippocampal long-term potentiation

Journal of Neuroscience

Volumn 17, Issue 12, 1997, Pages 4688-4699

  Lüthi, Andreas ^a,f   Van Der Putten, Herman ^b   Botteri, Florence M ^e   Mansuy, Isabelle M ^e,g   Meins, Marita ^e   Frey, Uwe ^c   Sansig, Gilles ^b   Portet, Chantal ^b   Schmutz, Markus ^b   Schröder, Markus ^b   Nitsch, Cordula ^d   Laurent, Jean Paul ^a   Monard, Denis ^e  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

^b NOVARTIS PHARMA AG   (Switzerland)

^c LEIBNIZ INSTITUTE FOR NEUROBIOLOGY   (Germany)

^d UNIVERSITY OF BASEL   (Switzerland)

^e FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH   (Switzerland)

^f UNIVERSITY OF BRISTOL   (United Kingdom)

^g Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain   (United States)

Author keywords

Epileptiform activity; Knock out and transgenic mice; Long term potentiation; Protease modulation; Protease nexin 1; Synaptical activity

Indexed keywords

4 AMINOBUTYRIC ACID; COMPLEMENTARY DNA; DNA FRAGMENT; GLUTAMATE RECEPTOR AGONIST; KAINIC ACID; MESSENGER RNA; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PROTEASE NEXIN I; SERINE PROTEINASE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CONTROLLED STUDY; EPILEPTIC DISCHARGE; HIPPOCAMPUS; HISTOLOGY; LONG TERM POTENTIATION; MOUSE; NERVE CELL EXCITABILITY; NERVE CELL PLASTICITY; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; SYNAPTIC TRANSMISSION; TRANSGENIC MOUSE; VOLTAGE CLAMP;

EID: 16944366420     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.17-12-04688.1997     Document Type: Article

References (21)

1. Alger BE, Nicoll RA (1982) Feed-forward dendritic inhibition in rat hippocampal pyramidal cells studied in vitro. J Physiol (Lond) 328:105-123.
2. Anderson WW, Swartzwelder HS, Wilson WA (1987) The NMDA receptor antagonist 2-amino-5-phosphonovalerate blocks stimulus train-induced epileptogenesis but not epileptiform bursting in the rat hippocampal slice. J Neurophysiol 57:1-21.
3. Baker JB, Low DA, Simmer RL, Cunningham DD (1980) Protease nexin: a cellular component that links thrombin and plasminogen activator and mediates their binding to cells. Cell 21:37-45.
4. Blanton M, LoTurco J, Kriegstein A (1990) Whole-cell recording from neurons in slices of reptilian and mammalian cortex. J Neurosci Methods 30:203-210.
5. Bliss TVP, Collingridge GL (1993) A synaptic model of memory: long-term potentiation in the hippocampus. Nature 361:31-39.
6. Botteri FM, van der Putten H, Wong DF, Sauvage CA, Evans RM (1987) Unexpected thymic hyperplasia in transgenic mice harboring a neuronal promoter fused with simian virus 40 large T antigen. Mol Cell Biol 7:3178-3184.
7. Buhl EH, Otis TS, Mody I (1996) Zinc-induced collapse of augmented inhibition by GABA in a temporal lobe epilepsy model. Science 271:369-373.
8. 2+/ calmodulin-dependent kinase-II α-subunit mutation. Proc Natl Acad Sci USA 92:6852-6855.
9. Carmignoto G, Vicini S (1992) Activity-dependent decrease in NMDA receptor responses during development of the visual cortex. Science 258:1007-1011.
10. Chamak B, Morandi V, Mallat M (1994) Brain macrophages stimulate neurite outgrowth and regeneration by secreting thrombospondin. J Neurosci Res 38:221-233.
11. Chen BM, Grinnell AD (1995) Integrins and modulation of transmitter release from motor nerve terminals by stretch. Science 269:1578-1580.
12. Chen S, Botteri FM, van der Putten H, Landel CP, Evans GA (1987) A lymphoproliferative abnormality associated with inappropriate expression of the Thy-1 antigen in transgenic mice. Cell 51:7-19.
13. Collinge J, Whittington MA, Sidle KCL, Smith CJ, Palmer MS, Clarke AR, Jefferys JGR (1994) Prion protein is necessary for normal synaptic function. Nature 370:295-297.
14. Crair MC, Malenka RC (1995) A critical period for long-term potentiation at thalamocortical synapses. Nature 375:325-328.
15. Davies CH, Davies SN, Collingridge GL (1990) Paired-pulse depression of monosynaptic GABA-mcdiated inhibitory postsynaptic responses in rat hippocampus. J Physiol (Lond) 424:513-531.
16. DeFreitas MF, Yoshida CK, Frazier WA, Mendrick DL, Kypta RM, Reichardt LF (1995) Identification of integrin α3 β1 as a neuronal thrombospondin receptor mediating neurite outgrowth. Neuron 15:333-343.
17. Dihanich M, Kaser M, Reinhard E, Cunningham D, Monard D (1991) Prothrombin mRNA is expressed by cells of the nervous system. Neuron 6:575-581.
18. Masukawa LM, Higashima M, Hart GJ, Spencer DD, O'Connor MJ (1991) NMDA receptor activation during epileptiform responses in the dentate gyrus of epileptic patients. Brain Res 562:176-180.
19. McDonald JW, Johnston MV (1990) Physiological and pathophysiological roles of excitatory amino acids during central nervous system development. Brain Res Rev 15:41-70.
20. McNamara JO (1994) Cellular and molecular basis of epilepsy. J Neurosci 14:3413-3425.
21. Meier CL, Dudek FE (1993) Spontaneous and stimulus-induced synchronized afterdischarges in the isolated CA1 of kainate-treated rats. Soc Neurosci Abstr 33:1464.