Activity of Recombinant Dengue 2 Virus NS3 Protease in the Presence of a Truncated NS2B Co-factor, Small Peptide Substrates, and Inhibitors

Journal of Biological Chemistry

Volumn 276, Issue 49, 2001, Pages 45762-45771

  Leung, Donmienne ^a   Schroder, Kate ^a   White, Helen ^a   Fang, Ning Xia ^a   Stoermer, Martin J ^a   Abbenante, Giovanni ^a   Martin, Jennifer L ^a   Young, Paul R ^a   Fairlie, David P ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME IMMOBILIZATION; ESCHERICHIA COLI; GLYCEROL; PROTEINS; SUBSTRATES; VIRUSES;

PROTEASE INHIBITORS;

DISEASES;

APROTININ; PROTEINASE; RECOMBINANT ENZYME; SERINE PROTEINASE INHIBITOR; UNCLASSIFIED DRUG; VIRUS ENZYME; VIRUS NS3 PROTEASE; NS2B PROTEIN, FLAVIVIRUS; PEPTIDE; PRIMER DNA; PROTEINASE INHIBITOR; RECOMBINANT PROTEIN; VIRUS PROTEIN;

ARTICLE; COMPETITIVE INHIBITION; DENGUE VIRUS; ENZYME ACTIVITY; ESCHERICHIA COLI; FLAVIVIRUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROCESSING; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; CHEMISTRY; ENZYME SPECIFICITY; GENETICS; KINETICS; METABOLISM; NUCLEOTIDE SEQUENCE; POLYACRYLAMIDE GEL ELECTROPHORESIS;

DENGUE VIRUS; DENGUE VIRUS TYPE 2; ESCHERICHIA COLI; FLAVIVIRUS; RNA VIRUSES;

BASE SEQUENCE; DNA PRIMERS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; KINETICS; PEPTIDES; PROTEASE INHIBITORS; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY; SUPPORT, NON-U.S. GOV'T; VIRAL NONSTRUCTURAL PROTEINS;

EID: 0035824539     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M107360200     Document Type: Article

References (39)

1. Jacobs, M. G., and Young, P. R. (1998) Curr. Opin. Infect. Dis. 11, 319-324
2. Chambers, T. J., Hahn, C. S., Galler, R., and Rice, C. M. (1990) Annu. Rev. Microbiol. 44, 649-688
3. Falgout, B., Pethel, M., Zhang, Y. M., and Lai, C. J. (1991) J. Virol. 65, 2467-2475
4. Wengler, G., and Wengler, G. (1991) Virology 184, 707-715
5. Li, H. T., Clum, S., You, S. H., Ebner, K. E., and Padmanabhan, R. (1999) J. Virol. 73, 3108-3116
6. Bazan, J. F., and Fletterick, R. J. (1989) Virology 171, 637-639
7. Bazan, J. F., and Fletterick, R. J. (1990) Semin. Virol. 1, 311-322
8. Gorbalenya, A. E., Donchenko, A. P., Koonin, E. V., and Blinov, V. M. (1989) Nucleic Acids Res. 17, 3889-3897
9. Chambers, T. J., Weir, R. C., Grakoui, A., McCourt, D. W., Bazan, J. F., Fletterick, R. J., and Rice, C. M. (1990) Proc. Natl. Acad. Sci. U. S. A. 87, 8898-8902
10. Preugschat, F., Yao, C. W., and Strauss, J. H. (1990) J. Virol. 64, 4364-4374
11. Preugschat, F., Lenches, E. M., and Strauss, J. H. (1991) J. Virol. 65, 4749-4758
12. Falgout, B., and Markoff, L. (1995) J. Virol. 69, 7232-7243
13. Speight, G., Coia, G., Parker, M. D., and Westaway, E. G. (1988) J. Gen. Virol. 69, 23-34
14. Nowak, T., Farber, P. M., Wengler, G., and Wengler, G. (1989) Virology 169, 365-376
15. Stadler, K., Allison, S. L., Schalich, J., and Heinz, F. X. (1997) J. Virol. 71, 8475-8481
16. Falgout, B., Miller, R. H., and Lai, C. J. (1993) J. Virol. 67, 2034-2042
17. Clum, S., Ebner, K. E., and Padmanabhan, R. (1997) J. Biol. Chem. 272, 30715-30723
18. Yusof, R., Clum, S., Wetzel, M., Krishna Murthy, H. M., and Padmanabhan, R. (2000) J. Biol. Chem. 275, 9963-9969
19. Leung, D., Abbenante, G., and Fairlie, D. P. (2000) J. Med. Chem. 43, 305-341
20. Seife, C. (1997) Science 277, 1602-1603
21. Ripka, A. S., and Rich, D. H. (1998) Curr. Opin. Chem. Biol. 2, 441-452
22. Kempf, D. J., and Sham, H. L. (1996) Curr. Pharm. Des. 2, 225-246
23. West, M. L., Fairlie, D. P. (1995) Trends Pharmacol. Sci. 16, 67-75
24. Abbenante, G., Leung, D., Bond, T., and Fairlie, D. P. (2001) Lett. Pept. Sci., in press
25. Webb, T. R., Reiner, J. E., Tamura, S. Y., Ripka, W. C., and Dagnino, R., Jr. (May 7, 1996) U.S. Patent 5,514,777
26. Ripka, W. C., Webb, T. R., Dagnino, R., Jr., Nutt, R. F., Reiner, J. E., and Tamura, S. Y. (March 24, 1998) U.S. Patent 5,731,413
27. Tamura, S. Y., Semple, J. E., Ardecky, R. J., Leon, P., Carpenter, S. H., Yu, G., Shamblin, B. M., Weinhouse, M. I., Ripka, W. C., and Nutt, R. F. (1996) Tetrahedron Lett. 37, 4109-4112
28. Semple, J. E., Minami, N. K., Tamura, S. Y., Brunck, T. K., Nutt, R. F., and Ripka, W. C. (1997) Bioorg. Med. Chem. Lett. 7, 2421-2426
29. Brinkworth, R. I., Fairlie, D. P., Leung, D., and Young, P. R. (1999) J. Gen. Virol. 80, 1167-1177
30. Steinkuhler, C., Tomei, L., and De Francesco, R. (1996) J. Biol. Chem. 271, 6367-6373
31. Steinkuhler, C., Urbani, A., Tomei, L., Biasiol, G., Sardana, M., Bianchi, E., Pessi, A., and De Francesco, R. (1996) J. Virol. 70, 6694-6700
32. Droll, D. A., Murthy, H. M. K., and Chambers, T. J. (2000) Virology 275, 335-347
33. Edwards, P. D., and Bernstein, P. R. (1994) Med. Res. Rev. 14, 127-194
34. Babine, R. E., and Bender, S. L. (1997) Chem. Rev. 97, 1359-1472
35. Han, W., Hu, Z., Jiang, X., and Decicco, C. P. (2000) Bioorg. Med. Chem. Lett. 10, 711-713
36. Bennett, J. M., Campbell, A. D., Campbell, A. J., Carr, M. G., Dunsdon, R. M., Greening, J. R., Hurst, D. N., Jennings, N. S., Jones, P. S., Jordan, S., Kay, P. B., O'Brien, M. A., King-Underwood, J., Raynham, T. M., Wilkinson, C. S., Wilkinson, T. C., and Wilson, F. X. (2001) Bioorg. Med. Chem. Lett. 11, 355-357
37. Leung, D. (2001) Studies of Serine and Cysteine Protease Inhibitors. Ph.D. Dissertation, University of Queensland, Brisbane, Australia
38. Murthy, H. M., Clum, S., and Padmanabhan, R. (1999) J. Biol. Chem. 274, 5573-5580
39. Murthy, H. M., Judge, K., DeLucas, L., and Padmanabhan, R. (2000) J. Mol. Biol. 301, 759-767