The thrombin E192Q-BPTI complex reveals gross structural rearrangements: Implications for the interaction with antithrombin and thrombomodulin

EMBO Journal

Volumn 16, Issue 11, 1997, Pages 2977-2984

  Van De Locht, Andreas ^a   Bode, Wolfram ^a   Huber, Robert ^a   Le Bonniec, Bernard F ^b,e   Stone, Stuart R ^c   Esmon, Charles T ^d   Stubbs, Milton T ^f  

^a MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c MONASH UNIVERSITY   (Australia)

^d HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^e INSERM   (France)

^f PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

Antithrombin; Conformational change; Kunitz inhibitor; Thrombin; Thrombomodulin

Indexed keywords

ANTITHROMBIN; APROTININ; THROMBIN; THROMBOMODULIN;

ARTICLE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME CONFORMATION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN PROTEIN INTERACTION;

ANTITHROMBIN III; APROTININ; CRYSTALLOGRAPHY; HUMANS; HYDROGEN BONDING; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN CONFORMATION; THROMBIN; THROMBOMODULIN;

EID: 0030959346     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/16.11.2977     Document Type: Article

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