MTI-MMP expression promotes tumor growth and angiogenesis through an up-regulation of vascular endothelial growth factor expression

FASEB Journal

Volumn 16, Issue 6, 2002, Pages 555-564

  Sounni, N E ^a,b   Devy, L ^a,b   Hajitou, A ^a,b   Frankenne, F ^a,b   Munaut, C ^a,b   Gilles, C ^a,b   Deroanne, C ^a,b   Thompson, E W ^a,b   Foidart, J M ^a,b   Noel, A ^a,b  

^a UNIVERSITY OF LIÈGE   (Belgium)

^b ST VINCENT'S INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

Matrix metalloproteinases; MCF7 cells; MT1 MMP; Overexpression; VEGF

Indexed keywords

ANGIOGENESIS INHIBITOR; COMPLEMENTARY DNA; GELATINASE A; MATRIGEL; MATRIX METALLOPROTEINASE 14; MEMBRANE PROTEIN; VASCULOTROPIN; VASCULOTROPIN INHIBITOR; ENDOTHELIAL CELL GROWTH FACTOR; LYMPHOKINE; MATRIX METALLOPROTEINASE; MESSENGER RNA; METALLOPROTEINASE; MMP14 PROTEIN, MOUSE; VASCULOTROPIN A;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST ADENOCARCINOMA; CONTROLLED STUDY; DNA TRANSFECTION; ENZYME ACTIVATION; EXTRACELLULAR MATRIX; FEMALE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; NUDE MOUSE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSCRIPTION REGULATION; TUMOR CELL; TUMOR GROWTH; VASCULAR RING; ANIMAL; AORTA; BIOSYNTHESIS; CANCER TRANSPLANTATION; CELL CLONE; CELL CULTURE; CELL DIVISION; CELL MOTION; CULTURE TECHNIQUE; EXPERIMENTAL NEOPLASM; GENETIC TRANSFECTION; GENETICS; IN VITRO STUDY; METABOLISM; NEOVASCULARIZATION (PATHOLOGY); PATHOLOGY; PHYSIOLOGY; RAT; TRANSACTIVATION; UPREGULATION; VASCULARIZATION;

ANIMALIA; MUS MUSCULUS;

ANIMALS; AORTA; CELL DIVISION; CELL MOVEMENT; CLONE CELLS; CULTURE TECHNIQUES; ENDOTHELIAL GROWTH FACTORS; FEMALE; HUMANS; LYMPHOKINES; MAMMARY NEOPLASMS, EXPERIMENTAL; MATRIX METALLOPROTEINASE 14; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASES, MEMBRANE-ASSOCIATED; METALLOENDOPEPTIDASES; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; NEOVASCULARIZATION, PATHOLOGIC; RATS; RNA, MESSENGER; TRANS-ACTIVATION (GENETICS); TRANSFECTION; TUMOR CELLS, CULTURED; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 18344366604     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.01-0790com     Document Type: Article

References (44)

1. Emerging roles for proteinases in cancer
2. Matrix metalloproteinases: Multifunctional contributors to tumor progression
3. Matrix metalloproteinases in angiogenesis: A moving target for therapeutic intervention
4. A matrix metalloproteinase expressed on the surface of invasive tumour cells
5. Membrane-type matrix metalloproteinases 1 and 2 exhibit broad-spectrum proteolytic capacities comparable to many matrix metalloproteinases
6. Membrane type 1 matrix metalloproteinase digests interstitial collagens and other extracellular matrix macromolecules
7. Role of cell surface metalloprotease MT1-MMP in epithelial cell migration over laminin-5
8. Matrix metalloproteinases regulate neovascularization by acting as pericellular fibrinolysins
9. Cellular mechanisms for human procollagenase-3 (MMP-13) activation. Evidence that MT1-MMP (MMP-14) and gelatinase a (MMP-2) are able to generate active enzyme
10. Mechanism of cell surface activation of 72-kDa type IV collagenase. Isolation of the activated form of the membrane metalloprotease
11. Membrane type 1 matrix metalloproteinase-associated degradation of tissue inhibitor of metalloproteinase 2 in human tumor cell lines
12. Activation of the precursor of gelatinase A/72 kDa type IV collagenase/MMP-2 in lung carcinomas correlates with the expression of membrane-type matrix metalloproteinase (MT-MMP) and with lymph node metastasis
13. Expression of matrix metalloproteinases and their inhibitors in human bronchopulmonary carcinomas: Quantitative and morphological analyses
14. Expression of membrane-type matrix metalloproteinase in human gastric carcinomas
15. Analysis of MT1-MMP and MMP2 expression in human gastric cancers
16. Membrane-type matrix metalloproteinase (MT-MMP) gene is expressed in stromal cells of human colon, breast, and head and neck carcinomas
17. Dual over-expression pattern of membrane-type metalloproteinase-1 in cancer and stromal cells in human gastrointestinal carcinoma revealed by in situ hybridization and immunoelectron microscopy
18. MT-MMP expression and localisation in human lung and breast cancers
19. Expression and tissue localization of membrane-types 1, 2, and 3 matrix metalloproteinases in human invasive breast carcinomas
20. High level of MT-MMP expression is associated with invasiveness of cervical cancer cells
21. Membrane-type 1 matrix metalloprotease (MT1-MMP) enables invasive migration of glioma cells in central nervous system white matter
22. Expression and activation of matrix metalloproteinase-2 (MMP-2) and its colocalization with membrane-type 1 matrix metalloproteinase (MT1-MMP) correlate with melanoma progression
23. MT1-MMP-deficient mice develop dwarfism, osteopenia, arthritis, and connective tissue disease due to inadequate collagen turnover
24. Impaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase I
25. Type IV collagenase(s) and TIMPs modulate endothelial cell morphogenesis in vitro
26. Down-regulation of vascular endothelial growth factor by tissue inhibitor of metalloproteinase-2: Effect on in vivo mammary tumor growth and angiogenesis
27. Expression of membrane type 1 matrix metalloproteinase (MT1-MMP) in A2058 melanoma cells is associated with MMP-2 activation and increased tumor growth and vascularization
28. Emergence of MCF-7 cells overexpressing a transfected epidermal growth factor receptor (EGFR) under estrogen-depleted conditions: Evidence for a role of EGFR in breast cancer growth and progression
29. A simple, rapid, and sensitive DNA assay procedure
30. Enhancement of tumorigenicity of human breast adenocarcinoma cells in nude mice by matrigel and fibroblasts
31. Absence of host plasminogen activator inhibitor 1 prevents cancer invasion and vascularization
32. Growth of microvessels in serum-free matrix culture of rat aorta. A quantitative assay of angiogenesis in vitro
33. Improved quantification of angiogenesis in the rat aortic ring assay
34. Identification and isolation of endothelial cells based on their increased uptake of acetylated-low density lipoprotein
35. Mutation analysis of membrane type-1 matrix metalloproteinase (MT1-MMP). The role of the cytoplasmic tail Cys(574), the active site Glu (240), and furin cleavage motifs in oligomerization, processing, and self-proteolysis of MT1-MMP expressed in breast carcinoma cells
36. Role of matrix, fibroblasts and type IV collagenases in tumor progression and invasion
37. Gelatinase A expression and localization in human breast cancers. An in situ hybridization study and immunohistochemical detection using confocal microscopy
38. Activation of the extracellular signal-regulated protein kinase (ERK) cascade by membrane-type-1 matrix metalloproteinase (MT1-MMP)
39. Functional activation of integrin alpha V beta 3 in tumor cells expressing membrane-type 1 matrix metalloproteinase
40. MT1- MMP initiates activation of pro-MMP-2 and integrin alphavbeta3 promotes maturation of MMP-2 in breast carcinoma cells
41. Reduced angiogenesis and tumor progression in gelatinase A-deficient mice
42. Matrix metalloproteinase-2 is required for the switch to the angiogenic phenotype in a tumor model
43. MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis
44. Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis