Selection of human elastase inhibitors from a conformationally constrained combinatorial peptide library

European Journal of Biochemistry

Volumn 266, Issue 2, 1999, Pages 403-412

  McBride, Jeffrey D ^a   Freeman, Hamzah N M ^b   Leatherbarrow, Robin J ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Bowman Birk inhibitor; Canonical loop; Combinatorial chemistry; Elastase; Peptide library

Indexed keywords

ALANINE; ALKYL GROUP; BOWMAN BIRK INHIBITOR; CYCLOPEPTIDE; LEUKOCYTE ELASTASE; LEUKOCYTE ELASTASE INHIBITOR; PANCREATIC ELASTASE; PEPTIDE LIBRARY; PROTEINASE INHIBITOR; THREONINE; VALINE; PEPTIDE; PROTEIN;

AMINO ACID SUBSTITUTION; ARTICLE; CONSENSUS SEQUENCE; ENZYME INHIBITION; ENZYME INHIBITOR INTERACTION; ENZYME SPECIFICITY; HUMAN; PEPTIDE ANALYSIS; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN CONFORMATION; ANIMAL; CHEMICAL MODEL; CHEMISTRY; DRUG ANTAGONISM; GENE LIBRARY; HYDROLYSIS; KINETICS; PROTEIN BINDING; SWINE; TIME;

ANIMALS; GENE LIBRARY; HUMANS; HYDROLYSIS; KINETICS; LEUKOCYTE ELASTASE; MODELS, CHEMICAL; PANCREATIC ELASTASE; PEPTIDE LIBRARY; PEPTIDES; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEINS; SUBSTRATE SPECIFICITY; SWINE; THREONINE; TIME FACTORS; VALINE;

EID: 0033485402     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.1999.00867.x     Document Type: Article

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