Effects of serpin binding on the target proteinase: Global stabilization, localized increased structural flexibility, and conserved hydrogen bonding at the active site

Biochemistry

Volumn 36, Issue 18, 1997, Pages 5455-5464

  Kaslik, Gyula ^a   Kardos, József ^a,b   Szabó, Erika ^a,c   Szilágyi, László ^a   Závodszky, Péter ^b   Westler, William M ^d   Markley, John L ^d   Gráf, László ^a  

^a EÖTVÖS LORÁND UNIVERSITY   (Hungary)

^b INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^c SZENT ISTVÁN UNIVERSITY   (Hungary)

^d UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEINASE; SERINE PROTEINASE INHIBITOR;

ARTICLE; COMPLEX FORMATION; ENZYME ACTIVE SITE; ENZYME STABILITY; HYDROGEN BOND; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; STRUCTURE ACTIVITY RELATION;

ALPHA 1-ANTITRYPSIN; ANILINO NAPHTHALENESULFONATES; ANIMALS; BINDING SITES; CALORIMETRY, DIFFERENTIAL SCANNING; CIRCULAR DICHROISM; DISULFIDES; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME STABILITY; FLUORESCENT DYES; HUMANS; HYDROGEN BONDING; MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN FOLDING; RATS; TRYPSIN; UREA;

EID: 0030982322     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi962931m     Document Type: Article

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