Crystal structure of MC159 reveals molecular mechanism of DISC assembly and FLIP inhibition

Molecular Cell

Volumn 20, Issue 6, 2005, Pages 939-949

  Yang, Jin Kuk ^a   Wang, Liwei ^a   Zheng, Lixin ^b   Wan, Fengyi ^b   Ahmed, Misonara ^a   Lenardo, Michael J ^b   Wu, Hao ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 8; DEATH INDUCING SIGNALING COMPLEX; FAS ANTIGEN; FAS ASSOCIATED DEATH DOMAIN PROTEIN; FLICE INHIBITORY PROTEIN; PROTEIN DERIVATIVE; PROTEIN MC159; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; EMBRYO; ENZYME ACTIVATION; HUMAN; HUMAN CELL; HYDROPHOBICITY; MOLLUSCIPOXVIRUS; NONHUMAN; OLIGOMERIZATION; PROTEIN ASSEMBLY; PROTEIN FAMILY; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, CD95; APOPTOSIS; CASP8 AND FADD-LIKE APOPTOSIS REGULATING PROTEIN; CASPASE 10; CASPASE 8; CASPASES; CRYSTALLOGRAPHY, X-RAY; DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS; FAS-ASSOCIATED DEATH DOMAIN PROTEIN; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLLUSCUM CONTAGIOSUM VIRUS; MULTIPROTEIN COMPLEXES; MUTATION; PROTEIN CONFORMATION; SEQUENCE ALIGNMENT; TUMOR NECROSIS FACTOR RECEPTOR-ASSOCIATED PEPTIDES AND PROTEINS; VIRAL PROTEINS;

MOLLUSCIPOXVIRUS;

EID: 29144463250     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molcel.2005.10.023     Document Type: Article

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