Subcellular localization and CARD-dependent oligomerization of the death adaptor RAIDD

Cell Death and Differentiation

Volumn 7, Issue 2, 2000, Pages 155-165

  Shearwin Whyatt, L M ^a   Harvey, N L ^a   Kumar, S ^a  

^a INSTITUTE OF MEDICAL AND VETERINARY SCIENCE   (Australia)

Author keywords

Caspase activation; Caspase prodomain; Caspase 2; Death adaptors; Oligomerization; RAIDD

Indexed keywords

CASPASE; NUCLEAR PROTEIN; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RECEPTOR;

ANIMAL CELL; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOPLASM; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HELA CELL; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION;

ANIMALIA;

EID: 0034097347     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4400632     Document Type: Article

References (47)

1. Thornberry NA and Lazebnik Y (1998) Caspases: enemies within. Science 281: 312-316
2. Cryns V and Yuan J (1998) Proteases to die for, Genes Dev. 12: 1551-1570
3. Kumar S (1999) Regulation of caspase activation in apoptosis: Implications in pathogenesis and treatment of disease. Clin. Expt. Pharmacol. Physiol. 26: 295-303
4. Kumar S and Colussi PA (1999) Prodomains-adaptors-oligomerization: the pursuit of caspase activation in apoptosis. Trends Biochem. Sci. 24: 1-4
5. Colussi PA, Harvey NL and Kumar S (1998) Prodomain-dependent nuclear localization of the caspase-2(Nedd2) precursor. A novel function for a caspase prodomain. J. Biol. Chem. 273: 24535-24542
6. Slee EA, Harte MT, Kluck RM, Wolf BB, Casiano CA, Newmeyer DD, Wang H-G, Reed JC, Nicholson DW, Alnemri ES, Green DR and Martin SJ (1999) Ordering of cytochrome c-initiated caspase cascade: Hierarchical activation of caspase-2, -3, -6, -7, -8 and -10 in a caspase-9-dependent manner. J. Cell Biol. 144: 281-292
7. Ashkenazi A and Dixit VM (1998) Death receptors: signaling and modulation. Science 281: 305-308
8. Nagata S (1997) Apoptosis by death factor. Cell 88: 355-365
9. Hofmann K, Bucher P and Tschopp J (1997) The CARD domain: a new apoptotic signalling motif. Trends Biochem. Sci. 22: 155-156
10. Huang B, Eberstadt M, Olejniczak ET, Meadows RP and Fesik SW (1996) NMR structure and mutagenesis of the Fas (APO-1/CD95) death domain. Nature 384: 638-641
11. Eberstadt M, Huang B, Chen Z, Meadows RP, Ng S-I, Zheng L, Lenardo MJ and Fesik SW (1998) NMR structure and mutagenesis of the FADD (Mort1) death-effector domain. Nature 392: 941-945
12. Chou JJ, Matsuo H, Duan H and Wagner G (1998) Solution structure of the RAIDD-CARD and model for CARD/CARD interaction in caspase-2 and caspase-9 recruitment. Cell 94: 171-180
13. Qin H, Srinivasula SM, Wu G, Fernandes-Alnemri T, Alnemri ES and Shi Y (1999) Structural basis of procaspase-9 recruitment by the apoptotic protease-activatingfactor 1. Nature 399: 549-557
14. Kumar S, Kinoshita M, Noda M, Copeland NG and Jenkins NA (1994) Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1 β-converting enzyme. Genes Dev. 8: 1613-1626
15. Wang L, Miura M, Bergeron L, Zhu H and Yuan J (1994) Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death. Cell 78: 739-750
16. Harvey NL, Butt AJ and Kumar S (1997) Functional activation of Nedd2/ICH-1 (caspase-2) is an early process in apoptosis. J. Biol. Chem. 272: 13134-13139
17. MacFarlane M, Cain K, Sun X-M, Alnemri ES and Cohen GM (1997) Processing/ activation of at least four interleukin-1 β-converting enzyme-like proteases occurs during the execution phase of apoptosis in human monocytic tumor cells. J. Cell. Biol. 137: 469-479
18. Li H, Bergeron L, Cryns V, Pasternack MS, Zhu H, Shi L, Greenberg A and Yuan J (1997) Activation of caspase-2 in apoptosis. J. Biol. Chem. 272: 21010-21017
19. Harvey KF, Harvey NL, Michael JM, Parasivam G, Waterhouse N, Alnemri ES, Watters D and Kumar S (1998) Caspase-mediated cleavage of the ubiquitin-protein ligase Nedd4 during apoptosis. J. Biol. Chem. 273: 13524-13530
20. Butt AJ, Harvey NL, Parasivam G and Kumar S (1998) Dimerization and autoprocessing of the Nedd2(caspase-2) precursor requires both the prodomain and the carboxyl-terminal regions. J. Biol. Chem. 273: 6763-6768
21. Ahmad M, Srinivasula SM, Wang L, Talanian RV, Litwak G, Fernandes-Alnemri T and Alnemri ES (1997) CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIP. Cancer Res. 57: 615-619
22. Duan H and Dixit VM (1997) RAIDD is a new 'death' adaptor molecule. Nature 385: 86-89
23. Hsu H, Xiong J and Goeddel DV (1995) The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa β activation. Cell 81: 495-504
24. Boldin MP, Goncharov TM, Goltsev YV and Wallach D (1996) Involvement of MACH, a novel Mort1/FADD-interacting protease, in Fas/AP01- and TNF receptor-induced cell death. Cell 85: 803-815
25. Muzio M, Chinnaiyan AM, Kischkel FC, O'Rourke K, Shevchenko A, Scaffidi C, Bretz JD, Zhang M, Ni J, Gentz R, Mann N, Krammer PH, Peter ME and Dixit VM (1996) FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex. Cell 85: 817-827
26. Chinnaiyan AM, O'Rourke K, Tewari M and Dixit VM (1995) FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell 81: 505-512
27. Medema JP, Scaffidi C, Kischkel FC, Shevchenko A, Mann M, Krammer PH and Peter ME (1997) FLICE is activated by association with the CD95 death-inducing signalling complex (DISC). EMBO J. 16: 2794-2804
28. Perez D and White E (1998) E1B 19K inhibits Fas-mediated apoptosis through FADD-dependent sequestration of FLICE. J. Cell Biol. 141: 1255-1266
29. Siegel RM, Martin DA, Zheng L, Ng SY, Bertin J, Cohen J and Lenardo MJ (1998) Death-effector filaments: Novel cytoplasmic structures that recruit caspases and trigger apoptosis. J. Cell Biol. 141: 1243-1253
30. Zhivotovsky B, Samali A, Gahm A and Orrenius S (1999) Caspases: their intracellular localization and translocation during apoptosis. Cell Death Differ. 6: 644-651
31. Muzio M, Stockwell BR, Stennicke HR, Salvesen GS and Dixit VM (1998) An induced proximity model for caspase-8 activation. J. Biol. Chem. 273: 2926-2930
32. Martin DA, Siegel RM, Zheng L and Lenardo MJ (1998) Membrane oligomerization and release activates the caspase 8 (FLICE/MACHα1) death signal. J. Biol. Chem. 273: 4345-4349
33. MacCorkle RA, Freeman KW and Spencer DM (1998) Synthetic activation of caspases: artificial death switches. Proc. Natl. Acad. Sci. U.S.A. 95: 3655-3660
34. Srinivasula SM, Ahmed M, Fernandes-Alnemri T and Alnemri ES (1998) Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization. Mol. Cell. 1: 949-957
35. Yang X, Chang HY and Baltimore D (1998) Autoproteolytic activation of procaspases by oligomerization. Mol. Cell. 1: 319-325
36. Yang X, Chang HY and Baltimore D (1998) Essential role of CED-4 oligomerisation in CED-3 activation and apoptosis. Science 281: 1355-1357
37. Colussi PA, Harvey NL, Shearwin-Whyatt LM and Kumar S (1998) Conversion of procaspase-3 to an autoactivating caspase by fusion to the caspase-2 prodomain. J. Biol. Chem. 273: 26566-26570
38. Nigg EA (1997) Nucleocytoplasmic transport: signals, mechanisms and regulation. Nature 386: 779-786
39. Stegh AH, Schickling O, Ehret A, Scaffidi C, Peterhansel C, Hofmann TG, Grummt I, Krammer PH and Peter ME (1998) DEDD, a novel death effector domain-containing protein targeted to the nucleolus. EMBO J. 17: 5974-5986
40. Jaunin F, Burns K, Tschopp J, Martin TE and Fakan S (1998) Ultrastructural distribution of the death-domain-containing MyD88 protein in HeLa Cells. Exp. Cell Res. 243: 67-75
41. Mao P-L, Jiang Y, Wee BY and Porter AG (1998) Activation of caspase-1 in the nucleus requires nuclear translocation of pro-caspase-1 mediated by its prodomain. J. Biol. Chem. 273: 23621-23624
42. Krajewski S, Krajewska M, Ellerby LM, Welsh K, Xie Z, Deveraux QL, Salvesen GS, Bredesen DE, Rosenthal RE, Fiskum G and Reed JC (1999) Release of caspase-9 from mitochondria during neuronal apoptosis and cerebral ischemia. Proc. Natl. Acad. Sci. U.S.A. 96: 5752-5757
43. Susin SA, Lorenzo HK, Zamzami N, Marzo I, Snow BE, Brothers GM, Mangion J, Jacotot E, Costantini P, Loeffler M, Larochette N, Goodlett DR, Aebersold R, Siderovski DP, Penninger JM and Kroemer G (1999) Molecular characterization of mitochondrial apoptosis-inducing factor. Nature 397: 441-446
44. Bergeron L, Perez GI, Macdonald G, Shi L, Sun Y, Jurisicova A, Varmuza S, Latham KE, Flaws A, Salter JCM, Hara H, Moskowitz MA, Li E, Greenberg A, Tilly JL and Yuan J (1998) Defects in regulation of apoptosis in caspase-2-deficient mice. Genes Dev. 12: 1304-1314
45. Kelliher MA, Grimm S, Ishida Y, Kuo F, Stanger BZ and Leder P (1998) The death domain kinase RIP mediates the TNF-induced NF-kappaB signal. Immunity 8: 297-303
46. Varfolomeev EE, Schuchmann M, Luria V, Chiannikulchai N, Beckmann JS, Mett L, Rebrikov D, Brodianski VM, Kemper OC, Kollet O, Lapidot T, Soffer D, Tama S, Avraham KB, Goncharov T, Holtmann H, Lonai P and Wallach D (1998) Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally. Immunity 9: 267-276
47. Tang D, Lahti JM, Grenet J and Kidd VJ (1999) Cycloheximide-induced T-cell death is mediated by a Fas-associated death domain-dependent mechanism. J. Biol. Chem. 274: 7245-7252