Caspase-9 and APAF-1 form an active holoenzyme

Genes and Development

Volumn 13, Issue 24, 1999, Pages 3179-3184

  Rodriguez, Joe ^a,b   Lazebnik, Yuri ^a  

^a Watson School of Biological Sciences   (United States)

^b STONY BROOK UNIVERSITY   (United States)

Author keywords

APAF 1; Apoptosis; Cancer; Capase 9; Caspases

Indexed keywords

CASPASE; CASPASE 9; HOLOENZYME; PROTEINASE;

APOPTOSIS; ARTICLE; CATALYSIS; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME SUBSTRATE; FIBROBLAST CULTURE; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; PRIORITY JOURNAL;

ALLOSTERIC REGULATION; APOPTOSIS; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; CASPASE 9; CASPASES; CATALYTIC DOMAIN; CELL LINE; CELL-FREE SYSTEM; CENTRIFUGATION, DENSITY GRADIENT; HUMANS; KINETICS; PROTEINS; SUBSTRATE SPECIFICITY;

EID: 0033573020     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.13.24.3179     Document Type: Article

References (27)

1. Cain, K., D.G. Brown, C. Langlais, and G.M. Cohen. 1999. Caspase activation involves the formation of the aposome, a large (approximately 700 kDa) caspase-activating complex. J. Biol. Chem. 274: 22686-22692.
2. Fearnhead, H.O., J. Rodriguez, E.E. Govek, W. Guo, R. Kobayashi, G. Hannon, and Y.A. Lazebnik. 1998. Oncogene-dependent apoptosis is mediated by caspase-9. Proc. Natl. Acad. Sci. 95: 13664-13669.
3. Hakem, R., A. Hakem, G.S. Duncan, J.T. Henderson, M. Woo, M.S. Soengas, A. Elia, J.L. de la Pompa, D. Kagi, W. Khoo et al. 1998. Differential requirement for caspase 9 in apoptotic pathways in vivo. Cell 94: 339-352.
4. Hu, Y., M. Benedict, L. Ding, and G. Nunez. 1999. Role of cytochrome c and dATP/ATP hydrolysis in Apaf-1-mediated caspase-9 activation and apoptosis. EMBO J. 18: 3586-3595.
5. Imai, Y., T. Kimura, A. Murakami, N. Yajima, K. Sakamaki, and S. Yonehara. 1999. The CED-4 homologous protein FLASH is involved in Fas-mediated activation of caspase-8 during apoptosis. Nature 398: 777-785.
6. Jesty, J. and Y. Nemerson. 1995 The pathway of blood coagulation. In Williams hematology (eds. E. Beutker, M.A. Lichtman, B.S. Coller, and T.J. Kipps) pp. 1227-1238. McGraw-Hill, New York, NY.
7. Juin, P., A.O. Hueber, T. Littlewood, and G. Evan. 1999. c-Myc-induced sensitization to apoptosis is mediated through cytochrome c release. Genes & Dev. 13: 1367-1381.
8. Khan, A. and M. James. 1998. Molecular mechanisms for the conversion of zymogens to active proteolytic enzymes. Protein Sci. 7: 815-836.
9. Kuida, K., T.F. Haydar, C.Y. Kuan, Y. Gu, C. Taya, H. Karasuyama, M.S. Su, P. Rakic, and R.A. Flavell. 1998. Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9. Cell 94: 325-337.
10. Li, P., D. Nijhawan, I. Budihardjo, S.M. Srinivasula, M. Ahmad, E.S. Alnemri, and X.D. Wang. 1997. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 91: 479-489.
11. Liu, X., C.N. Kim, J. Yang, R. Jemmerson, and X. Wang. 1996. Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell 86: 147-157.
12. Mangel, W.F., D.L. Toledo, J.Z. Ding, R.M. Sweet, and W.J. McGrath. 1997. Temporal and spatial control of the adenovirus proteinase by both a peptide and the viral DNA. Trends Biochem. Sci. 22: 393-398.
13. Mann, K., S. Krishnaswamy, and J. Lawson. 1992. Surface-dependent hemostasis. Semin. Hematol 29: 213-226.
14. Muzio, M., B.R. Stockwell, H.R. Stennicke, G.S. Salvesen, and V.M. Dixit. 1998. An induced proximity model for caspase-8 activation. J. Biol. Chem. 273: 2926-2930.
15. Qin, H., S.M. Srinivasula, G. Wu, T. Fernandes-Alnemri, E.S. Alnemri, and Y. Shi. 1999. Structural basis of procaspase-9 recruitment by the apoptotic protease-activating factor 1. Nature 399: 549-557.
16. Saleh, A., S.M. Srinivasula, S. Acharya, R. Fishel, and E.S. Alnemri. 1999. Cytochrome c and dATP-mediated oligomerization of apaf-1 is a prerequisite for procaspase-9 activation. J. Biol, Chem. 274: 17941-17945.
17. Seol, D.W. and T.R. Billiar. 1999. A caspase-9 variant missing the catalytic site is an endogenous inhibitor of apoptosis. J. Biol. Chem. 274: 2072-2076.
18. Soengas, M.S., R.M. Alarcon, H. Yoshida, A.J. Giaccia, R. Hakem, T.W. Mak, and S.W. Lowe. 1999. Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition. Science 284: 156-159.
19. Srinivasula, S.M., M. Ahmad, T. Fernandes-Alnemri, and E.S. Alnemri. 1998. Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization. Mol. Cell 1: 949-957.
20. Srinivasula, S.M., M. Ahmad, Y. Guo, Y. Zhan, Y. Lazebnik, T. Fernandes-Alnemri, and E.S. Alnemri. 1999. Identification of an endogenous dominant-negative short isoform of caspase-9 that can regulate apoptosis. Cancer Res. 59: 999-1002.
21. Stennicke, H.R., Q.L. Deveraux, E.W. Humke, J.C. Reed, V.M. Dixit, and G.S. Salvesen. 1999. Caspase-9 can be activated without proteolytic processing. J. Biol. Chem. 274: 8359-8362.
22. Thornberry, N.A. and Y. Lazebnik. 1998. Caspases: enemies within. Science 281: 1312-1316.
23. Wang, J., L. Zheng, A. Lobito, F. Chan, K. Dale, M. Sneller, X. Yao, J. Puck, S. Straus, and M. Lenardo. 1999. Inherited human caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II. Cell 98: 47-58.
24. Yang, X., H.Y. Chang, and D. Baltimore. 1998a. Essential role of CED-4 oligomerization in CED-3 activation and apoptosis. Science 281: 1355-1357.
25. _. 1998b. Autoproteolytic activation of pro-caspases by oligomerization. Mol. Cell 1: 319-325.
26. Zou, H., W.J. Henzel, X. Liu, A. Lutschg, and X. Wang. 1997. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell 90: 405-413.
27. Zou, H., Y. Li, X. Liu and X. Wang. 1999. An APAF-1.Cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9. J. Biol Chem. 274: 11549-11556.