Molecular Cloning and Characterization of DEFCAP-L and -S, Two Isoforms of a Novel Member of the Mammalian Ced-4 Family of Apoptosis Proteins

Journal of Biological Chemistry

Volumn 276, Issue 12, 2001, Pages 9230-9238

  Hlaing, Tommy ^a   Guo, Ren Feng ^a   Dilley, Kari A ^a   Loussia, Jennifer M ^a   Morrish, Tammy A ^a   Shi, Michael M ^a,b   Vincenz, Claudius ^a   Ward, Peter A ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BIOASSAY; BIOLOGICAL MEMBRANES; CELLS; GENETIC ENGINEERING; IMMUNOLOGY; PRECIPITATION (CHEMICAL); PROTEINS;

APOTOSIS; CASPASE RECRUITMENT DOMAIN (CARD);

BIOCHEMISTRY;

APOPTOSIS PROTEIN; APOPTOTIC PROTEASE ACTIVATING FACTOR 1; ASPARTYLGLUTAMYLPHENYLALANYLCYSTEINYLALANYLPROLYLLEUCINE; ASPARTYLGLUTAMYLPHENYLALANYLCYSTEINYLALANYLPROLYLSERINE; ASPARTYLGLUTAMYLVALYLASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; BETA GALACTOSIDASE; CASPASE; CASPASE 2; CASPASE 9; CED 4 PROTEIN; CELL PROTEIN; ISOPROTEIN; LEUCINE; MAGNESIUM; NOD1 PROTEIN; NUCLEOTIDE; PEPTIDE DERIVATIVE; PROLINE; UNCLASSIFIED DRUG; APOPTOSIS REGULATORY PROTEIN; CAENORHABDITIS ELEGANS PROTEIN; CALCIUM BINDING PROTEIN; CARRIER PROTEIN; CED 4 PROTEIN, C ELEGANS; CED-4 PROTEIN, C ELEGANS; COMPLEMENTARY DNA; HELMINTH PROTEIN; HYBRID PROTEIN; MESSENGER RNA; NALP1 PROTEIN, HUMAN; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ALTERNATIVE RNA SPLICING; AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; APOPTOSIS; ARTICLE; BINDING SITE; BREAST ADENOCARCINOMA; CANCER CELL CULTURE; CASPASE RECRUITMENT DOMAIN; CELL ASSAY; CELL DEATH; CELL KILLING; CELL STRAIN MCF 7; CONSENSUS SEQUENCE; CONTROLLED STUDY; GENE CONSTRUCT; GENE DELETION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; LEUCINE RICH REPEAT; MOLECULAR CLONING; NUCLEOTIDE REPEAT; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; REGULATORY MECHANISM; REPORTER GENE; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; CELL LINE; CHEMISTRY; CHROMOSOME MAP; GENETICS; METABOLISM; MOLECULAR GENETICS; SITE DIRECTED MUTAGENESIS;

MAMMALIA; MINK CELL FOCUS-FORMING VIRUS;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID SEQUENCE; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BASE SEQUENCE; CAENORHABDITIS ELEGANS PROTEINS; CALCIUM-BINDING PROTEINS; CARRIER PROTEINS; CELL LINE; CHROMOSOME MAPPING; CLONING, MOLECULAR; DNA, COMPLEMENTARY; HELMINTH PROTEINS; HUMANS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN ISOFORMS; RECOMBINANT FUSION PROTEINS; RNA, MESSENGER; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 0035937775     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M009853200     Document Type: Article

References (29)

1. Kerr, J. F., Wyllie, A. H., and Currie, A. R. (1972) Br. J. Cancer 26, 239-257
2. Thompson, C. B. (1995) Science 267, 1456-1462
3. Hengartner, M. O., and Horvitz, H. R. (1994) Philos. Trans. R. Soc. Lond-B Biol. Sci. 345, 243-246
4. Yuan, J., and Horvitz, H. R. (1992) Development 116, 309-320
5. Zou, H., Henzel, W. J., Liu, X., Lutschg, A., and Wang, X. (1997) Cell 90, 405-413
6. Inohara, N., Koseki, T., del Peso, L., Hu, Y., Yee, C., Chen, S., Carrio, R., Merino, J., Liu, D., Ni, J., and Nunez, G. (1999) J. Biol. Chem. 274, 14560-14567
7. Bertin, J., Nir, W. J., Fischer, C. M., Tayber, O. V., Errada, P. R., Grant, J. R., Keilty, J. J., Gosselin, M. L., Robison, K. E., Wong, G. H., Glucksmann, M. A., and DiStefano, P. S. (1999) J. Biol. Chem. 274, 12955-12958
8. Kanuka, H., Sawamoto, K., Inohara, N., Matsuno, K., Okano, H., and Miura, M. (1999) Mol. Cell 4, 757-769
9. Rodriguez, A., Oliver, H., Zou, H., Chen, P., Wang, X., and Abrams, J. M. (1999) Nat. Cell Biol. 1, 272-279
10. Li, P., Nijhawan, D., Budihardjo, I., Srinivasula, S. M., Ahmad, M., Alnemri, E. S., and Wang, X. (1997) Cell 91, 479-489
11. Zou, H., Li, Y., Liu, X., and Wang, X. (1999) J. Biol. Chem. 274, 11549-11556
12. Cain, K., Bratton, S. B., Langlais, C., Walker, G., Brown, D. G., Sun, X. M., and Cohen, G. M. (2000) J. Biol. Chem. 275, 6067-6070
13. Inohara, N., Koseki, T., Lin, J., del Peso, L., Lucas, P. C., Chen, F. F., Ogura, Y., and Nunez, G. (2000) J. Biol. Chem. 275, 27823-27831
14. Siegel, R. M., Martin, D. A., Zheng, L., Ng, S. Y., Bertin, J., Cohen, J., and Lenardo, M. J. (1998) J. Cell Biol. 141, 1243-1253
15. Church, G. M., and Gilbert, W. (1984) Proc. Natl. Acad. Sci. U. S. A. 81, 1991-1995
16. Duan, H., Chinnaiyan, A. M., Hudson, P. L., Wing, J. P., He, W. W., and Dixit, V. M. (1996) J. Biol. Chem. 271, 1621-1625
17. Tewari, M., Quan, L. T., O'Rourke, K., Desnoyers, S., Zeng, Z., Beidler, D. R., Poirier, G. G., Salvesen, G. S., and Dixit, V. M. (1995) Cell 81, 801-809
18. Muzio, M., Chinnaiyan, A. M., Kischkel, F. C., O'Rourke, K., Shevchenko, A., Ni, J., Scaffidi, C., Bretz, J. D., Zhang, M., Gentz, R., Mann, M., Krammer, P. H., Peter, M. E., and Dixit, V. M. (1996) Cell 85, 817-827
19. Duan, H., Orth, K., Chinnaiyan, A. M., Poirier, G. G., Froelich, C. J., He, W. W., and Dixit, V. M. (1996) J. Biol. Chem. 271, 16720-16724
20. Vincenz, C., and Dixit, V. M. (1997) J. Biol. Chem. 272, 6578-6583
21. Nagase, T., Ishikawa, K., Suyama, M., Kikuno, R., Hirosawa, M., Miyajima, N., Tanaka, A., Kotani, H., Nomura, N., and Ohara, O. (1999) DNA Res. 6, 63-70
22. Masumoto, J., Taniguchi, S., Ayukawa, K., Sarvotham, H., Kishino, T., Niikawa, N., Hidaka, E., Katsuyama, T., Higuchi, T., and Sagara, J. (1999) J. Biol. Chem. 274, 33835-33838
23. Kobe, B., and Deisenhofer, J. (1994) Trends Biochem. Sci. 19, 415-421
24. Shearwin-Whyatt, L. M., Harvey, N. L., and Kumar, S. (2000) Cell Death Differ. 7, 155-165
25. Mancini, M., Machamer, C. E., Roy, S., Nicholson, D. W., Thornberry, N. A., Casciola-Rosen, L. A., and Rosen, A. (2000) J. Cell Biol. 149, 603-612
26. Susin, S. A., Lorenzo, H. K., Zamzami, N., Marzo, I., Brenner, C., Larochette, N., Prevost, M. C., Alzari, P. M., and Kroemer, G. (1999) J. Exp. Med. 189, 381-394
27. Li, H., Bergeron, L., Cryns, V., Pasternack, M. S., Zhu, H., Shi, L., Greenberg, A., and Yuan, J. (1997) J. Biol. Chem. 272, 21010-21017
28. Bergeron, L., Perez, G. I., Macdonald, G., Shi, L., Sun, Y., Jurisicova, A., Varmuza, S., Latham, K. E., Flaws, J. A., Salter, J. C., Hara, H., Moskowitz, M. A., Li, E., Greenberg, A., Tilly, J. L., and Yuan, J. (1998) Genes Dev. 12, 1304-1314
29. Chen, F., Hersh, B. M., Conradt, B., Zhou, Z., Riemer, D., Gruenbaum, Y., and Horvitz, H. R. (2000) Science 287, 1485-1489