Innate immune recognition: Mechanisms and pathways

Immunological Reviews

Volumn 173, Issue , 2000, Pages 89-97

  Medzhitov, Ruslan ^a   Janeway Jr , Charles ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL RECEPTOR; PROTEIN KINASE; TUMOR NECROSIS FACTOR RECEPTOR;

ANTIGEN RECOGNITION; EVOLUTION; GENE EXPRESSION REGULATION; HOST RESISTANCE; IMMUNITY; PATTERN RECOGNITION; PRIORITY JOURNAL; REVIEW;

AMINO ACID SEQUENCE; ANTIGENS; CONSERVED SEQUENCE; EVOLUTION; IMMUNE SYSTEM; IMMUNITY, NATURAL; MOLECULAR SEQUENCE DATA; NF-KAPPA B; RECEPTORS, IMMUNOLOGIC; SIGNAL TRANSDUCTION; TRANS-ACTIVATION (GENETICS);

EID: 0033975869     PISSN: 01052896     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-065X.2000.917309.x     Document Type: Review

References (39)

1. 1. Janeway CA Jr. Approaching the asymptote? Evolution and revolution in immunology. Cold Spring Harb Symp Quant Biol 1989;54:1-13.
2. 2. Long EO. Regulation of immune responses by inhibitory receptors. Adv Exp Med Biol 1998;452:19-28.
3. 3. Lanier LL. NK cell receptors. Annu Rev Immunol 1998;16:359-393.
4. 4. Medzhitov R, Janeway CA Jr. Innate immunity: impact on the adaptive immune response. Curr Opin Immunol 1997;9:4-9.
5. 5. Fraser IP, Koziel H, Ezekowitz RA. The serum mannose-binding protein and the macrophage mannose receptor are pattern recognition molecules that link innate and adaptive immunity. Semin Immunol 1998;10:363-372.
6. 6. Stahl PD, Ezekowitz RA. The mannose receptor is a pattern recognition receptor involved in host defense. Curr Opin Immunol 1998;10:50-55.
7. 7. Medzhitov R, Preston-Hurlburt P, Janeway CA Jr. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 1997;388:394-397.
8. 8. Rock FL, Hardiman G, Timans JC, Kastelein RA, Bazan JF. A family of human receptors structurally related to Drosophila Toll. Proc Natl Acad Sci USA 1998;95:588-593.
9. 9. Lemaitre B, Nicolas E, Michaut L, Reichhart JM, Hoffmann JA. The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell 1996;86:973-983.
10. 10. Williams MJ, Rodriguez A, Kimbrell DA, Eldon ED. The 18-wheeler mutation reveals complex antibacterial gene regulation in Drosophila host defense. EMBO J 1997;16:6120-6130.
11. 11. Kopp EB, Medzhitov R. The Toll-receptor family and control of innate immunity. Curr Opin Immunol 1999;11:13-18.
12. 12. Lemaitre B, Reichhart JM, Hoffmann JA. Drosophila host defense: differential induction of antimicrobial peptide genes after infection by various classes of microorganisms. Proc Natl Acad Sci USA 1997;94:14614-14619.
13. 13. Poltorak A, et al. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 1998;282:2085-2088.
14. 14. Qureshi ST, et al. Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4) [published erratum appears in J Exp Med 1999;189:1518]. J Exp Med 1999;189:615-625.
15. 15. Yoshimura A, Lien E, Ingalls RR, Tuomanen E, Dziarski R, Golenbock D. Recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2. J Immunol 1999;163:1-5.
16. 16. Schwandner R, Dziarski R, Wesche H, Rothe M, Kirschning CJ. Peptidoglycan-and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2. J Biol Chem 1999;274:17406-17409.
17. 17. Medzhitov R, Janeway CA Jr. An ancient system of host defense. Curr Opin Immunol 1998;10:12-15.
18. 18. Medzhitov R, et al. MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways. Mol Cell 1998;2:253-258.
19. 19. Muzio M, Natoli G, Saccani S, Levrero M, Mantovani A. The human toll signaling pathway: divergence of nuclear factor κB and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6). J Exp Med 1998;187:2097-2101.
20. 20. Hardiman G, Rock FL, Balasubramanian S, Kastelein RA, Bazan JF. Molecular characterization and modular analysis of human MyD88. Oncogene 1996;13:2467-2475.
21. 21. Muzio M, Ni J, Feng P, Dixit VM. IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. Science 1997;278:1612-1615.
22. 22. Burns K, et al. MyD88, an adapter protein involved in interleukin-1 signaling. J Biol Chem 1998;273:12203-12209.
23. 23. Wesche H, Henzel WJ, Shillinglaw W, Li S, Cao Z. MyD88: an adapter that recruits IRAK to the IL-1 receptor complex. Immunity 1997;7:837-847.
24. 24. Cao Z, Xiong J, Takeuchi M, Kurama T, Goeddel DV. TRAF6 is a signal transducer for interleukin-1. Nature 1996;383:443-446.
25. 25. Arch RH, Gedrich RW, Thompson CB. Tumor necrosis factor receptor-associated factors (TRAFs) - a family of adapter proteins that regulates life and death. Genes Dev 1998;12:2821-2830.
26. 26. Lomaga MA, et al. TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling. Genes Dev 1999;13:1015-1024.
27. 27. Nishitoh H, et al. ASK1 is essential for JNK/SAPK activation by TRAF2. Mol Cell 1998;2:389-395.
28. 28. Ninomiya-Tsuji J, Kishimoto K, Hiyama A, Inoue J, Cao Z, Matsumoto K. The kinase TAK1 can activate the NIK-I κB as well as the MAP kinase cascade in the IL-1 signalling pathway. Nature 1999;398:252-256.
29. 29. Kopp E, et al. ECSIT is an evolutionary conserved intermediate in the Toll/IL-1R signal transduction pathway. Genes Dev 1999;13:2059-2071.
30. 30. Karin M, Delhase M. JNK or IKK, AP-1 or NF-κB, which are the targets for MEK kinase 1 action? Proc Natl Acad Sci USA 1998;95:9067-9069.
31. 31. Belvin MP, Anderson KV. A conserved signaling pathway: the Drosophila toll-dorsal pathway. Annu Rev Cell Dev Biol 1996;12:393-416.
32. 32. Towb P, Galindo RL, Wasserman SA. Recruitment of Tube and Pelle to signaling sites at the surface of the Drosophila embryo. Development 1998;125:2443-2450.
33. 33. Liu H, Su YC, Becker E, Treisman J, Skolnik EY. A Drosophila TNF-receptor-associated factor (TRAF) binds the ste20 kinase Misshapen and activates Jun kinase. Curr Biol 1999;9:101-104.
34. 34. Hammond-Kosack KE. Jones JD. Resistance gene-dependent plant defense responses. Plant Cell 1996;8:1773-1791.
35. 35. McCarthy JV, Ni J, Dixit VM. RIP2 is a novel NF-κB-activating and cell death-inducing kinase. J Biol Chem 1998;273:16968-16975.
36. 36. Inohara N, del Peso L, Koseki T, Chen S, Nunez G. RICK, a novel protein kinase containing a caspase recruitment domain, interacts with CLARP and regulates CD95-mediated apoptosis [published erratum appears in J Biol Chem 1998;273:18675]. J Biol Chem 1998;273:12296-12300.
37. 37. Thome M, et al. Identification of CARDIAK, a RIP-like kinase that associates with caspase-1. Curr Biol 1998;8:885-888.
38. 38. Bertin J, et al. Human CARD4 protein is a novel CED-4/Apaf-1 cell death family member that activates NF-κB. J Biol Chem 1999;274:12955-12958.
39. 39. Inohara N, et al. Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-κ B. J Biol Chem 1999;274:14560-14567.