ASC is essential for LPS-induced activation of procaspase-1 independently of TLR-associated signal adaptor molecules

Genes to Cells

Volumn 9, Issue 11, 2004, Pages 1055-1067

  Yamamoto, Masatatsu ^a,b   Yaginuma, Katsuyuki ^b   Tsutsui, Hiroko ^c,d   Sagara, Junji ^a   Guan, Xin ^a   Seki, Ekihiro ^c,d   Yasuda, Koubun ^c,d   Yamamoto, Masahiro ^e   Akira, Shizuo ^e   Nakanishi, Kenji ^c,d   Noda, Tetsuo ^b,f,g   Taniguchi, Shun'ichiro ^a  

^a SHINSHU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b The Japan Foundation   (Japan)

^c HYOGO COLLEGE OF MEDICINE   (Japan)

^d JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^e OSAKA UNIVERSITY   (Japan)

^f TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^g INST OF PHYS AND CHEMICAL RESEARCH   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; CASPASE; CELL PROTEIN; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; MYELOID DIFFERENTIATION FACTOR 88; PROCASPASE 1; PROTEIN ASC; PROTEIN TRIF; TOLL LIKE RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME ACTIVATION; HOST RESISTANCE; LIVER INJURY; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROCESSING; SHOCK; SIGNAL TRANSDUCTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ANTIGENS, DIFFERENTIATION; CASPASE 1; CASPASES; CYTOKINES; CYTOSKELETAL PROTEINS; ENZYME ACTIVATION; ENZYME PRECURSORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; LIPOPOLYSACCHARIDES; MEMBRANE GLYCOPROTEINS; MICE; MICE, KNOCKOUT; MYELOID DIFFERENTIATION FACTOR 88; RECEPTORS, CELL SURFACE; RECEPTORS, IMMUNOLOGIC; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTORS;

EID: 7944231451     PISSN: 13569597     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2443.2004.00789.x     Document Type: Article

References (49)

1. Adachi, O., Kawai, T., Takeda, K., et al. (1998) Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function. Immunity 9, 143-150.
2. Agostini, L., Martinon, F., Burns, K., McDermott, M.F., Hawkins, P.N. & Tschopp, J. (2004) NALP3 forms an IL-1β -processing inflammasome with increased activity in Muckele-Wells autoinflammatory disorder. Immunity 20, 319-325.
3. Alnemri, E.S., Livingston, D.J., Nicholson, D.W., et al. (1996) Human ICE/CED-3 protease nomenclature. Cell 87, 171.
4. Ayala, J.M., Yamin, T.T., Egger, L.A., Chin, J., Kostura, M.J. & Miller, D.K. (1994) IL-1β converting enzyme is present in monocyte cells as an inactive 45-kDa precursor. J. Immunol. 153 2592-2599.
5. Bouchier-Hayes, L. & Martin, S.J. (2002) CARD games in apoptosis and immunity. EMBO Report 3, 616-621.
6. Go, Y., Kuida, K., Tsutsui, H., et al. (1997) Activation of interferon-γ inducing factor mediated by interleukin-1β converting enzyme. Science 275, 206-209.
7. Guan, X., Sagara, J., Yokoyama, T., et al. (2003) ASC/TMS1, a caspase-1 activating adaptor, is downregulated by aberrant methylation in human melanoma. Int. J. Cancer 107, 202-208.
8. Hoshino, K., Takeuchi, O., Kawai, T., et al. (1999) Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J. Immunol. 162, 3749-3752.
9. Inohara, N. & Nuñez, G. (2003) NODs: intraceluular proteins involved in inflammation and apoptosis. Nat. Rev. Immunol. 3, 371-382.
10. The International FMF Consortium. (1997) Ancient missense mutations in a new member of the RoRet gene family are likely to cause familial Mediterranean fever. Cell 90, 797-807.
11. Janeway, C.A.J. & Medzhitov, R. (2002) Innate immune recognition. Annu. Rev. Immunol. 20, 197-216.
12. + release. AM. J Physiol. Cell Physiol. 286, C1100-C1108.
13. Kaisho, T., Takeuchi, O., Kawai, T., Hoshino, K. & Akira, S. (2001) Endotoxin-induced maturation of MyD88-deficient dendritic cells. J. Immunol. 166, 5688-5694.
14. Kawai, T., Takeuchi, O., Fujita, T., et al. (2001) Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-γ regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes. J. Immunol. 167 5887-5894.
15. Kuida, K., Lippke, J.A., Ku, G., et al. (1995) Altered cytokine export apoptosis in mice deficient in interleukin-1β converting enzyme. Science 267, 2000-2003.
16. Li, P., Allen, H., Banerjee, S., et al. (1995) Mice deficient in IL-1β-converting enzyme are defective in production of mature IL-1β and resistant to endotoxin shock. Cell 80, 401-411.
17. Lin, X.Y., Choi, M.S.K. & Porter, A.G. (2000) Expression analysis of the human caspase-1 subfamily reveals specific regulation of the CASP5 gene by lipopolysaccharide and interferon-γ. J. Biol. Chem. 275, 39920-39926.
18. Liu, T., Rojas, A., Ye, Y. & Gozik, A. (2003) Homology modeling provides insights into the binding mode of the PAAD/DAPIN/pyrin domain, a forth memeber of the CARD/DD/DED domain family. Protein Sci. 12, 1872-1881.
19. Manji, G.A., Wang, L., Geddes, B.J., et al. (2002) PYPAF1, a PYRIN-containing Apaf1-like protein that assembles with ASC and regulates activation of NF-κB. J Biol. Chem. 277, 11570-11575.
20. Mariathasan, S., Newton, K., Monack, D.M., et al. (2004) Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf. Nature 430, 213-218.
21. Martinon, F., Hofmann, K. & Tschopp, J. (2001) The pyrin domain: a possible member of the death domain-fold family implicated in apoptosis and inflammation. Curr. Biol. 10, R118-R120.
22. Martinon, F., Burns, K. & Tschopp, J. (2002) The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of pro-IL-1β. Mol. Cell 10, 417-426.
23. Masumoto, J., Taniguchi, S., Ayukawa, K., et al. (1999) ASC, a novel 22-kDa protein, aggregates during apoptosis of human promyelocytic leukemia HL-60 cells. J. Biol. Chem. 274, 33835-33838.
24. Masumoto, J., Taniguchi, S., Nakayama, J., et al. (2001a) Expression of apoptosis-associated speck-like protein containing a caspase recruitment domain, a Pyrin N-terminal homology domain-containing protein, in normal human tissues. J. Histochem. Cyotochem. 49, 1269-1275.
25. Masumoto, J., Taniguchi, S. & Sagara, J. (2001b) Pyrin N-terminal homology domain- and caspase recruitment domain-dependent oligomerization of ASC. Biochem. Biophys. Res. Commun. 280, 652-655.
26. Masumoto, J., Dowds, T.A., Schaner, P., et al. (2003a) ASC is an activating adaptor for NF-κB and caspase-8-dependent apoptosis. Biochem. Biophys. Res. Commun. 303, 69-73.
27. Masumoto, J., Zhou, W., Chen, F.F., et al. (2003b) Caspy, a zebrafish caspase, activated by ASC oligomerization is required for pharyngeal arth development. J. Biol. Chem. 278, 4268-4276.
28. McConnell, B.B. & Vertino, P.M. (2000) Activation of a caspase-9-mediated apoptotic pathway by subcellular redistribution of the novel caspase recruitment domain protein TMS1. Cancer Res. 60 6243-6247.
29. McConnell, B.B. & Vertino, P.M. (2004) TMS1/ASC: the cancer connection. Apoptosis 9, 5-18.
30. Medzhitov, R., Preston-Hurburt, P. & Janeway, C.A.J. (1997) Innate immunity: the virtues of a nonclonal system of recognition. Cell 91, 295-298.
31. Nakanishi, K., Yoshimoto, T., Tsutsui, H. & Okamura, H. (2001) Interleukin-18 regulates both Th1 and Th2 responses. Annu. Rev. Immunol. 19, 423-474.
32. Ohtsuka, T., Ryu, H., Minamishima, Y.A., et al. (2004) ASC is a Bax adaptor and regulates the p53-Bax mitochondrial apoptosis pathway. Nat. Cell. Biol. 6, 121-128.
33. Okamura, H., Tsutsui, H., Komatsu, T., et al. (1995) Cloning of a new cytokine that induces IFN-γ production by T cells. Nature 378, 88-91.
34. Poyet, J.L., Srinivasula, S.M., Tnani, M., Razmara, M., Fernandes-Alnemri, T. & Alnemri, E.S. (2001) Identification of Ipaf, a human caspase-1-activating protein related to Apaf-1. J. Biol. Chem. 276, 28309-28313.
35. Richards, N., Schaner, P., Diaz, A., et al. (2001) Interaction between Pyrin and the apoptotic speck protein (ASC) modulates ASC-induced apoptotis. J. Biol. Chem. 276, 39320-39329.
36. Sakao, Y., Takeda, K., Tsutsui, H., et al. (1999) IL-18-deficient mice are resistant to endotoxin-induced liver injury but highly susceptible to endotoxin shock. Int. Immunol. 11, 471-480.
37. Schumann, R.R., Belka, C., Reuter, D., et al. (1998) Lipopolysaccharide activates caspase-1 (interleukin-1-converting enzyme) in cultured monocytic and endothelial cells. Blood 91, 577-584.
38. Seki, E., Tsutsui, H., Nakano, H., et al. (2001) LPS-induced IL-18 secretion from murine Kupffer cells independently of MyD88 that is critically involved in induction of production of IL-12 and IL-1β. J. Immunol. 166, 2651-2657.
39. Shiohara, M., Taniguchi, S., Masumoto, J., et al. (2002) ASC, which is composed of a PYD and a CARD, is up-regulated by inflammation and apoptosis in human neutrophils. Biochem. Biophys. Res. Commun. 293, 1314-1318.
40. Srinivasula, S.M., Poyet, J.L., Pazmara, M., Datta, P., Zhang, Z. & Alnemri, E.S. (2002) The PYRIN-CARD protein ASC is an activating adaptor for caspase-1. J. Biol. Chem. 277, 21119-21122.
41. Stehlik, C., Fiorentino, L., Dorfleutner, A., et al. (2002) The PAAD/PYRIN-family protein ASC is a dual regulator of a conserved step in nuclear factor κB activation pathways. J. Exp. Med. 196, 1605-1615.
42. Takeda, K., Kaisho, T. & Akira, S. (2003) Toll-like receptors. Annu. Rev. Immunol. 21, 335-376.
43. Tsutsui, H., Kayagaki, N., Kuida, K., et al. (1999) Caspase-1-independent, Fas/Fas ligand-mediated IL-18 secretion from macrophages causes acute liver injury in mice. Immunity 11, 359-367.
44. Tsutsui, H., Matsui, K., Kawada, N., et al. (1997) IL-18 accounts for both TNF-α- and Fas ligand-mediated hepatotoxic pathways in endotoxin-induced liver injury in mice. J. Immunol. 159, 3961-3967.
45. Tsutsui, H., Matsui, K., Okamura, H. & Nakanishi, K. (2000) Pathophysiological roles of interleukin-18 for inflammatory liver diseases. Immunol. Rev. 174, 192-209.
46. Wang, L., Manji, G.A., Grenier, J.M., et al. (2002) PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-κB and caspase-1-dependent cytokine processing. J. Biol. Chem. 277, 29874-29880.
47. Wang, S., Miura, M. Jung, Y.K., Zhu, H., Li, E. & Yuan, J. (1998) Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE. Cell 92, 501-509.
48. Yamamoto, M., Sato, S., Hemmi, H., et al. (2003) Role of adaptor TRIF in the MyD88-independent Toll-like receptor signaling pathway. Science 301, 640-643.
49. Yao, R., Ito, C., Natsume, Y., et al. (2002) Lack of acrosome formation in mice lacking a Golgi protein, GOPC. Proc. Natl. Acad. Soc. USA 99, 11211-11216.