The 1.4-MDa apoptosome is a critical intermediate in apoptosome maturation

American Journal of Physiology - Cell Physiology

Volumn 287, Issue 3 56-3, 2004, Pages

  Beem, Elaine ^a   Holliday, L Shannon ^b   Segal, Mark S ^a,c  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF FLORIDA COLLEGE OF DENTISTRY   (United States)

^c NONE   (United States)

Author keywords

Apoptosis; Caspase; PH; Potassium

Indexed keywords

APOPTOSOME; CASPASE 9; CYTOCHROME C; POTASSIUM CHLORIDE;

ACIDIFICATION; ALKALINITY; APOPTOSIS; ARTICLE; CELL MATURATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VIVO STUDY; PH MEASUREMENT; PRIORITY JOURNAL;

APOPTOSIS; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; CASPASE 9; CASPASES; CYTOCHROMES C; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME ACTIVATION; HUMANS; HYDROGEN-ION CONCENTRATION; IMMUNOBLOTTING; JURKAT CELLS; MODELS, BIOLOGICAL; POTASSIUM CHLORIDE; PROTEINS; RECOMBINANT PROTEINS;

EID: 4143093635     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.00232.2003     Document Type: Article

References (30)

1. Acehan D, Jiang X, Morgan DG, Heuser JE, Wang X, and Akey CW. Three-dimensional structure of the apoptosome: implications for assembly, procaspase-9 binding, and activation. Mol Cell 9: 423-432, 2002.
2. Baltz JM. Intracellular pH regulation in the early embryo. Bioessays 15: 523-530, 1993.
3. +, cell shrinkage, and mitochondrial membrane potential during lymphocyte apoptosis. J Biol Chem 274: 21953-21962, 1999.
4. + efflux in the activation of apoptosis. J Biol Chem 272: 32436-32442, 1997.
5. Brenner C and Kroemer G. Apoptosis: mitochondria - the death signal integrators. Science 289: 1150-1151, 2000.
6. Cai J, Yang J, and Jones DP. Mitochondrial control of apoptosis: the role of cytochrome c. Biochim Biophyx Acta 1366: 139-149, 1998.
7. Cain K, Bratton SB, Langlais C, Walker G, Brown DG, Sun XM, and Cohen GM. Apaf-1 oligomerizes into biologically active ∼700-kDa and inactive ∼1.4-MDa apoptosome complexes. J Biol Chem 275: 6067-6070, 2000.
8. + inhibit cytochrome c-dependent formation of the apoptosome. J Biol Chem 276: 41985-41990, 2001.
9. Chen Q, Benson RS, Whetton AD, Brant SR, Donowitz M, Montrose MH, Dive C, and Watson AJ. Role of acid/base homeostasis in the suppression of apoptosis in haemopoietic cells by v-Ab1 protein tyrosine kinase. J Cell Sci 110: 379-387, 1997.
10. Cohen GM. Caspases: the executioners of apoptosis. Biochem J 326: 1-16, 1997.
11. Fadok VA, Voelker DR, Campbell PA, Cohen JJ, Bratton DL, and Henson PM. Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages. J Immunol 148: 2207-2216, 1992.
12. Furlong IJ, Ascaso R, Lopez Rivas A, and Collins MK. Intracellular acidification induces apoptosis by stimulating ICE-like protease activity. J Cell Sci 110: 653-661, 1997.
13. Gendron MC, Schrantz N, Métivier D, Kroemer G, Maciorowska Z, Sureau F, Koester S, and Petit PX. Oxidation of pyridine nucleotides during Fas- and ceramide-induced apoptosis in Jurkat cells: correlation with changes in mitochondria, glutathione depletion, intracellular acidification and caspase 3 activation. Biochem J 353: 357-367, 2001.
14. Green DR and Reed JC. Mitochondria and apoptosis. Science 281: 1309-1312, 1998.
15. Hirpara JL, Clément MV, and Pervaiz S. Intracellular acidification triggered by mitochondrial-derived hydrogen peroxide is an effector mechanism for drug-induced apoptosis in lumor cells. J Biol Chem 276: 514-521, 2001.
16. Hiura TS, Li N, Kaplan R, Horwitz M, Seagrave JC, and Nel AE. The role of a mitochondrial pathway in the induction of apoptosis by chemicals extracted from diesel exhaust particles. J Immunol 165: 2703-2711, 2000.
17. Iguchi K, Usui S, Ishida R, and Hirano K. Imidazole-induced cell death, associated with intracellular acidification, caspase-3 activation, DFF-45 cleavage. but not oligonucleosomal DNA fragmentation. Apoptosis 7: 519-525, 2002.
18. Kita T, Brown MS, and Goldstein JL. Feedback regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in livers of mice treated with mevinolin, a competitive inhibitor of the reductase. J Clin Invest 66; 1094-1100, 1980.
19. Kroemer G, Dallaporta B, and Resche-Rigon M. The mitochondrial death/life regulator in apoptosis and necrosis. Annu Rev Physiol 60: 619-642, 1998.
20. Li H, Kolluri SK, Gu J, Dawson MI, Cao X, Hobhs PD, Lin B, Chen G, Lu J, Lin F, Xie Z, Fontana JA, Reed JC, and Zhang X. Cytochrome c release and apoptosis induced by mitochondrial targeting of nuclear orphan receptor TR3. Science 289: 1159-1164, 2000.
21. Liu D, Martino G, Thangaraju M, Sharma M, Halwani F, Shen SH, Patel YC, and Srikant CB. Caspase-8-mediated intracellular acidification precedes mitochondrial dysfunction in somatostatin-induced apoptosis. J Biol Chem 275: 9244-9250, 2000.
22. Matsuyama S, Llopis J, Deveraux QL, Tsien RY, and Reed JC. Changes in intramitochondrial and cytosolic pH: early events that modulate caspase activation during apoptosis. Nat Cell Biol 2: 318-325, 2000.
23. Pérez-Sala D, Collado-Escobar D, and Mollinedo F. Intracellular alkalinization suppresses lovastatin-induced apoptosis in HL-60 cells through the inactivation of a pH-dependent endonuclease. J Biol Chem 270: 6235-6242, 1995.
24. Renatus M, Stennicke HR, Scott FL, Liddington RC, and Salvesen GS. Dimer formation drives the activation of the cell death protease caspase 9. Proc Nat Acad Sci USA 98: 14250-14255, 2001.
25. Roherteon AM, Bird CC, Waddell AW, and Currie AR. Morphological aspects of glucocorticoid-induced cell death in human lymphoblastoid cells. J Pathol 126: 181-187, 1978.
26. Segal MS and Beem E. Effect of pH, ionic charge, and osmolality on cytochrome c-mediated caspase-3 activity. Am J Physiol Cell Physiol 281: C1196-C1204, 2001.
27. + exchanger isoform I. Hypertension 27: 859-866, 1996.
28. Von Ahsen O, Renken C, Perkins G, Kluck RM, Bossy-Wetzel E, and Newmeyer DD. Preservation of mitochondrial structure and function after Bid- or Bax-mediated cytochrome c release. J Cell Biol 150: 1027-1036, 2000.
29. Winer BJ. Statistical Principles in Experimental Design (2nd ed.). New York: McGraw-Hill, 1971.
30. Wyllie AH. Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature 284: 555-556, 1980.