-
1
-
-
0037312509
-
NALPs: A novel protein family involved in inflammation
-
Tschopp J., Martinon F., Burns K. NALPs: a novel protein family involved in inflammation. Nat Rev Mol Cell Biol. 4:2003;95-104.
-
(2003)
Nat Rev Mol Cell Biol
, vol.4
, pp. 95-104
-
-
Tschopp, J.1
Martinon, F.2
Burns, K.3
-
2
-
-
0036205587
-
Mechanisms of caspase activation and inhibition during apoptosis
-
Shi Y. Mechanisms of caspase activation and inhibition during apoptosis. Mol Cell. 9:2002;459-470.
-
(2002)
Mol Cell
, vol.9
, pp. 459-470
-
-
Shi, Y.1
-
3
-
-
0033605722
-
Caspase-9 can be activated without proteolytic processing
-
Stennicke H.R., Deveraux Q.L., Humke E.W., Reed J.C., Dixit V.M., Salvesen G.S. Caspase-9 can be activated without proteolytic processing. J Biol Chem. 274:1999;8359-8362.
-
(1999)
J Biol Chem
, vol.274
, pp. 8359-8362
-
-
Stennicke, H.R.1
Deveraux, Q.L.2
Humke, E.W.3
Reed, J.C.4
Dixit, V.M.5
Salvesen, G.S.6
-
4
-
-
0037291871
-
A unified model for apical caspase activation
-
This work demonstrates that the zymogens of initiator caspases-8, -9 and -10 exist as latent monomers, whereas the zymogens of executioner caspases-3 and -7 exist as latent dimers. Together with Donepudi, this work shows that the inititator caspases are activated by dimerization, independent of cleavage.
-
Boatright K.M., Renatus M., Scott F.L., Sperandio S., Shin H., Pedersen I., Ricci J.-E., Edris W.A., Sutherlin D.P., Green D.R., et al. A unified model for apical caspase activation. Mol Cell. 11:2003;529-541 This work demonstrates that the zymogens of initiator caspases-8, -9 and -10 exist as latent monomers, whereas the zymogens of executioner caspases-3 and -7 exist as latent dimers. Together with Donepudi, this work shows that the inititator caspases are activated by dimerization, independent of cleavage.
-
(2003)
Mol Cell
, vol.11
, pp. 529-541
-
-
Boatright, K.M.1
Renatus, M.2
Scott, F.L.3
Sperandio, S.4
Shin, H.5
Pedersen, I.6
Ricci, J.-E.7
Edris, W.A.8
Sutherlin, D.P.9
Green, D.R.10
-
5
-
-
0037291890
-
Insights into the regulatory mechanism for caspase-8 activation
-
••] by demonstrating that recombinant caspase-8 is activated through dimerization rather than by cleavage.
-
••] by demonstrating that recombinant caspase-8 is activated through dimerization rather than by cleavage.
-
(2003)
Mol Cell
, vol.11
, pp. 543-549
-
-
Donepudi, M.1
Mac Sweeney, A.2
Briand, C.3
Gruetter, M.G.4
-
6
-
-
0032575714
-
Death receptors: Signaling and modulation
-
Ashkenazi A., Dixit V.M. Death receptors: signaling and modulation. Science. 281:1998;1305-1308.
-
(1998)
Science
, vol.281
, pp. 1305-1308
-
-
Ashkenazi, A.1
Dixit, V.M.2
-
7
-
-
0036133127
-
Molecular ordering of the initial signaling events of CD95
-
This paper provides a detailed account of the events following death receptor ligation and the eventual internalization of the receptor.
-
Algeciras-Schimnich A., Shen L., Barnhart B.C., Murmann A.E., Burkhardt J.K., Peter M.E. Molecular ordering of the initial signaling events of CD95. Mol Cell Biol. 22:2002;207-220 This paper provides a detailed account of the events following death receptor ligation and the eventual internalization of the receptor.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 207-220
-
-
Algeciras-Schimnich, A.1
Shen, L.2
Barnhart, B.C.3
Murmann, A.E.4
Burkhardt, J.K.5
Peter, M.E.6
-
8
-
-
0033613143
-
Caspase activation: The induced-proximity model
-
Salvesen G.S., Dixit V.M. Caspase activation: the induced-proximity model. Proc Natl Acad Sci USA. 96:1999;10964-10967.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 10964-10967
-
-
Salvesen, G.S.1
Dixit, V.M.2
-
9
-
-
0042466637
-
Inter-dimer processing mechanism of procaspase-8 activation
-
Chang D.W., Xing Z., Capacio V.L., Peter M.E., Yang X. Inter-dimer processing mechanism of procaspase-8 activation. EMBO J. 22:2003;4132-4142.
-
(2003)
EMBO J
, vol.22
, pp. 4132-4142
-
-
Chang, D.W.1
Xing, Z.2
Capacio, V.L.3
Peter, M.E.4
Yang, X.5
-
10
-
-
0032505127
-
Essential requirement for caspase-8/FLICE in the initiation of the Fas-induced apoptotic cascade
-
Juo P., Kuo C.J., Yuan J., Blenis J. Essential requirement for caspase-8/FLICE in the initiation of the Fas-induced apoptotic cascade. Curr Biol. 8:1998;1001-1008.
-
(1998)
Curr Biol
, vol.8
, pp. 1001-1008
-
-
Juo, P.1
Kuo, C.J.2
Yuan, J.3
Blenis, J.4
-
11
-
-
0035824635
-
Death receptor recruitment of endogenous caspase-10 and apoptosis initiation in the absence of caspase-8
-
Kischkel F.C., Lawrence D.A., Tinel A., LeBlanc H., Virmani A., Schow P., Gazdar A., Blenis J., Arnott D., Ashkenazi A. Death receptor recruitment of endogenous caspase-10 and apoptosis initiation in the absence of caspase-8. J Biol Chem. 276:2001;46639-46646.
-
(2001)
J Biol Chem
, vol.276
, pp. 46639-46646
-
-
Kischkel, F.C.1
Lawrence, D.A.2
Tinel, A.3
Leblanc, H.4
Virmani, A.5
Schow, P.6
Gazdar, A.7
Blenis, J.8
Arnott, D.9
Ashkenazi, A.10
-
12
-
-
0035923653
-
Caspase-10 is an initiator caspase in death receptor signaling
-
Wang J., Chun H.J., Wong W., Spencer D.M., Lenardo M.J. Caspase-10 is an initiator caspase in death receptor signaling. Proc Natl Acad Sci USA. 98:2001;13884-13888.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 13884-13888
-
-
Wang, J.1
Chun, H.J.2
Wong, W.3
Spencer, D.M.4
Lenardo, M.J.5
-
13
-
-
0037009370
-
Caspase-10 is recruited to and activated at the native TRAIL and CD95 death-inducing signalling complexes in a FADD-dependent manner but can not functionally substitute caspase-8
-
Sprick M.R., Rieser E., Stahl H., Grosse-Wilde A., Weigand M.A., Walczak H. Caspase-10 is recruited to and activated at the native TRAIL and CD95 death-inducing signalling complexes in a FADD-dependent manner but can not functionally substitute caspase-8. EMBO J. 21:2002;4520-4530.
-
(2002)
EMBO J
, vol.21
, pp. 4520-4530
-
-
Sprick, M.R.1
Rieser, E.2
Stahl, H.3
Grosse-Wilde, A.4
Weigand, M.A.5
Walczak, H.6
-
14
-
-
0033538475
-
Inherited human Caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II
-
Wang J., Zheng L., Lobito A., Chan F.K., Dale J., Sneller M., Yao X., Puck J.M., Straus S.E., Lenardo M.J. Inherited human Caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II. Cell. 98:1999;47-58.
-
(1999)
Cell
, vol.98
, pp. 47-58
-
-
Wang, J.1
Zheng, L.2
Lobito, A.3
Chan, F.K.4
Dale, J.5
Sneller, M.6
Yao, X.7
Puck, J.M.8
Straus, S.E.9
Lenardo, M.J.10
-
15
-
-
18544383460
-
Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency
-
A detailed study of human patients exhibiting immunodeficiency linked to a homozygous mutation in the caspase-8 gene that renders the enzyme unstable and inactive. The study provides strong evidence that caspase-8 is involved in lymphocyte activation.
-
Chun H.J., Zheng L., Ahmad M., Wang J., Speirs C.K., Siegel R.M., Dale J.K., Puck J., Davis J., Hall C.G., et al. Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency. Nature. 419:2002;395-399 A detailed study of human patients exhibiting immunodeficiency linked to a homozygous mutation in the caspase-8 gene that renders the enzyme unstable and inactive. The study provides strong evidence that caspase-8 is involved in lymphocyte activation.
-
(2002)
Nature
, vol.419
, pp. 395-399
-
-
Chun, H.J.1
Zheng, L.2
Ahmad, M.3
Wang, J.4
Speirs, C.K.5
Siegel, R.M.6
Dale, J.K.7
Puck, J.8
Davis, J.9
Hall, C.G.10
-
16
-
-
0032143986
-
Targeted disruption of the mouse Caspase-8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally
-
Varfolomeev E.E., Schuchmann M., Luria V., Chiannilkulchai N., Beckmann J.S., Mett I.L., Rebrikov D., Brodianski V.M., Kemper O.C., Kollet O., et al. Targeted disruption of the mouse Caspase-8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally. Immunity. 9:1998;267-276.
-
(1998)
Immunity
, vol.9
, pp. 267-276
-
-
Varfolomeev, E.E.1
Schuchmann, M.2
Luria, V.3
Chiannilkulchai, N.4
Beckmann, J.S.5
Mett, I.L.6
Rebrikov, D.7
Brodianski, V.M.8
Kemper, O.C.9
Kollet, O.10
-
17
-
-
0037099678
-
C-FLIP(L) is a dual function regulator for caspase-8 activation and CD95-mediated apoptosis
-
L is shown to activate caspase-8, presumably through heterodimerization.
-
L is shown to activate caspase-8, presumably through heterodimerization.
-
(2002)
EMBO J
, vol.21
, pp. 3704-3714
-
-
Chang, D.W.1
Xing, Z.2
Pan, Y.3
Algeciras-Schimnich, A.4
Barnhart, B.C.5
Yaish-Ohad, S.6
Peter, M.E.7
Yang, X.8
-
18
-
-
0037160117
-
The long form of FLIP is an activator of Caspase-8 at the Fas death-inducing signaling complex
-
L to activate caspase-8 through the formation of heterodimers with catalytic activity.
-
L to activate caspase-8 through the formation of heterodimers with catalytic activity.
-
(2002)
J Biol Chem
, vol.277
, pp. 45162-45171
-
-
Micheau, O.1
Thome, M.2
Schneider, P.3
Holler, N.4
Tschopp, J.5
Nicholson, D.W.6
Briand, C.7
Grutter, M.G.8
-
19
-
-
0033596980
-
An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9
-
Zou H., Li Y., Liu X., Wang X. An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9. J Biol Chem. 274:1999;11549-11556.
-
(1999)
J Biol Chem
, vol.274
, pp. 11549-11556
-
-
Zou, H.1
Li, Y.2
Liu, X.3
Wang, X.4
-
20
-
-
0030715323
-
Cytochrome c and dATP-dependent formation of Apaf-1/Caspase-9 complex initiates an apoptotic protease cascade
-
Li P., Nijhawan D., Budihardjo I., Srinivasula S.M., Ahmad M., Alnemri E.S., Wang X. Cytochrome c and dATP-dependent formation of Apaf-1/Caspase-9 complex initiates an apoptotic protease cascade. Cell. 91:1997;479-489.
-
(1997)
Cell
, vol.91
, pp. 479-489
-
-
Li, P.1
Nijhawan, D.2
Budihardjo, I.3
Srinivasula, S.M.4
Ahmad, M.5
Alnemri, E.S.6
Wang, X.7
-
21
-
-
0036187036
-
Three-dimensional structure of the apoptosome: Implications for assembly, procaspase-9 binding and activation
-
Acehan D., Jiang X., Morgan D.G., Heuser J.E., Wang X., Akey C.W. Three-dimensional structure of the apoptosome: implications for assembly, procaspase-9 binding and activation. Mol Cell. 9:2002;423-432.
-
(2002)
Mol Cell
, vol.9
, pp. 423-432
-
-
Acehan, D.1
Jiang, X.2
Morgan, D.G.3
Heuser, J.E.4
Wang, X.5
Akey, C.W.6
-
22
-
-
0035807966
-
Dimer formation drives the activation of the cell death protease caspase 9
-
Renatus M., Stennicke H.R., Scott F.L., Liddington R.C., Salvesen G.S. Dimer formation drives the activation of the cell death protease caspase 9. Proc Natl Acad Sci USA. 98:2001;14250-14255.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 14250-14255
-
-
Renatus, M.1
Stennicke, H.R.2
Scott, F.L.3
Liddington, R.C.4
Salvesen, G.S.5
-
23
-
-
0035282570
-
A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis
-
Srinivasula S.M., Hegde R., Saleh A., Datta P., Shiozaki E., Chai J., Lee R.A., Robbins P.D., Fernandes-Alnemri T., Shi Y., et al. A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis. Nature. 410:2001;112-116.
-
(2001)
Nature
, vol.410
, pp. 112-116
-
-
Srinivasula, S.M.1
Hegde, R.2
Saleh, A.3
Datta, P.4
Shiozaki, E.5
Chai, J.6
Lee, R.A.7
Robbins, P.D.8
Fernandes-Alnemri, T.9
Shi, Y.10
-
24
-
-
0035879074
-
Death in the balance: Alternative participation of the caspase-2 and -9 pathways in neuronal death induced by nerve growth factor deprivation
-
Troy C.M., Rabacchi S.A., Hohl J.B., Angelastro J.M., Greene L.A., Shelanski M.L. Death in the balance: alternative participation of the caspase-2 and -9 pathways in neuronal death induced by nerve growth factor deprivation. J Neurosci. 21:2001;5007-5016.
-
(2001)
J Neurosci
, vol.21
, pp. 5007-5016
-
-
Troy, C.M.1
Rabacchi, S.A.2
Hohl, J.B.3
Angelastro, J.M.4
Greene, L.A.5
Shelanski, M.L.6
-
25
-
-
0037162833
-
Requirement for caspase-2 in stress-induced apoptosis before mitochondrial permeabilization
-
Using siRNA, Lassus and colleagues provide strong evidence that caspase-2 is required for certain forms of stress-induced apoptosis. Their work suggests that caspase-2 functions upstream of the mitochondrial release of cytochrome c.
-
Lassus P., Opitz-Araya X., Lazebnik Y. Requirement for caspase-2 in stress-induced apoptosis before mitochondrial permeabilization. Science. 297:2002;1352-1354 Using siRNA, Lassus and colleagues provide strong evidence that caspase-2 is required for certain forms of stress-induced apoptosis. Their work suggests that caspase-2 functions upstream of the mitochondrial release of cytochrome c.
-
(2002)
Science
, vol.297
, pp. 1352-1354
-
-
Lassus, P.1
Opitz-Araya, X.2
Lazebnik, Y.3
-
26
-
-
0037049549
-
A novel Apaf-1-independent putative caspase-2 activation complex
-
This work reveals that, in vitro, caspase-2 is activated by association with a high-molecular-weight complex that is free of cytochrome c or Apaf-1. The authors go on to show that the caspase-2 zymogen is a monomer, and that cleavage is not required for its activation.
-
Read S.H., Baliga B.C., Ekert P.G., Vaux D.L., Kumar S. A novel Apaf-1-independent putative caspase-2 activation complex. J Cell Biol. 159:2002;739-745 This work reveals that, in vitro, caspase-2 is activated by association with a high-molecular-weight complex that is free of cytochrome c or Apaf-1. The authors go on to show that the caspase-2 zymogen is a monomer, and that cleavage is not required for its activation.
-
(2002)
J Cell Biol
, vol.159
, pp. 739-745
-
-
Read, S.H.1
Baliga, B.C.2
Ekert, P.G.3
Vaux, D.L.4
Kumar, S.5
-
27
-
-
0037097012
-
The structure of procaspase 6 is similar to that of active mature caspase 6
-
Kang B.H., Ko E., Kwon O.K., Choi K.Y. The structure of procaspase 6 is similar to that of active mature caspase 6. Biochem J. 364:2002;629-634.
-
(2002)
Biochem J
, vol.364
, pp. 629-634
-
-
Kang, B.H.1
Ko, E.2
Kwon, O.K.3
Choi, K.Y.4
-
28
-
-
0034095571
-
The structures of caspases-1, -3, -7 and -8 reveal the basis for substrate and inhibitor selectivity
-
Wei Y., Fox T., Chambers S.P., Sintchak J., Coll J.T., Golec J.M., Swenson L., Wilson K.P., Charifson P.S. The structures of caspases-1, -3, -7 and -8 reveal the basis for substrate and inhibitor selectivity. Chem Biol. 7:2000;423-432.
-
(2000)
Chem Biol
, vol.7
, pp. 423-432
-
-
Wei, Y.1
Fox, T.2
Chambers, S.P.3
Sintchak, J.4
Coll, J.T.5
Golec, J.M.6
Swenson, L.7
Wilson, K.P.8
Charifson, P.S.9
-
29
-
-
0035798361
-
Crystal structure of a procaspase-7 zymogen. Mechanisms of activation and substrate binding
-
••], is fundamental to our understanding of executioner caspase activation.
-
••], is fundamental to our understanding of executioner caspase activation.
-
(2001)
Cell
, vol.107
, pp. 399-407
-
-
Chai, J.1
Wu, Q.2
Shiozaki, E.3
Srinivasula, S.M.4
Alnemri, E.S.5
Shi, Y.6
-
30
-
-
0035909889
-
Structural basis for the activation of human procaspase-7
-
••].
-
••].
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 14790-14795
-
-
Riedl, S.J.1
Fuentes-Prior, P.2
Renatus, M.3
Kairies, N.4
Krapp, R.5
Huber, R.6
Salvesen, G.S.7
Bode, W.8
-
31
-
-
0035960562
-
Dimeric procaspase-3 unfolds via a four-state equilibrium process
-
Bose K., Clark A.C. Dimeric procaspase-3 unfolds via a four-state equilibrium process. Biochemistry. 40:2001;14236-14242.
-
(2001)
Biochemistry
, vol.40
, pp. 14236-14242
-
-
Bose, K.1
Clark, A.C.2
-
32
-
-
15144345497
-
Pro-caspase-3 is a major physiologic target of caspase-8
-
Stennicke H.R., Jurgensmeier J.M., Shin H., Deveraux Q., Wolf B.B., Yang X., Zhou Q., Ellerby H.M., Ellerby L.M., Bredesen D., et al. Pro-caspase-3 is a major physiologic target of caspase-8. J Biol Chem. 273:1998;27084-27090.
-
(1998)
J Biol Chem
, vol.273
, pp. 27084-27090
-
-
Stennicke, H.R.1
Jurgensmeier, J.M.2
Shin, H.3
Deveraux, Q.4
Wolf, B.B.5
Yang, X.6
Zhou, Q.7
Ellerby, H.M.8
Ellerby, L.M.9
Bredesen, D.10
-
33
-
-
0141817959
-
Human caspase-7 activity and regulation by its N-terminal peptide
-
Denault J.B., Salvesen G.S. Human caspase-7 activity and regulation by its N-terminal peptide. J Biol Chem. 278:2003;34042-34050.
-
(2003)
J Biol Chem
, vol.278
, pp. 34042-34050
-
-
Denault, J.B.1
Salvesen, G.S.2
-
34
-
-
0034234532
-
The short prodomain influences caspase-3 activation in HeLa cells
-
Meergans T., Hildebrandt A.K., Horak D., Haenisch C., Wendel A. The short prodomain influences caspase-3 activation in HeLa cells. Biochem J. 349:2000;135-140.
-
(2000)
Biochem J
, vol.349
, pp. 135-140
-
-
Meergans, T.1
Hildebrandt, A.K.2
Horak, D.3
Haenisch, C.4
Wendel, A.5
-
35
-
-
0036671894
-
The inflammasome: A molecular platform triggering activation of inflammatory caspases and processing of proIL-β
-
This paper describes the identification of a large multiprotein complex responsible for activation of the inflammatory caspases-1 and -5. The authors term this complex the inflammasome.
-
Martinon F., Burns K., Tschopp J. The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-β Mol Cell. 10:2002;417-426 This paper describes the identification of a large multiprotein complex responsible for activation of the inflammatory caspases-1 and -5. The authors term this complex the inflammasome.
-
(2002)
Mol Cell
, vol.10
, pp. 417-426
-
-
Martinon, F.1
Burns, K.2
Tschopp, J.3
-
36
-
-
0032548919
-
Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE
-
Wang S., Miura M., Jung Y.-K., Zhu H., Yuan J. Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE. Cell. 92:1998;501-509.
-
(1998)
Cell
, vol.92
, pp. 501-509
-
-
Wang, S.1
Miura, M.2
Jung, Y.-K.3
Zhu, H.4
Yuan, J.5
-
37
-
-
0037815277
-
Fas-associated death domain protein and caspase-8 are not recruited to the tumor necrosis factor receptor 1 signaling complex during tumor necrosis factor-induced apoptosis
-
This work nicely complements that of Micheau and Tschopp by providing clear evidence that caspase-8 is not activated at the TNFR1 signalling complex.
-
Harper N., Hughes M., MacFarlane M., Cohen G.M. Fas-associated death domain protein and caspase-8 are not recruited to the tumor necrosis factor receptor 1 signaling complex during tumor necrosis factor-induced apoptosis. J Biol Chem. 278:2003;25534-25541 This work nicely complements that of Micheau and Tschopp by providing clear evidence that caspase-8 is not activated at the TNFR1 signalling complex.
-
(2003)
J Biol Chem
, vol.278
, pp. 25534-25541
-
-
Harper, N.1
Hughes, M.2
Macfarlane, M.3
Cohen, G.M.4
-
38
-
-
0041853690
-
Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes
-
The authors clearly show an association of endogenous caspase-8 with a cytosolic complex. Their work suggests that this is the activating complex for caspase-8 in the TNF-induced pathway.
-
Micheau O., Tschopp J. Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell. 114:2003;181-190 The authors clearly show an association of endogenous caspase-8 with a cytosolic complex. Their work suggests that this is the activating complex for caspase-8 in the TNF-induced pathway.
-
(2003)
Cell
, vol.114
, pp. 181-190
-
-
Micheau, O.1
Tschopp, J.2
-
39
-
-
0142242170
-
Crystal structure of caspase-2, apical initiator of the intrinsic apoptotic pathway
-
in press
-
Schweizer A, Briand C, Grutter MG: Crystal structure of caspase-2, apical initiator of the intrinsic apoptotic pathway. J Biol Chem 2003, in press.
-
(2003)
J Biol Chem
-
-
Schweizer, A.1
Briand, C.2
Grutter, M.G.3
|