Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors

Nature

Volumn 386, Issue 6624, 1997, Pages 517-521

  Thome, Margot ^a   Schneider, Pascal ^a   Hofmann, Kay ^b   Fickenscher, Helmut ^c   Meinl, Edgar ^c   Neipel, Frank ^c   Mattmann, Chantal ^a   Burns, Kim ^a   Bodmer, Jean Luc ^a   Schröter, Michael ^a   Scaffidi, Carsten ^d   Krammer, Peter H ^d   Peter, Marcus E ^d   Tschopp, Jürg ^a  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

^b SWISS INST FOR EXP CANCER RESEARCH   (Switzerland)

^c UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^d GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS; ARTICLE; CARCINOGENICITY; HERPES VIRUS; HUMAN; HUMAN CELL; PRIORITY JOURNAL; VIRUS CELL INTERACTION; VIRUS INFECTION; VIRUS INHIBITION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, CD95; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CARRIER PROTEINS; CASPASE 8; CASPASE 9; CASPASES; CELL LINE; CELL TRANSFORMATION, VIRAL; CYSTEINE ENDOPEPTIDASES; FAS-ASSOCIATED DEATH DOMAIN PROTEIN; GAMMAHERPESVIRINAE; HERPESVIRUS 2, SAIMIRIINE; HUMANS; MEMBRANE GLYCOPROTEINS; MICE; MOLECULAR SEQUENCE DATA; RECEPTORS, TUMOR NECROSIS FACTOR; RECEPTORS, TUMOR NECROSIS FACTOR, MEMBER 25; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION; TNF-RELATED APOPTOSIS-INDUCING LIGAND; TUMOR NECROSIS FACTOR-ALPHA; VIRAL PROTEINS; VIRUS REPLICATION;

EID: 0030970013     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/386517a0     Document Type: Article

References (30)

1. Shen, Y. & Shenk, T. E. Viruses and apoptosis. Curr. Biol. 5, 105-111 (1995).
2. Smith, C. A., Farrah, T. & Goodwin, R. G. The TNF receptor superfamily of cellular and viral proteins-activation, costimulation, and death. Cell 76, 959-962 (1994).
3. Nagata, S. Apoptosis by death factor. Cell 88, 355-365 (1997).
4. Senkvich, T. G. et al. Genome sequence of a human tumorigenic poxvirus: prediction of specific host response-evasion genes. Science 273, 813-816 (1996).
5. Boldin M. P. et al. A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain. J. Biol. Chim. 270, 7795-7798 (1995).
6. Chinnaiyan, A. M., O'Rourke, K., Tewari, M. & Dixit, V. M. FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell 81, 505-512 (1995).
7. Muzio, M. et al. FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex. Cell 85, 817-827 (1996).
8. Boldin, M. P., Goncharov, T. M., Goltsev, Y. V. & Wallach, D. Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death. Cell 85, 803-815 (1996).
9. Bodmer, J. L. et al. TRAMP, a novel apoptosis-mediating receptor with sequence homology to tumor necrosis factor receptor 1 and Fas(Apo-1/CD95). Immunity 6, 79-88 (1997).
10. Marsters, S. A. et al. Apo-3, a new member of the tumor necrosis factor receptor family, contains a death domain and activates apoptosis and NF-κ-B. Curr. Biol. 6, 1669-1676 (1996).
11. Kitson, J. et al. A death-domain-containing receptor that mediates apoptosis. Nature 384, 372-373 (1996).
12. Yu, G. L. et al. Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95. Science 274, 990-992 (1996).
13. Chang, Y. et al. Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science 266, 1865-1869 (1994).
14. Tschopp, J. & Hofmann, K. Cytotoxic T cells: more weapons for new targets? Trends Microbiol. 4, 91-94 (1996).
15. Henkart, P. A. ICE family proteases: mediators of all apoptotic cell death? Immunity 4, 195-201 (1996).
16. Kischkel, F. C. et al. Cytotoxicity-dependent Apo-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor. EMBO J. 14, 5579-5588 (1995).
17. Medema, J. et al. FLICE is activated by association with the CD95 death-inducing signaling complex. EMBO J. (in the press).
18. Chinnaiyan, A. M. et al. FADD/MORT1 is a common mediator of CD95 (Fas/APO-1) and tumor necrosis factor receptor-induced apoptosis. J. Biol. Chem. 271, 4961-4965 (1996).
19. Bucher, P., Karplus K., Moeri, N. & Hofmann, K. A flexible search technique based on generalized profiles. Comp. Chem. 20, 3-24 (1996).
20. Fernandes-Alnemri, T. et al. In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains. Proc. Natl Acad. Sci. USA 93, 7464-7469 (1996).
21. Wiley, S. R. et al. Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity 3, 673-682 (1995).
22. Fickensher, H., Biesinger, B., Knappe, A., Wittmann, S. & Fleckenstein, B. Regulation of the herpesvirus saimiri oncogene stpC, similar to that of T-cell activation genes, in growth-transformed human T lymphocytes. J. Virol. 70, 6012-6019 (1996).
23. Yang, E. & Korsmeyer, S. J. Molecular thanatopsis: a discourse on the BCL2 family and cell death. Blood 88, 386-401 (1996).
24. Huang, D. C. S., Cory, S. & Strasser, A. Bcl-2, Bcl-xL and adenovirus protein E1B19kD are functionally equivalent in their ability to inhibit cell death. Oncogene 14, 405-414 (1997).
25. Hahne, M. et al. Melanoma cells express Fas(Apo-1/CD95) ligand: Implications for tumor immune escape. Science 274, 1363-1366 (1996).
26. Strand, S. et al. Lymphocyte apoptosis induced by CD95 (Apo-1/Fas) ligand-expressing tumor cells-A mechanism of immune evasion? Nature Med. 2, 1361-1366 (1996).
27. Rensing-Ehl, A. et al. Local Fas/APO-1 (CD95) ligand-mediated tumor cell killing in vivo. Eur. J. Immunol. 25, 2253-2258 (1995).
28. Nicoletti, I., Migliorati, G., Pagliacci, M. C., Grignani, F. & Riccardi, C. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J. Immunol. Meth. 139, 271-279 (1991).
29. Russo, J. J. et al. Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8). Proc. Natl Acad. Sci. USA 93, 14862-14867 (1996).
30. Bertin, J. et al. Death effector domain-containing herpesvirus and poxvirus proteins inhibit Fas- and TNFR1-induced apoptosis. Proc. Natl Acad. Sci. USA 94, 1172-1176 (1997).