The PIDDosome, a Protein Complex Implicated in Activation of Caspase-2 in Response to Genotoxic Stress

Science

Volumn 304, Issue 5672, 2004, Pages 843-846

  Tinel, Antoine ^a   Tschopp, Jürg ^a  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; CHEMICAL ACTIVATION; COMPLEXATION; MOLECULAR STRUCTURE;

APOPTOSOME; STRESS-INDUCED APOPTOSIS;

PROTEINS;

CASPASE 2; CELL PROTEIN; PROTEIN P53; PROTEIN PIDD; UNCLASSIFIED DRUG;

GENOTOXICITY; MEDICINE;

APOPTOSIS; ARTICLE; COMPLEX FORMATION; ENZYME ACTIVATION; GENOTOXICITY; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN EXPRESSION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; APOPTOSIS; CARRIER PROTEINS; CASPASE 2; CASPASES; CELL LINE; CELL LINE, TUMOR; CLONING, MOLECULAR; CRADD SIGNALING ADAPTOR PROTEIN; DNA DAMAGE; DOXORUBICIN; ENZYME ACTIVATION; ETOPOSIDE; HUMANS; PROTEIN STRUCTURE, TERTIARY; PROTEINS; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRANSFECTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 2442453730     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1095432     Document Type: Article

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23. We thank H. Everett, S. Janssen, and P. Schneider for helpful comments. We are grateful to Junying Yuan for the caspase-2-deficient MEFs. Supported by grants of the Swiss National Science Foundation and CTI.