RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems

Nature

Volumn 416, Issue 6877, 2002, Pages 194-199

  Kobayashi, Koichi ^a   Inohara, Naohiro ^b   Hernandez, Lorraine D ^c   Galán, Jorge E ^c   Nüñez, Gabriel ^b   Janeway, Charles A ^a   Medzhitov, Ruslan ^a   Flavell, Richard A ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGENS; DNA; PROTEINS; SIGNAL PROCESSING;

RECEPTORS;

IMMUNOLOGY;

BACTERIAL DNA; CASPASE; CD4 ANTIGEN; CHEMOKINE; CONCANAVALIN A; CYTOPLASM PROTEIN; DOUBLE STRANDED RNA; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 18; INTERLEUKIN 18 RECEPTOR; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 6; LEUCINE; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; PEPTIDOGLYCAN; PROTEIN; PROTEIN SERINE THREONINE KINASE; T LYMPHOCYTE RECEPTOR; TOLL LIKE RECEPTOR;

ADAPTATION; BIOCHEMISTRY; IMMUNE SYSTEM; IMMUNITY;

ARTICLE; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; IMMUNE SYSTEM; IMMUNOBLOTTING; IMMUNOPRECIPITATION; LYMPHOCYTE DIFFERENTIATION; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; CARRIER PROTEINS; CELL DIFFERENTIATION; CELLS, CULTURED; DROSOPHILA PROTEINS; GENE DELETION; IMMUNITY, NATURAL; INTERLEUKINS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KILLER CELLS, NATURAL; LISTERIA INFECTIONS; LISTERIA MONOCYTOGENES; LYMPHOCYTE ACTIVATION; MACROPHAGES; MEMBRANE GLYCOPROTEINS; MICE; MICE, KNOCKOUT; NF-KAPPA B; NOD1 SIGNALING ADAPTOR PROTEIN; NOD2 SIGNALING ADAPTOR PROTEIN; PROTEIN-SERINE-THREONINE KINASES; RECEPTOR-INTERACTING PROTEIN SERINE-THREONINE KINASE 2; RECEPTOR-INTERACTING PROTEIN SERINE-THREONINE KINASES; RECEPTORS, ANTIGEN, T-CELL; RECEPTORS, CELL SURFACE; RECEPTORS, CYTOKINE; RECEPTORS, INTERLEUKIN; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTORS; TUMOR NECROSIS FACTOR-ALPHA;

BACTERIA (MICROORGANISMS);

EID: 0037075551     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/416194a     Document Type: Article

References (29)

1. RICK, a novel protein kinase containing a caspase recruitment domain, interacts with CLARP and regulates CD95-mediated apoptosis
2. RIP2 is a novel NF-κB-activating and cell death-inducing kinase
3. Identification of CARDIAK, a RIP-like kinase that associates with caspase-1
4. Innate immune recognition: Mechanisms and pathways
5. The death domain kinase RIP mediates the TNF-induced NF-κB signal
6. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene
7. Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components
8. A Toll-like receptor recognizes bacterial DNA
9. Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3
10. Differential regulation of cytokine and cytokine receptor mRNA expression upon infection of bone marrow-derived macrophages with Listeria monocytogenes
11. ICEBERG: A novel inhibitor of interleukin-1β generation
12. MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways
13. Unresponsiveness of MyD88-deficient mice to endotoxin
14. Human CARD4 protein is a novel CED-4/Apaf-1 cell death family member that activates NF-κB
15. Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-κB
16. Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-κB
17. Human nod1 confers responsiveness to bacterial lipopolysaccharides
18. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
19. CARD4/Nod1 mediates NF-κB and JNK activation by invasive Shigella flexneri
20. High-resolution genetic and physical map of the Lgn1 interval in C57BL/6J implicates Naip2 or Naip5 in Legionella pneumophila pathogenesis
21. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
22. CARD 15 mutations in Blau syndrome
23. IL-18-stimulated GADD45-β required in cytokine-induced, but not TCR-induced, IFN-γ production
24. Regulation of naive T cell differentiation by varying the potency of TCR signal transduction
25. Bcl10 is a positive regulator of antigen receptor-induced activation of NF-κB and neural tube closure
26. PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes
27. Preferential role for NF-κ B/Rel signaling in the type 1 but not type 2 T cell-dependent immune response in vivo
28. Evidence for a γ-interferon receptor that regulates macrophage tumoricidal activity
29. Expression of a murine homologue of the inhibitor of apoptosis protein is related to cell proliferation