Engineering a dimeric caspase-9: A re-evaluation of the induced proximity model for caspase activation

PLoS Biology

Volumn 3, Issue 6, 2005, Pages 1079-1087

  Chao, Yang ^a   Shiozaki, Eric N ^a   Srinivasula, Srinivasa M ^b   Rigotti, Daniel J ^c   Fairman, Robert ^c   Shi, Yigong ^a  

^a PRINCETON UNIVERSITY   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c HAVERFORD COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOTIC PROTEASE ACTIVATING FACTOR 1; CASPASE; CASPASE 9; RECOMBINANT PROTEIN;

ARTICLE; CATALYSIS; CELL DEATH; COMPARATIVE STUDY; CONFORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DIMERIZATION; ENGINEERING; ENZYME ACTIVATION; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; QUALITATIVE ANALYSIS; STRUCTURE ANALYSIS; WILD TYPE; BIOLOGICAL MODEL; CHEMISTRY; ESCHERICHIA COLI; GENETIC ENGINEERING; GENETICS; METABOLISM; MOLECULAR CLONING; X RAY CRYSTALLOGRAPHY;

CASPASE 9; CASPASES; CATALYSIS; CLONING, MOLECULAR; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; ENZYME ACTIVATION; ESCHERICHIA COLI; GENETIC ENGINEERING; MODELS, BIOLOGICAL; RECOMBINANT PROTEINS;

EID: 22744436580     PISSN: 15449173     EISSN: None     Source Type: Journal    
DOI: 10.1371/journal.pbio.0030183     Document Type: Article

References (33)

1. Shi Y (2002) Mechanisms of caspase inhibition and activation during apoptosis. Mol Cell 9: 459-470.
2. Thornberry NA, Lazebnik Y (1998) Caspases: Enemies within. Science 281: 1312-1316.
3. Budihardjo I, Oliver H, Lutter M, Luo X, Wang X (1999) Biochemical pathways of caspase activation during apoptosis. Annu Rev Cell Dev Biol 15: 269-290.
4. Earnshaw WC, Martins LM, Kaufmann SH (1999) Mammalian caspases: structure, activation, substrates, and functions during apoptosis. Annu Rev Biochem 68: 383-424.
5. Fesik SW (2000) Insights into programmed cell death through structural biology. Cell 103: 273-282.
6. Riedl SJ, Shi Y (2004) Molecular mechanisms of caspase regulation during apoptosis. Nat Rev Mol Cell Biol 5: 897-907.
7. Acehan D, Jiang X, Morgan DG, Heuser JE, Wang X, et al. (2002) Three-dimensional structure of the apoptosome: Implications for assembly, procaspase-9 binding and activation. Mol Cell 9: 423-432.
8. Shi Y (2002) Apoptosome: The cellular engine for the activation of caspase-9. Structure 10: 285-288.
9. Adams JM, Cory S (2002) Apoptosomes: Engines for caspase activation. Curr Opin Cell Biol 14: 715-720.
10. Chai J, Wu Q, Shiozaki E, Srinivasula SM, Alnemri ES, et al. (2001) Crystal Structure of a procaspase-7 zymogen: Mechanisms of activation and substrate binding. Cell 107: 399-407.
11. Riedl SJ, Fuentes-Prior P, Renatus M, Kairies N, Krapp S, et al. (2001) Structural basis for the activation of human procaspase-7. Proc Natl Acad Sci U S A 98: 14790-14795.
12. Shi Y (2004) Caspase activation: Revisiting the induced proximity model. Cell 117: 855-858.
13. Yang X, Chang HY, Baltimore D (1998) Autoproteolytic activation of procaspases by oligomerization. Mol Cell 1: 319-325.
14. Muzio M, Stockwell BR, Stennicke HR, Salvesen GS, Dixit VM (1998) An induced proximity model for caspase-8 activation. J Biol Chem 273: 2926-2930.
15. MacCorkle RA, Freeman KW, Spencer DM (1998) Synthetic activation of caspases: Artificial death switches. Proc Natl Acad Sci U S A 95: 3655-3660.
16. Srinivasula SM, Ahmad M, Fernandes-Alnemri T, Alnemri ES (1998) Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization. Mol Cell 1: 949-957.
17. Yang X, Chang HY, Baltimore D (1998) Essential role of CED-4 oligomerization in CED-3 activation and apoptosis. Science 281: 1355-1357.
18. Salvesen GS, Dixit VM (1999) Caspase activation: The induced-proximity model. Proc Natl Acad Sci U S A 96: 10964-10967.
19. Renatus M, Stennicke HR, Scott FL, Liddington RC, Salvesen GS (2001) Dimer formation drives the activation of the cell death protease caspase 9. Proc Natl Acad Sci U S A 98: 14250-14255.
20. Boatright KM, Renatus M, Scott FL, Sperandio S, Shin H, et al. (2003) A unified model for apical caspase activation. Mol Cell 11: 529-541.
21. Donepudi M, Mac Sweeney A, Briand C, Grutter MG (2003) Insights into the regulatory mechanism for caspase-8 activation. Mol Cell 11: 543-549.
22. Shiozaki EN, Chai J, Rigotti DJ, Riedl SJ, Li P, et al. (2003) Mechanism of XIAP-mediated inhibition of caspase-9. Mol Cell 11: 519-527.
23. Boatright KM, Salvesen GS (2003) Mechanisms of caspase activation. Curr Opin Cell Biol 15: 725-731.
24. Hu Y, Ding L, Spencer DM, Nunez G (1998) WD-40 repeat region regulates Apaf-1 self-association and procaspase-9 activation. J Biol Chem 273: 33489-33494.
25. Hu Y, Benedict MA, Ding L, Nunez G (1999) Role of cytochrome c and dATP/ATP hydrolysis in Apaf-1-mediated caspase-9 activation and apoptosis. EMBO J 18: 3586-3595.
26. Rodriguez J, Lazebnik Y (1999) Caspase-9 and Apaf-1 form an active holoenzyme. Genes Dev 13: 3179-3184.
27. Srinivasula SM, Saleh A, Hedge R, Datta P, Shiozaki E, et al. (2001) A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO mediates opposing effects on caspase activity and apoptosis. Nature 409: 112-116.
28. Zou H, Li Y, Liu X, Wang X (1999) An APAF-1-cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9. J Biol Chem 274: 11549-11556.
29. Shiozaki E, Chai J, Shi Y (2002) Oligomerization and activation of caspase-9 induced by Apaf-1 CARD. Proc Natl Acad Sci U S A 99: 4197-4202.
30. Otwinowski Z, Minor W (1997) Processing of X-ray diffraction data collected in oscillation mode. Methods Enzymol 276: 307-326.
31. Navaza J (1994) AMoRe and automated package for molecular replacement. Acta Crystallogr A50 157: 163.
32. Jones TA, Zou J-Y, Cowan SW, Kjeldgaard M (1991) Improved methods for building protein models in electron density maps and the location of errors in these models. Acta Crystallogr A47 110: 119.
33. Brunger AT, Adams PD, Clore GM, Delano WL, Gros P, et al. (1998) Crystallography and NMR system: A new software suite for macromolecular structure determination. Acta Crystallogr D54 905: 921.