The PAAD/PYRIN-only protein POP1/ASC2 is a modulator of ASC-mediated nuclear-factor-κB and pro-caspase-1 regulation

Biochemical Journal

Volumn 373, Issue 1, 2003, Pages 101-113

  Stehlik, Christian ^a   Krajewska, Maryla ^a   Welsh, Kate ^a   Krajewski, Stanislaw ^a   Godzik, Adam ^a   Reed, John C ^a  

^a BURNHAM INSTITUTE   (United States)

Author keywords

Cryopyrin; Innate immunity; Interleukin 1 ; Nuclear factor (NF ) B inhibitor kinase complex (IKK complex); Pyrin

Indexed keywords

DISEASES; GENES; PROTEINS;

CASPASE-RECRUITMENT DOMAINS (CARD);

BIOCHEMISTRY;

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; PROTEIN; PROTEIN ASC 2; PROTEIN PAAD; PROTEIN POP 1; PYRIN; UNCLASSIFIED DRUG;

ARTICLE; CHROMOSOME 16; ENZYME ACTIVATION; ENZYME REGULATION; GENE DUPLICATION; GENE TRANSFER; HUMAN; HUMAN CELL; IMMUNITY; IMMUNOHISTOCHEMISTRY; MODULATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN INTERACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

AMINO ACID SEQUENCE; ANIMALS; APOPTOSIS REGULATORY PROTEINS; CARRIER PROTEINS; CASPASE 1; CASPASES; CELL LINE; CERCOPITHECUS AETHIOPS; CLONING, MOLECULAR; COS CELLS; CYTOSKELETAL PROTEINS; ENZYME ACTIVATION; ENZYME PRECURSORS; GENES, REPORTER; HUMANS; LUCIFERASES; MOLECULAR SEQUENCE DATA; NF-KAPPA B; OPEN READING FRAMES; POLYMERASE CHAIN REACTION; PROTEINS; RECOMBINANT PROTEINS; RIBONUCLEOPROTEINS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; TRANSFECTION;

EID: 0038682430     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20030304     Document Type: Article

References (42)

1. Aravind, L., Dixit, V. M. and Koonin, E. V. (1999) The domains of death: evolution of the apoptosis machinery. Trends Biochem. Sci. 24, 47-53
2. Bertin, J. and DiStefano, P. S. (2000) The PYRIN domain: a novel motif found in apoptosis and inflammation proteins. Cell Death Differ. 7, 1273-1274
3. Fairbrother, W. J., Gordon, N. C., Humke, E. W., O'Rourke, K. M., Starovasnik, M. A., Yin, J.-P. and Dixit, V. M. (2001) The PYRIN domain: a member of the death domain-fold superfamily. Protein Sci. 10, 1911-1918
4. Martinon, F., Hofmann, K. and Tschopp, J. (2001) The pyrin domain: a possible member of the death domain-fold family implicated in apoptosis and inflammation. Curr. Biol. 11, R118-R120
5. Pawlowski, K., Pio, F., Chu, Z. -L., Reed, J. C. and Godzik, A. (2001) PAAD - a new protein domain associated with apoptosis, cancer and autoimmune diseases. Trends Biochem. Sci. 26, 85-87
6. Staub, E., Dahl, E. and Rosenthal, A. (2001) The DAPIN family: a novel domain links apoptotic and interferon response proteins. Trends Biochem. Sci. 26, 83-85
7. Weber, C. H. and Vincenz, C. (2001) The death domain superfamily: a tale of two interfaces? Trends Biochem. Sci. 26, 475-481
8. The French FMF Consortium (1997) A candidate gene for familial Mediterranean fever. Nat. Genet. 17, 25-31
9. Feldmann, J., Prieur, A. M., Quartier, P., Berquin, P., Cortis, E., Teillac-Hamel, D. and Fischer, A. (2002) Chronic infantile neurological cutaneous and articular syndrome is caused by mutations in CIAS1, a gene highly expressed in polymorphonuclear cells and chondrocytes. Am. J. Hum. Genet. 71, 198-203
10. Hoffman, H. M., Mueller, J. L., Broide, D. H., Wanderer, A. A. and Kolodner, R. D. (2001) Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome. Nat. Genet. 29, 301-305
11. Stehlik, C., Fiorentino, L., Dorfleutner, A., Bruey, J. M., Ariza, E. M., Sagara, J. and Reed, J. C. (2002) The PAAD/PYRIN-family protein ASC is a dual regulator of a conserved step in nuclear factor κB activation pathways. J. Exp. Med. 196, 1605-1615
12. Manji, G. A., Wang, L., Geddes, B. J., Brown, M., Merriam, S., Al-Garawi, A., Mak, S., Lora, J. M., Briskin, M., Jurman, M., et al. (2002) PYPAF1: A PYRIN-containing Apaf1-like protein that assembles with ASC and regulates activation of NF-κB. J. Biol. Chem. 277, 11570-11575
13. Fiorentino, L., Stehlik, C., Oliveira, V., Ariza, M. E., Godzik, A. and Reed, J. C. (2002) A novel PAAD-containing protein that modulates NF-κB induction by cytokines tumor necrosis factor-α and interleukin-1β. J. Biol. Chem. 277, 35333-35340
14. Chu, Z.-L., Pio, F., Xie, Z., Welsh, K., Krajewska, M., Krajewski, S., Godzik, A. and Reed, J. C. (2001) A novel enhancer of the Apaf1 apoptosome involved in cytochrome c-dependent caspase activation and apoptosis. J. Biol. Chem. 276, 9239-9245
15. Hlaing, T., Guo, R.-F., Dilley, K. A., Loussia, J. M., Morrish, T. A., Shi, M. M., Vincenz, C. and Ward, P. A. (2001) Molecular cloning and characterization of DEFCAP-L and -S, two isoforms of a novel member of the mammalian Ced-4 family of apoptosis proteins. J. Biol. Chem. 276, 9230-9238
16. Masumoto, J., Taniguchi, S., Ayukawa, K., Sarvotham, H., Kishino, T., Niikawa, N., Hidaka, E., Katsuyama, T., Higuchi, T. and Sagara, J. (1999) ASC, a novel 22-kDa protein, aggregates during apoptosis of human promyelocytic leukemia HL-60 cells. J. Biol. Chem. 274, 33835-33838
17. Conway, K. E., McConnell, B. B., Bowring, C. E., Donald, C. D., Warren, S. T. and Vertino, P. M. (2000) TMS1, a novel proapoptotic caspase recruitment domain protein, is a target of methylation-induced gene silencing in human breast cancers Cancer Res. 60, 6236-6242
18. Karin, M. and Delhase, M. (2000) The IκB kinase (IKK) and NF-κ B: key elements of proinflammatory signalling. Semin. Immunol. 12, 85-98
19. Silverman, N. and Maniatis, T. (2001) NF-κB signaling pathways in mammalian and insect innate immunity. Genes Dev. 15, 2321-2342
20. Srinivasula, S. M., Poyet, J.-L., Razmara, M., Datta, P., Zhang, Z. and Alnemri, E. S. (2002) The PYRIN-CARD protein ASC is an activating adaptor for caspase-1. J. Biol. Chem. 277, 21119-21122
21. Wang, L., Manji, G. A., Grenier, J. M., Al-Garawi, A., Merriam, S., Lora, J. M., Geddes, B. J., Briskin, M., DiStefano, P. S. and Bertin, J. (2002) PYPAF7: a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-κB and caspase-1-dependent cytokine processing. J. Biol. Chem. 277, 29874-29880
22. Dinarello, C. A. (1997) Interleukin-1. Cytokine Growth Factor Rev. 8, 253-265
23. Li, W. Z., Pio, F., Pawlowski, K. and Godzik, A. (2000) Saturated BLAST: an automated multiple intermediate sequence search used to detect distant homology. Bioinformatics 16, 1105-1110
24. Burge, C. and Karlin, S. (1997) Prediction of complete gene structures in human genomic DNA. J. Mol. Biol. 268, 78-94
25. Lee, S.-H., Stehlik, C. and Reed, J. C. (2001) COP, a CARD-containing protein and inhibitor of pro-interleukin-1β processing. J. Biol. Chem. 276, 34495-34500
26. Perkins, N. D., Schmid, R. M., Duckett, C. S., Leung, K., Rice, N. R. and Nabel, G. J. (1992) Distinct combinations of NF-κB subunits determine the specificity of transcriptional activation. Proc. Natl. Acad. Sci. U.S.A. 89, 1529-1533
27. Schmid, R. M., Perkins, N. D., Duckett, C. S., Andrews, P. C. and Nabel, G. J. (1991) Cloning of an NF-κB subunit which stimulates HIV transcription in synergy with p65 Nature (London) 352, 733-736
28. Krajewski, S., Krajewska, M., Shabaik, A., Miyashita, T., Wang, H. -G. and Reed, J. C. (1994) Immunohistochemical determination of in vivo distribution of Bax, a dominant inhibitor of Bcl-2. Am. J. Pathol. 145, 1323-1333
29. Tschopp, J., Martinon, F. and Burns, K. (2003) NALPs: a novel protein family involved in inflammation. Nat. Rev. Mol. Cell Biol. 4, 95-104
30. Richards, N., Schaner, P., Diaz, A., Stcukey, J., Shelden, E., Wadhwa, A. and Gumucio, D. L. (2001) Interaction between Pyrin and the apoptotic speck protein (ASC) modulates ASC-induced apoptosis. J. Biol. Chem. 276, 39320-39329
31. Carpentier, I. and Beyaert, R. (1999) TRAF1 is a TNF inducible regulator of NF-κB activation. FEBS Lett. 460, 246-250
32. Humke, E. W., Shriver, S. K. Starovasnik, M. A., Fairbrother, W. J. and Dixit, V. M. (2000) ICEBERG: a novel inhibitor of interleukin-1β generation. Cell 103, 99-111
33. Druilhe, A., Srinivasula, S. M., Razmara, M., Ahmad, M. and Alnemri, E. S. (2001) Regulation of IL-1β generation by Pseudo-ICE and ICEBERG, two dominant negative caspase recruitment domain proteins. Cell Death Differ. 8, 649-657
34. Condorelli, G., Viggotta, G., Cafieri, A., Trencia, A., Andalo, P., Oriente, F., Miele, C., Caruso, M., Formisano, P. and Beguinot, F. (1999) PED/PEA-15: an anti-apoptotic molecule that regulates FAS/TNFR1-induced apoptosis Oncogene 18, 4409-4415
35. Krueger, A., Schmitz, I., Baumann, S., Krammer, P. H. and Kirchhoff, S. (2001) Cellular FLICE-inhibitory protein splice variants inhibit different steps of caspase-8 activation at the CD95 death-inducing signaling complex. J. Biol. Chem. 276, 20633-20640
36. Masumoto, J., Taniguchi, S.-I., Nakayama, J., Shiohara, M., Hidaka, E., Katsuyama, T., Murase, S. and Sagara, J. (2001) Expression of apoptosis-associated speck-like protein containing a caspase recruitment domain, a Pyrin N-terminal homology domain-containing protein, in normal human tissues. J. Histochem. Cytochem. 49, 1269-1275
37. Shiohara, M., Taniguchi, S., Masumoto, J., Yasui, K., Koike, K., Komiyama, A. and Sagara, J. (2002) ASC, which is composed of a PYD and a CARD, is up-regulated by inflammation and apoptosis in human neutrophils. Biochem. Biophys. Res. Commun. 293, 1314-1318
38. Blom, N., Gammeltoft, S. and Brunak, S. (1999) Sequence- and structure-based prediction of eukaryotic protein phosphorylation sites J. Mol. Biol. 294, 1351-1362
39. Koonin, E. V. and Aravind, L. (2000) The NACHT family-a new group of predicted NTPases implicated in apoptosis and MHC transcription activation. Trends Biol. Sci. 25, 223-224
40. Schulze-Osthoff, K. and Stroh, C. (2000) Induced proximity model attracts NF-κB researchers. Cell Death Differ. 7, 1025-1026
41. Martinon, F., Burns, K. and Tschopp, J. (2002) The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-β. Mol. Cell 10, 417-426
42. Salvesen, G. S. and Dixit, V. M. (1999) Caspase activation: the induced-proximity model. Proc. Natl. Acad. Sci. U.S.A. 96, 10964-10967