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Volumn 8, Issue 2, 2006, Pages 60-77

HIV type 1 tropism and inhibitors of viral entry: Clinical implications

Author keywords

CCR5; Coreceptor; CXCR4; Entry inhibitors; HIV

Indexed keywords

1 ACETYL N [3 [4 (4 CARBAMOYLBENZYL) 1 PIPERIDINYL]PROPYL] N (3 CHLORO 4 METHYLPHENYL) 4 PIPERIDINECARBOXAMIDE; 1 BENZOYL 4 [(4,7 DIMETHOXY 1H PYRROLO[2,3 C]PYRIDIN 3 YL)OXOACETYL]PIPERAZINE; 1,1' [1,4 PHENYLENEBIS(METHYLENE)]BIS(1,4,8,11 TETRAAZACYCLOTETRADECANE); 4 [(4 BROMOPHENYL)(ETHOXYIMINO)METHYL] 1' [(2,4 DIMETHYL 3 PYRIDINYL)CARBONYL] 4' METHYL 1,4' BIPIPERIDINE; 4 BENZOYL 1 [(4 METHOXY 1H PYRROLO[2,3 B]PYRIDIN 3 YL)OXOACETYL] 2 METHYLPIPERAZINE; 4,4' [CARBONYLBIS[IMINO 1H PYRROLE 4,2 DIYLCARBONYLIMINO(1 METHYL 1H PYRROLE 4,2 DIYL)CARBONYLIMINO]]BIS(1,7 NAPHTHALENESULFONIC ACID); ALPHA N ACETYLNONA DEXTRO ARGININE AMIDE; AMD 070; ANTIRETROVIRUS AGENT; APLAVIROC; CD4 ANTIGEN; CD4 IMMUNOGLOBULIN G2; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CCR5 ANTAGONIST; CHEMOKINE RECEPTOR CXCR4; CHEMOKINE RECEPTOR CXCR4 ANTAGONIST; COSALANE; CYANOVIRIN N; DEXTRAN SULFATE; GLYCOPROTEIN GP 120; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; MARAVIROC; N (6 AMINOHEXYL)GLYCYL N (3 GUANIDINOPROPYL)GLYCYL N (3 GUANIDINOPROPYL)GLYCYL N BENZYLGLYCYL N (3 GUANIDINOPROPYL)GLYCYL DEXTRO LYSYL DEXTRO LYSYL DEXTRO ARGINYL DEXTRO PROLINAMIDE; N [4 [[[6,7 DIHYDRO 2 (4 METHYLPHENYL) 5H BENZOCYCLOHEPTEN 8 YL]CARBONYL]AMINO]BENZYL] N,N DIMETHYL 2H TETRAHYDROPYRAN 4 AMINIUM CHLORIDE; PRO 140; TNX 355; UNCLASSIFIED DRUG; UNINDEXED DRUG; VICRIVIROC; VIRUS RECEPTOR; ZINTEVIR;

EID: 33745893769     PISSN: 11396121     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (35)

References (248)
  • 2
    • 0021720872 scopus 로고
    • T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV
    • Klatzmann D, Champagne E, Chamaret S, et al. T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV. Nature (London) 1984;312:767-8.
    • (1984) Nature (London) , vol.312 , pp. 767-768
    • Klatzmann, D.1    Champagne, E.2    Chamaret, S.3
  • 4
    • 0027531918 scopus 로고
    • Pathogenesis of HIV infection
    • Levy J. Pathogenesis of HIV infection. Microbiol Rev 1993;57:183-289.
    • (1993) Microbiol Rev , vol.57 , pp. 183-289
    • Levy, J.1
  • 5
    • 0029417004 scopus 로고
    • Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells
    • (see comments)
    • Cocchi F, DeVico A, Garzino-Demo A, Arya S, Gallo R, Lusso P. Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells (see comments). Science 1995;270:1811-15.
    • (1995) Science , vol.270 , pp. 1811-1815
    • Cocchi, F.1    DeVico, A.2    Garzino-Demo, A.3    Arya, S.4    Gallo, R.5    Lusso, P.6
  • 6
    • 15844389650 scopus 로고    scopus 로고
    • HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC- CKR-5
    • Dragic T, Litwin V, Allaway G, et al. HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC- CKR-5. Nature (London) 1996;381:667-73.
    • (1996) Nature (London) , vol.381 , pp. 667-673
    • Dragic, T.1    Litwin, V.2    Allaway, G.3
  • 7
    • 0030002637 scopus 로고    scopus 로고
    • HIV-1 entry cofactor: Functional cDNA cloning of a seven-transmembrane. G protein-coupled receptor
    • Feng Y, Broder C, Kennedy P, Berger E. HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane. G protein-coupled receptor. Science 1996;272:872-7.
    • (1996) Science , vol.272 , pp. 872-877
    • Feng, Y.1    Broder, C.2    Kennedy, P.3    Berger, E.4
  • 8
    • 15844419153 scopus 로고    scopus 로고
    • Identification of a major coreceptor for primary isolates of HIV-1
    • Deng H, Liu R, Ellmeier W, et al. Identification of a major coreceptor for primary isolates of HIV-1. Nature (London) 1996;381:661-6.
    • (1996) Nature (London) , vol.381 , pp. 661-666
    • Deng, H.1    Liu, R.2    Ellmeier, W.3
  • 9
    • 0023896246 scopus 로고
    • Differential syncytium-inducing capacity of HIV isolates: Frequent detection of syncytium-inducing isolates in patients with AIDS and AIDS-related complex
    • Tersmette M, de Goede R, Al B, et al. Differential syncytium-inducing capacity of HIV isolates: frequent detection of syncytium-inducing isolates in patients with AIDS and AIDS-related complex. J Virol 1988;62:2026-32.
    • (1988) J Virol , vol.62 , pp. 2026-2032
    • Tersmette, M.1    de Goede, R.2    Al, B.3
  • 10
    • 0023790118 scopus 로고
    • Distinct replicative and cytopathic characteristics of HIV isolates
    • Fenyo E, Morfeldt-Manson L, Chiodi F, et al. Distinct replicative and cytopathic characteristics of HIV isolates. J Virol 1988;62:4414-9.
    • (1988) J Virol , vol.62 , pp. 4414-4419
    • Fenyo, E.1    Morfeldt-Manson, L.2    Chiodi, F.3
  • 11
    • 0024816426 scopus 로고
    • Replicative capacity, cytopathic effect and cell tropism of HIV
    • Fenyo E, Albert J, Asjo B. Replicative capacity, cytopathic effect and cell tropism of HIV. AIDS 1989;3 Suppl 1:S5-12.
    • (1989) AIDS , vol.3 , Issue.SUPPL. 1
    • Fenyo, E.1    Albert, J.2    Asjo, B.3
  • 13
    • 0026600926 scopus 로고
    • Biological phenotype of HIV-1 clones at different stages of infection: Progression of disease is associated with a shift from monocytotropic to T-cell-tropic virus population
    • Schuitemaker H, Koot M, Kootstra N, et al. Biological phenotype of HIV-1 clones at different stages of infection: progression of disease is associated with a shift from monocytotropic to T-cell-tropic virus population. J Virol 1992;66:1354-60.
    • (1992) J Virol , vol.66 , pp. 1354-1360
    • Schuitemaker, H.1    Koot, M.2    Kootstra, N.3
  • 15
    • 0033012398 scopus 로고    scopus 로고
    • Chemokine receptors as HIV-1 coreceptors: Roles in viral entry, tropism, and disease
    • Berger E, Murphy P, Farber J. Chemokine receptors as HIV-1 coreceptors: roles in viral entry, tropism, and disease. Annu Rev Immunol 1999;17:657-700.
    • (1999) Annu Rev Immunol , vol.17 , pp. 657-700
    • Berger, E.1    Murphy, P.2    Farber, J.3
  • 16
    • 1842415431 scopus 로고    scopus 로고
    • Coreceptor usage of primary HIV-1 isolates varies according to biological phenotype
    • Bjorndal A, Deng H, Jansson M, et al. Coreceptor usage of primary HIV-1 isolates varies according to biological phenotype. J Virol 1997;71:7478-87.
    • (1997) J Virol , vol.71 , pp. 7478-7487
    • Bjorndal, A.1    Deng, H.2    Jansson, M.3
  • 17
    • 0033647217 scopus 로고    scopus 로고
    • The effect of genetic variation in chemokines and their receptors on HIV transmission and progression to AIDS
    • O'Brien S, Moore J. The effect of genetic variation in chemokines and their receptors on HIV transmission and progression to AIDS. Immunol Rev 2000;177:99-111.
    • (2000) Immunol Rev , vol.177 , pp. 99-111
    • O'Brien, S.1    Moore, J.2
  • 18
    • 0001633495 scopus 로고    scopus 로고
    • Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene. Hemophilia Growth and Development Study, Multicenter AIDS Cohort Study, Multicenter Hemophilia Cohort Study, San Francisco City Cohort, ALIVE Study
    • Dean M, Carrington M, Winkler C, et al. Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene. Hemophilia Growth and Development Study, Multicenter AIDS Cohort Study, Multicenter Hemophilia Cohort Study, San Francisco City Cohort, ALIVE Study. Science 1996;273:1856-62.
    • (1996) Science , vol.273 , pp. 1856-1862
    • Dean, M.1    Carrington, M.2    Winkler, C.3
  • 19
    • 0034009126 scopus 로고    scopus 로고
    • HIV-infected human Langerhans cells transmit infection to human lymphoid tissue ex vivo
    • Blauvelt A, Glushakova S, Margolis LB. HIV-infected human Langerhans cells transmit infection to human lymphoid tissue ex vivo. AIDS 2000;14:647-51.
    • (2000) AIDS , vol.14 , pp. 647-651
    • Blauvelt, A.1    Glushakova, S.2    Margolis, L.B.3
  • 20
    • 0345717207 scopus 로고    scopus 로고
    • HIV-1 Langerhans cell tropism associated with heterosexual transmission of HIV
    • Soto-Ramirez L, Renjifo B, McLane M, et al. HIV-1 Langerhans cell tropism associated with heterosexual transmission of HIV. Science 1996;271:1291-3.
    • (1996) Science , vol.271 , pp. 1291-1293
    • Soto-Ramirez, L.1    Renjifo, B.2    McLane, M.3
  • 21
    • 22244447444 scopus 로고    scopus 로고
    • The host environment drives HIV-1 fitness
    • Van Opijnen T, Berkhout B. The host environment drives HIV-1 fitness. Rev Med Virol 2005;15:219-33.
    • (2005) Rev Med Virol , vol.15 , pp. 219-233
    • Van Opijnen, T.1    Berkhout, B.2
  • 22
    • 0022485649 scopus 로고
    • Replicative capacity of HIV from patients with varying severity of HIV infection
    • Asjo B, Morfeldt-Manson L, Albert J, et al. Replicative capacity of HIV from patients with varying severity of HIV infection. Lancet 1986;2:660-662.
    • (1986) Lancet , vol.2 , pp. 660-662
    • Asjo, B.1    Morfeldt-Manson, L.2    Albert, J.3
  • 23
    • 0028228751 scopus 로고
    • HIV-1 variants with increased replicative capacity develop during the asymptomatic stage before disease progression
    • Connor R, Ho D. HIV-1 variants with increased replicative capacity develop during the asymptomatic stage before disease progression. J Virol 1994;68:4400-08.
    • (1994) J Virol , vol.68 , pp. 4400-4408
    • Connor, R.1    Ho, D.2
  • 24
    • 0028027078 scopus 로고
    • The impact of the syncytium-inducing phenotype of HIV on disease progression
    • Richman D, Bozzette S. The impact of the syncytium-inducing phenotype of HIV on disease progression. J Infect Dis 1994; 169:968-74.
    • (1994) J Infect Dis , vol.169 , pp. 968-974
    • Richman, D.1    Bozzette, S.2
  • 25
    • 0033786824 scopus 로고    scopus 로고
    • Differential coreceptor expression allows for independent evolution of non-syncytium-inducing and syncytium-inducing HIV-1
    • Van Rij R, Blaak H, Visser J, et al. Differential coreceptor expression allows for independent evolution of non-syncytium-inducing and syncytium-inducing HIV-1. J Clin Invest 2000;106:1039-52.
    • (2000) J Clin Invest , vol.106 , pp. 1039-1052
    • Van Rij, R.1    Blaak, H.2    Visser, J.3
  • 26
    • 0031042433 scopus 로고    scopus 로고
    • The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes
    • Bleul C, Wu L, Hoxie J, Springer T, Mackay C. The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes. Proc Natl Acad Sci USA 1997;94:1925-30.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 1925-1930
    • Bleul, C.1    Wu, L.2    Hoxie, J.3    Springer, T.4    Mackay, C.5
  • 27
    • 30644462096 scopus 로고    scopus 로고
    • Virus fitness: Concept, quantification, and application to HIV population dynamics
    • Quinones-Mateu M, Arts E. Virus fitness: concept, quantification, and application to HIV population dynamics. Curr Top Microbiol Immunol 2006;299:83-140.
    • (2006) Curr Top Microbiol Immunol , vol.299 , pp. 83-140
    • Quinones-Mateu, M.1    Arts, E.2
  • 28
    • 0001769435 scopus 로고    scopus 로고
    • HIV-1 fitness: Implications for drug resistance, disease progression, and global epidemic evolution
    • Kuiken C, Foley B, Hahn B, et al. eds. Los Alamos, NM: Theoretical Biology and Biophysics Group, Los Alamos National Laboratory
    • Quinones-Mateu M, Arts E. HIV-1 fitness: implications for drug resistance, disease progression, and global epidemic evolution. In: Kuiken C, Foley B, Hahn B, et al. eds. HIV Sequence Compendium 2001. Los Alamos, NM: Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, 2001:134-70.
    • HIV Sequence Compendium 2001 , vol.2001 , pp. 134-170
    • Quinones-Mateu, M.1    Arts, E.2
  • 29
    • 0038637409 scopus 로고    scopus 로고
    • Predicting HIV-1 coreceptor usage with sequence analysis
    • Jensen M, 't Wout A. Predicting HIV-1 coreceptor usage with sequence analysis. AIDS Rev 2003;5:104-12.
    • (2003) AIDS Rev , vol.5 , pp. 104-112
    • Jensen, M.1    't Wout, A.2
  • 30
    • 33745440781 scopus 로고    scopus 로고
    • HIV tropism: Diagnostic tools and implications for disease progression and treatment with entry inhibitors
    • in press
    • Poveda E, Briz V, Quinones-Mateu M, Soriano V. HIV tropism: diagnostic tools and implications for disease progression and treatment with entry inhibitors. AIDS 2006;in press.
    • (2006) AIDS
    • Poveda, E.1    Briz, V.2    Quinones-Mateu, M.3    Soriano, V.4
  • 31
    • 0025837284 scopus 로고
    • Host range, replicative, and cytopathic properties of HIV-1 are determined by very few amino acid changes in tat and gp120
    • Cheng-Mayer C, Shioda T, Levy J. Host range, replicative, and cytopathic properties of HIV-1 are determined by very few amino acid changes in tat and gp120. J Virol 1991;65:6931-41.
    • (1991) J Virol , vol.65 , pp. 6931-6941
    • Cheng-Mayer, C.1    Shioda, T.2    Levy, J.3
  • 32
    • 0031025113 scopus 로고    scopus 로고
    • Macrophage tropism of HIV-1 and utilization of the CC-CKR5 coreceptor
    • Cheng-Mayer C, Liu R, Landau N, Stamatatos L. Macrophage tropism of HIV-1 and utilization of the CC-CKR5 coreceptor. J Virol 1997;71:1657-61.
    • (1997) J Virol , vol.71 , pp. 1657-1661
    • Cheng-Mayer, C.1    Liu, R.2    Landau, N.3    Stamatatos, L.4
  • 33
    • 0025004459 scopus 로고
    • Viral determinants of HIV-1 T-cell or macrophage tropism, cytopathogenicity, and CD4 antigen modulation
    • Cheng-Mayer C, Quiroga M, Tung J, Dina D, Levy J. Viral determinants of HIV-1 T-cell or macrophage tropism, cytopathogenicity, and CD4 antigen modulation. J Virol 1990;64:4390-8.
    • (1990) J Virol , vol.64 , pp. 4390-4398
    • Cheng-Mayer, C.1    Quiroga, M.2    Tung, J.3    Dina, D.4    Levy, J.5
  • 34
    • 0025783669 scopus 로고
    • Identification of the envelope V3 loop as the primary determinant of cell tropism in HIV-1
    • Hwang S, Boyle T, Lyerly H, Cullen B. Identification of the envelope V3 loop as the primary determinant of cell tropism in HIV-1. Science 1991;253:71-4.
    • (1991) Science , vol.253 , pp. 71-74
    • Hwang, S.1    Boyle, T.2    Lyerly, H.3    Cullen, B.4
  • 35
    • 0026501677 scopus 로고
    • HIV-1 clones chimeric for the envelope V3 domain differ in syncytium formation and replication capacity
    • De Jong J, Goudsmit J, Keulen W, et al. HIV-1 clones chimeric for the envelope V3 domain differ in syncytium formation and replication capacity. J Virol 1992;66:757-65.
    • (1992) J Virol , vol.66 , pp. 757-765
    • De Jong, J.1    Goudsmit, J.2    Keulen, W.3
  • 36
    • 0026606727 scopus 로고
    • Phenotype-associated sequence variation in the third variable domain of the HIV-1 gp120 molecule
    • Fouchier R, Groenink M, Kootstra NA, et al. Phenotype-associated sequence variation in the third variable domain of the HIV-1 gp120 molecule. J Virol 1992;66:3183-7.
    • (1992) J Virol , vol.66 , pp. 3183-3187
    • Fouchier, R.1    Groenink, M.2    Kootstra, N.A.3
  • 37
    • 0028926538 scopus 로고
    • Correlation between genetic and biological properties of biologically cloned HIV-1 viruses representing subtypes A, B, and D
    • Zhong P, Peeters M, Janssens W, et al. Correlation between genetic and biological properties of biologically cloned HIV-1 viruses representing subtypes A, B, and D. AIDS Res Hum Retroviruses 1995;11:239-48.
    • (1995) AIDS Res Hum Retroviruses , vol.11 , pp. 239-248
    • Zhong, P.1    Peeters, M.2    Janssens, W.3
  • 38
    • 0034631402 scopus 로고    scopus 로고
    • Determinants for the syncytium-inducing phenotype of HIV-1 subtype F isolates are located in the V3 region
    • Holm-Hansen C, Baan E, Asjo B, Pascu F, Goudsmit J, de Jong J. Determinants for the syncytium-inducing phenotype of HIV-1 subtype F isolates are located in the V3 region. AIDS Res Hum Retroviruses 2000;16:867-70.
    • (2000) AIDS Res Hum Retroviruses , vol.16 , pp. 867-870
    • Holm-Hansen, C.1    Baan, E.2    Asjo, B.3    Pascu, F.4    Goudsmit, J.5    de Jong, J.6
  • 39
    • 0027297763 scopus 로고
    • Both the V2 and V3 regions of the HIV-1 surface glycoprotein functionally interact with other envelope regions in syncytium formation
    • Andeweg A, Leeflang P, Osterhaus A, Bosch M. Both the V2 and V3 regions of the HIV-1 surface glycoprotein functionally interact with other envelope regions in syncytium formation. J Virol 1993;67:3232-9.
    • (1993) J Virol , vol.67 , pp. 3232-3239
    • Andeweg, A.1    Leeflang, P.2    Osterhaus, A.3    Bosch, M.4
  • 40
    • 0027154014 scopus 로고
    • A single amino acid substitution in the V1 loop of HIV-1 gp120 alters cellular tropism
    • Boyd M, Simpson G, Cann A, Johnson M, Weiss R. A single amino acid substitution in the V1 loop of HIV-1 gp120 alters cellular tropism. J Virol 1993;67:3649-52.
    • (1993) J Virol , vol.67 , pp. 3649-3652
    • Boyd, M.1    Simpson, G.2    Cann, A.3    Johnson, M.4    Weiss, R.5
  • 41
    • 0027205624 scopus 로고
    • Relation of phenotype evolution of HIV-1 to envelope V2 configuration
    • Groenink M, Fouchier R, Broersen S, et al. Relation of phenotype evolution of HIV-1 to envelope V2 configuration. Science 1993; 260:1513-6.
    • (1993) Science , vol.260 , pp. 1513-1516
    • Groenink, M.1    Fouchier, R.2    Broersen, S.3
  • 42
    • 0026640859 scopus 로고
    • Phenotype-associated env gene variation among eight related HIV-1 clones: Evidence for in vivo recombination and determinants of cytotropism outside the V3 domain
    • Groenink M, Andeweg A, Fouchier R, et al. Phenotype-associated env gene variation among eight related HIV-1 clones: evidence for in vivo recombination and determinants of cytotropism outside the V3 domain. J Virol 1992;66:6175-80.
    • (1992) J Virol , vol.66 , pp. 6175-6180
    • Groenink, M.1    Andeweg, A.2    Fouchier, R.3
  • 43
    • 0034755058 scopus 로고    scopus 로고
    • Length variation of glycoprotein 120 V2 region in relation to biological phenotypes and coreceptor usage of primary HIV type 1 isolates
    • Jansson M, Backstrom E, Scarlatti G, et al. Length variation of glycoprotein 120 V2 region in relation to biological phenotypes and coreceptor usage of primary HIV type 1 isolates. AIDS Res Hum Retroviruses 2001;17:1405-14.
    • (2001) AIDS Res Hum Retroviruses , vol.17 , pp. 1405-1414
    • Jansson, M.1    Backstrom, E.2    Scarlatti, G.3
  • 44
    • 0036196484 scopus 로고    scopus 로고
    • Variability in the HIV-1 gp120 Env protein linked to phenotype-associated changes in the V3 loop
    • Hoffman N, Seillier-Moiseiwitsch F, Ann J, Walker J, Swanstrom R. Variability in the HIV-1 gp120 Env protein linked to phenotype-associated changes in the V3 loop. J Virol 2002;76:3852-64.
    • (2002) J Virol , vol.76 , pp. 3852-3864
    • Hoffman, N.1    Seillier-Moiseiwitsch, F.2    Ann, J.3    Walker, J.4    Swanstrom, R.5
  • 45
    • 0024536114 scopus 로고
    • Evidence for a role of virulent HIV variants in the pathogenesis of AIDS: Studies on sequential HIV isolates
    • Tersmette M, Gruters R, de Wolf F, et al. Evidence for a role of virulent HIV variants in the pathogenesis of AIDS: studies on sequential HIV isolates. J Virol 1989;63:2118-25.
    • (1989) J Virol , vol.63 , pp. 2118-2125
    • Tersmette, M.1    Gruters, R.2    de Wolf, F.3
  • 46
    • 0026533899 scopus 로고
    • HIV-1 biological phenotype in long-term infected individuals evaluated with an MT-2 co-cultivation assay
    • Koot M, Vos A, Keet R, et al. HIV-1 biological phenotype in long-term infected individuals evaluated with an MT-2 co-cultivation assay. AIDS 1992;6:49-54.
    • (1992) AIDS , vol.6 , pp. 49-54
    • Koot, M.1    Vos, A.2    Keet, R.3
  • 47
    • 0027488802 scopus 로고
    • A cross-sectional comparison of persons with syncytium- and non-syncytium-inducing HIV
    • Bozzette S, McCutchan J, Spector S, Wright B, Richman D. A cross-sectional comparison of persons with syncytium- and non-syncytium-inducing HIV. J Infect Dis 1993;168:1374-9.
    • (1993) J Infect Dis , vol.168 , pp. 1374-1379
    • Bozzette, S.1    McCutchan, J.2    Spector, S.3    Wright, B.4    Richman, D.5
  • 49
    • 24944469979 scopus 로고    scopus 로고
    • Determination of coreceptor usage of HIV-1
    • Schuitemaker H, Kootstra N. Determination of coreceptor usage of HIV-1. Methods Mol Biol 2005;304:327-32.
    • (2005) Methods Mol Biol , vol.304 , pp. 327-332
    • Schuitemaker, H.1    Kootstra, N.2
  • 50
    • 0342506507 scopus 로고    scopus 로고
    • Indicator cell lines for detection of primary strains of human and simian immunodeficiency viruses
    • Vodicka M, Goh W, Wu L, et al. Indicator cell lines for detection of primary strains of human and simian immunodeficiency viruses. Virology 1997;233:193-8.
    • (1997) Virology , vol.233 , pp. 193-198
    • Vodicka, M.1    Goh, W.2    Wu, L.3
  • 51
    • 0033542116 scopus 로고    scopus 로고
    • Establishment of a new system for determination of coreceptor usages of HIV based on the human glioma NP-2 cell line
    • Soda Y, Shimizu N, Jinno A, et al. Establishment of a new system for determination of coreceptor usages of HIV based on the human glioma NP-2 cell line. Biochem Biophys Res Commun 1999;258:313-21.
    • (1999) Biochem Biophys Res Commun , vol.258 , pp. 313-321
    • Soda, Y.1    Shimizu, N.2    Jinno, A.3
  • 52
    • 0344766077 scopus 로고    scopus 로고
    • Primary HIV-2 isolates, like HIV-1 isolates, frequently use CCR5 but show promiscuity in coreceptor usage
    • Morner A, Bjorndal A, Albert J, et al. Primary HIV-2 isolates, like HIV-1 isolates, frequently use CCR5 but show promiscuity in coreceptor usage. J Virol 1999;73:2343-9.
    • (1999) J Virol , vol.73 , pp. 2343-2349
    • Morner, A.1    Bjorndal, A.2    Albert, J.3
  • 53
    • 0031936306 scopus 로고    scopus 로고
    • Neutralization sensitivity of HIV-1 primary isolates to antibodies and CD4-based reagents is independent of coreceptor usage
    • Trkola A, Ketas T, KewalRamani V, et al. Neutralization sensitivity of HIV-1 primary isolates to antibodies and CD4-based reagents is independent of coreceptor usage. J Virol 1998;72:1876-85.
    • (1998) J Virol , vol.72 , pp. 1876-1885
    • Trkola, A.1    Ketas, T.2    KewalRamani, V.3
  • 54
    • 0036633807 scopus 로고    scopus 로고
    • Coreceptor phenotype of natural HIV with nef deleted evolves in vivo, leading to increased virulence
    • Jekle A, Schramm B, Jayakumar P, et al. Coreceptor phenotype of natural HIV with nef deleted evolves in vivo, leading to increased virulence. J Virol 2002;76:6966-73.
    • (2002) J Virol , vol.76 , pp. 6966-6973
    • Jekle, A.1    Schramm, B.2    Jayakumar, P.3
  • 55
    • 0033927570 scopus 로고    scopus 로고
    • Use of inhibitors to evaluate coreceptor usage by simian and simian/ human immunodeficiency viruses and HIV type 2 in primary cells
    • Zhang Y, Lou B, Lal R, Gettie A, Marx P, Moore J. Use of inhibitors to evaluate coreceptor usage by simian and simian/human immunodeficiency viruses and HIV type 2 in primary cells. J Virol 2000;74:6893-910.
    • (2000) J Virol , vol.74 , pp. 6893-6910
    • Zhang, Y.1    Lou, B.2    Lal, R.3    Gettie, A.4    Marx, P.5    Moore, J.6
  • 56
    • 0024469503 scopus 로고
    • Temporal fluctuations in HIV quasispecies in vivo are not reflected by sequential HIV isolations
    • Meyerhans A, Cheynler R, Albert J, et al. Temporal fluctuations in HIV quasispecies in vivo are not reflected by sequential HIV isolations. Cell 1989;58:901-10.
    • (1989) Cell , vol.58 , pp. 901-910
    • Meyerhans, A.1    Cheynler, R.2    Albert, J.3
  • 57
    • 0034749279 scopus 로고    scopus 로고
    • Determination of coreceptor usage of HIV-1 from patient plasma samples by using a recombinant phenotypic assay
    • Trouplin V, Salvatori F, Cappello F, et al. Determination of coreceptor usage of HIV-1 from patient plasma samples by using a recombinant phenotypic assay. J Virol 2001;75:251-9.
    • (2001) J Virol , vol.75 , pp. 251-259
    • Trouplin, V.1    Salvatori, F.2    Cappello, F.3
  • 58
    • 0031002027 scopus 로고    scopus 로고
    • Differential regulation of HIV-1 fusion cofactor expression by CD28 co-stimulation of CD4+ T-cells
    • Carroll R, Riley J, Levine B, et al. Differential regulation of HIV-1 fusion cofactor expression by CD28 co-stimulation of CD4+ T-cells. Science 1997;276:273-6.
    • (1997) Science , vol.276 , pp. 273-276
    • Carroll, R.1    Riley, J.2    Levine, B.3
  • 59
    • 0037059049 scopus 로고    scopus 로고
    • Sensitivity of HIV-1 to entry inhibitors correlates with envelope/ coreceptor affinity, receptor density, and fusion kinetics
    • Reeves J, Gallo S, Ahmad N, et al. Sensitivity of HIV-1 to entry inhibitors correlates with envelope/coreceptor affinity, receptor density, and fusion kinetics. Proc Natl Acad Sci USA 2002;99:16249-54.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 16249-16254
    • Reeves, J.1    Gallo, S.2    Ahmad, N.3
  • 60
    • 0037223692 scopus 로고    scopus 로고
    • Baseline susceptibility of primary HIV-1 to entry inhibitors
    • Labrosse B, Labernardiere J, Dam E, et al. Baseline susceptibility of primary HIV-1 to entry inhibitors. J Virol 2003;77:1610-3.
    • (2003) J Virol , vol.77 , pp. 1610-1613
    • Labrosse, B.1    Labernardiere, J.2    Dam, E.3
  • 61
    • 0029910803 scopus 로고    scopus 로고
    • V3 loop sequence analysis of seven HIV-1 group O isolates phenotyped in peripheral blood mononuclear cells and MT-2 cells
    • De Jong J, Simon F, van der Groen G, et al. V3 loop sequence analysis of seven HIV-1 group O isolates phenotyped in peripheral blood mononuclear cells and MT-2 cells. AIDS Res Hum Retroviruses 1996;16:1503-7.
    • (1996) AIDS Res Hum Retroviruses , vol.16 , pp. 1503-1507
    • De Jong, J.1    Simon, F.2    van der Groen, G.3
  • 62
    • 0027221071 scopus 로고
    • V3 Loop of the HIV-1 Env protein: Interpreting sequence variability
    • Milich L, Margolin B, Swanstrom R. V3 Loop of the HIV-1 Env protein: interpreting sequence variability. J Virol 1993;67:5623-34.
    • (1993) J Virol , vol.67 , pp. 5623-5634
    • Milich, L.1    Margolin, B.2    Swanstrom, R.3
  • 64
    • 0031455910 scopus 로고    scopus 로고
    • Patterns of amino acid variability in NSI-like and SI-like V3 sequences and a linked change in the CD4-binding domain of the HIV-1 Env protein
    • Milich L, Margolin B, Swanstrom R. Patterns of amino acid variability in NSI-like and SI-like V3 sequences and a linked change in the CD4-binding domain of the HIV-1 Env protein. Virology 1997;239:108-18.
    • (1997) Virology , vol.239 , pp. 108-118
    • Milich, L.1    Margolin, B.2    Swanstrom, R.3
  • 65
    • 0026454213 scopus 로고
    • Relationship of the HIV-1 gp120 third variable loop to a component of the CD4 binding site in the fourth conserved region
    • Wyatt R, Thali M, Tilley S, et al. Relationship of the HIV-1 gp120 third variable loop to a component of the CD4 binding site in the fourth conserved region. J Virol 1992;66:6997-7004.
    • (1992) J Virol , vol.66 , pp. 6997-7004
    • Wyatt, R.1    Thali, M.2    Tilley, S.3
  • 66
    • 0027301670 scopus 로고
    • Immunochemical analysis of the gp120 surface glycoprotein of HIV-1: Probing the structure of the C4 and V4 domains and the interaction of the C4 domain with the V3 loop
    • Moore J, Thali M, Jameson B, et al. Immunochemical analysis of the gp120 surface glycoprotein of HIV-1: probing the structure of the C4 and V4 domains and the interaction of the C4 domain with the V3 loop. J Virol 1993;67:4785-96.
    • (1993) J Virol , vol.67 , pp. 4785-4796
    • Moore, J.1    Thali, M.2    Jameson, B.3
  • 67
    • 0141568790 scopus 로고    scopus 로고
    • Evolution of R5 and X4 HIV-1 gag sequences in vivo: Evidence for recombination
    • Van Rij R, Worobey M, Visser J, Schuitemaker H. Evolution of R5 and X4 HIV-1 gag sequences in vivo: evidence for recombination. Virology 2003;314:451-9.
    • (2003) Virology , vol.314 , pp. 451-459
    • Van Rij, R.1    Worobey, M.2    Visser, J.3    Schuitemaker, H.4
  • 68
    • 0027297096 scopus 로고
    • Co-variation of mutations in the V3 loop of HIV-1 envelope protein: An information theoretic analysis
    • Korber B, Farber R, Wolpert D, Lapedes A. Co-variation of mutations in the V3 loop of HIV-1 envelope protein: an information theoretic analysis. Proc Natl Acad Sci USA 1993;90:7176-80.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 7176-7180
    • Korber, B.1    Farber, R.2    Wolpert, D.3    Lapedes, A.4
  • 70
    • 10744231634 scopus 로고    scopus 로고
    • Improved coreceptor usage prediction and genotypic monitoring of R5-to-X4 transition by motif analysis of HIV-1 env V3 loop sequences
    • Jensen M, Li F, 't Wout A, et al. Improved coreceptor usage prediction and genotypic monitoring of R5-to-X4 transition by motif analysis of HIV-1 env V3 loop sequences. J Virol 2003;77:13376-88.
    • (2003) J Virol , vol.77 , pp. 13376-13388
    • Jensen, M.1    Li, F.2    't Wout, A.3
  • 71
    • 0036727207 scopus 로고    scopus 로고
    • Prediction of MHC class I binding peptides using profile motifs
    • Reche P, Glutting J, Reinherz E. Prediction of MHC class I binding peptides using profile motifs. Hum Immunol 2002;63:701-9.
    • (2002) Hum Immunol , vol.63 , pp. 701-709
    • Reche, P.1    Glutting, J.2    Reinherz, E.3
  • 72
    • 27744541149 scopus 로고    scopus 로고
    • Computational methods for the design of effective therapies against drug resistant HIV strains
    • Beerenwinkel N, Sing T, Lengauer T, et al. Computational methods for the design of effective therapies against drug resistant HIV strains. Bioinformatics 2005;21:3943-50.
    • (2005) Bioinformatics , vol.21 , pp. 3943-3950
    • Beerenwinkel, N.1    Sing, T.2    Lengauer, T.3
  • 73
    • 33745450676 scopus 로고    scopus 로고
    • Learning mixtures of localized rules by maximizing the area under the ROC curve
    • Workshop on ROC Analysis in AI, 2004 (accepted)
    • Sing T, Beerenwinkel N, Lengauer T. Learning mixtures of localized rules by maximizing the area under the ROC curve. 16th European Conference on Artificial Intelligence (ECAI), Workshop on ROC Analysis in AI, 2004 (accepted). 2004.
    • (2004) 16th European Conference on Artificial Intelligence (ECAI)
    • Sing, T.1    Beerenwinkel, N.2    Lengauer, T.3
  • 75
    • 0141814730 scopus 로고    scopus 로고
    • The entry of entry inhibitors: A fusion of science and medicine
    • Moore J, Doms R. The entry of entry inhibitors: a fusion of science and medicine. Proc Natl Acad Sci USA 2003;100:10598-602.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 10598-10602
    • Moore, J.1    Doms, R.2
  • 76
    • 0025886458 scopus 로고
    • Resistance of primary isolates of HIV-1 to soluble CD4 is independent of CD4-rgp120 binding affinity
    • Ashkenazi A, Smith D, Marsters S, et al. Resistance of primary isolates of HIV-1 to soluble CD4 is independent of CD4-rgp120 binding affinity. Proc Natl Acad Sci USA 1991;88:7056-60.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 7056-7060
    • Ashkenazi, A.1    Smith, D.2    Marsters, S.3
  • 77
    • 0029062687 scopus 로고
    • Expression and characterization of CD4-IgG2, a novel heterotetramer that neutralizes primary HIV type 1 isolates
    • Allaway G, Davis-Bruno K, Beaudry G, et al. Expression and characterization of CD4-IgG2, a novel heterotetramer that neutralizes primary HIV type 1 isolates. AIDS Res Hum Retroviruses 1995;11:533-9.
    • (1995) AIDS Res Hum Retroviruses , vol.11 , pp. 533-539
    • Allaway, G.1    Davis-Bruno, K.2    Beaudry, G.3
  • 78
    • 0028865465 scopus 로고
    • Cross-clade neutralization of primary isolates of HIV-1 by human monoclonal antibodies and tetrameric CD4-IgG
    • Trkola A, Pomales A, Yuan H, et al. Cross-clade neutralization of primary isolates of HIV-1 by human monoclonal antibodies and tetrameric CD4-IgG. J Virol 1995;69:6609-17.
    • (1995) J Virol , vol.69 , pp. 6609-6617
    • Trkola, A.1    Pomales, A.2    Yuan, H.3
  • 79
    • 0029875107 scopus 로고    scopus 로고
    • Effective ex vivo neutralization of HIV-1 in plasma by recombinant immunoglobulin molecules
    • Gauduin M, Allaway G, Maddon P, Barbas C III, Burton D, Koup R. Effective ex vivo neutralization of HIV-1 in plasma by recombinant immunoglobulin molecules. J Virol 1996;70:2586-92.
    • (1996) J Virol , vol.70 , pp. 2586-2592
    • Gauduin, M.1    Allaway, G.2    Maddon, P.3    Barbas III, C.4    Burton, D.5    Koup, R.6
  • 80
    • 0034984290 scopus 로고    scopus 로고
    • Structural flexibility and functional valence of CD4-IgG2 (PRO 542): Potential for cross-linking HIV-1 envelope spikes
    • Zhu P, Olson W, Roux K. Structural flexibility and functional valence of CD4-IgG2 (PRO 542): potential for cross-linking HIV-1 envelope spikes. J Virol 2001;75:6682-6.
    • (2001) J Virol , vol.75 , pp. 6682-6686
    • Zhu, P.1    Olson, W.2    Roux, K.3
  • 81
    • 0033914939 scopus 로고    scopus 로고
    • Single-dose safety, pharmacology, and antiviral activity of the HIV-1 entry inhibitor PRO 542 in HIV-infected adults
    • Jacobson J, Lowy I, Fletcher C, et al. Single-dose safety, pharmacology, and antiviral activity of the HIV-1 entry inhibitor PRO 542 in HIV-infected adults. J Infect Dis 2000;182:326-9.
    • (2000) J Infect Dis , vol.182 , pp. 326-329
    • Jacobson, J.1    Lowy, I.2    Fletcher, C.3
  • 82
    • 12244281787 scopus 로고    scopus 로고
    • Rational design of a CD4 mimic that inhibits HIV-1 entry and exposes cryptic neutralization epitopes
    • Martin L, Stricher F, Misse D, et al. Rational design of a CD4 mimic that inhibits HIV-1 entry and exposes cryptic neutralization epitopes. Nat Biotechnol 2003;21:71-6.
    • (2003) Nat Biotechnol , vol.21 , pp. 71-76
    • Martin, L.1    Stricher, F.2    Misse, D.3
  • 83
    • 9144236197 scopus 로고    scopus 로고
    • Antiretroviral activity of the anti-CD4 monoclonal antibody TNX-355 in patients infected with HIV type 1
    • Kuritzkes D, Jacobson J, Powderly W, et al. Antiretroviral activity of the anti-CD4 monoclonal antibody TNX-355 in patients infected with HIV type 1. J Infect Dis 2004;189:286-91.
    • (2004) J Infect Dis , vol.189 , pp. 286-291
    • Kuritzkes, D.1    Jacobson, J.2    Powderly, W.3
  • 84
    • 0028914092 scopus 로고
    • Mediation of HIV-1 binding by interaction of cell surface heparan sulfate proteoglycans with the V3 region of envelope gp120-gp41
    • Roderiquez G, Oravecz T, Yanagishita M, Bou-Habib D, Mostowski H, Norcross M. Mediation of HIV-1 binding by interaction of cell surface heparan sulfate proteoglycans with the V3 region of envelope gp120-gp41. J Virol 1995;69:2233-9.
    • (1995) J Virol , vol.69 , pp. 2233-2239
    • Roderiquez, G.1    Oravecz, T.2    Yanagishita, M.3    Bou-Habib, D.4    Mostowski, H.5    Norcross, M.6
  • 85
    • 0033920212 scopus 로고    scopus 로고
    • Selective interactions of polyanions with basic surfaces on HIV-1 gp120
    • Moulard M, Lortat-Jacob H, Mondor I, et al. Selective interactions of polyanions with basic surfaces on HIV-1 gp120. J Virol 2000; 74:1948-60.
    • (2000) J Virol , vol.74 , pp. 1948-1960
    • Moulard, M.1    Lortat-Jacob, H.2    Mondor, I.3
  • 86
    • 0028129972 scopus 로고
    • Characterization of HIV-1 gp120 binding to liposomes containing galactosylceramide
    • Long D, Berson J, Cook D, Doms R. Characterization of HIV-1 gp120 binding to liposomes containing galactosylceramide. J Virol 1994;68:5890-8.
    • (1994) J Virol , vol.68 , pp. 5890-5898
    • Long, D.1    Berson, J.2    Cook, D.3    Doms, R.4
  • 87
    • 0037331514 scopus 로고    scopus 로고
    • Involvement of macrophage mannose receptor in the binding and transmission of HIV by macrophages
    • Nguyen D, Hildreth J. Involvement of macrophage mannose receptor in the binding and transmission of HIV by macrophages. Eur J Immunol 2003;33:483-93.
    • (2003) Eur J Immunol , vol.33 , pp. 483-493
    • Nguyen, D.1    Hildreth, J.2
  • 88
    • 0034598934 scopus 로고    scopus 로고
    • Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responses
    • Geijtenbeek T, Torensma R, van Vliet S, et al. Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responses. Cell 2000;100:575-85.
    • (2000) Cell , vol.100 , pp. 575-585
    • Geijtenbeek, T.1    Torensma, R.2    van Vliet, S.3
  • 89
    • 0034009465 scopus 로고    scopus 로고
    • Increased infectivity of HIV-1 particles bound to cell surface and solid-phase ICAM-1 and VCAM-1 through acquired adhesion molecules LFA-1 and VLA-4
    • Llao Z, Roos J, Hildreth J. Increased infectivity of HIV-1 particles bound to cell surface and solid-phase ICAM-1 and VCAM-1 through acquired adhesion molecules LFA-1 and VLA-4. AIDS Res Hum Retroviruses 2000;16:355-66.
    • (2000) AIDS Res Hum Retroviruses , vol.16 , pp. 355-366
    • Llao, Z.1    Roos, J.2    Hildreth, J.3
  • 90
    • 0035173252 scopus 로고    scopus 로고
    • LFA-1 expression on target cells promotes HIV-1 infection and transmission
    • Hioe C, Chien P, Lu C, et al. LFA-1 expression on target cells promotes HIV-1 infection and transmission. J Virol 2001;75:1077-82.
    • (2001) J Virol , vol.75 , pp. 1077-1082
    • Hioe, C.1    Chien, P.2    Lu, C.3
  • 91
    • 0029731557 scopus 로고    scopus 로고
    • SPC3, a V3 loop-derived synthetic peptide inhibitor of HIV-1 infection, binds to cell surface glycosphingolipids
    • Delezay O, Hammache D, Fantini J, Yahi N. SPC3, a V3 loop-derived synthetic peptide inhibitor of HIV-1 infection, binds to cell surface glycosphingolipids. Biochemistry 1996;35:15663-71.
    • (1996) Biochemistry , vol.35 , pp. 15663-15671
    • Delezay, O.1    Hammache, D.2    Fantini, J.3    Yahi, N.4
  • 92
    • 0033951494 scopus 로고    scopus 로고
    • Relationships between the anti-HIV V(3)-derived peptide SPC(3) and lymphocyte membrane properties involved in virus entry: SPC(3) interferes with CXCR(4)
    • Barbouche R, Papandreou M, Miquelis R, Guieu R, Fenouillet E. Relationships between the anti-HIV V(3)-derived peptide SPC(3) and lymphocyte membrane properties involved in virus entry: SPC(3) interferes with CXCR(4). FEMS Microbiol Lett 2000;183:235-40.
    • (2000) FEMS Microbiol Lett , vol.183 , pp. 235-240
    • Barbouche, R.1    Papandreou, M.2    Miquelis, R.3    Guieu, R.4    Fenouillet, E.5
  • 93
    • 0036223804 scopus 로고    scopus 로고
    • Liposomal encapsulation enhances antiviral efficacy of SPC3 against HIV-1 infection in human lymphocytes
    • De Mareuil J, Mabrouk K, Doria E, et al. Liposomal encapsulation enhances antiviral efficacy of SPC3 against HIV-1 infection in human lymphocytes. Antiviral Res 2002;54:175-88
    • (2002) Antiviral Res , vol.54 , pp. 175-188
    • De Mareuil, J.1    Mabrouk, K.2    Doria, E.3
  • 95
    • 0033082156 scopus 로고    scopus 로고
    • Orally administered dextran sulfate is absorbed in HIV-positive individuals
    • Hiebert L, Wice S, Jaques L, Williams K, Conly J. Orally administered dextran sulfate is absorbed in HIV-positive individuals. J Lab Clin Med 1999;133:161-70.
    • (1999) J Lab Clin Med , vol.133 , pp. 161-170
    • Hiebert, L.1    Wice, S.2    Jaques, L.3    Williams, K.4    Conly, J.5
  • 96
    • 10644268549 scopus 로고    scopus 로고
    • Anti-HIV drug development-an overview
    • Pereira C, Paridaen J. Anti-HIV drug development-an overview. Curr Pharm Des 2004;10:4005-37.
    • (2004) Curr Pharm Des , vol.10 , pp. 4005-4037
    • Pereira, C.1    Paridaen, J.2
  • 97
    • 0036846898 scopus 로고    scopus 로고
    • New anti-HIV agents and targets
    • De Clercq E. New anti-HIV agents and targets. Med Res Rev 2002;22:531-65.
    • (2002) Med Res Rev , vol.22 , pp. 531-565
    • De Clercq, E.1
  • 98
    • 2942627670 scopus 로고    scopus 로고
    • HIV chemotherapy and prophylaxis: New drugs, leads and approaches
    • De Clercq E. HIV chemotherapy and prophylaxis: new drugs, leads and approaches. Int J Biochem Cell Biol 2004;36:1800-22.
    • (2004) Int J Biochem Cell Biol , vol.36 , pp. 1800-1822
    • De Clercq, E.1
  • 99
    • 0035283023 scopus 로고    scopus 로고
    • Correlation of anti-HIV activity with anion spacing in a series of cosalane analogues with extended polycarboxylate pharmacophores
    • Santhosh K, Paul G, De Clercq E, et al. Correlation of anti-HIV activity with anion spacing in a series of cosalane analogues with extended polycarboxylate pharmacophores. J Med Chem 2001;44:703-14.
    • (2001) J Med Chem , vol.44 , pp. 703-714
    • Santhosh, K.1    Paul, G.2    De Clercq, E.3
  • 100
    • 0030273307 scopus 로고    scopus 로고
    • Inhibition of HIV replication by the sulfonated stilbene dye resobene
    • Halliday S, Lackman-Smith C, Bader J, et al. Inhibition of HIV replication by the sulfonated stilbene dye resobene. Antiviral Res 1996;33:41-53.
    • (1996) Antiviral Res , vol.33 , pp. 41-53
    • Halliday, S.1    Lackman-Smith, C.2    Bader, J.3
  • 101
    • 0033844736 scopus 로고    scopus 로고
    • A fusion inhibitor (FP-21399) for the treatment of HIV infection: A phase I study
    • Dezube B, Dahl T, Wong T, et al. A fusion inhibitor (FP-21399) for the treatment of HIV infection: a phase I study. J Infect Dis 2000;182:607-10.
    • (2000) J Infect Dis , vol.182 , pp. 607-610
    • Dezube, B.1    Dahl, T.2    Wong, T.3
  • 102
    • 0028824505 scopus 로고
    • T30177, an oligonucleotide stabilized by an intramolecular guanosine octet, is a potent inhibitor of laboratory strains and clinical isolates of HIV-1
    • Ojwang J, Buckheit R, Pommier Y, et al. T30177, an oligonucleotide stabilized by an intramolecular guanosine octet, is a potent inhibitor of laboratory strains and clinical isolates of HIV-1. Antimicrob Agents Chemother 1995;39:2426-35.
    • (1995) Antimicrob Agents Chemother , vol.39 , pp. 2426-2435
    • Ojwang, J.1    Buckheit, R.2    Pommier, Y.3
  • 103
    • 0031886388 scopus 로고    scopus 로고
    • HIV glycoprotein gp120 as the primary target for the antiviral action of AR177 (Zintevir)
    • Este J, Cabrera C, Schols D, et al. HIV glycoprotein gp120 as the primary target for the antiviral action of AR177 (Zintevir). Mol Pharmacol 1998;53:340-5.
    • (1998) Mol Pharmacol , vol.53 , pp. 340-345
    • Este, J.1    Cabrera, C.2    Schols, D.3
  • 104
    • 0141680855 scopus 로고    scopus 로고
    • Discovery of 4-benzoyl-1-[(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl) oxoacetyl]-2-(R)-methylpiperazine (BMS-378806): A novel HIV-1 attachment inhibitor that interferes with CD4-gp120 interactions
    • Wang T, Zhang Z, Wallace O, et al. Discovery of 4-benzoyl-1-[(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)oxoacetyl]-2- (R)-methylpiperazine (BMS-378806): a novel HIV-1 attachment inhibitor that interferes with CD4-gp120 interactions. J Med Chem 2003;46:4236-9.
    • (2003) J Med Chem , vol.46 , pp. 4236-4239
    • Wang, T.1    Zhang, Z.2    Wallace, O.3
  • 105
    • 0141703204 scopus 로고    scopus 로고
    • A small molecule HIV-1 inhibitor that targets the HIV-1 envelope and inhibits CD4 receptor binding
    • Lin P, Blair W, Wang T, et al. A small molecule HIV-1 inhibitor that targets the HIV-1 envelope and inhibits CD4 receptor binding. Proc Natl Acad Sci USA 2003;100:11013-8.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 11013-11018
    • Lin, P.1    Blair, W.2    Wang, T.3
  • 106
    • 0141856289 scopus 로고    scopus 로고
    • Biochemical and genetic characterizations of a novel HIV-1 inhibitor that blocks gp120-CD4 interactions
    • Guo Q, Ho H, Dicker I, et al. Biochemical and genetic characterizations of a novel HIV-1 inhibitor that blocks gp120-CD4 interactions. J Virol 2003;77:10528-36.
    • (2003) J Virol , vol.77 , pp. 10528-10536
    • Guo, Q.1    Ho, H.2    Dicker, I.3
  • 107
    • 18644369147 scopus 로고    scopus 로고
    • The appealing story of HIV entry inhibitors: From discovery of biological mechanisms to drug development
    • Castagna A, Biswas P, Beretta A, Lazzarin A. The appealing story of HIV entry inhibitors: from discovery of biological mechanisms to drug development. Drugs 2005;65:879-904.
    • (2005) Drugs , vol.65 , pp. 879-904
    • Castagna, A.1    Biswas, P.2    Beretta, A.3    Lazzarin, A.4
  • 108
    • 0030790094 scopus 로고    scopus 로고
    • Discovery of cyanovirin-N, a novel HIV-inactivating protein that binds viral surface envelope glycoprotein gp120: Potential applications to microbicide development
    • Boyd M, Gustafson K, McMahon J, Discovery of cyanovirin-N, a novel HIV-inactivating protein that binds viral surface envelope glycoprotein gp120: potential applications to microbicide development. Antimicrob Agents Chemother 1997;41:1521-30.
    • (1997) Antimicrob Agents Chemother , vol.41 , pp. 1521-1530
    • Boyd, M.1    Gustafson, K.2    McMahon, J.3
  • 109
    • 0034799906 scopus 로고    scopus 로고
    • The potent anti-HIV protein cyanovirin-N contains two novel carbohydrate binding sites that selectively bind to Man(8) D1D3 and Man(9) with nanomolar affinity: Implications for binding to the HIV envelope protein gp120
    • Bewley C, Otero-Quintero S. The potent anti-HIV protein cyanovirin-N contains two novel carbohydrate binding sites that selectively bind to Man(8) D1D3 and Man(9) with nanomolar affinity: implications for binding to the HIV envelope protein gp120. J Am Chem Soc 2001;123:3892-902.
    • (2001) J Am Chem Soc , vol.123 , pp. 3892-3902
    • Bewley, C.1    Otero-Quintero, S.2
  • 110
    • 19944403933 scopus 로고    scopus 로고
    • Resistance of HIV-1 to the high-mannose binding agents cyanovirin N and concanavalin A
    • Witvrouw M, Fikkert V, Hantson A, et al. Resistance of HIV-1 to the high-mannose binding agents cyanovirin N and concanavalin A. J Virol 2005;79:7777-84.
    • (2005) J Virol , vol.79 , pp. 7777-7784
    • Witvrouw, M.1    Fikkert, V.2    Hantson, A.3
  • 111
    • 0036436747 scopus 로고    scopus 로고
    • CADA inhibits HIV and human herpesvirus 7 replication by down-modulation of the cellular CD4 receptor
    • Vermeire K, Zhang Y, Princen K, et al. CADA inhibits HIV and human herpesvirus 7 replication by down-modulation of the cellular CD4 receptor. Virology 2002;302:342-53.
    • (2002) Virology , vol.302 , pp. 342-353
    • Vermeire, K.1    Zhang, Y.2    Princen, K.3
  • 112
    • 0347320929 scopus 로고    scopus 로고
    • Specific CD4 down-modulating compounds with potent anti-HIV activity
    • Vermeire K, Schols D. Specific CD4 down-modulating compounds with potent anti-HIV activity. J Leukoc Biol 2003;74:667-75.
    • (2003) J Leukoc Biol , vol.74 , pp. 667-675
    • Vermeire, K.1    Schols, D.2
  • 113
    • 33144467275 scopus 로고    scopus 로고
    • Synthesis and structure-activity relationship studies of CD4 down-modulating cyclotriazadisulfonamide (CADA) analogues
    • Bell T, Anugu S, Bailey P, et al. Synthesis and structure-activity relationship studies of CD4 down-modulating cyclotriazadisulfonamide (CADA) analogues. J Med Chem 2006;49:1291-312.
    • (2006) J Med Chem , vol.49 , pp. 1291-1312
    • Bell, T.1    Anugu, S.2    Bailey, P.3
  • 114
    • 0141814730 scopus 로고    scopus 로고
    • The entry of entry inhibitors: A fusion of science and medicine
    • Moore J, Doms R. The entry of entry inhibitors: a fusion of science and medicine. Proc Natl Acad Sci USA 2003;100:10598-602.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 10598-10602
    • Moore, J.1    Doms, R.2
  • 115
    • 0035031017 scopus 로고    scopus 로고
    • Chemokine receptors as anti-retroviral targets
    • Heveker N. Chemokine receptors as anti-retroviral targets. Curr Drug Targets 2001;2:21-39.
    • (2001) Curr Drug Targets , vol.2 , pp. 21-39
    • Heveker, N.1
  • 116
    • 24944540240 scopus 로고    scopus 로고
    • Progress in targeting HIV-1 entry
    • Ryser H, Fluckiger R. Progress in targeting HIV-1 entry. Drug Discov Today 2005;10:1085-94.
    • (2005) Drug Discov Today , vol.10 , pp. 1085-1094
    • Ryser, H.1    Fluckiger, R.2
  • 117
    • 0032507962 scopus 로고    scopus 로고
    • Function of the chemokine receptor CXCR4 in hematopoiesis and in cerebellar development
    • Zou Y, Kottmann A, Kuroda M, Taniuchi I, Littman D. Function of the chemokine receptor CXCR4 in hematopoiesis and in cerebellar development. Nature 1998;393:595-9
    • (1998) Nature , vol.393 , pp. 595-599
    • Zou, Y.1    Kottmann, A.2    Kuroda, M.3    Taniuchi, I.4    Littman, D.5
  • 118
    • 0032482926 scopus 로고    scopus 로고
    • Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice
    • Ma Q, Jones D, Borghesani P, et al. Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice. Proc Natl Acad Sci USA 1998;95:9448-53.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 9448-9453
    • Ma, Q.1    Jones, D.2    Borghesani, P.3
  • 119
    • 15844388931 scopus 로고    scopus 로고
    • Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection
    • Liu R, Paxton W, Choe S, et al. Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection. Cell 1996;86:367-77
    • (1996) Cell , vol.86 , pp. 367-377
    • Liu, R.1    Paxton, W.2    Choe, S.3
  • 120
    • 0029775576 scopus 로고    scopus 로고
    • The lymphocyte chemo-attractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry
    • Bleul C, Farzan M, Choe H, et al. The lymphocyte chemo-attractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry. Nature 1996;382:829-33.
    • (1996) Nature , vol.382 , pp. 829-833
    • Bleul, C.1    Farzan, M.2    Choe, H.3
  • 121
    • 0032568336 scopus 로고    scopus 로고
    • Dissociation of the signaling and antiviral properties of SDF-1-derived small peptides
    • Heveker N, Montes M, Germeroth L, et al. Dissociation of the signaling and antiviral properties of SDF-1-derived small peptides. Curr Biol 1998;8:369-76.
    • (1998) Curr Biol , vol.8 , pp. 369-376
    • Heveker, N.1    Montes, M.2    Germeroth, L.3
  • 122
    • 0037124101 scopus 로고    scopus 로고
    • Exploring the stereochemistry of CXCR4-peptide recognition and inhibiting HIV-1 entry with D-peptides derived from chemokines
    • Zhou N, Luo Z, Luo J, et al. Exploring the stereochemistry of CXCR4-peptide recognition and inhibiting HIV-1 entry with D-peptides derived from chemokines. J Biol Chem 2002;277:17476-85.
    • (2002) J Biol Chem , vol.277 , pp. 17476-17485
    • Zhou, N.1    Luo, Z.2    Luo, J.3
  • 123
    • 2642549923 scopus 로고    scopus 로고
    • Anti-HIV activity and conformational studies of peptides derived from the C-terminal sequence of SDF-1
    • Dettin M, Pasquato A, Scarinci C, Zanchetta M, De Rossi A, Di Bello C. Anti-HIV activity and conformational studies of peptides derived from the C-terminal sequence of SDF-1. J Med Chem 2004;47:3058-64.
    • (2004) J Med Chem , vol.47 , pp. 3058-3064
    • Dettin, M.1    Pasquato, A.2    Scarinci, C.3    Zanchetta, M.4    De Rossi, A.5    Di Bello, C.6
  • 124
    • 18744416007 scopus 로고    scopus 로고
    • HAART: Current state of the art, new agents and their pharmacologic interactions useful for improving therapeutic outcome
    • Barbaro G, Scozzafava A, Mastrolorenzo A, Supuran C. HAART: current state of the art, new agents and their pharmacologic interactions useful for improving therapeutic outcome. Curr Pharm Des 2005;11:1805-43.
    • (2005) Curr Pharm Des , vol.11 , pp. 1805-1843
    • Barbaro, G.1    Scozzafava, A.2    Mastrolorenzo, A.3    Supuran, C.4
  • 126
    • 0026625277 scopus 로고
    • Anti-HIV activity of a novel synthetic peptide, T22 ([Tyr-5, 12, Lys-7]polyphemusin II): A possible inhibitor of virus-cell fusion
    • Nakashima H, Masuda M, Murakami T, et al. Anti-HIV activity of a novel synthetic peptide, T22 ([Tyr-5, 12, Lys-7]polyphemusin II): a possible inhibitor of virus-cell fusion. Antimicrob Agents Chemother 1992;36:1249-55.
    • (1992) Antimicrob Agents Chemother , vol.36 , pp. 1249-1255
    • Nakashima, H.1    Masuda, M.2    Murakami, T.3
  • 127
    • 0028556402 scopus 로고
    • Structure-activity relationships of an anti-HIV peptide, T22
    • Tamamura H, Murakami T, Masuda M, et al. Structure-activity relationships of an anti-HIV peptide, T22. Biochem Biophys Res Commun 1994;205:1729-35.
    • (1994) Biochem Biophys Res Commun , vol.205 , pp. 1729-1735
    • Tamamura, H.1    Murakami, T.2    Masuda, M.3
  • 128
    • 0033586442 scopus 로고    scopus 로고
    • Marked increase in anti-HIV activity, as well as inhibitory activity against HIV entry mediated by CXCR4, linked to enhancement of the binding ability of tachyplesin analogs to CXCR4
    • Xu Y, Tamamura H, Arakaki R, et al. Marked increase in anti-HIV activity, as well as inhibitory activity against HIV entry mediated by CXCR4, linked to enhancement of the binding ability of tachyplesin analogs to CXCR4. AIDS Res Hum Retroviruses 1999;20;15:419-27.
    • (1999) AIDS Res Hum Retroviruses , vol.20 , Issue.15 , pp. 419-427
    • Xu, Y.1    Tamamura, H.2    Arakaki, R.3
  • 129
    • 0032954383 scopus 로고    scopus 로고
    • T134, a small-molecule CXCR4 inhibitor, has no cross-drug resistance with AMD3100, a CXCR4 antagonist with a different structure
    • Arakaki R, Tamamura H, Premanathan M, et al. T134, a small-molecule CXCR4 inhibitor, has no cross-drug resistance with AMD3100, a CXCR4 antagonist with a different structure. J Virol 1999;73:1719-23.
    • (1999) J Virol , vol.73 , pp. 1719-1723
    • Arakaki, R.1    Tamamura, H.2    Premanathan, M.3
  • 130
    • 0032583575 scopus 로고    scopus 로고
    • A low-molecular-weight inhibitor against the chemokine receptor CXCR4: A strong anti-HIV peptide T140
    • Tamamura H, Xu Y, Hattori T, et al. A low-molecular-weight inhibitor against the chemokine receptor CXCR4: a strong anti-HIV peptide T140. Biochem Biophys Res Commun 1998;253:877-82.
    • (1998) Biochem Biophys Res Commun , vol.253 , pp. 877-882
    • Tamamura, H.1    Xu, Y.2    Hattori, T.3
  • 131
    • 0345412742 scopus 로고    scopus 로고
    • Enhancement of the T140-based pharmacophores leads to the development of more potent and bio-stable CXCR4 antagonists
    • Tamamura H, Hiramatsu K, Mizumoto M, et al. Enhancement of the T140-based pharmacophores leads to the development of more potent and bio-stable CXCR4 antagonists. Org Biomol Chem 2003;1:3663-9.
    • (2003) Org Biomol Chem , vol.1 , pp. 3663-3669
    • Tamamura, H.1    Hiramatsu, K.2    Mizumoto, M.3
  • 132
    • 0029911702 scopus 로고    scopus 로고
    • Anti-HIV-1 activity of an oligocationic compound mediated via gp120 V3 interactions
    • O'Brien W, Sumner-Smith M, Mao S, Sadeghi S, Zhao J, Chen I. Anti-HIV-1 activity of an oligocationic compound mediated via gp120 V3 interactions. J Virol 1996;70:2825-31.
    • (1996) J Virol , vol.70 , pp. 2825-2831
    • O'Brien, W.1    Sumner-Smith, M.2    Mao, S.3    Sadeghi, S.4    Zhao, J.5    Chen, I.6
  • 134
    • 0042668582 scopus 로고    scopus 로고
    • Binding of ALX40-4C to APJ, a CNS-based receptor, inhibits its utilization as a coreceptor by HIV-1
    • Zhou N, Fang J, Acheampong E, Mukhtar M, Pomerantz R. Binding of ALX40-4C to APJ, a CNS-based receptor, inhibits its utilization as a coreceptor by HIV-1. Virology 2003;312:196-203.
    • (2003) Virology , vol.312 , pp. 196-203
    • Zhou, N.1    Fang, J.2    Acheampong, E.3    Mukhtar, M.4    Pomerantz, R.5
  • 135
    • 0347627799 scopus 로고    scopus 로고
    • The N-terminal domain of APJ, a CNS-based coreceptor for HIV-1, is essential for its receptor function and coreceptor activity
    • Zhou N, Zhang X, Fan X, et al. The N-terminal domain of APJ, a CNS-based coreceptor for HIV-1, is essential for its receptor function and coreceptor activity. Virology 2003;317:84-94.
    • (2003) Virology , vol.317 , pp. 84-94
    • Zhou, N.1    Zhang, X.2    Fan, X.3
  • 136
    • 0032701519 scopus 로고    scopus 로고
    • Secreted phospholipases A(2), a new class of HIV inhibitors that block virus entry into host cells
    • Fenard D, Lambeau G, Valentin E, Lefebvre J, Lazdunski M, Doglio A. Secreted phospholipases A(2), a new class of HIV inhibitors that block virus entry into host cells. J Clin Invest 1999;104:611-8.
    • (1999) J Clin Invest , vol.104 , pp. 611-618
    • Fenard, D.1    Lambeau, G.2    Valentin, E.3    Lefebvre, J.4    Lazdunski, M.5    Doglio, A.6
  • 137
    • 0034915340 scopus 로고    scopus 로고
    • A peptide derived from bee venom-secreted phospholipase A2 inhibits replication of T-cell tropic HIV-1 strains via interaction with the CXCR4 chemokine receptor
    • Fenard D, Lambeau G, Maurin T, Lefebvre J, Doglio A. A peptide derived from bee venom-secreted phospholipase A2 inhibits replication of T-cell tropic HIV-1 strains via interaction with the CXCR4 chemokine receptor. Mol Pharmacol 2001;60:341-7.
    • (2001) Mol Pharmacol , vol.60 , pp. 341-347
    • Fenard, D.1    Lambeau, G.2    Maurin, T.3    Lefebvre, J.4    Doglio, A.5
  • 138
    • 0030976612 scopus 로고    scopus 로고
    • An inhibitor of the Tat/TAR RNA interaction that effectively suppresses HIV-1 replication
    • Hamy F, Felder E, Heizmann G, et al. An inhibitor of the Tat/TAR RNA interaction that effectively suppresses HIV-1 replication. Proc Natl Acad Sci USA 1997;94:3548-53.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 3548-3553
    • Hamy, F.1    Felder, E.2    Heizmann, G.3
  • 139
    • 0033971512 scopus 로고    scopus 로고
    • A second target for the peptoid Tat/transactivation response element inhibitor CGP64222: Inhibition of HIV replication by blocking CXC-chemokine receptor 4-mediated virus entry
    • Daelemans D, Schols D, Witvrouw M, et al. A second target for the peptoid Tat/transactivation response element inhibitor CGP64222: inhibition of HIV replication by blocking CXC-chemokine receptor 4-mediated virus entry. Mol Pharmacol 2000;57:116-24.
    • (2000) Mol Pharmacol , vol.57 , pp. 116-124
    • Daelemans, D.1    Schols, D.2    Witvrouw, M.3
  • 140
    • 0030835663 scopus 로고    scopus 로고
    • Bicyclams, a class of potent anti-HIV agents, are targeted at the HIV coreceptor fusin/CXCR-4
    • Schols D, Este J, Henson G, De Clercq E. Bicyclams, a class of potent anti-HIV agents, are targeted at the HIV coreceptor fusin/CXCR-4. Antiviral Res 1997;35:147-56.
    • (1997) Antiviral Res , vol.35 , pp. 147-156
    • Schols, D.1    Este, J.2    Henson, G.3    De Clercq, E.4
  • 141
    • 0034062515 scopus 로고    scopus 로고
    • Inhibition of HIV infection by bicyclams, highly potent and specific CXCR4 antagonists
    • De Clercq E. Inhibition of HIV infection by bicyclams, highly potent and specific CXCR4 antagonists. Mol Pharmacol 2000;57:833-9.
    • (2000) Mol Pharmacol , vol.57 , pp. 833-839
    • De Clercq, E.1
  • 142
    • 0035199047 scopus 로고    scopus 로고
    • HIV resistance to entry inhibitors
    • Este J. HIV resistance to entry inhibitors. AIDS Rev 2001;3:121-32.
    • (2001) AIDS Rev , vol.3 , pp. 121-132
    • Este, J.1
  • 143
    • 0034120373 scopus 로고    scopus 로고
    • Pharmacokinetics and safety of AMD-3100, a novel antagonist of the CXCR-4 chemokine receptor, in human volunteers
    • Hendrix C, Flexner C, MacFarland R, et al. Pharmacokinetics and safety of AMD-3100, a novel antagonist of the CXCR-4 chemokine receptor, in human volunteers. Antimicrob Agents Chemother 2000;44:1667-73.
    • (2000) Antimicrob Agents Chemother , vol.44 , pp. 1667-1673
    • Hendrix, C.1    Flexner, C.2    MacFarland, R.3
  • 144
    • 4644227515 scopus 로고    scopus 로고
    • Safety, pharmacokinetics, and antiviral activity of AMD3100, a selective CXCR4 receptor inhibitor, in HIV-1 infection
    • Hendrix C, Collier A, Lederman M, et al. Safety, pharmacokinetics, and antiviral activity of AMD3100, a selective CXCR4 receptor inhibitor, in HIV-1 infection. J Acquir Immune Defic Syndr 2004;37:1253-62.
    • (2004) J Acquir Immune Defic Syndr , vol.37 , pp. 1253-1262
    • Hendrix, C.1    Collier, A.2    Lederman, M.3
  • 145
    • 23044456806 scopus 로고    scopus 로고
    • AMD3465, a monomacrocyclic CXCR4 antagonist and potent HIV entry inhibitor
    • Hatse S, Princen K, De Clercq E, et al. AMD3465, a monomacrocyclic CXCR4 antagonist and potent HIV entry inhibitor. Biochem Pharmacol 2005;70:752-61.
    • (2005) Biochem Pharmacol , vol.70 , pp. 752-761
    • Hatse, S.1    Princen, K.2    De Clercq, E.3
  • 146
    • 3042595910 scopus 로고    scopus 로고
    • Small-molecule antagonists of CCR5 and CXCR4: A promising new class of anti-HIV-1 drugs
    • Seibert C, Sakmar T. Small-molecule antagonists of CCR5 and CXCR4: a promising new class of anti-HIV-1 drugs. Curr Pharm Des 2004;10:2041-62.
    • (2004) Curr Pharm Des , vol.10 , pp. 2041-2062
    • Seibert, C.1    Sakmar, T.2
  • 147
    • 0037388121 scopus 로고    scopus 로고
    • A duodenally absorbable CXC chemokine receptor 4 antagonist, KRH-1636, exhibits a potent and selective anti-HIV-1 activity
    • Ichiyama K, Yokoyama-Kumakura S, Tanaka Y, et al. A duodenally absorbable CXC chemokine receptor 4 antagonist, KRH-1636, exhibits a potent and selective anti-HIV-1 activity. Proc Natl Acad Sci USA 2003;100:4185-90.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 4185-4190
    • Ichiyama, K.1    Yokoyama-Kumakura, S.2    Tanaka, Y.3
  • 148
    • 0034304841 scopus 로고    scopus 로고
    • New targets for inhibitors of HIV-1 replication
    • Moore J, Stevenson M. New targets for inhibitors of HIV-1 replication. Nat Rev Mol Cell Biol 2000;1:40-9.
    • (2000) Nat Rev Mol Cell Biol , vol.1 , pp. 40-49
    • Moore, J.1    Stevenson, M.2
  • 149
    • 3042764204 scopus 로고    scopus 로고
    • Chemokine receptor-directed agents as novel anti-HIV-1 therapies
    • Mills S, DeMartino J. Chemokine receptor-directed agents as novel anti-HIV-1 therapies. Curr Top Med Chem 2004;4:1017-33.
    • (2004) Curr Top Med Chem , vol.4 , pp. 1017-1033
    • Mills, S.1    DeMartino, J.2
  • 150
    • 0032080672 scopus 로고    scopus 로고
    • Blockade of CC chemokine receptor 5 (CCR5)-tropic HIV-1 replication in human lymphoid tissue by CC chemokines
    • Margolis L, Glushakova S, Grivel J, Murphy P. Blockade of CC chemokine receptor 5 (CCR5)-tropic HIV-1 replication in human lymphoid tissue by CC chemokines. J Clin Invest 1998;101: 1876-80.
    • (1998) J Clin Invest , vol.101 , pp. 1876-1880
    • Margolis, L.1    Glushakova, S.2    Grivel, J.3    Murphy, P.4
  • 151
    • 0032543650 scopus 로고    scopus 로고
    • Synthetic full-length and truncated RANTES inhibit HIV-1 infection of primary macrophages
    • Ylisastigui L, Vizzavona J, Drakopoulou E, et al. Synthetic full-length and truncated RANTES inhibit HIV-1 infection of primary macrophages. AIDS 1998;12:977-84.
    • (1998) AIDS , vol.12 , pp. 977-984
    • Ylisastigui, L.1    Vizzavona, J.2    Drakopoulou, E.3
  • 152
    • 3042799382 scopus 로고    scopus 로고
    • Prospects of HIV-1 entry inhibitors as novel therapeutics
    • Pierson T, Doms R, Pohlmann S. Prospects of HIV-1 entry inhibitors as novel therapeutics. Rev Med Virol 2004;14:255-70.
    • (2004) Rev Med Virol , vol.14 , pp. 255-270
    • Pierson, T.1    Doms, R.2    Pohlmann, S.3
  • 153
    • 0030951442 scopus 로고    scopus 로고
    • Potent inhibition of HIV-1 infectivity in macrophages and lymphocytes by a novel CCR5 antagonist
    • Simmons G, Clapham P, Picard L, et al. Potent inhibition of HIV-1 infectivity in macrophages and lymphocytes by a novel CCR5 antagonist. Science 1997;276:276-9.
    • (1997) Science , vol.276 , pp. 276-279
    • Simmons, G.1    Clapham, P.2    Picard, L.3
  • 154
    • 0032924183 scopus 로고    scopus 로고
    • Highly potent RANTES analogs either prevent CCR5-using HIV-1 infection in vivo or rapidly select for CXCR4-using variants
    • Mosier D, Picchio G, Gulizia R, et al. Highly potent RANTES analogs either prevent CCR5-using HIV-1 infection in vivo or rapidly select for CXCR4-using variants. J Virol 1999;73:3544-50.
    • (1999) J Virol , vol.73 , pp. 3544-3550
    • Mosier, D.1    Picchio, G.2    Gulizia, R.3
  • 155
    • 0030022954 scopus 로고    scopus 로고
    • Extension of recombinant human RANTES by the retention of the initiating methionine produces a potent antagonist
    • Proudfoot A, Power C, Hoogewerf A, et al. Extension of recombinant human RANTES by the retention of the initiating methionine produces a potent antagonist. J Biol Chem 1996;271:2599-603.
    • (1996) J Biol Chem , vol.271 , pp. 2599-2603
    • Proudfoot, A.1    Power, C.2    Hoogewerf, A.3
  • 156
    • 0034004857 scopus 로고    scopus 로고
    • Variable sensitivity of CCR5-tropic HIV-1 isolates to inhibition by RANTES analogs
    • Torre V, Marozsan A, Albright J, et al. Variable sensitivity of CCR5-tropic HIV-1 isolates to inhibition by RANTES analogs. J Virol 2000;74:4868-76.
    • (2000) J Virol , vol.74 , pp. 4868-4876
    • Torre, V.1    Marozsan, A.2    Albright, J.3
  • 157
    • 0033605592 scopus 로고    scopus 로고
    • Differential effects of CC chemokines on CC chemokine receptor 5 (CCR5) phosphorylation and identification of phosphorylation sites on the CCR5 carboxyl terminus
    • Oppermann M, Mack M, Proudfoot A, Olbrich H. Differential effects of CC chemokines on CC chemokine receptor 5 (CCR5) phosphorylation and identification of phosphorylation sites on the CCR5 carboxyl terminus. J Biol Chem 1999;274:8875-85.
    • (1999) J Biol Chem , vol.274 , pp. 8875-8885
    • Oppermann, M.1    Mack, M.2    Proudfoot, A.3    Olbrich, H.4
  • 158
    • 0033746503 scopus 로고    scopus 로고
    • Enhancement of the HIV-1 inhibitory activity of RANTES by modification of the N-terminal region: Dissociation from CCR5 activation
    • Polo S, Nardese V, De Santis C, et al. Enhancement of the HIV-1 inhibitory activity of RANTES by modification of the N-terminal region: dissociation from CCR5 activation. Eur J Immunol 2000; 30:3190-8.
    • (2000) Eur J Immunol , vol.30 , pp. 3190-3198
    • Polo, S.1    Nardese, V.2    De Santis, C.3
  • 159
    • 0038619045 scopus 로고    scopus 로고
    • HIV-1 entry inhibitors selected on living cells from a library of phage chemokines
    • Hartley O, Dorgham K, Perez-Bercoff D, et al. HIV-1 entry inhibitors selected on living cells from a library of phage chemokines. J Virol 2003;77:6637-44.
    • (2003) J Virol , vol.77 , pp. 6637-6644
    • Hartley, O.1    Dorgham, K.2    Perez-Bercoff, D.3
  • 160
    • 5644247983 scopus 로고    scopus 로고
    • Prevention of vaginal SHIV transmission in rhesus macaques through inhibition of CCR5
    • Lederman M, Veazey R, Offord R, et al. Prevention of vaginal SHIV transmission in rhesus macaques through inhibition of CCR5. Science 2004;306:485-7.
    • (2004) Science , vol.306 , pp. 485-487
    • Lederman, M.1    Veazey, R.2    Offord, R.3
  • 161
    • 28244432554 scopus 로고    scopus 로고
    • Preferential targeting of CD4-CCR5 complexes with bifunctional inhibitors: A novel approach to block HIV-1 infection
    • Mack M, Pfirstinger J, Haas J, et al. Preferential targeting of CD4-CCR5 complexes with bifunctional inhibitors: a novel approach to block HIV-1 infection. J Immunol 2005;175:7586-93.
    • (2005) J Immunol , vol.175 , pp. 7586-7593
    • Mack, M.1    Pfirstinger, J.2    Haas, J.3
  • 162
    • 13044256383 scopus 로고    scopus 로고
    • A small-molecule, nonpeptide CCR5 antagonist with highly potent and selective anti-HIV-1 activity
    • Baba M, Nishimura O, Kanzaki N, et al. A small-molecule, nonpeptide CCR5 antagonist with highly potent and selective anti-HIV-1 activity. Proc Natl Acad Sci USA 1999;96:5698-703.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 5698-5703
    • Baba, M.1    Nishimura, O.2    Kanzaki, N.3
  • 163
    • 0034625144 scopus 로고    scopus 로고
    • A binding pocket for a small molecule inhibitor of HIV-1 entry within the transmembrane helices of CCR5
    • Dragic T, Trkola A, Thompson D, et al. A binding pocket for a small molecule inhibitor of HIV-1 entry within the transmembrane helices of CCR5. Proc Natl Acad Sci USA 2000;97:5639-44.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 5639-5644
    • Dragic, T.1    Trkola, A.2    Thompson, D.3
  • 164
    • 23044515844 scopus 로고    scopus 로고
    • Highly potent inhibition of HIV-1 replication by TAK-220, an orally bioavailable small-molecule CCR5 antagonist
    • Takashima K, Miyake H, Kanzaki N, et al. Highly potent inhibition of HIV-1 replication by TAK-220, an orally bioavailable small-molecule CCR5 antagonist. Antimicrob Agents Chemother 2005;49:3474-82.
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 3474-3482
    • Takashima, K.1    Miyake, H.2    Kanzaki, N.3
  • 165
    • 27644506926 scopus 로고    scopus 로고
    • TAK-652 inhibits CCR5-mediated HIV-1 infection in vitro and has favorable pharmacokinetics in humans
    • Baba M, Takashima K, Miyake H, et al. TAK-652 inhibits CCR5-mediated HIV-1 infection in vitro and has favorable pharmacokinetics in humans. Antimicrob Agents Chemother 2005;49:4584-91.
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 4584-4591
    • Baba, M.1    Takashima, K.2    Miyake, H.3
  • 166
    • 23044484979 scopus 로고    scopus 로고
    • TAK-220, a novel small-molecule CCR5 antagonist, has favorable anti-HIV interactions with other antiretrovirals in vitro
    • Tremblay C, Giguel F, Guan Y, Chou T, Takashima K, Hirsch M. TAK-220, a novel small-molecule CCR5 antagonist, has favorable anti-HIV interactions with other antiretrovirals in vitro. Antimicrob Agents Chemother 2005;49:3483-5.
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 3483-3485
    • Tremblay, C.1    Giguel, F.2    Guan, Y.3    Chou, T.4    Takashima, K.5    Hirsch, M.6
  • 167
    • 27644446851 scopus 로고    scopus 로고
    • Analysis of binding sites for the new small-molecule CCR5 antagonist TAK-220 on human CCR5
    • Nishikawa M, Takashima K, Nishi T, et al. Analysis of binding sites for the new small-molecule CCR5 antagonist TAK-220 on human CCR5. Antimicrob Agents Chemother 2005;49:4708-15.
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 4708-4715
    • Nishikawa, M.1    Takashima, K.2    Nishi, T.3
  • 168
    • 0035921055 scopus 로고    scopus 로고
    • Piperazine-based CCR5 antagonists as HIV-1 inhibitors. I: 2(S)-methyl piperazine as a key pharmacophore element
    • Tagat J, McCombie S, Steensma R, et al. Piperazine-based CCR5 antagonists as HIV-1 inhibitors. I: 2(S)-methyl piperazine as a key pharmacophore element. Bioorg Med Chem Lett 2001;11:2143-6.
    • (2001) Bioorg Med Chem Lett , vol.11 , pp. 2143-2146
    • Tagat, J.1    McCombie, S.2    Steensma, R.3
  • 169
    • 0035846074 scopus 로고    scopus 로고
    • Discovery of 4-[(Z)-(4-bromophenyl)-(ethoxyimino)methyl]-1′- [(2,4-dimethyl-3-pyridinyl)carbonyl]-4′-methyl-1,4′- bipiperidine N-oxide (SCH 351125): An orally bioavailable human CCR5 antagonist for the treatment of HIV infection
    • Palani A, Shapiro S, Clader J, et al. Discovery of 4-[(Z)-(4-bromophenyl)- (ethoxyimino)methyl]-1′-[(2,4-dimethyl-3- pyridinyl) carbonyl]-4′-methyl-1,4′- bipiperidine N-oxide (SCH 351125): an orally bioavailable human CCR5 antagonist for the treatment of HIV infection. J Med Chem 2001;44:3339-42.
    • (2001) J Med Chem , vol.44 , pp. 3339-3342
    • Palani, A.1    Shapiro, S.2    Clader, J.3
  • 170
    • 0035940445 scopus 로고    scopus 로고
    • SCH-C (SCH 351125), an orally bioavailable, small molecule antagonist of the chemokine receptor CCR5, is a potent inhibitor of HIV-1 infection in vitro and in vivo
    • Strizki J, Xu S, Wagner N, et al. SCH-C (SCH 351125), an orally bioavailable, small molecule antagonist of the chemokine receptor CCR5, is a potent inhibitor of HIV-1 infection in vitro and in vivo. Proc Natl Acad Sci USA 2001;98:12718-23.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 12718-12723
    • Strizki, J.1    Xu, S.2    Wagner, N.3
  • 171
    • 0042924181 scopus 로고    scopus 로고
    • Virus entry as a target for anti-HIV intervention
    • Este J. Virus entry as a target for anti-HIV intervention. Curr Med Chem 2003;10:1617-32.
    • (2003) Curr Med Chem , vol.10 , pp. 1617-1632
    • Este, J.1
  • 172
    • 28944454412 scopus 로고    scopus 로고
    • Discovery and characterization of vicriviroc (SCH 417690), a CCR5 antagonist with potent activity against HIV-1
    • Strizki J, Tremblay C, Xu S, et al. Discovery and characterization of vicriviroc (SCH 417690), a CCR5 antagonist with potent activity against HIV-1. Antimicrob Agents Chemother 2005;49:4911-9.
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 4911-4919
    • Strizki, J.1    Tremblay, C.2    Xu, S.3
  • 173
    • 0037039380 scopus 로고    scopus 로고
    • HIV-1 escape from a small molecule, CCR5-specific entry inhibitor does not involve CXCR4 use
    • Trkola A, Kuhmann S, Strizki J, et al. HIV-1 escape from a small molecule, CCR5-specific entry inhibitor does not involve CXCR4 use. Proc Natl Acad Sci USA 2002;99:395-400.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 395-400
    • Trkola, A.1    Kuhmann, S.2    Strizki, J.3
  • 174
    • 20644453529 scopus 로고    scopus 로고
    • Generation and properties of a HIV-1 isolate resistant to the small molecule CCR5 inhibitor, SCH-417690 (SCH-D)
    • Marozsan A, Kuhmann S, Morgan T, et al. Generation and properties of a HIV-1 isolate resistant to the small molecule CCR5 inhibitor, SCH-417690 (SCH-D). Virology 2005;338:182-99.
    • (2005) Virology , vol.338 , pp. 182-199
    • Marozsan, A.1    Kuhmann, S.2    Morgan, T.3
  • 175
    • 27744548649 scopus 로고    scopus 로고
    • The discovery of the CCR5 receptor antagonist, UK-427,857, a new agent for the treatment of HIV infection and AIDS
    • Wood A, Armour D. The discovery of the CCR5 receptor antagonist, UK-427,857, a new agent for the treatment of HIV infection and AIDS. Prog Med Chem 2005;43:239-71.
    • (2005) Prog Med Chem , vol.43 , pp. 239-271
    • Wood, A.1    Armour, D.2
  • 176
    • 27644510382 scopus 로고    scopus 로고
    • Maraviroc (UK-427,857), a potent, orally bioavailable, and selective small-molecule inhibitor of chemokine receptor CCR5 with broad-spectrum anti-HIV type 1 activity
    • Dorr P, Westby M, Dobbs S, et al. Maraviroc (UK-427,857), a potent, orally bioavailable, and selective small-molecule inhibitor of chemokine receptor CCR5 with broad-spectrum anti-HIV type 1 activity. Antimicrob Agents Chemother 2005;49:4721-32.
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 4721-4732
    • Dorr, P.1    Westby, M.2    Dobbs, S.3
  • 177
    • 30744447460 scopus 로고    scopus 로고
    • Efficacy of short-term monotherapy with maraviroc, a new CCR5 antagonist, in patients infected with HIV-1
    • Fatkenheuer G, Pozniak A, Johnson M, et al. Efficacy of short-term monotherapy with maraviroc, a new CCR5 antagonist, in patients infected with HIV-1. Nat Med 2005;11:1170-2.
    • (2005) Nat Med , vol.11 , pp. 1170-1172
    • Fatkenheuer, G.1    Pozniak, A.2    Johnson, M.3
  • 178
    • 0035860744 scopus 로고    scopus 로고
    • Novel low molecular weight spirodiketopiperazine derivatives potently inhibit R5 HIV-1 infection through their antagonistic effects on CCR5
    • Maeda K, Yoshimura K, Shibayama S, et al. Novel low molecular weight spirodiketopiperazine derivatives potently inhibit R5 HIV-1 infection through their antagonistic effects on CCR5. J Biol Chem 2001;276:35194-200
    • (2001) J Biol Chem , vol.276 , pp. 35194-35200
    • Maeda, K.1    Yoshimura, K.2    Shibayama, S.3
  • 179
    • 3543144738 scopus 로고    scopus 로고
    • Spirodiketopiperazine-based CCR5 inhibitor which preserves CC-chemokine/ CCR5 interactions and exerts potent activity against R5 HIV-1 in vitro
    • Maeda K, Nakata H, Koh Y, et al. Spirodiketopiperazine-based CCR5 inhibitor which preserves CC-chemokine/CCR5 interactions and exerts potent activity against R5 HIV-1 in vitro. J Virol 2004;78:8654-62.
    • (2004) J Virol , vol.78 , pp. 8654-8662
    • Maeda, K.1    Nakata, H.2    Koh, Y.3
  • 180
    • 0035173073 scopus 로고    scopus 로고
    • Potent, broad-spectrum inhibition of HIV-1 by the CCR5 monoclonal antibody PRO 140
    • Trkola A, Ketas T, Nagashima K, et al. Potent, broad-spectrum inhibition of HIV-1 by the CCR5 monoclonal antibody PRO 140. J Virol 2001;75:579-88.
    • (2001) J Virol , vol.75 , pp. 579-588
    • Trkola, A.1    Ketas, T.2    Nagashima, K.3
  • 182
    • 14444282418 scopus 로고    scopus 로고
    • Inhibition of in vitro and in vivo HIV replication by a distamycin analog that interferes with chemokine receptor function: A candidate for chemotherapeutic and microbicidal application
    • Howard O, Oppenheim J, Hollingshead M, et al. Inhibition of in vitro and in vivo HIV replication by a distamycin analog that interferes with chemokine receptor function: a candidate for chemotherapeutic and microbicidal application. J Med Chem 1998;41:2184-93.
    • (1998) J Med Chem , vol.41 , pp. 2184-2193
    • Howard, O.1    Oppenheim, J.2    Hollingshead, M.3
  • 183
    • 0031775589 scopus 로고    scopus 로고
    • Small molecule inhibitor of HIV-1 cell fusion blocks chemokine receptor-mediated function
    • Howard O, Korte T, Tarasova N, et al. Small molecule inhibitor of HIV-1 cell fusion blocks chemokine receptor-mediated function. J Leukoc Biol 1998;64:6-13.
    • (1998) J Leukoc Biol , vol.64 , pp. 6-13
    • Howard, O.1    Korte, T.2    Tarasova, N.3
  • 184
    • 10744225125 scopus 로고    scopus 로고
    • Use of a small molecule CCR5 inhibitor in macaques to treat SIV infection or prevent simian-HIV infection
    • Veazey R, Klasse P, Ketas T, et al. Use of a small molecule CCR5 inhibitor in macaques to treat SIV infection or prevent simian-HIV infection. J Exp Med 2003;198:1551-62.
    • (2003) J Exp Med , vol.198 , pp. 1551-1562
    • Veazey, R.1    Klasse, P.2    Ketas, T.3
  • 185
    • 4544299731 scopus 로고    scopus 로고
    • Effect of a CCR5 inhibitor on viral loads in macaques dual-infected with R5 and X4 primate immunodeficiency viruses
    • Wolinsky S, Veazey R, Kunstman K, et al. Effect of a CCR5 inhibitor on viral loads in macaques dual-infected with R5 and X4 primate immunodeficiency viruses. Virology 2004;328:19-29.
    • (2004) Virology , vol.328 , pp. 19-29
    • Wolinsky, S.1    Veazey, R.2    Kunstman, K.3
  • 186
    • 0030970693 scopus 로고    scopus 로고
    • Core structure of gp41 from the HIV envelope glycoprotein
    • Chan D, Fass D, Berger J, Kim P. Core structure of gp41 from the HIV envelope glycoprotein. Cell 1997;89:263-73.
    • (1997) Cell , vol.89 , pp. 263-273
    • Chan, D.1    Fass, D.2    Berger, J.3    Kim, P.4
  • 187
    • 0035793406 scopus 로고    scopus 로고
    • Protein design of an HIV-1 entry inhibitor
    • Root M, Kay M, Kim P. Protein design of an HIV-1 entry inhibitor. Science 2001;291:884-8
    • (2001) Science , vol.291 , pp. 884-888
    • Root, M.1    Kay, M.2    Kim, P.3
  • 188
    • 0027959493 scopus 로고
    • Peptides corresponding to a predictive alpha-helical domain of HIV-1 gp41 are potent inhibitors of virus infection
    • Wild C, Shugars D, Greenwell T, McDanal C, Matthews T. Peptides corresponding to a predictive alpha-helical domain of HIV-1 gp41 are potent inhibitors of virus infection. Proc Natl Acad Sci USA 1994;91:9770-4.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 9770-9774
    • Wild, C.1    Shugars, D.2    Greenwell, T.3    McDanal, C.4    Matthews, T.5
  • 189
    • 0031729823 scopus 로고    scopus 로고
    • Potent suppression of HIV-1 replication in humans by T-20, a peptide inhibitor of gp41-mediated virus entry
    • Kilby J, Hopkins S, Venetta T, DiMassimo B, et al. Potent suppression of HIV-1 replication in humans by T-20, a peptide inhibitor of gp41-mediated virus entry. Nat Med 1998;4:1302-7.
    • (1998) Nat Med , vol.4 , pp. 1302-1307
    • Kilby, J.1    Hopkins, S.2    Venetta, T.3    DiMassimo, B.4
  • 190
    • 10744229122 scopus 로고    scopus 로고
    • A controlled Phase II trial assessing three doses of enfuvirtide (T-20) in combination with abacavir, amprenavir, ritonavir and efavirenz in non-nucleoside reverse transcriptase inhibitor-naive HIV-infected adults
    • Lalezari J, DeJesus E, Northfelt D, et al. A controlled Phase II trial assessing three doses of enfuvirtide (T-20) in combination with abacavir, amprenavir, ritonavir and efavirenz in non-nucleoside reverse transcriptase inhibitor-naive HIV-infected adults. Antivir Ther 2003;8:279-87.
    • (2003) Antivir Ther , vol.8 , pp. 279-287
    • Lalezari, J.1    DeJesus, E.2    Northfelt, D.3
  • 191
    • 0037471311 scopus 로고    scopus 로고
    • A phase II clinical study of the long-term safety and antiviral activity of enfuvirtide-based antiretroviral therapy
    • Lalezari J, Eron J, Carlson M, et al. A phase II clinical study of the long-term safety and antiviral activity of enfuvirtide-based antiretroviral therapy. AIDS 2003;17:691-8.
    • (2003) AIDS , vol.17 , pp. 691-698
    • Lalezari, J.1    Eron, J.2    Carlson, M.3
  • 192
    • 0038576281 scopus 로고    scopus 로고
    • Enfuvirtide, an HIV-1 fusion inhibitor, for drug-resistant HIV infection in North and South America
    • Lalezari J, Henry K, O'Hearn M, et al. Enfuvirtide, an HIV-1 fusion inhibitor, for drug-resistant HIV infection in North and South America. N Engl J Med 2003;348:2175-85.
    • (2003) N Engl J Med , vol.348 , pp. 2175-2185
    • Lalezari, J.1    Henry, K.2    O'Hearn, M.3
  • 193
    • 0033214895 scopus 로고    scopus 로고
    • Inhibiting HIV-1 entry: Discovery of D-peptide inhibitors that target the gp41 coiled-coil pocket
    • Eckert D, Malashkevich V, Hong L, Carr P, Kim P. Inhibiting HIV-1 entry: discovery of D-peptide inhibitors that target the gp41 coiled-coil pocket. Cell 1999;99:103-15.
    • (1999) Cell , vol.99 , pp. 103-115
    • Eckert, D.1    Malashkevich, V.2    Hong, L.3    Carr, P.4    Kim, P.5
  • 194
    • 0010459359 scopus 로고    scopus 로고
    • Virus sensitivity to T-20 and T-1249 is independent of coreceptor usage
    • 8th CROI
    • Greenberg M, McDanal C, Stanfield-Oakley S, et al. Virus sensitivity to T-20 and T-1249 is independent of coreceptor usage. 8th CROI 2001.
    • (2001)
    • Greenberg, M.1    McDanal, C.2    Stanfield-Oakley, S.3
  • 195
    • 20144386372 scopus 로고    scopus 로고
    • T-1249 retains potent antiretroviral activity in patients who had experienced virologic failure while on an enfuvirtide-containing treatment regimen
    • Lalezari J, Bellos N, Sathasivam K, et al. T-1249 retains potent antiretroviral activity in patients who had experienced virologic failure while on an enfuvirtide-containing treatment regimen. J Infect Dis 2005;191:1155-63.
    • (2005) J Infect Dis , vol.191 , pp. 1155-1163
    • Lalezari, J.1    Bellos, N.2    Sathasivam, K.3
  • 196
    • 3042794175 scopus 로고    scopus 로고
    • Recent advances in understanding the molecular mechanisms of HIV-1 entry and fusion: Revisiting current targets and considering new options for therapeutic intervention
    • Markovic I, Clouse K. Recent advances in understanding the molecular mechanisms of HIV-1 entry and fusion: revisiting current targets and considering new options for therapeutic intervention. Curr HIV Res 2004;2:223-34.
    • (2004) Curr HIV Res , vol.2 , pp. 223-234
    • Markovic, I.1    Clouse, K.2
  • 197
    • 2342550183 scopus 로고    scopus 로고
    • Discontinuation of the clinical development of fusion inhibitor T-1249
    • Martin-Carbonero L. Discontinuation of the clinical development of fusion inhibitor T-1249. AIDS Rev 2004;6:61.
    • (2004) AIDS Rev , vol.6 , pp. 61
    • Martin-Carbonero, L.1
  • 198
    • 33747618387 scopus 로고    scopus 로고
    • Next generation HIV peptide fusion inhibitor candidates achieve potent, durable suppression of virus replication in vitro and improved pharmacokinetic properties
    • 13th CROI Denver [abstract]
    • Delmedico M, Bray B, Cammack N. Next generation HIV peptide fusion inhibitor candidates achieve potent, durable suppression of virus replication in vitro and improved pharmacokinetic properties. 13th CROI Denver. 2006 [abstract].
    • (2006)
    • Delmedico, M.1    Bray, B.2    Cammack, N.3
  • 199
    • 24644518008 scopus 로고    scopus 로고
    • Design of improved protein inhibitors of HIV-1 cell entry: Optimization of electrostatic interactions at the binding interface
    • Green D, Tidor B. Design of improved protein inhibitors of HIV-1 cell entry: Optimization of electrostatic interactions at the binding interface. Proteins 2005;60:644-57.
    • (2005) Proteins , vol.60 , pp. 644-657
    • Green, D.1    Tidor, B.2
  • 200
    • 1442283560 scopus 로고    scopus 로고
    • Thiol/disulfide exchange is a prerequisite for CXCR4-tropic HIV-1 envelope-mediated T-cell fusion during viral entry
    • Markovic I, Stantchev T, Fields K, et al. Thiol/disulfide exchange is a prerequisite for CXCR4-tropic HIV-1 envelope-mediated T-cell fusion during viral entry. Blood 2004;103:1586-94.
    • (2004) Blood , vol.103 , pp. 1586-1594
    • Markovic, I.1    Stantchev, T.2    Fields, K.3
  • 201
    • 0028223281 scopus 로고
    • Triterpene derivatives that block entry of HIV-1 into cells
    • Mayaux J, Bousseau A, Pauwels R, et al. Triterpene derivatives that block entry of HIV-1 into cells. Proc Natl Acad Sci USA 1994;91:3564-8.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 3564-3568
    • Mayaux, J.1    Bousseau, A.2    Pauwels, R.3
  • 202
    • 13344269031 scopus 로고    scopus 로고
    • Betulinic acid derivatives: A new class of specific inhibitors of HIV-1 entry
    • Soler F, Poujade C, Evers M, et al. Betulinic acid derivatives: a new class of specific inhibitors of HIV-1 entry. J Med Chem 1996;39:1069-83.
    • (1996) J Med Chem , vol.39 , pp. 1069-1083
    • Soler, F.1    Poujade, C.2    Evers, M.3
  • 203
    • 0037068463 scopus 로고    scopus 로고
    • Anti-AIDS agents 49. Synthesis, anti-HIV, and anti-fusion activities of IC9564 analogues based on betulinic acid
    • Sun I, Chen C, Kashiwada Y, Wu J, Wang H, Lee K. Anti-AIDS agents 49. Synthesis, anti-HIV, and anti-fusion activities of IC9564 analogues based on betulinic acid. J Med Chem 2002;45:4271-5.
    • (2002) J Med Chem , vol.45 , pp. 4271-4275
    • Sun, I.1    Chen, C.2    Kashiwada, Y.3    Wu, J.4    Wang, H.5    Lee, K.6
  • 204
    • 0442309451 scopus 로고    scopus 로고
    • Tannin inhibits HIV-1 entry by targeting gp41
    • Lu L, Liu S, Jiang S, Wu S. Tannin inhibits HIV-1 entry by targeting gp41. Acta Pharmacol Sin 2004;25:213-8.
    • (2004) Acta Pharmacol Sin , vol.25 , pp. 213-218
    • Lu, L.1    Liu, S.2    Jiang, S.3    Wu, S.4
  • 205
    • 26044470938 scopus 로고    scopus 로고
    • Pharmacokinetics of sifuvirtide, a novel anti-HIV-1 peptide, in monkeys and its inhibitory concentration in vitro
    • Dai S, Dou G, Qiang X, et al. Pharmacokinetics of sifuvirtide, a novel anti-HIV-1 peptide, in monkeys and its inhibitory concentration in vitro. Acta Pharmacol Sin 2005;26:1274-80.
    • (2005) Acta Pharmacol Sin , vol.26 , pp. 1274-1280
    • Dai, S.1    Dou, G.2    Qiang, X.3
  • 206
    • 0033607028 scopus 로고    scopus 로고
    • Structure-based identification of small molecule antiviral compounds targeted to the gp41 core structure of the HIV-1
    • Debnath A, Radigan L, Jiang S. Structure-based identification of small molecule antiviral compounds targeted to the gp41 core structure of the HIV-1. J Med Chem 1999;42:3203-9.
    • (1999) J Med Chem , vol.42 , pp. 3203-3209
    • Debnath, A.1    Radigan, L.2    Jiang, S.3
  • 207
    • 1342279557 scopus 로고    scopus 로고
    • Synthesis and anti-HIV-1 activity of 4-[4-(4,6-bisphenylamino- triazin-2-ylamino)-5-methoxy-2-methyl-phenylazo]-5-hydroxynaphthalene- 2,7-disulfonic acid and its derivatives
    • Naicker K, Jiang S, Lu H, et al. Synthesis and anti-HIV-1 activity of 4-[4-(4,6-bisphenylamino-triazin-2-ylamino)-5-methoxy-2-methyl- phenylazo]-5-hydroxynaphthalene-2,7-disulfonic acid and its derivatives. Bioorg Med Chem 2004;12:1215-20.
    • (2004) Bioorg Med Chem , vol.12 , pp. 1215-1220
    • Naicker, K.1    Jiang, S.2    Lu, H.3
  • 208
    • 27644505400 scopus 로고    scopus 로고
    • The anti-HIV activity of ADS-J1 targets the HIV-1 gp120
    • Armand-Ugon M, Clotet-Codina I, Tintori C, et al. The anti-HIV activity of ADS-J1 targets the HIV-1 gp120. Virology 2005;343:141-9.
    • (2005) Virology , vol.343 , pp. 141-149
    • Armand-Ugon, M.1    Clotet-Codina, I.2    Tintori, C.3
  • 209
    • 0037508515 scopus 로고    scopus 로고
    • Topical microbicides for disease prevention: Status and challenges
    • Harrison P, Rosenberg Z, Bowcut J. Topical microbicides for disease prevention: status and challenges. Clin Infect Dis 2003;36:1290-4.
    • (2003) Clin Infect Dis , vol.36 , pp. 1290-1294
    • Harrison, P.1    Rosenberg, Z.2    Bowcut, J.3
  • 210
    • 0346025452 scopus 로고    scopus 로고
    • Clinical development of microbicides for the prevention of HIV infection
    • D'Cruz O, Uckun F. Clinical development of microbicides for the prevention of HIV infection. Curr Pharm Des 2004;10:315-36.
    • (2004) Curr Pharm Des , vol.10 , pp. 315-336
    • D'Cruz, O.1    Uckun, F.2
  • 211
    • 27744498389 scopus 로고    scopus 로고
    • Microbicides for prevention of transmission of sexually transmitted diseases
    • Howett M, Kuhl J. Microbicides for prevention of transmission of sexually transmitted diseases. Curr Pharm Des 2005;11:3731-46.
    • (2005) Curr Pharm Des , vol.11 , pp. 3731-3746
    • Howett, M.1    Kuhl, J.2
  • 212
    • 29744459673 scopus 로고    scopus 로고
    • Microbicides to prevent HIV transmission: Overcoming obstacles to chemical barrier protection
    • Dhawan D, Mayer K. Microbicides to prevent HIV transmission: overcoming obstacles to chemical barrier protection. J Infect Dis 2006;193:36-44.
    • (2006) J Infect Dis , vol.193 , pp. 36-44
    • Dhawan, D.1    Mayer, K.2
  • 213
    • 19944427993 scopus 로고    scopus 로고
    • Expression, purification, and characterization of recombinant cyanovirin-N for vaginal anti-HIV microbicide development
    • Colleluori D, Tien D, Kang F, et al. Expression, purification, and characterization of recombinant cyanovirin-N for vaginal anti-HIV microbicide development. Protein Expr Purif 2005;39:229-36.
    • (2005) Protein Expr Purif , vol.39 , pp. 229-236
    • Colleluori, D.1    Tien, D.2    Kang, F.3
  • 214
    • 0742272702 scopus 로고    scopus 로고
    • Cyanovirin-N inhibits AIDS virus infections in vaginal transmission models
    • Tsai C, Emau P, Jiang Y, et al. Cyanovirin-N inhibits AIDS virus infections in vaginal transmission models. AIDS Res Hum Retroviruses 2004;20:11-8.
    • (2004) AIDS Res Hum Retroviruses , vol.20 , pp. 11-18
    • Tsai, C.1    Emau, P.2    Jiang, Y.3
  • 215
    • 16444385352 scopus 로고    scopus 로고
    • SPL7013 gel as a topical microbicide for prevention of vaginal transmission of SHIV89.6P in macaques
    • Jiang Y, Emau P, Cairns J, et al. SPL7013 gel as a topical microbicide for prevention of vaginal transmission of SHIV89.6P in macaques. AIDS Res Hum Retroviruses 2005;21:207-13.
    • (2005) AIDS Res Hum Retroviruses , vol.21 , pp. 207-213
    • Jiang, Y.1    Emau, P.2    Cairns, J.3
  • 216
    • 24144438231 scopus 로고    scopus 로고
    • Candidate sulfonated and sulfated topical microbicides: Comparison of anti-HIV activities and mechanisms of action
    • Scordi-Bello I, Mosoian A, He C, et al. Candidate sulfonated and sulfated topical microbicides: comparison of anti-HIV activities and mechanisms of action. Antimicrob Agents Chemother 2005;49:3607-15.
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 3607-3615
    • Scordi-Bello, I.1    Mosoian, A.2    He, C.3
  • 217
    • 29744466672 scopus 로고    scopus 로고
    • PRO 2000 gel inhibits HIV and herpes simplex virus infection following vaginal application: A double-blind placebo-controlled trial
    • Keller M, Zerhouni-Layachi B, Cheshenko N, et al. PRO 2000 gel inhibits HIV and herpes simplex virus infection following vaginal application: a double-blind placebo-controlled trial. J Infect Dis 2006;193:27-35.
    • (2006) J Infect Dis , vol.193 , pp. 27-35
    • Keller, M.1    Zerhouni-Layachi, B.2    Cheshenko, N.3
  • 218
    • 33646228397 scopus 로고    scopus 로고
    • Biochemical analysis of human milk treated with sodium dodecyl sulfate, an alkyl sulfate microbicide that inactivates HIV-1
    • Hartmann S, Wigdahl B, Neely E, et al. Biochemical analysis of human milk treated with sodium dodecyl sulfate, an alkyl sulfate microbicide that inactivates HIV-1. J Hum Lact 2005;22:61-74.
    • (2005) J Hum Lact , vol.22 , pp. 61-74
    • Hartmann, S.1    Wigdahl, B.2    Neely, E.3
  • 219
    • 0037190597 scopus 로고    scopus 로고
    • Effectiveness of COL-1492, a nonoxynol-9 vaginal gel, on HIV-1 transmission in female sex workers: A randomized controlled trial
    • Van Damme L, Ramjee G, Alary M, et al. Effectiveness of COL-1492, a nonoxynol-9 vaginal gel, on HIV-1 transmission in female sex workers: a randomized controlled trial. Lancet 2002;360:971-7.
    • (2002) Lancet , vol.360 , pp. 971-977
    • Van Damme, L.1    Ramjee, G.2    Alary, M.3
  • 220
    • 20144388837 scopus 로고    scopus 로고
    • Comparative safety evaluation of the candidate vaginal microbicide C31G
    • Catalone B, Kish-Catalone T, Neely E, et al. Comparative safety evaluation of the candidate vaginal microbicide C31G. Antimicrob Agents Chemother 2005;49:1509-20.
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 1509-1520
    • Catalone, B.1    Kish-Catalone, T.2    Neely, E.3
  • 221
    • 0025961011 scopus 로고
    • Identification of the principal neutralizing determinant of HIV-1 as a fusion domain
    • Freed E, Myers D, Risser R. Identification of the principal neutralizing determinant of HIV-1 as a fusion domain. J Virol 1991; 65:190-4.
    • (1991) J Virol , vol.65 , pp. 190-194
    • Freed, E.1    Myers, D.2    Risser, R.3
  • 222
    • 0026672676 scopus 로고
    • Macrophage-tropic HIV isolates from different patients exhibit unusual V3 envelope sequence homogeneity in comparison with T-cell-tropic isolates: Definition of critical amino acids involved in cell tropism
    • Chesebro B, Wehrly K, Nishio J, Perryman S. Macrophage-tropic HIV isolates from different patients exhibit unusual V3 envelope sequence homogeneity in comparison with T-cell-tropic isolates: definition of critical amino acids involved in cell tropism. J Virol 1992;66:6547-54.
    • (1992) J Virol , vol.66 , pp. 6547-6554
    • Chesebro, B.1    Wehrly, K.2    Nishio, J.3    Perryman, S.4
  • 223
    • 0026702003 scopus 로고
    • Minimal requirements for the HIV-1 V3 domain to support the syncytium-inducing phenotype: Analysis by single amino acid substitution
    • De Jong J, De Ronde A, Keulen W, Tersmette M, Goudsmit J. Minimal requirements for the HIV-1 V3 domain to support the syncytium-inducing phenotype: analysis by single amino acid substitution. J Virol 1992;66:6777-80.
    • (1992) J Virol , vol.66 , pp. 6777-6780
    • De Jong, J.1    De Ronde, A.2    Keulen, W.3    Tersmette, M.4    Goudsmit, J.5
  • 224
    • 0026754683 scopus 로고
    • Small amino acid changes in the V3 hypervariable region of gp120 can affect the T-cell-line and macrophage tropism of HIV-1
    • Shioda T, Levy J, Cheng-Mayer C. Small amino acid changes in the V3 hypervariable region of gp120 can affect the T-cell-line and macrophage tropism of HIV-1. Proc Natl Acad Sci USA 1992;89:9434-8.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 9434-9438
    • Shioda, T.1    Levy, J.2    Cheng-Mayer, C.3
  • 225
    • 0027442206 scopus 로고
    • Identification of HIV1 determinants for T lymphoid cell line infection
    • Carrillo A, Trowbridge D, Westervelt P, Ratner L. Identification of HIV1 determinants for T lymphoid cell line infection. Virology 1993;197:817-24.
    • (1993) Virology , vol.197 , pp. 817-824
    • Carrillo, A.1    Trowbridge, D.2    Westervelt, P.3    Ratner, L.4
  • 226
    • 0027938980 scopus 로고
    • Syncytium-inducing and non-syncytium-inducing capacity of HIV-1 subtypes other than B: Phenotypic and genotypic characteristics
    • WHO Network for HIV Isolation and Characterization
    • De Wolf F, Hogervorst E, Goudsmit J, et al. and WHO Network for HIV Isolation and Characterization. Syncytium-inducing and non-syncytium-inducing capacity of HIV-1 subtypes other than B: phenotypic and genotypic characteristics. AIDS Res Hum Retroviruses 1994;10:1387-400.
    • (1994) AIDS Res Hum Retroviruses , vol.10 , pp. 1387-1400
    • De Wolf, F.1    Hogervorst, E.2    Goudsmit, J.3
  • 227
    • 0032866483 scopus 로고    scopus 로고
    • HIV-1 subtype C syncytium- and non-syncytium-inducing phenotypes and coreceptor usage among Ethiopian patients with AIDS
    • Abebe A, Demissie D, Goudsmit J, et al. HIV-1 subtype C syncytium- and non-syncytium-inducing phenotypes and coreceptor usage among Ethiopian patients with AIDS. AIDS 1999; 13:1305-11.
    • (1999) AIDS , vol.13 , pp. 1305-1311
    • Abebe, A.1    Demissie, D.2    Goudsmit, J.3
  • 228
    • 0028877422 scopus 로고
    • Syncytium induction in primary CD4+ T-cell lines from normal donors by HIV-1 isolates with non-syncytium-inducing genotype and phenotype in MT-2 cells
    • Todd B, Kedar P, Pope J. Syncytium induction in primary CD4+ T-cell lines from normal donors by HIV-1 isolates with non-syncytium-inducing genotype and phenotype in MT-2 cells. J Virol 1995;69:7099-105.
    • (1995) J Virol , vol.69 , pp. 7099-7105
    • Todd, B.1    Kedar, P.2    Pope, J.3
  • 229
    • 14844333093 scopus 로고    scopus 로고
    • Epidemiology and predictive factors for chemokine receptor use in HIV-1 infection
    • Moyle G, Wildfire A, Mandalia S, et al. Epidemiology and predictive factors for chemokine receptor use in HIV-1 infection. J Infect Dis 2005;191:866-72.
    • (2005) J Infect Dis , vol.191 , pp. 866-872
    • Moyle, G.1    Wildfire, A.2    Mandalia, S.3
  • 230
    • 0027980445 scopus 로고
    • Mutational trends in V3 loop protein sequences observed in different genetic lineages of HIV-1
    • Korber B, MacInnes K, Smith R, Myers G. Mutational trends in V3 loop protein sequences observed in different genetic lineages of HIV-1. J Virol 1994;68:6730-44.
    • (1994) J Virol , vol.68 , pp. 6730-6744
    • Korber, B.1    MacInnes, K.2    Smith, R.3    Myers, G.4
  • 231
    • 0031029083 scopus 로고    scopus 로고
    • Evolutionary mechanisms and population dynamics of the third variable envelope region of HIV within single hosts
    • Yamaguchi Y, Gojobori T. Evolutionary mechanisms and population dynamics of the third variable envelope region of HIV within single hosts. Proc Natl Acad Sci USA 1997;94:1264-9.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 1264-1269
    • Yamaguchi, Y.1    Gojobori, T.2
  • 233
    • 0034523325 scopus 로고    scopus 로고
    • Envelope V3 amino acid sequence predicts HIV-1 phenotype (coreceptor usage and tropism for macrophages)
    • Briggs D, Tuttle D, Sleasman J, Goodenow M. Envelope V3 amino acid sequence predicts HIV-1 phenotype (coreceptor usage and tropism for macrophages). AIDS 2000;14:2937-9.
    • (2000) AIDS , vol.14 , pp. 2937-2939
    • Briggs, D.1    Tuttle, D.2    Sleasman, J.3    Goodenow, M.4
  • 234
    • 0035884899 scopus 로고    scopus 로고
    • Improved success of phenotype prediction of HIV-1 from envelope variable loop 3 sequence using neural networks
    • Resch W, Hoffman N, Swanstrom R. Improved success of phenotype prediction of HIV-1 from envelope variable loop 3 sequence using neural networks. Virology 2001;288:51-62.
    • (2001) Virology , vol.288 , pp. 51-62
    • Resch, W.1    Hoffman, N.2    Swanstrom, R.3
  • 235
    • 0033995286 scopus 로고    scopus 로고
    • Reevaluation of amino acid variability of HIV-1 gp120 envelope glycoprotein and prediction of new discontinuous epitopes
    • Yamaguchi-Kabata Y, Gojobori T. Reevaluation of amino acid variability of HIV-1 gp120 envelope glycoprotein and prediction of new discontinuous epitopes. J Virol 2000;74:4335-50.
    • (2000) J Virol , vol.74 , pp. 4335-4350
    • Yamaguchi-Kabata, Y.1    Gojobori, T.2
  • 236
    • 84856043672 scopus 로고
    • A mathematical theory of communication
    • Shannon C. A mathematical theory of communication. Bell Syst Technol J 1948;27:379-423.
    • (1948) Bell Syst Technol J , vol.27 , pp. 379-423
    • Shannon, C.1
  • 237
    • 0035313589 scopus 로고    scopus 로고
    • HIV-1 entry inhibitors PRO 542 and T-20 are potently synergistic in blocking virus-cell and cell-cell fusion
    • Nagashima K, Thompson D, Rosenfield S, Maddon P, Dragic T, Olson W. HIV-1 entry inhibitors PRO 542 and T-20 are potently synergistic in blocking virus-cell and cell-cell fusion. J Infect Dis 2001;183:1121-5.
    • (2001) J Infect Dis , vol.183 , pp. 1121-1125
    • Nagashima, K.1    Thompson, D.2    Rosenfield, S.3    Maddon, P.4    Dragic, T.5    Olson, W.6
  • 238
    • 9144250171 scopus 로고    scopus 로고
    • Treatment of advanced HIV-1 disease with the viral entry inhibitor PRO 542
    • Jacobson J, Israel R, Lowy I, et al. Treatment of advanced HIV-1 disease with the viral entry inhibitor PRO 542. Antimicrob Agents Chemother 2004;48:423-9.
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 423-429
    • Jacobson, J.1    Israel, R.2    Lowy, I.3
  • 239
    • 2642541113 scopus 로고    scopus 로고
    • Antiviral activity, safety, and tolerability of a novel, oral small-molecule HIV-1 attachment inhibitor, BMS-488043, in HIV-1-infected subjects
    • 11th CROI San Francisco. [abstract]
    • Hanna,G, Lalezari J, Hellinger J. Antiviral activity, safety, and tolerability of a novel, oral small-molecule HIV-1 attachment inhibitor, BMS-488043, in HIV-1-infected subjects. 11th CROI San Francisco. 2004 [abstract].
    • (2004)
    • Hanna, G.1    Lalezari, J.2    Hellinger, J.3
  • 240
    • 0036892030 scopus 로고    scopus 로고
    • Dextrin sulfate as a vaginal microbicide: Randomized, double-blind, placebo-controlled trial including healthy female volunteers and their male partners
    • Low-Beer N, Gabe R, McCormack S, Kitchen V, Lacey C, Nunn A. Dextrin sulfate as a vaginal microbicide: randomized, double-blind, placebo-controlled trial including healthy female volunteers and their male partners. J Acquir Immune Defic Syndr 2002;31:391-8.
    • (2002) J Acquir Immune Defic Syndr , vol.31 , pp. 391-398
    • Low-Beer, N.1    Gabe, R.2    McCormack, S.3    Kitchen, V.4    Lacey, C.5    Nunn, A.6
  • 241
    • 28644443679 scopus 로고    scopus 로고
    • A dose-ranging phase I study of dextrin sulphate, a vaginal microbicide, in HIV-negative and HIV-positive female volunteers
    • McCormack S, Jespers V, Low-Beer N, et al. A dose-ranging phase I study of dextrin sulphate, a vaginal microbicide, in HIV-negative and HIV-positive female volunteers. Sex Transm Dis 2005;32:765-70.
    • (2005) Sex Transm Dis , vol.32 , pp. 765-770
    • McCormack, S.1    Jespers, V.2    Low-Beer, N.3
  • 242
    • 0033957973 scopus 로고    scopus 로고
    • Acute, multiple-dose, and genetic toxicology of AR177, an anti-HIV oligonucleotide
    • Wallace T, Gamba-Vitalo C, Loveday K, Cossum P. Acute, multiple-dose, and genetic toxicology of AR177, an anti-HIV oligonucleotide. Toxicol Sci 2000;53:63-70.
    • (2000) Toxicol Sci , vol.53 , pp. 63-70
    • Wallace, T.1    Gamba-Vitalo, C.2    Loveday, K.3    Cossum, P.4
  • 243
    • 33745192699 scopus 로고    scopus 로고
    • KRH-2731: An orally bioavailable CXCR4 antagonist is a potent inhibitor of HIV-1 infection
    • 11th CROI San Francisco [abstract]
    • Murakami T, Yoshida A, Tanaka R. KRH-2731: An orally bioavailable CXCR4 antagonist is a potent inhibitor of HIV-1 infection. 11th CROI, San Francisco, 2004 [abstract].
    • (2004)
    • Murakami, T.1    Yoshida, A.2    Tanaka, R.3
  • 244
    • 33745881988 scopus 로고    scopus 로고
    • Development of novel orally bioavailable CXCR4 antagonists, KRH-3955 and KRH-3140: Binding specificity, pharmacokinetics and anti-HIV-1 activity in vivo and in vitro
    • 13th CROI Denver [abstract]
    • Tanaka Y, Yokuma K, Tanaka R. Development of novel orally bioavailable CXCR4 antagonists, KRH-3955 and KRH-3140: binding specificity, pharmacokinetics and anti-HIV-1 activity in vivo and in vitro. 13th CROI, Denver, 2006 [abstract].
    • (2006)
    • Tanaka, Y.1    Yokuma, K.2    Tanaka, R.3
  • 245
    • 0030951442 scopus 로고    scopus 로고
    • Potent inhibition of HIV-1 infectivity in macrophages and lymphocytes by a novel CCR5 antagonist
    • Simmons G, Clapham P, Picard L, et al. Potent inhibition of HIV-1 infectivity in macrophages and lymphocytes by a novel CCR5 antagonist. Science 1997;276:276-9.
    • (1997) Science , vol.276 , pp. 276-279
    • Simmons, G.1    Clapham, P.2    Picard, L.3
  • 246
    • 28644432424 scopus 로고    scopus 로고
    • Protection of macaques from vaginal SHIV challenge by an orally delivered CCR5 inhibitor
    • Veazey R, Springer M, Marx P, Dufour J, Klasse P, Moore J. Protection of macaques from vaginal SHIV challenge by an orally delivered CCR5 inhibitor. Nat Med 2005;11:1293-4.
    • (2005) Nat Med , vol.11 , pp. 1293-1294
    • Veazey, R.1    Springer, M.2    Marx, P.3    Dufour, J.4    Klasse, P.5    Moore, J.6
  • 247
    • 10744229122 scopus 로고    scopus 로고
    • A controlled Phase II trial assessing three doses of enfuvirtide (T-20) in combination with abacavir, amprenavir, ritonavir and efavirenz in non-nucleoside reverse transcriptase inhibitor-naive HIV-infected adults
    • Lalezari J, DeJesus E, Northfelt D, et al. A controlled Phase II trial assessing three doses of enfuvirtide (T-20) in combination with abacavir, amprenavir, ritonavir and efavirenz in non-nucleoside reverse transcriptase inhibitor-naive HIV-infected adults. Antivir Ther 2003;8:279-87.
    • (2003) Antivir Ther , vol.8 , pp. 279-287
    • Lalezari, J.1    DeJesus, E.2    Northfelt, D.3
  • 248
    • 4444310448 scopus 로고    scopus 로고
    • Characterization of determinants of genotypic and phenotypic resistance to enfuvirtide in baseline and on-treatment HIV-1 isolates
    • Sista P, Melby T, Davison D, et al. Characterization of determinants of genotypic and phenotypic resistance to enfuvirtide in baseline and on-treatment HIV-1 isolates. AIDS 2004:18:1787-94.
    • (2004) AIDS , vol.18 , pp. 1787-1794
    • Sista, P.1    Melby, T.2    Davison, D.3


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