Analysis of binding sites for the new small-molecule CCR5 antagonist TAK-220 on human CCR5

Antimicrobial Agents and Chemotherapy

Volumn 49, Issue 11, 2005, Pages 4708-4715

  Nishikawa, Masao ^a   Takashima, Katsunori ^b   Nishi, Toshiya ^b   Furuta, Rika A ^a   Kanzaki, Naoyuki ^b   Yamamoto, Yoshio ^b   Fujisawa, Jun Ichi ^a  

^a KANSAI MEDICAL UNIVERSITY   (Japan)

^b TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1 ACETYL N [3 [4 (4 CARBAMOYLBENZYL) 1 PIPERIDINYL]PROPYL] N (3 CHLORO 4 METHYLPHENYL) 4 PIPERIDINECARBOXAMIDE; ASPARAGINE; CHEMOKINE RECEPTOR ANTAGONIST; CHEMOKINE RECEPTOR CCR5; G PROTEIN COUPLED RECEPTOR; GLYCINE; LEUCINE; N [4 [[[6,7 DIHYDRO 2 (4 METHYLPHENYL) 5H BENZOCYCLOHEPTEN 8 YL]CARBONYL]AMINO]BENZYL] N,N DIMETHYL 2H TETRAHYDROPYRAN 4 AMINIUM CHLORIDE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; DRUG BINDING SITE; EMBRYO; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MOLECULAR MODEL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN;

AMIDES; AMINO ACID SEQUENCE; ANTI-HIV AGENTS; BINDING SITES; HIV-1; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PIPERIDINES; QUATERNARY AMMONIUM COMPOUNDS; RECEPTORS, CCR5;

EID: 27644446851     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.49.11.4708-4715.2005     Document Type: Article

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