Novel Low Molecular Weight Spirodiketopiperazine Derivatives Potently Inhibit R5 HIV-1 Infection through Their Antagonistic Effects on CCR5

Journal of Biological Chemistry

Volumn 276, Issue 37, 2001, Pages 35194-35200

  Maeda, Kenji ^a   Yoshimura, Kazuhisa ^a   Shibayama, Shiro ^b   Habashita, Hiromu ^b   Tada, Hideaki ^b   Sagawa, Kenji ^b   Miyakawa, Toshikazu ^a   Aoki, Manabu ^a   Fukushima, Daikichi ^b   Mitsuya, Hiroaki ^a,c  

^a KUMAMOTO UNIV SCHOOL OF MEDICINE   (Japan)

^b ONO PHARMACEUTICAL CO   (Japan)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODIES; CELLS; DATA REDUCTION; DERIVATIVES; MOLECULAR WEIGHT; VIRUSES;

IMMUNODEFICIENCY;

BIOCHEMISTRY;

1 BUTYL 2,5 DIOXO 3 CYCLOHEXYLMETHYL 9 (1,4 BENZODIOXAN 6 YLMETHYL) 1,4,9 TRIAZASPIRO[5.5]UNDECANE; 1,1' [1,4 PHENYLENEBIS(METHYLENE)]BIS(1,4,8,11 TETRAAZACYCLOTETRADECANE); ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; CALCIUM ION; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CCR5 ANTAGONIST; DIDANOSINE; E 913; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; NELFINAVIR; PIPERAZINE DERIVATIVE; PROTEIN INHIBITOR; PROTEINASE INHIBITOR; SAQUINAVIR; SPIRODIKETOPIPERAZINE DERIVATIVE; STAVUDINE; UNCLASSIFIED DRUG; ZIDOVUDINE; CALCIUM; HETEROCYCLIC COMPOUND; MACROPHAGE INFLAMMATORY PROTEIN 1;

ARTICLE; CALCIUM MOBILIZATION; DRUG BIOAVAILABILITY; DRUG MECHANISM; DRUG STRUCTURE; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IC 50; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ANALYSIS; VIRUS REPLICATION; ANIMAL; CELL LINE; CHO CELL; DRUG ANTAGONISM; DRUG EFFECT; HAMSTER; HUMAN; METABOLISM; MULTIDRUG RESISTANCE; PHYSIOLOGY;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; RNA VIRUSES; RODENTIA;

ANIMALS; ANTI-HIV AGENTS; CALCIUM; CELL LINE; CHO CELLS; CRICETINAE; DRUG RESISTANCE, MULTIPLE; HETEROCYCLIC COMPOUNDS; HIV-1; HUMANS; MACROPHAGE INFLAMMATORY PROTEIN-1; MOLECULAR WEIGHT; PIPERAZINES; RECEPTORS, CCR5; VIRUS REPLICATION;

EID: 0035860744     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M105670200     Document Type: Article

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