Enhancement of the T140-based pharmacophores leads to the development of more potent and bio-stable CXCR4 antagonists

Organic and Biomolecular Chemistry

Volumn 1, Issue 21, 2003, Pages 3663-3669

  Tamamura, Hirokazu ^a   Hiramatsu, Kenichi ^a   Mizumoto, Makiko ^a   Ueda, Satoshi ^a   Kusano, Shuichi ^b   Terakubo, Shigemi ^b   Akamatsu, Miki ^a   Yamamoto, Naoki ^c   Trent, John O ^d   Wang, Zixuan ^e   Peiper, Stephen C ^e   Nakashima, Hideki ^b   Otaka, Akira ^a   Fujii, Nobutaka ^a  

^a KYOTO UNIVERSITY   (Japan)

^b ST MARIANNA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^d UNIVERSITY OF LOUISVILLE   (United States)

^e MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; BIODEGRADATION; CHEMICAL MODIFICATION; DERIVATIVES; ORGANIC ACIDS; STRAIN; STRUCTURE (COMPOSITION); SUBSTITUTION REACTIONS;

ALKYL AMIDATION; ANTAGONISTIC PEPTIDE; BIOSTABILITY; PHARMACOPHORES;

BIOLOGICAL MATERIALS;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

CHEMOKINE RECEPTOR CXCR4; OLIGOPEPTIDE; T 140;

ARTICLE; CHEMISTRY; CIRCULAR DICHROISM; DRUG ANTAGONISM; ELECTROSPRAY MASS SPECTROMETRY; PROTEIN CONFORMATION;

CIRCULAR DICHROISM; OLIGOPEPTIDES; PROTEIN CONFORMATION; RECEPTORS, CXCR4; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 0345412742     PISSN: 14770520     EISSN: None     Source Type: Journal    
DOI: 10.1039/b306613b     Document Type: Article

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