AMD3465, a monomacrocyclic CXCR4 antagonist and potent HIV entry inhibitor

Biochemical Pharmacology

Volumn 70, Issue 5, 2005, Pages 752-761

  Hatse, Sigrid ^a   Princen, Katrien ^a   De Clercq, Erik ^a   Rosenkilde, Mette M ^b   Schwartz, Thue W ^b   Hernandez Abad, Pedro E ^c   Skerlj, Renato T ^d   Bridger, Gary J ^d   Schols, Dominique ^a  

^a REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c Johnson Matthey Pharmaceutical Res   (United States)

^d GENZYME CORPORATION   (United States)

Author keywords

Calcium signaling; Chemokine binding; Chemotaxis; CXCR4 antagonist; HIV entry; MAP kinase

Indexed keywords

1,1' [1,4 PHENYLENEBIS(METHYLENE)]BIS(1,4,8,11 TETRAAZACYCLOTETRADECANE); AMD 3465; ANTIVIRUS AGENT; CHEMOKINE RECEPTOR ANTAGONIST; CHEMOKINE RECEPTOR CCR5; MACROCYCLIC COMPOUND; MITOGEN ACTIVATED PROTEIN KINASE; N [1,4,8,11 TETRAAZACYCLOTETRADECANYL 1,4 PHENYLENEBIS(METHYLENE)] 2 (AMINOMETHYL)PYRIDINE; STROMAL CELL DERIVED FACTOR 1; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CALCIUM SIGNALING; CELL ADHESION; CELL SURFACE; CHEMOTAXIS; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG BIOAVAILABILITY; DRUG EFFICACY; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; ENDOCYTOSIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; IC 50; INHIBITION KINETICS; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PHOSPHORYLATION; RECEPTOR BINDING; STRUCTURE ACTIVITY RELATION; VIRUS ADSORPTION; VIRUS REPLICATION;

ANTI-HIV AGENTS; CELL LINE; CELL MOVEMENT; CHEMOKINES, CXC; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PYRIDINES; RECEPTORS, CXCR4; SIGNAL TRANSDUCTION;

EID: 23044456806     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2005.05.035     Document Type: Article

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