Recent advances in understanding the molecular mechanisms of HIV-1 entry and fusion: Revisiting current targets and considering new options for therapeutic intervention

Current HIV Research

Volumn 2, Issue 3, 2004, Pages 223-234

  Markovic, Ingrid ^a   Clouse, Kathleen A ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

Antiviral therapy; CCR5; CD4; Conformational restructuring; CXCR4; Envelope glycoprotein; HIV 1 pathogenesis; Membrane fusion; Thiol disulfide exchange; Viral entry

Indexed keywords

1,1' [1,4 PHENYLENEBIS(METHYLENE)]BIS(1,4,8,11 TETRAAZACYCLOTETRADECANE); ANTIRETROVIRUS AGENT; BACITRACIN; CD4 ANTIGEN; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR4; CORE PROTEIN; DISULFIDE; ENFUVIRTIDE; FUSEON; GLYCOPROTEIN GP 120; HUMAN IMMUNODEFICIENCY VIRUS FUSION INHIBITOR; LIGAND; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 2F5; MONOCLONAL ANTIBODY 2G12; MONOCLONAL ANTIBODY 4E10; MONOCLONAL ANTIBODY 5A8; N [4 [[[6,7 DIHYDRO 2 (4 METHYLPHENYL) 5H BENZOCYCLOHEPTEN 8 YL]CARBONYL]AMINO]BENZYL] N,N DIMETHYL 2H TETRAHYDROPYRAN 4 AMINIUM CHLORIDE; OXIDOREDUCTASE; OXIDOREDUCTASE INHIBITOR; PRO 140; PROTEIN DISULFIDE ISOMERASE; PROTEINASE INHIBITOR; RNA DIRECTED DNA POLYMERASE INHIBITOR; SOLUBLE CD4 ANTIGEN; T 1249; T 140; THIOL DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VIRUS ENVELOPE PROTEIN;

CELL MEMBRANE; CLINICAL TRIAL; DRUG POTENTIATION; DRUG RECEPTOR BINDING; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MOLECULAR DYNAMICS; NONHUMAN; OXIDATION REDUCTION STATE; PROTEIN CONFORMATION; PROTEIN PROTEIN INTERACTION; REVIEW; SIDE EFFECT; VIRION; VIRUS ADSORPTION; VIRUS ENVELOPE; VIRUS PATHOGENESIS;

ANTIBODIES, MONOCLONAL; ANTIBODIES, VIRAL; CELL MEMBRANE; HIV ENVELOPE PROTEIN GP120; HIV ENVELOPE PROTEIN GP41; HIV FUSION INHIBITORS; HIV INFECTIONS; HIV-1; HUMANS; MEMBRANE FUSION; PROTEIN CONFORMATION; PROTEIN DISULFIDE REDUCTASE (GLUTATHIONE); RECEPTORS, HIV;

EID: 3042794175     PISSN: 1570162X     EISSN: None     Source Type: Journal    
DOI: 10.2174/1570162043351327     Document Type: Review

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